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| 1 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044s6cn5c6unuocw660x.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 2 | Engineered trimeric ACE2 binds viral spike protein and locks it in'Thfee-up'conformation to potently inhibit SARS-CoV-2 infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in a severe global pandemic Following SARS-CoV,SARS-CoV-2 is yet another emerge nt beta-coronavirus threate ning human health.1 However,seventeen years after the SARS pandemic,no targeted vaccines or therapeutics have been approved for SARS,while some of them might have held promise for treating COVID-19.Many neutralizing antibodies against SARS-CoV-2 are currently being developed.However,RNA viruses are known to have high mutation rates. | Liang Guo Wenwen Bi Xinling Wang Wei Xu Renhong Yan Yuanyuan Zhang Kai Zhao Yaning Li Mingfeng Zhang Xia Cai Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Bobo Dang | 2021 | Cell Research2021，31，1： | 5 |
| 3 | Fine particulate matter(PM_(2.5)/PM_(1.0)) in Beijing,China: Variations and chemical compositions as well as sources显示文摘Particulate matter(i.e.,PM_(1.0) and PM_(2.5)),considered as the key atmospheric pollutants,exerts negative effects on visibility,global climate,and human health by associated chemical compositions.However,our understanding of PM and its chemical compositions in Beijing under the current atmospheric environment is still not complete after witnessing marked alleviation during 2013–2017.Continuous measurements can be crucial for further air quality improvement by better characterizing PM pollution and chemical compositions in Beijing.Here,we conducted simultaneous measurements on PM in Beijing during 2018–2019.Results indicate that annualmean PM_(1.0) and PM_(2.5) concentrations were 35.49±18.61μg/m^(3) and 66.58±60.17μg/m^(3),showing a positive response to emission controls.The contribution of sulfate,nitrate,and ammonium(SNA)played an enhanced role with elevated PM loading and acted as the main contributors to pollution episodes.Discrepancies observed among chemical species between PM_(1.0) and PM_(2.5) in spring suggest that sand particles trend to accumulate in the range of 1–2.5μm.Pollution episodes occurred accompanied with southerly clusters and high formation of SNA by heterogeneous reactions in summer and winter,respectively.Results from positive matrix factorization(PMF)combined with potential source contribution function(PSCF)models showed that potential areas were seasonal dependent,secondary and vehicular sources became much more important compared with previous studies in Beijing.Our study presented a continuous investigation on PM and sources origins in Beijing,which provides a better understanding for further emission control as well as a reference for other cities in developing countries. | Lining Luo Xiaoxuan Bai Shuhan Liu Bobo Wu Wei Liu Yunqian Lv Zhihui Guo Shumin Lin Shuang Zhao Yan Hao Jiming Hao Kai Zhang Aihua Zheng Hezhong Tian | 2022 | Journal of Environmental Sciences2022，34，11： | 3 |
| 4 | Primary pancreatic anaplastic large cell lymphoma, ALK negative: A case report显示文摘We present the fourth case of a primary pancreatic anaplastic large cell lymphoma (ALCL), ALK-. An 80-year-old man was admitted to our clinic for further investigation of a fever of unknown origin. He noted anorexia, weight loss and fatigue. His laboratory tests showed anemia and a great elevation of ESR, LDH, and β2 microglobulin. In CT and MRI scan, a soft tissue mass in the pancreas was observed. A repeated endoscopy after his admission revealed an ulcerated mass-like deformity of the duodenal bulb. Explorative laparotomy confirmed a diffuse spread of an unresectable malignant pancreatic mass extending to the adjacent organs. Duodenal and surgical biopsies identified an ALCL of T-cell lineage, ALK-. The patient died in the Intensive Care Unit due to hemodynamic instability.Our case is the first one indicating that primary pancreatic lymphoma should be suspected in a patient with pancreatic mass and elevated serum LDH and β2 microglobulin. | Christos G Savopoulos NE Tsesmeli GD Kaiafa AT Zantidis MT Bobos AI Hatzitolios ST Papavramidis IS Kostopoulos | 2005 | World Journal of Gastroenterology2005，11，39： | 3 |
