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| 1 | Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression显示文摘Dear Editor,F0XA1,a forkhead(FKHD)family transcription factor,is highly expressed in the epithelium of endoderm-derived organs, including the prostate gland.1 Transgenic mouse studies have shown that F0XA1 expression is required for prostate epithelial cell differentiation and ductal morphogenesis during development and for the maintenance of this differentiated epithelial phenotype in the adult. Mechanistically, F0XA1 binds FKHD motifs in the DNA to open chromatin and in crease local accessibility. | Bohan Xu Bing Song Xiaodong Lu Jung Kim Ming Hu Jonathan C.Zhao Jindan Yu | 2019 | Cell Research2019，29，9： | 4 |
| 2 | Antitumor effects of Endostar on non-Hodgkin's lymphoma by regulating endothelial progenitor cells through protein kinase B-dependent pathway显示文摘Endothelial 祖先房间(EPC ) 在 non-Hodgkin 的淋巴瘤(NHL ) 起一个重要作用开发。Endostar 是设计由废弃停止癌症的 anti-angiogenic 药一个肿瘤获得氧和营养素的能力。在这研究,分别地,我们在 vitro 并且在 vivo 在 NHL 房间线和 NHL 的鼠科的异种皮移植模型上检验了 Endostar 的 anti-angiogenic 活动并且探索了 Endostar 的内在的 antiangiogenic 机制。结果证明 Endostar 可以由减少 p 蛋白质 kinase B,然而并非津贴表示的表示禁止 EPC 增长。我们发现能在 NHL 上导致 Endostar 的效果的更好的理解。 | Dandan Yu Hongge Wu Bohan Yang Kunyu Yang Hongli Liu Gang Wu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 2 |
| 3 | A silk-based self-adaptive flexible opto-electro neural probe显示文摘The combination of optogenetics and electrophysiological recording enables high-precision bidirectional interactions between neural interfaces and neural circuits,which provides a promising approach for the study of progressive neurophysiological phenomena.Opto-electrophysiological neural probes with sufficient flexibility and biocompatibility are desirable to match the low mechanical stiffness of brain tissue for chronic reliable performance.However,lack of rigidity poses challenges for the accurate implantation of flexible neural probes with less invasiveness.Herein,we report a hybrid probe(Silk-Optrode)consisting of a silk protein optical fiber and multiple flexible microelectrode arrays.The Silk-Optrode can be accurately inserted into the brain and perform synchronized optogenetic stimulation and multichannel recording in freely behaving animals.Silk plays an important role due to its high transparency,excellent biocompatibility,and mechanical controllability.Through the hydration of the silk optical fiber,the Silk-Optrode probe enables itself to actively adapt to the environment after implantation and reduce its own mechanical stiffness to implant into the brain with high fidelity while maintaining mechanical compliance with the surrounding tissue.The probes with 128 recording channels can detect high-yield well-isolated single units while performing intracranial light stimulation with low optical losses,surpassing previous work of a similar type.Two months of post-surgery results suggested that as-reported Silk-Optrode probes exhibit better implant-neural interfaces with less immunoreactive glial responses and tissue lesions. | Yu Zhou Chi Gu Jizhi Liang Bohan Zhang Huiran Yang Zhitao Zhou Meng Li Liuyang Sun Tiger H.Tao Xiaoling Wei | 2022 | Microsystems & Nanoengineering2022，8，6： | 1 |
| 4 | Effect of concentrated growth factors on beagle periodontal ligamentstem cells in vitro显示文摘 | Bohan Yu Zuolin Wang | 2014 | Molecular Medicine Reports2014，，1： | 1 |
| 5 | Rationally designed Fe-MCM-41 by protein size to enhance lipase immobiliza- tion, catalytic efficiency and performance 显示文摘 | Lin Jiafu Zhao Bohan Cao Yu | 2014 | Appl Catal A: General2014，478，： | 1 |
| 6 | C-Band 53.76 Tbit/s Transmission Based on Bit Allocation Optimization with Raman Amplification显示文摘We experimentally demonstrate an 80-channel wavelength division multiplexing(WDM)transmission system over a 400 km fiber link.Raman amplification results in a non-flat WDM signal spectrum.Therefore,bit allocation optimization is used to enable different channels to carry different order quadrature amplitude modulation signals according to their optical signal-noise-ratios.A neural network equalizer based on a convolutional neural network(CNN),long shortterm memory(LSTM)network,and fully connected(FC)layer structure is adopted in Rx digital signal processing,in which CNN is used for characteristic extraction,LSTM is used for equalization and demodulation,and FC layers are used for output.After transmission,the bit error rate of all channels is below the 25%soft-decision forward error correction threshold,and the line rate reaches 53.76 Tbit/s. | Ding Junjie Wang Chen Ju Zhou Zhu Bowen Sang Bohan Liu Bo Yu Jianjun | 2023 | 激光与光电子学进展2023，60，7： | 0 |
