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| 1 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 2 | De novo synthesis of bifunctional conjugated microporous polymers for synergistic coordination mediated uranium entrapment显示文摘This work reports a de novo synthesis of novel bifunctional conjugated microporous polymers(CMPs)exhibiting a synergistic-effect involved coordination behavior to uranium.It is highlighted that the synthetic strategy enables the engineering of the coordination environment within amidoxime functionalized CMP frameworks by specifically introducing ortho-substituted amino functionalities,enhancing the affinity to uranyl ions via forming synergistic complexes.The CMPs exhibit high Brunauer-Emmett-Teller(BET)surface area,well-developed three-dimensional(3D)networks with hierarchical porosity,and favorable chemical and thermal stability because of the covalently cross-linked structure.Compared with the amino-free counterparts,the adsorption capacity of bifunctional CMPs was increased by almost 70%,from 105 to 174 mg/g,indicating evidently enhanced binding ability to uranium.Moreover,new insights into coordination mechanism were obtained by in-depth X-ray photoelectron spectroscopy(XPS)analysis and density functional theory(DFT)calculation,suggesting a dominant role of the oxime ligands forming a 1:1 metal ions/ligands(M/L)coordination model with uranyl ions while demonstrating the synergistic engagement of the amino functionalities via direct binding to uranium center and hydrogen-bonding involved secondary-sphere interaction.This work sheds light on the underlying principles of ortho-substituted functionalities directed synergistic effect to promote the coordination of amidoxime with uranyl ions.And the synthetic strategy established here would enable the task-specific development of more novel CMP-based functional materials for broadened applications. | Boxuan Yu Lei Zhang Gang Ye Qingzhi Liu Jiongli Li Xudong Wang Jing Chen Shengming Xu Shengqian Ma | 2021 | Nano Research2021，14，3： | 2 |
| 3 | A fully absorbable biomimetic polymeric micelle loaded with cisplatin as drug carrier for cancer therapy显示文摘cis-dichlorodiammineplatinum(II)(CDDP)-loaded polymeric micelles for cancer therapy have been developed to reduce the serious side effects of cisplatin CDDP.Herein,polymeric micelles incorporated with cisplatin are prepared based on the complexation between CDDP and hydrophilic poly(L-glutamic acid)-b-poly(2-methacryloyloxyethyl phosphorylcholine)(PLG-b-PMPC)diblock copolymers.These CDDP-loaded micelles possess an average size of 91nm with narrow distribution,providing remarkable stability in media containing proteins.The release of CDDP from the micelles is faster at pH 5.0 and pH 6.0 than that at pH 7.4 and in a sustained manner without initial burst release.In addition,there is almost no difference in cellular uptake between these CDDP-loaded micelles and free CDDP.Moreover,in vitro cytotoxicity test shows they possess high efficacy to kill 4T1 cells as compared with free drug.Thus,PLG-b-PMPC copolymer might be a promising carrier for CDDP incorporating in cancer therapy. | Weihua Zhuang Boxuan Ma Gongyan Liu Xiaobing Chen Yunbing Wang | 2018 | Regenerative Biomaterials2018，5，1： | 1 |
| 4 | A biomimetic and pH-sensitive polymeric micelle as carrier for paclitaxel delivery显示文摘As nano-scale drug delivery systems,smart micelles that are sensitive to specific biological environment and allowed for target site-triggered drug release by reversible stabilization of micelle structure are attractive.In this work,a biocompatible and pH-sensitive copolymer is synthesized through bridging poly(2-methacryloyloxyethyl phosphorylcholine)(PMPC)block and poly(D,L-lactide)(PLA)block by a benzoyl imine linkage(Blink).Biomimetic micelles with excellent biocompatibility based on such PLA-Blink-PMPC copolymer are prepared as carriers for paclitaxel(PTX)delivery.Due to the rapid breakage of the benzoyl imine linkage under acidic condition,the micelle structure is disrupted with accelerated PTX release.Such pH-sensitive triggered drug release behavior in synchronization with acidic conditions at tumor site is helpful for improving the utilization of drug and facilitating antitumor efficacy.These micelles can be used as promising drug delivery systems due to their biocompatible and smart properties. | Boxuan Ma Weihua Zhuang Gongyan Liu Yunbing Wang | 2018 | Regenerative Biomaterials2018，5，1： | 1 |