| 5 | Q-switched fiber laser based on saturable absorption of ferroferric-oxide nanoparticles显示文摘We demonstrate that ferroferric-oxide(Fe_3O_4) nanoparticles exhibit nonlinear saturable absorption property at1.55 μm, and fabricate two filmy saturable absorbers by embedding the nanoparticles into a polyvinyl alcohol(PVA) film or polyimide(PI) film separately. In the Fe_3O_4-PVA(Fe_3O_4-PI) Q-switched fiber laser, the pulse repetition rate increases from 8.5 kHz(5.5 kHz) to 28 kHz(49 kHz) and the pulse duration decreases from 23.5 μs(47 μs) to 6 μs(3.5 μs) by varying the pump power from 25 m W(23 mW) to 150 m W(650 mW). Experiment results indicate that PI-based saturable absorbers can afford larger powers than PVA-based saturable absorbers, which can be attributed to the higher fusion point of the PI film. The Fe_3O_4-PI saturable absorber exhibits features of high damage threshold, low cost, and good flexibility, which could be applied in fields of near-infrared pulse generation and frequency conversions. | Dong Mao Xiaoqi Cui Wending Zhang Mingkun Li Tianxian Feng Bobo Du Hua Lu Jianlin Zhao | 2017 | Photonics Research2017，5，1： | 3 |
| 6 | An overview on GNSS carrier-phase time transfer research显示文摘Global navigation satellite system(GNSS)carrier phase observations are two orders of higher accuracy than pseudo-range observations,and they are less affected by multipath besides.As a result,the time transfer accuracy can reach 0.1 ns,and the frequency transfer stability can reach 1×10^-15 with carrier phase(CP)method,therefore CP method is considered the most accurate and promising time transfer technology.The focus of this paper is to present a comprehensive summary of CP method,with specific attention directed toward day-boundary clock jump,ambiguity resolution(AR),multi-system time transfer and real-time time transfer.Day-boundary clock jump is essentially caused by pseudo-range noise.Several approaches were proposed to solve the problem,such as continuously processing strategy,sliding batch and bidirectional filtering methods which were compared in this study.Additionally,researches on AR in CP method were introduced.Many scholars attempted to fix the single-difference ambiguities to improve the time transfer result,however,owing to the uncalibrated phase delay(UPD)was not considered,the current studies on AR in CP method were still immature.Moreover,because four GNSS systems could be used for time-transfer currently,which was helpful to increase the accuracy and reliability,the researches on multi-system time transfer were reviewed.What’s more,real-time time transfer attracted more attention nowadays,the preliminary research results were presented. | ZHANG Ming Lü JinHu BAI ZhengDong JIANG ZhiQi CHEN BoBo | 2020 | Science China(Technological Sciences)2020，63，4： | 3 |
| 7 | Optical and scintillation properties of Bi_4Si_3O_(12):RE(RE=Eu^(3+), Sm^(3+),Ho^(3+), Tb^(3+))single crystals显示文摘Bi_4 Si_3 O_(12):RE(BSO:RE, RE = Eu^(3+), Sm^(3+), Ho^(3+), Tb^(3+)) crystals were grown by the modified vertical Bridgeman method, and doping effects on scintillation properties were investigated. Under γ-ray irradiation, the light yield of BSO doped with small doses of Eu^(3+) increases slightly, and the energy resolution improves significantly compared to pure BSO, therefore the ability of distinguishing between particles will be improved for BSO crystals with a small amount of Eu^(3+) dopant. The results show that a small amount of Eu^(3+) doping can sensitize the Bi^(3+) ions. The sensitization effect enables the reduction of intrinsic defects, and thus improves the scintillation properties. However, the relative light yield of BSO:Tb(1.0 mol%) crystal is 4.3%, which is smaller than 5.0% of pure BSO. The improved light yield and energy resolution in the BSO:Eu and BSO:Sm crystals are considered an impressive achievement in the optimization of this scintillator which is already suitable for applications such as dual-readout calorimeters and homogeneous hadron calorimeters. | Xuefeng Xiao Jiayue Xu Haicheng Wei Yaoqing Chu Bobo Yang Xuefeng Zhang | 2019 | Journal of Rare Earths2019，37，3： | 2 |