| 7 | New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine显示文摘Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly recognized.Chemokine interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes,including host homeostasis and responses to disease.Genetic and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional heterogeneity.Imbalances and defects in the system contribute to the pathogenesis of a variety of diseases,including cancer,immune and inflammatory diseases,and metabolic and neurological disorders,which render the system a focus of studies aiming to discover therapies and important biomarkers.The integrated view of chemokine biology underpinning divergence and plasticity has provided insights into immune dysfunction in disease states,including,among others,coronavirus disease 2019(COVID-19).In this review,by reporting the latest advances in chemokine biology and results fromanalyses of a plethora of sequencing-based datasets,we outline recent advances in the understanding of the genetic variations and nongenetic heterogeneity of chemokines and receptors and provide an updated view of their contribution to the pathophysiological network,focusing on chemokine-mediated inflammation and cancer.Clarification of the molecular basis of dynamic chemokine-receptor interactions will help advance the understanding of chemokine biology to achieve precision medicine application in the clinic. | Hanli Xu Shuye Lin Ziyun Zhou Duoduo Li Xiting Zhang Muhan Yu Ruoyi Zhao Yiheng Wang Junru Qian Xinyi Li Bohan Li Chuhan Wei Keqiang Chen Teizo Yoshimura Ji Ming Wang Jiaqiang Huang | 2023 | Cellular & Molecular Immunology2023，20，7： | 0 |
| 8 | In vivo bioorthogonal labeling of rare-earth doped nanoparticles for improved NIR-II tumor imaging by extracellular vesiclemediated targeting显示文摘The development of efficient contrast agents for tumor-targeted imaging remains a critical challenge in the clinic.Herein,we proposed a tumor-derived extracellular vesicle(EV)-mediated targeting approach to improve in vivo tumor imaging using ternary downconversion nanoparticles(DCNPs)with strong near infrared II(NIR-II)luminescence at 1,525 nm.The EVs were metabolically engineered with azide group,followed by in vivo labeling of DCNPs through copper-free click chemistry.By taking advantage of the homologous targeting property of tumor derived EVs,remarkable improvement in the tumor accumulation(6.5%injection dose(ID)/g)was achieved in the subcutaneous colorectal cancer model when compared to that of individual DCNPs via passive targeting(1.1%ID/g).Importantly,such bioorthogonal labeling significantly increased NIR-II luminescence signals and prolonged the retention at tumor sites.Our work demonstrates the great potential of EVs-mediated bioorthogonal approach for in vivo labeling of NIR-II optical probes,which provides a robust tool for tumor-specific imaging and targeted therapy. | Hui Li Yanfeng Zhong Shumin Wang Menglei Zha Wenxing Gu Guoyong Liu Bohan Wang Zhendong Yu Yu Wang Kai Li Yuxin Yin Jing Mu Xiaoyuan Chen | 2023 | Nano Research2023，16，2： | 0 |
| 9 | g-C_(3)N_(4) templated mesoporous carbon with abundant heteroatoms as high-rate anode material for dual-carbon sodium ion hybrid capacitors显示文摘Sodium ion hybrid capacitors(SIHCs)are regarded as advanced power supply systems.Nevertheless,the kinetics imbalance of cathode and anode suppresses the further performance improvement of SIHCs.The carbonaceous anode materials are promising and many strategies have been utilized to increase the capacity of sloping region or accelerate the reaction rate of plateau region.However,it is still challenging to simultaneously realize high mesopore/micropore volume ratio,large interlayer distance(>0.37 nm),and abundant and favorable heteroatoms-doping by a simple method.Herein,we report N,P,O ternarydoped mesoporous carbon(PNPOC-T,T=700,800 or 900)with large interlayer distance(~0.4 nm)as anode materials.The PNPOC-T were prepared by a simple in-situ polymerization of aniline and phytic acid on the exfoliated graphitic nitrogen carbide(g-C3N4)and subsequent carbonization.The obtained PNPOC-800 exhibits an excellent rate performance(101.5 mA·h·g^(-1) at 20 A·g^(-1)),which can be attributed to the high surface-controlled capacitive behavior ratio and rapid ion diffusion.The optimum SIHCs display a high energy density of 105.48 W·h·kg^(-1) and a high power density of 13.59 kW$kg1.Furthermore,the capacitance retention rate of SIHCs can reach 87.43%after 9000 cycles at 1 A·g^(-1). | Chong Wang Qingtao Yu Ning Zhao Bohan Li Wanci Shen Feiyu Kang Zheng-Hong Huang Ruitao Lv | 2022 | Journal of Materiomics2022，8，6： | 0 |
