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| 1 | Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver显示文摘AIM: To determine whether Nigella sativa prevents hepatic ischemia-reperfusion injury to the liver. METHODS: Thirty rats were divided into three groups as sham (Group 1), control (Group 2), and Nigella sati-va (NS) treatment group (Group 3). All rats underwent hepatic ischemia for 45 min followed by 60 min period of reperfusion. Rats were intraperitoneally infused with only 0.9% saline solution in group 2. Rats in group 3 received NS (0.2 mL/kg) intraperitoneally, before isch-emia and before reperfusion. Blood samples and liver tissues were harvested from the rats, and then the rats were sacrifi ced. Serum aspartate aminotransfera-se (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined. Total antioxidant capacity (TAC), catalase (CAT), total oxida-tive status (TOS), oxidative stress index (OSI) and my-eloperoxidase (MPO) in hepatic tissue were measured. Also liver tissue histopathology was evaluated by light microscopy. RESULTS: The levels of liver enzymes in group 3 weresignifi cantly lower than those in the group 2. TAC in liver tissue was significantly higher in group 3 than in group 2. TOS, OSI and MPO in hepatic tissue were signifi cantly lower in group 3 than the group 2. Histo-logical tissue damage was milder in the NS treatment group than that in the control group. CONCLUSION: Our results suggest that Nigella sa-tiva treatment protects the rat liver against to hepatic ischemia-reperfusion injury. | Fahrettin Yildiz Sacit Coban Alpaslan Terzi Mustafa Ates Nurten Aksoy Hale Cakir Ali Riza Ocak Muharrem Bitiren | 2008 | World Journal of Gastroenterology2008，14，33： | 8 |
| 2 | Assessment of clinical and pathological features of patients who underwent thyroid surgery: A retrospective clinical study显示文摘AIM To evaluate whether there was any correlation between the clinical parameters and final pathological results among patients who underwent thyroid surgery. METHODS We retrospectively analyzed parameters, including age, sex, complete blood cell count parameters, nodule diameter, nodule localization, thyroid function testing, and pathology reports, in patients who underwent thyroid surgery. The patients were divided into malignant (n = 92) and benign (n = 413) groups depending on the final pathological results. Both groups were compared for demographic and clinicalparameters. The Kolmogorov-Smirnov normality test was used to determine if the quantitative variables had a normal distribution. The nonparametric MannWhitney U test was used to compare quantitative data that were not normally distributed, and Pearson's chisquared test was used to compare the qualitative data. The correlation between the final pathological results and fine-needle aspiration biopsy findings was calculated using the cross-tabulation method.RESULTS This study included 406 women and 99 men aged between 15 and 85 years. No significant differences were found between the groups with respect to age, sex, white blood cell count, neutrophil count, lymphocyte count, thrombocyte count, red cell distribution width, platelet distribution width, mean platelet volume, platecrit, nodule localization, and thyroid function testing. On the other hand, there were significant differences between the groups with respect to nodule size (P = 0.001), cervical lymphadenopathy(P = 0.0001) and nodular calcification (P = 0.0001). Compared with the malignant group, the benign group had a significantly greater nodule size (35.4 mm vs 27.6 mm). The best cut-off point (≤ 28 mm) for nodule size, as determined by the receiver operating characteristic curve, had a sensitivity and specificity of 67.7% and 64.4%, respectively. The correlation between fine-needle aspiration biopsy and the final pathological results was assessed using the cross-table method. The sensitivity and specificity of fine-needle aspiration biopsy were 60% and 98%, respectively.CONCLUSION This study showed that significant differences existed between the malignant and benign groups with regard to nodule size, cervical lymphadenopathy, and nodular calcification. | Arif Emre Sami Akbulut Mehmet Sertkaya Muharrem Bitiren Ilhami Taner Kale Ertan Bulbuloglu Cemil Colak | 2018 | World Journal of Clinical Cases2018，6，3： | 2 |
| 3 | Effects of selenium on histopathological and enzymatic changes in experimental liver injury of rats显示文摘 | BITIREN M KARAKILCIK A Z | 2004 | Exp Toxicol Pathol2004，56，12： | 1 |
| 4 | Effects of selenium on histopathological and enzymatic changes in experimental liver injury of rats显示文摘 | Ozardali I Bitiren M Karakilcik AZ | 2004 | Exp Toxicol Pathol2004，56，12： | 1 |
| 5 | The relationship between expression of P53/bcl-2 and clinicopathological criteria in cervix squamous cell carcinomas 显示文摘 | Bitiren M Cakmak EA Gocmen A | 2003 | Eur J Gynaecol Oncol2003，24，5： | 1 |
| 6 | Two sisters with idiopathic pul- monaryhaemosiderosis 显示文摘 | Gencer M Ceylan E Bitiren M | 2007 | Can Respir J2007，14，8： | 1 |
| 7 | Two sisters with idiopathic pulmonary hemosiderosis 显示文摘 | Gencer M Ceylan E Bitiren M | 2007 | Can Respir J2007，14，8： | 1 |
| 8 | Two sisters with idiopathic pulmonary hacmosiderosis显示文摘 | Gencer M Ceylan E Bitiren M | | 0，，08： | 1 |
| 9 | Two sisters with idiopathic pulmonary hemosiderosis 显示文摘 | Gencer M Ceylan E Bitiren M | 2007 | Can Respir J2007，14，8： | 1 |
| 10 | Two sisters with idiopathic pulmonary hemosiderosis 显示文摘 | GENCER M CEYLAN E BITIREN M | 2007 | Can Respir J2007，14，8： | 1 |
| 11 | Two sisters with idiopathic pulmonary hemosiderosis显示文摘 | Gencer M Ceylan E Bitiren M | 2007 | Can Respir J2007，14，8： | 1 |
| 12 | Protective Effects of Selenium and Vitamin E Combination on Experimental Colitis in Blood Plasma and Colon of Rats显示文摘 | Muharrem Bitiren Ali Ziya Karakilcik Mustafa Zerin Ilyas Ozardal? Sehabettin Selek Ya?ar Nazl?gül Abdullah Ozgonul Davut Musa Ali Uzunkoy | 2010 | Biological Trace Element Research2010，，1： | 1 |
| 13 | Protective effects of Nigella sativa against ischemia-reperfusion injury of kidneys显示文摘 | Yildiz F Coban S Terzi A Savas M Bitiren M Celik H Aksoy N | | 0，，01： | 1 |
| 14 | Experimental intravitrealapplication of trovafloxacin in rabbits显示文摘 | Gurler B Ozkul Y Bitiren M | 2001 | Ophthalmic Res2001，33，4： | 1 |
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