| 8 | Generalized Liouville Theorem in Nonnegatively Curved Alexandrov Spaces显示文摘In this paper, Yau’s conjecture on harmonic functions in Riemannian manifolds is generalized to Alexandrov spaces. It is proved that the space of harmonic functions with polynomial growth of a fixed rate is finite dimensional and strong Liouville theorem holds in Alexandrov spaces with nonnegative curvature. | Bobo HUA | 2009 | Chinese Annals of Mathematics,Series B2009，30，2： | 2 |
| 9 | Energy-saving and accurate motion control of a hydraulic actuator with uncertain negative loads显示文摘Pump controlled hydraulic actuators are wildly used in the aerospace industry owing to the advantages of energy-saving and integrated configurations.Negative loads may occur to actuators due to external force loads or the inertial force when the actuator decelerates significantly.Uncertain negative load working conditions may cause cavitation,actuator vibration,and even instability to the motion control if the actuator is without sufficient meter-out damping.Various types of hydraulic configuration schemes have been proposed to deal with negative loads of hydraulic actuators.However,few of them can simultaneously achieve energy saving and high control accuracy.This study proposes an energy-saving and accurate motion tracking strategy for a hydraulic actuator with uncertain negative loads.The actuator’s motion is driven by a servomotor pump,which gives full play to the advantage of energy-saving.The meter-out pressure is controlled by proportional valves to provide the optimized meter-out damping.The nonlinear adaptive robust control law is designed,which guarantees the control stability and achieve high tracking accuracy.An integrated direct/indirect adaptation law obtains satisfactory parameter estimations and model compensation for asymptotic motion tracking.Comparative experiments under different working conditions were performed to validate the advantages of the proposed control strategy. | Bobo HELIAN Zheng CHEN Bin YAO | 2021 | Chinese Journal of Aeronautics2021，34，5： | 2 |
| 10 | A Hand Gesture Based Interactive Presentation System Utilizing Heterogeneous Cameras显示文摘In this paper, a real-time system that utilizes hand gestures to interactively control the presentation is proposed. The system employs a thermal camera for robust human body segmentation to handle the complex background and varying illumination posed by the projector. A fast and robust hand localization algorithm is proposed, with which the head, torso, and arm are sequentially localized. Hand trajectories are segmented and recognized as gestures for interactions. A dual-step calibration algorithm is utilized to map the interaction regions between the thermal camera and the projected contents by integrating a Web camera. Experiments show that the system has a high recognition rate for hand gestures, and corresponding interactions can be performed correctly. | Bobo Zeng Guijin Wang Xinggang Lin | 2012 | Tsinghua Science and Technology2012，17，3： | 2 |
| 11 | Development of optical-thermal coupled model for phosphor-converted LEDs显示文摘In this review, first, we discussed the effect of phosphor features on optical properties by the software simulation in detail. A combination of these parameters: phosphor material, phosphor particle size and particle distribution, phosphor layer concentration, phosphor layer thickness, geometry, and location of the phosphor layer, will result in the final optical performance of the phosphor layer. Secondly, we introduced how to improve light extraction efficiency with various proposed methods. Thirdly, we summarized the thermal models to predict the phosphor temperature and the junction temperature. To stabilize the optical performance of phosphor-converted light emitting diodes (PC-LEDs), much effort has been made to reduce the junction temperature of the LED chips. The phosphor temperature, a critical reliability concern for PC-LEDs, should be attracted academic interest. Finally, we summed up optical-thermal coupled model for phosphors and summarized future optical- thermal issues exploring the light quality for LEDs. We foresee that optical-thermal coupled model for PC-LEDs should be paid more attention in the future. | Xinglu QIAN Jun ZOU Mingming SHI Bobo YANG Yang LI Ziming WANG Yiming LIU Zizhuan LIU Fei ZHENG | 2019 | Frontiers of Optoelectronics2019，12，3： | 2 |
