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| 1 | TRIM29 prevents hepatocellular carcinoma progression by inhibiting Wnt/β-catenin signaling pathway显示文摘TRIM29 plays an important role in many neoplasms.In this study,we aimed to elucidate its role in hepatocellular carcinoma (HCC) and explore the corresponding potential mechanism.The expression level of TRIM29 in HCC samples and hepatoma cell lines was detected.We found that TRIM29 was down-regulated in clinical HCC samples and cultured hepatoma cell lines by western blot analysis and quantitative polymerase chain reaction.In addition,we demonstrated that higher TRIM29 expression was associated with higher differentiation grade of HCC.To explore the effect of TRIM29 on hepatoma cells and its possible mechanisms,TRIM29-knockdown and overexpression cell models were constructed.The results showed that the depletion of TRIM29 promoted liver cancer cell proliferation,clone formation,migration and invasion in vitro probably through the Wnt/β-catenin signaling pathway.This study revealed the inhibitory roles of TRIM29 in HCC and the possible mechanisms. | Mingxing Xu Jingxiong Hu Boxuan Zhou Yuesi Zhong Nan Lin Ruiyun Xu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 9 |
| 2 | De novo synthesis of bifunctional conjugated microporous polymers for synergistic coordination mediated uranium entrapment显示文摘This work reports a de novo synthesis of novel bifunctional conjugated microporous polymers(CMPs)exhibiting a synergistic-effect involved coordination behavior to uranium.It is highlighted that the synthetic strategy enables the engineering of the coordination environment within amidoxime functionalized CMP frameworks by specifically introducing ortho-substituted amino functionalities,enhancing the affinity to uranyl ions via forming synergistic complexes.The CMPs exhibit high Brunauer-Emmett-Teller(BET)surface area,well-developed three-dimensional(3D)networks with hierarchical porosity,and favorable chemical and thermal stability because of the covalently cross-linked structure.Compared with the amino-free counterparts,the adsorption capacity of bifunctional CMPs was increased by almost 70%,from 105 to 174 mg/g,indicating evidently enhanced binding ability to uranium.Moreover,new insights into coordination mechanism were obtained by in-depth X-ray photoelectron spectroscopy(XPS)analysis and density functional theory(DFT)calculation,suggesting a dominant role of the oxime ligands forming a 1:1 metal ions/ligands(M/L)coordination model with uranyl ions while demonstrating the synergistic engagement of the amino functionalities via direct binding to uranium center and hydrogen-bonding involved secondary-sphere interaction.This work sheds light on the underlying principles of ortho-substituted functionalities directed synergistic effect to promote the coordination of amidoxime with uranyl ions.And the synthetic strategy established here would enable the task-specific development of more novel CMP-based functional materials for broadened applications. | Boxuan Yu Lei Zhang Gang Ye Qingzhi Liu Jiongli Li Xudong Wang Jing Chen Shengming Xu Shengqian Ma | 2021 | Nano Research2021，14，3： | 2 |
| 3 | Integrated prodrug micelles with two-photon bioimaging and pH-triggered drug delivery for cancer theranostics显示文摘Nanodrug carriers with fluorescence radiation are widely used in cancer diagnosis and therapy due to their real-time imaging,less side effect,better drug utilization as well as the good bioimaging ability.However,traditional nanocarriers still suffer from unexpectable drug leakage,unsatisfactory tumor-targeted drug delivery and shallow imaging depth,which limit their further application in cancer theranostics.In this study,an integrated nanoplatform is constructed by polymeric prodrug micelles with two-photon and aggregation-induced emission bioimaging,charge reversal and drug delivery triggered by acidic pH.The prodrug micelles can be self-assembled by the TPPEI(DA/DOX)-PEG prodrug polymer,which consists of the two-photon fluorophore(TP),dimethylmaleic anhydride(DA)grafted polyethyleneimine(PEI)and polyethylene glycol(PEG).The