| 10 | An ultralight geometry processing library for parallel mesh refinement显示文摘In applications such as parallel mesh refinement,it remains a challenging issue to ensure the refined surface respects the original Computer-Aided Design(CAD)model accurately.In this paper,an ultralight geometry processing library is developed to resolve this issue effectively and efficiently.Here,we say the kernel is ultralight because it has a very small set of data-structures and algorithms by comparison with industrial-level geometry kernels.Within the library,a simplified surface boundary representation(B-rep)and a radial edge structure are developed respectively to depict the geometry model and the surface mesh,plus hash tables that record the connections between the geometry model and the surface mesh.Based on these data structures,a set of efficient algorithms are developed,which initializes the connection tables,projects a point back to the original geometry,etc.With these data-structure and algorithmic infrastructures set up,the callings of eight well-designed Application Programming Interfaces(APIs)are powerful enough to enable the parallel mesh refinement algorithm outputs a mesh respecting the input CAD model accurately.Numerical experiments will be finally presented to evaluate the performance of the overall parallel mesh refinement algorithm and the algorithms in relation with the developed library. | Bohan Wang Bo Chen Kaixin Yu Lijun Xie Jianjun Chen | 2022 | Advances in Aerodynamics2022，4，1： | 0 |
| 11 | Nutritional value of domesticated duckweed variety DW2602 and its feeding effects on the growth performance and digestive activities of tilapia fingerlings显示文摘Duckweed are a family of fast-growing aquatic plants,in which wild plants of many species have been tested in animal feed.We domesticated a duckweed variety,Spirodela polyrhiza DW2602,which had 44.5%protein and 2.6% lysine and was grown on a large scale.The effects of DW2602 on the growth performance and the digestive enzyme activities of tilapia variety GIFT(Genetic Improvement of Farmed Tilapia,Oreochromis niloticus)fingerlings were evaluated.The dry powder of DW2602 was added to conventional tilapia feed at six inclusion levels of 0%,10%,15%,20%,25%,and 30%.The diets were fed to tilapia fingerlings with an initial weight of 2.0±0.15 g for 60 d.Results showed that DW2602 improved the growth performance and digestive enzyme activities significantly.The feeding effect was the best when the inclusion rate was 20%,in which the body weight increased to 37.24±1.21 g in 60 d,18.15%higher than the control(P<0.05).The weight gain rate,the specific growth rate,the condition factor,and the hepatosomatic index of the fish were all significantly higher than the control(P<0.05),and the amylase,protease,and lipase activities in the digestive system were all promoted by DW2602(P<0.05).Therefore,the duckweed variety DW2602 has great application prospect in tilapia culture. | Bingying Han Ting Chen Bohan Yu Yuepan Ren Yuhan Long Deguan Tan Lili Fu Jiaming Zhang | 2022 | Tropical Plants2022，1，1： | 0 |
| 12 | Low-temperature and flexible strategy to in-situ fabricate ZrSiO_(4)-based ceramic composites via doping and tuning solid-state reaction显示文摘Synthetic zircon(ZrSiO_(4))ceramics are typically fabricated at elevated temperatures(over 1500℃),which would lead to high manufacturing cost.Meanwhile,reports about preparing ZrSiO_(4)-based ceramic composites via controlling the solid-state reaction between zirconia(ZrO_(2))and silica(SiO_(2))are limited.In this work,we proposed a low-temperature strategy to flexibly design and fabricate ZrSiO_(4)-based ceramic composites via doping and tuning the solid-state reaction.Two ceramic composites and ZrSiO_(4) ceramics were in-situ prepared by reactive fast hot pressing(FHP)at approximately 1250℃ based on the proposed strategy,i.e.,a ZrSiO_(4)-SiO_(2) dual-phase composite with bicontinuous interpenetrating and hierarchical microstructures,a ZrSiO_(4)-ZrO_(2) dual-phase composite with a microstructure of ZrO_(2) submicron-and nano-particles embedded in a micron ZrSiO_(4) matrix,and ZrSiO_(4) ceramics with a small amount of residual ZrO_(2) nanoparticles.The results showed that the phase compositions,microstructure configurations,mechanical properties,and wear resistance of the materials can be flexibly regulated by the proposed strategy.Hence,ZrSiO_(4)-based ceramic composites with different properties can be easily fabricated based on different application scenarios.These findings would offer useful guidance for researchers to flexibly fabricate ZrSiO_(4)-based ceramic composites at low temperatures and tailor their microstructures and properties through doping and tuning the solid-state reaction. | Bohan Wang Le Fu Junjie Song Wenjun Yu Ying Deng Guofu Xu Jiwu Huang Wei Xia | 2023 | Journal of Advanced Ceramics2023，12，6： | 0 |
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