| 12 | Preparation of La0.67Ca0.23Sr0.1MnO3 thin films with interesting electrical and magnetic properties via pulsed-laser deposition显示文摘Manganese oxides with a perovskite-type Re_(1-x)D_xMnO_3(Re:heavy rare-earth elements,D:divalent alkali metal)structure have attracted interest because of the complex interaction between their electrons,lattices,and spins[1-5].Generally,manganese oxides with the structure Re_(1-x)D_xMnO_3 have special properties.For example,the half-metallic manganites,such as La_(2/3)Sr_(1/3)MnO_3 and La_(2/3)Ca_(1/3)MnO_3,wherein the conduction electrons are completely spin polarized。 | Shuai Xue XiaoLin Zhao JianLu Wang BoBo Tian Hai Huang CaiMin Meng Lan Liu Lei Ye JingLan Sun XiangJian Meng XiaoDong Zhang JunHao Chu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，2： | 2 |
| 13 | Optical and electrical properties of a spiral LED filament显示文摘This paper introduces a new type of spiral white light-emitting diodes(WLED) filament with high luminous efficiency and uniform optical performance. The optical and thermal properties of the flexible filament were investigated at different stretching heights, namely 0, 1, 2, and 3 cm. The results indicated that the filament showed the best optical characteristics at the stretching height of 2 cm, because of good heat dissipation. In addition, the radiation temperature of the filament was inversely proportional to the output luminous flux. The reliability of the filament at a stretching height of 2 cm was also evaluated after 1000 h of use. The result demonstrated that the luminous flux decay of the bulb was only 0.85%. The flexible spiral WLED filament exhibiting high luminous flux and good reliability could be adapted to promote industrial development in the near future. | Liping Wang Jun Zou Bobo Yang Wenbo Li Yang Li Mingming Shi Wei Zhu Canyun Zhang Fengchao Wang Yujie Lin | 2018 | Journal of Semiconductors2018，39，2： | 2 |
| 14 | Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy显示文摘Photodynamic therapy(PDT),which utilizes light excite photosensitizers(PSs)to generate reactive oxygen species(ROS)and consequently ablate cancer cells or diseased tissue,has attracted a great deal of attention in the last decades due to its unique advantages.However,the advancement of PDT is restricted by the inherent characteristics of PS and tumor microenvironment(TME).It is urgent to explore high-performance PSs with TME regulation capability and subsequently improve the therapeutic outcomes.Herein,we reported a newly engineered PS of polymer encapsulated carbonized hemin nanoparticles(P-CHNPs)via a facile synthesis procedure for boosting photodynamic anticancer therapy.Solvothermal treatment of hemin enabled the synthesized P-CHNPs to enhance oxidative stress in TME,which could be further amplified under light irradiation.Excellent in vitro and in vivo PDT effects were achieved due to the improved ROS(hydroxyl radicals and singlet oxygen)generation efficiency,hypoxia relief,and glutathione depletion.Moreover,the superior in vitro and in vivo biocompatibility and boosted PDT effect make the P-CHNPs a potential therapeutic agent for future translational research. | Liyun Lin Wen Pang Xinyan Jiang Shihui Ding Xunbin Wei Bobo Gu | 2022 | Light(Science & Applications)2022，11，3： | 2 |
| 15 | Research on High Temperature and High Density White Oil Based Drilling Fluid and Its Application in Well 201H7-6显示文摘As the depth and horizontal length of shale gas development wells increase,the requirement for the temperature resistance and the ability of the drilling fluids to stabilize the shale formation becomes higher.A new type of high temperature and high density white oil based drilling fluid system has been developed in laboratory.Research shows that the drilling fluid system has good rheological property,low filtration loss,strong anti-debris pollution capability and good plugging performance at high temperature and high density.The system has been successfully applied in the 201H7-6 well.Application results show that the drilling fluid rheology,high temperature and high pressure fluid loss and demulsification voltage meet the field requirements.The drilling fluid performance is stable in drilling an 1800 m horizontal section,and no stuck or shale swelling and wellbore collapsing are induced.It is the first well drilled successfully with domestic white oil-based drilling fluid in Zigong Region.It also sets several new records including the deepest well,the shortest drilling cycle,and the fastest drilling speed in that region,which provides valuable experience for the future drilling activities. | Bobo Qin Yidi Wang Chunzhi Luo Gang Liu | 2019 | Open Journal of Yangtze Oil and Gas2019，4，3： | 2 |