PEG segment,DOX and DA are bridged to polymer by acid cleavable bonds,which provides the micelles a‘stealth’property and a satisfactory stability during blood circulation,while the outside PEG segment is abandoned along with the DA protection in the tumor acidic microenvironment,thus leading to charge reversal-mediated accelerated endocytosis and tumor-targeted drug delivery.The great antitumor efficacy and reduced side effect of these pH-sensitive prodrug micelles are confirmed by antitumor assays in vitro and in vivo.Meanwhile,these micelles exhibited great deep-tissue two-photon bioimaging ability up to 150 lm in depth.The great antitumor efficacy,reduced side effect and deep two-photon tissue imaging make the TP-PEI(DA/DOX)-PEG prodrug micelles would be an efficient strategy for theranostic nanoplatform in cancer treatment. | Hong Xu Boxuan Ma Jizhou Jiang Sutong Xiao Rongrong Peng Weihua Zhuang Gaocan Li Yunbing Wang | 2020 | Regenerative Biomaterials2020，7，2： | 1 |
| 4 | Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents显示文摘 | MA Junjie HU Gang XIE Lijun CHEN Lei XU Boxuan GONG Ping | 2015 | Chemical Research in Chinese Universities2015，31，6： | 1 |
| 5 | Design, Synthesis, Biological Activity and Molecular Docking Study of Coumarin Derivatives Bearing 2-MethyIbiphenyl Moiety显示文摘A hybrid pharmacophore approach was used to design and synthesize a series of coumarin derivatives bearing 2-methylbiphenyl moiety, which were evaluated for their in vitro anticancer activities against four cancer cell lines(MCF-75 A549, H460 and HT29) and PD-1/PD-L1 inhibitory activities. Moreover, several compounds with excellent anticancer activities were selected to evaluate the cytotoxicities against one normal cell line(HEK-293). The most promising compound llo showed the best anticancer activities against the four tested cancer cell lines with the IC50 values of 6.45, 8.65, 6,57 and 8.13 gmol/L, respectively, and displayed weak cytotoxicity on the normal cell(HEK-293). Furthermore, screening of PD-1 /PD-L1 inhibitory activity revealed that compound llo could effectively inhibit the binding of PD-1/PD-L1, and the binding interactions of compound llo with PD-L1 protein were explored by molecular docking. All above evidences showed that compound llo might be worthy of further study as a valuable leading compound for the treatment of cancer. | MA Junjie HUANG Kun NI Xin CHEN Roufen XU Boxuan WANG Cuifang | 2019 | Chemical Research in Chinese Universities2019，35，3： | 0 |
| 6 | Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety显示文摘 | XU Boxuan DING Xiudong WU Yachuang CUI Lei QIAN Ping WANG Di ZHAO Yanfang | 2018 | Chemical Research in Chinese Universities2018，34，1： | 0 |
| 7 | PSHCAR: A Position-Irrelevant Scene-Aware Human Complex Activities Recognizing Algorithm on Mobile Phones显示文摘 | Boxuan Jia Jinbao Li Hui Xu | 2018 | 国际计算机前沿大会会议论文集2018，，1： | 0 |
| 8 | Natural Language Inference Using Evidence from Knowledge Graphs显示文摘Knowledge plays an essential role in inference,but is less explored by previous works in the Natural Language Inference(NLI)task.Although traditional neural models obtained impressive performance on standard benchmarks,they often encounter performance degradation when being applied to knowledge-intensive domains like medicine and science.To address this problem and further fill the knowledge gap,we present a simple Evidence-Based Inference Model(EBIM)to integrate clues collected from knowledge graphs as evidence for inference.To effectively incorporate the knowledge,we propose an efficient approach to retrieve paths in knowledge graphs as clues and then prune them to avoid involving too much irrelevant noise.In addition,we design a specialized CNN-based encoder according to the structure of clues to better model them.Experiments show that the proposed encoder outperforms strong baselines,and our EBIM model outperforms other knowledge-based approaches on the SciTail benchmark and establishes a new state-of-the-art performance on the MedNLI dataset. | Boxuan Jia Hui Xu Maosheng Guo | 2021 | 国际计算机前沿大会会议论文集2021，，2： | 0 |
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