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| 1 | Burn injury induces histopathological changes and cellproliferation in liver of rats显示文摘AIM: To investigate effects of severe burn injury(BI) in rat liver through the histopathological and inflammatory markers analysis. METHODS: Forty-two male Wistar rats were distributed into two groups, control(C) and subjected to scald BI(SBI). The animals were euthanized one, four and 14 d post sham or 45% of the total body surface BI. Liver fragments were submitted to histopathological, morphoquantitative(hepatocyte area and cell density), ciclooxigenase-2(COX-2) immunoexpression, and gene expression [real-time polymerase chain reaction for tumor necrosis factor(TNF)-α, inducible nitric oxide synthase(i NOS) and caspase-3] methods. RESULTS: Histopathological findings showed inflammatory process in all periods investigated and hepatocyte degeneration added to increased amount of connective tissue 14 d post injury. Hepatocyte area, the density of binucleated hepatocytes and density of sinusoidal cells of SBI groups were increased when compared with control. COX-2 immunoexpression was stronger in SBI groups. No differences were found in TNF-α, i NOS and caspase-3 gene expression. CONCLUSION: BI induces histopathological changes, upregulation of COX-2 immunoexpression, and cell proliferation in liver of rats. | Jeferson Andre Bortolin Hananiah Tardivo Quintana Tabata de Carvalho Tome Flavia Andressa Pidone Ribeiro Daniel Araki Ribeiro Flavia de Oliveira | 2016 | World Journal of Hepatology2016，8，6： | 4 |
| 2 | Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features显示文摘AIM To investigate the association between 16 insertiondeletions(INDEL) polymorphisms, colorectal cancer(CRC) risk and clinical features in an admixed population.METHODS O n e h u n d re d a n d fo r ty p a t i e n t s w i t h C R C a n d 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on Gene Mapper ID v3.2. Clinicopathological data were obtained by consulting the patients' clinical charts, intra-operative documentation, and pathology scoring.RESULTS Logistic regression analysis showed that polymorphism variations in IL4 gene was associated with increased CRC risk, while TYMS and UCP2 genes were associated with decreased risk. Reference to anatomical localization of tumor Del allele of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. In relation to the INDEL association with tumor node metastasis(TNM) stage risk, the Ins alleles of ACE, HLAG and TP53(6 bp INDEL) were associated with higher TNM stage. Furthermore, regarding INDEL association with relapse risk, the Ins alleles of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del allele of TYMS. Regarding INDEL association with death risk before 10 years, the Ins allele of SGSM3 and UGT1A1 were associated with death risk.CONCLUSION The INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings. | Diego Marques Layse Raynara Ferreira-Costa Lorenna Larissa Ferreira-Costa Romualdo da Silva Correa Aline Maciel Pinheiro Borges Fernanda Ribeiro Ito Carlos Cesar de Oliveira Ramos Raul Hernandes Bortolin André Ducati Luchessi Andrea Ribeiro-dos-Santos Sidney Santos Vivian Nogueira Silbiger | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 3 | Burn Injury Induces Skeletal Muscle Degeneration, Inflammatory Host Response, and Oxidative Stress in Wistar Rats显示文摘 | Nathalia Trasmonte da Silva Hananiah Tardivo Quintana Jeferson André Bortolin Daniel Araki Ribeiro Flavia de Oliveira | 2015 | Journal of Burn Care & Research2015，，3： | 2 |
| 4 | Effects of prenatal steroids in the development of necrotizing enterocolitis in Wistar rat neonates 显示文摘 | Bortolin L Boer M Christiansen S | 2011 | Arch Argent Pediatr2011，109，1： | 1 |
| 5 | Combination of PI3K/mTOR inhibitors: antitumor activity and molecular correlates 显示文摘 | Mazzoletti M Bortolin F Brunelli L | 2011 | Cancer Res2011，71，13： | 1 |
| 6 | Condensation in a square minichannel: application of the VOF method 显示文摘 | Bortolin S Da Riva E Del Col D | 2014 | Heat Transfer Engineering2014，35，2： | 1 |
| 7 | Analytical validation of the tag-it high-throughput microspherc-based universal array genotyping platform: application to the multiplex detection of a panel of thrombophilia-associated single-nucleotide polymorphisms显示文摘 | Susan Bortolin Margot Black Hemanshu Modi | 2004 | Clinical Chemistry2004，50，11： | 1 |
| 8 | Is platelet concentrate advantageous for the surgical treatment of periodontal disease? A systematic review and meta-analysis 显示文摘 | Del Fabbro M Bortolin M Taschieri S | 2011 | J Periodontol2011，82，8： | 1 |
| 9 | PSL study of irradiated food: NaC1 as possible reference material显示文摘 | Fuochi P G Alberti A Bortolin E | 2008 | Radiation Measurements2008，43，26： | 1 |
| 10 | Analytical validation of the tag-it high-throughput microsphere-based universal array genotyping platform: application to the multiplex detection of a panel of thrombophilia-associated single-nucleotide polymorphisms显示文摘 | Bortolin S M Black H Mod | 2004 | Clin Chem2004，50，： | 1 |
| 11 | Analytical validation of the tag-it high-throughput microsphere-based universal array genotyping platform: application to the multiplex detection of a panel of thrombophilia associated singlenucleotide polymorphisms 显示文摘 | Bortolin S Black M Modi H | 2004 | Clin Chem2004，50，11： | 1 |
| 12 | A large imprinted microRNA gene cluster at the mouse DLK1-GtI2 domain 显示文摘 | Seitz H Royo H Bortolin ML | 2004 | Genome Res2004，14，： | 1 |
| 13 | Analytical validation of the tagit high- throughput microsphere-based universal array genotyping platform:application to the multiplex detection of a panel of thrombophilia- associated single-nucleotide polymorphisms显示文摘 | Bortolin S Black M Modi H | 2004 | Clin Chem2004，50，11： | 1 |
| 14 | Site - specific pseudouridine formation in preribosomal RNA is guided by small nueleolar RNAs 显示文摘 | Ganot P Bortolin M L Kiss T | 1997 | Cell1997，89，： | 1 |
| 15 | A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain显示文摘 | Seitz H Royo H Bortolin M L | 2004 | Genome Res2004，14，9： | 1 |
| 16 | Condensation ina square minichannel: Application of the VOF method显示文摘 | BORTOLIN S RIVA E D COL 13 D | 2014 | Heat Transfer Engineering2014，，2： | 1 |
| 17 | Drowning显示文摘 | Schilling UM Bortolin M | 2012 | Minerva anestesiol2012，78，1： | 1 |
| 18 | A large imprinted microRNA gene cluster at the mouse Dlkl-Gtl2 domain 显示文摘 | Seitz H Royo H Bortolin ML | 2004 | Genome Res2004，14，9： | 1 |
| 19 | Analytical validation of the tag-it high-throughput microsphere-based universal array genotyping platform: application to the multiplex detection of a panel of thrombophilia-associated single-nucleotide polymorphisms 显示文摘 | Bortolin S Black M Modi H Boszko I Kobler D Fieldhouse D Lopes E Lacroix JM Grimwood R Wells P Janeczko R Zastawny R | 2004 | Clin Chem2004，50，11： | 1 |
| 20 | A Urge imprinted microRNA gene cluster at the mouse Dlkl-Gt12 domain显示文摘 | Seitz H Royo H Bortolin ML | 2004 | Genome Res2004，14，9： | 1 |
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