| 16 | GOECP/SEOR clinical guidelines on radiotherapy for malignant pleural mesothelioma显示文摘Malignant pleural mesothelioma(MPM)is a rare tumor with poor prognosis and rising incidence.Palliative care is common in MPM as radical treatment with curative intent is often not possible due to metastasis or extensive locoregional involvement.Numerous therapeutic advances have been made in recent years,including the use of less aggressive surgical techniques associated with lower morbidity and mortality(e.g.,pleurectomy/decortication),technological advancements in the field of radiotherapy(intensity-modulated radiotherapy,image-guided radiotherapy,stereotactic body radiotherapy,proton therapy),and developments in systemic therapies(chemotherapy and immunotherapy).These improvements have had as yet only a modest effect on local control and survival.Advances in the management of MPM and standardization of care are hampered by the evidence to date,limited by high heterogeneity among studies and small sample sizes.In this clinical guideline prepared by the oncological group for the study of lung cancer of the Spanish Society of Radiation Oncology,we review clinical,histologic,and therapeutic aspects of MPM,with a particular focus on all aspects relating to radiotherapy,including the current evidence base,associations with chemotherapy and surgery,treatment volumes and planning,technological advances,and reradiation. | Javier Luna Andrea Bobo Joaquín José Cabrera-Rodriguez María Pagola Margarita Martín-Martín María Ángeles González Ruiz Miguel Montijano Aurora Rodríguez Lira Pelari-Mici Almudena Corbacho Marta Moreno Felipe Couñago | 2021 | World Journal of Clinical Oncology2021，12，8： | 2 |
| 17 | 蜂巢轻质墙体结构与自承重结构体系研究与应用显示文摘2009年,经多学科专家评审,上海建筑建材业市场管理总站发行了我国第一本《海尔斯蜂巢轻质墙体建筑结构》产品推荐性应用图集(2009沪J/T-147)。并以沪建市管(2009)31号文通知各大建筑设计院和建设市场单位推广应用,先后在江、浙地区备案。201O年上海世博会上集中推介与科普宣传了该高科技仿生低碳的建材产品。各地的工程示范应用,也扩大其行业的认知度,蜂巢轻质墙体项目建设正在国内9t4ia然兴起。 | 邱玉东 Mamadou Bobo BALDE | 2013 | 建设科技2013，，21： | 2 |
| 18 | A novel coating technology for fast sealing of air leakage in underground coal mines显示文摘Air leakage in underground coal mines presents a serious hazard for coal production and the safety of miners.Coating technology is commonly used as an efficient means for preventing air leakage.To address existing problems with high dust concentrations in large operations involving complex processes and the high cost of traditional coating technology,a novel coating technology that ensures intrinsic safety by utilizing water pressure and wind pressure was developed.This new coating technology was designed to suction and spray,and the technical parameters of its spray performance was also studied.The experimental tests and evaluation indicated the optimum working range is 0.3–0.7 MPa of wind pressure,1.2–10.2 L/min of water quantity,and 1.0–3.5 m of spraying distance.Moreover,this novel coating technology was tested in the Dashuitou Coal Mine in Gansu Province of China.Compared with conventional counterparts,the proposed new technology is safe,efficient,and convenient to operate.During spraying,dust concentrations were kept at less than 10 mg/m3,and the average rebound ratio resilient rate of solid materials was below 13%.After spraying,the average leakage every 100 m was 4 m3/min,and the oxygen volume fraction in the adjacent goaf was approximately 4%,demonstrating excellent air leakage prevention. | Sihua Shao Chunlei Wu Min Hao Xiaolin Song Xueyou Su Weihan Wang Guosheng Li Bobo Shi | 2021 | International Journal of Mining Science and Technology2021，31，2： | 2 |
| 19 | Risk factors for failure to detect a cancer during clinical breast examination(United States)显示文摘 | BOBO jk Lawson HW Lee NC | 2003 | Cancer Causes Control2003，14，： | 1 |
| 20 | Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia : pooled data from three 6-week, placebo-controlled studies 显示文摘 | MELTZER HY BOBO WV NUAMAH IF | 2008 | J Clin Psychiat2008，69，5： | 1 |
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