| 5 | Revealing nonclassicality via s-ordered phase-space distribution显示文摘Nonclassical states play a crucial role in both theoretical and experimental investigations of quantum optics, and there is a wide interest in characterization and quantification of nonclassicality. By exploiting the freedom of the parameter s in the s-ordered phase-space distribution introduced by Cahill and Glauber [Phys. Rev. 177, 1882(1969)], we develop a method to reveal and quantify optical nonclassicality via the divided difference of the s-ordered phase-space distribution. Our approach yields naturally a family of quantifiers of optical nonclassicality, which have many desirable properties such as convexity and monotonicity under the Gaussian noise channels. The quantifiers are illustrated by evaluating nonclassicality of several typical states. Two simple and convenient criteria for nonclassicality are established, which in particular certify all nonclassical Gaussian states. | Yue Zhang Shuheng Liu Boxuan Jing Qiongyi He Shunlong Luo | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，11： | 0 |
| 6 | Advances in bismuth-telluride-based thermoelectric devices: Progress and challenges显示文摘By effectively converting waste heat into electricity,thermoelectric materials and devices can provide an alternative approach to tackle the energy crisis.Amongst thermoelectric materials,bismuth telluride(Bi_(2)Te_(3))and its derivatives exhibit high figure of merit ZT values in the near-room-temperature region and show great potential for application in thermoelectric devices.Considering the rapid development of Bi_(2)Te_(3)-based thermoelectric materials and their devices in the last few years,a short and systematic review is much needed.Here,we sum-marize the novel designs,properties,and applications of Bi_(2)Te_(3)-based thermoelectric devices in different contexts,including wearable,portable,implantable,and cross-disciplinary applications.The challenges and outlook for Bi_(2)Te_(3)-based thermoelectric devices are also considered.This work will guide the future development of Bi_(2)Te_(3)-based thermoelectric devices that target broader and more practical applications. | Tianyi Cao Xiao-Lei Shi Meng Li Boxuan Hu Wenyi Chen Wei-Di Liu Wanyu Lyu Jennifer MacLeod Zhi-Gang Chen | 2023 | eScience2023，3，3： | 0 |
| 7 | Genomic Shift in Population Dynamics of mcr-1-positive Escherichia coli in Human Carriage显示文摘Emergence of the colistin resistance gene,mcr-1,has attracted worldwide attention.Despite the prevalence of mcr-1-positive Escherichia coli(MCRPEC)strains in human carriage showing a significant decrease between 2016 and 2019,genetic differences in MCRPEC strains remain largely unknown.We therefore conducted a comparative genomic study on MCRPEC strains from fecal samples of healthy human subjects in 2016 and 2019.We identified three major differences in MCRPEC strains between these two time points.First,the insertion sequence ISApl1 was often deleted and the percentage of mcr-1-carrying IncI2 plasmids was increased in MCRPEC strains in 2019.Second,the antibiotic resistance genes(ARGs),aac(3)-IVa and blaCTX-M-1,emerged and coexisted with mcr-1 in 2019.Third,MCRPEC strains in 2019 contained more virulence genes,resulting in an increased proportion of extraintestinal pathogenic E.coli(ExPEC)strains(36.1%)in MCRPEC strains in 2019 compared to that in 2016(10.5%),implying that these strains could occupy intestinal ecological niches by competing with other commensal bacteria.Our results suggest that despite the significant reduction in the prevalence of MCRPEC strains in humans from 2016 to 2019,MCRPEC exhibits increased resistance to other clinically important ARGs and contains more virulence genes,which may pose a potential public health threat. | Yingbo Shen Rong Zhang Dongyan Shao Lu Yang Jiayue Lu Congcong Liu Xueyang Wang Junyao Jiang Boxuan Wang Congming Wu Julian Parkhill Yang Wang Timothy R.Walsh George F.Gao Zhangqi Shen | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 0 |
| 8 | Sodium zirconium cyclosilicate pretreatment for formula in vitro reduces potassium intake in infants with chronic kidney disease显示文摘To the Editor:Hyperkalemia is a common life-threatening complication of advanced chronic kidney disease(CKD)in infants.To manage hyperkalemia,dietary potassium intake restrictions is the most convenient,safe,and effective treatment.Kidney Disease Outcomes Quality Initiative(KDOQI)guideline recommends that the general restriction of potassium is 40 to 120 mg·kg^(-1)·day^(-1)for infants and 30 to 40 mg·kg^(-1)·day^(-1)for older children with CKD. | Boxuan Liu Teng Wang Zhi Chen | 2022 | Chinese Medical Journal2022，135，24： | 0 |
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