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| 1 | Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestine显示文摘AIM: To investigate the effects of lubiprostone and Polyethylene Glycol 3350 (PEG) on mucosal barrier repair in ischemic-injured porcine intestine. METHODS: Ileum from 6 piglets (approximately 15 kg body weight) was subjected to ischemic conditions by occluding the local mesenteric circulation for 45 min in vivo. Ileal tissues from each pig were then harvested and mounted in Ussing chambers and bathed in oxygenated Ringer's solution in vitro. Intestinal barrier function was assessed by measuring transepithelial electrical resistance (TER) and mucosal-to-serosal fluxes of 3H-mannitol and 14C-inulin. Statistical analyses of data collected over a 120-min time course included 2-way ANOVA for the effects of time and treatment on indices of barrier function. RESULTS: Application of 1 μmol/L lubiprostone to the mucosal surface of ischemic-injured ileum in vitro induced significant elevations in TER compared to non-treated tissue. Lubiprostone also reduced mucosal-to-serosal fluxes of 3H-mannitol and 14C-inulin. Alternatively,application of a polyethylene laxative (PEG,20 mmol/L) to the mucosal surface of ischemic tissues significantly increased flux of 3H-mannitol and 14C-inulin. CONCLUSION: This experiment demonstrates that lubiprostone stimulates recovery of barrier function in ischemic intestinal tissues whereas the PEG laxative had deleterious effects on mucosal repair. These results suggest that,unlike osmotic laxatives,lubiprostone stimulates repair of the injured intestinal barrier. | Adam J Moeser Prashant K Nighot Birgit Roerig Ryuji Ueno Anthony T Blikslager | 2008 | World Journal of Gastroenterology2008，14，39： | 2 |
| 2 | Variable expression of cystatin C in cultured trans-differentiating rat hepatic stellate cells显示文摘瞄准:学习 C (CysC ) ,它由转变生长 factor-beta1 (TGF-beta1 ) 的规定和导出血小板的生长因素(PDGF ) 和有在这个特殊房间发信号的 TGF-beta1 的 CysC 的潜在的干扰打的 cystatin 的表示。方法:我们计算了 CysC 表达式在有教养, profibrogenic 肝的星形细胞和区分 trans 的 myofibroblasts 由北、西方弄污并且共焦的激光扫描显微镜学。结果:CysC 在 trans 区别期间显著地被增加。TGF-beta1 和 PDGF-BB 压制了 CysC 表示。而且, CysC 分泌物被处理与 TGF-beta1 导致。尽管 CysC 导致了 TGF 贝它的一种增加的有约束力的亲密关系,受体是由化学 cross-linking 估计了与打 III (beta-glycan )[125I ] 它没调制的 -TGF-beta1, 由评估 Smad2/3 磷酸化地位出现的 TGF-beta1 信号转导变异并且[CAGA ]-MLP-luciferase 记者基因试金。有趣地,流类型 III TGF 贝它受体 beta-glycan 在对待 CysC 的房间被减少。我们的数据显示那 CysC 表情起来在 trans 区别期间调整了。结论:在患肝疾病的病人的浆液的增加的 CysC 层次是至少部分由于在激活的肝的星形细胞的更高的表情。而且, TGF-beta1 影响 CysC 的分泌物,加亮在肝的纤维发生的前进的半胱氨酸朊酶的一个潜在地重要的角色。 | Axel M Gressner Birgit Lahme Steffen K Meurer Olav Gressner Raif Weiskirchen | 2006 | World Journal of Gastroenterology2006，12，5： | 2 |
| 3 | Differential regulation of vascular endothelial growth factor and its receptor fms-like-tyrosine kinase is mediated by nitric oxide in rat renal mesangial cells显示文摘 | Stefan F Birgit S Heiko K | 1999 | Biochem J1999，338，： | 1 |
| 4 | Versatile EGFP reporter plasmids for cellular localization of recombinant gene products in filamentous fungi显示文摘 | Stefanie P?ggeler Sandra Masloff Birgit Hoff Severine Mayrhofer Ulrich Kück | 2003 | Current Genetics2003，，1： | 1 |
| 5 | Study of the isothermal curing of an epoxy prepreg by near-infrared spectroscopy显示文摘 | Qian Wang Birgit K Storm Lars P Houmler | 2003 | Journal of Applied Polymer Science2003，87，： | 1 |
| 6 | Sequence variability and candidate gene analysis in complex disease: association of μopioid receptor gene variation with substance dependence 显示文摘 | Margret RH Karla K Birgit W | 2000 | Hum Mol Genet2000，9，19： | 1 |
| 7 | Ultrasonic Dispersion of Inorganic Nanoparticles in Epoxy Resin显示文摘 | Birgit B Frank H Alois K | 2009 | Ultrasonics Sonochemistry2009，16，5： | 1 |
| 8 | Design of Fault Detection for a Hydraulic Looper Using Dynamic Neural Network 显示文摘 | TEODOR M BIRGIT K S REINHARD S | 2008 | Control Engineering Practice2008，16，： | 1 |
| 9 | Synchronization of porcine fetal fibroblast cells with topoisomerase-inhibitor hoechst 33342显示文摘 | Birgit Kühholzer Randall S Prather | 2001 | Animal Reproduction Science2001，66，： | 1 |
| 10 | Nucleation of Ω phase in an Al-Cu-Mg-Mn-Ag alloy aged at temperatures below 200 ℃显示文摘 | Mukhopadhyay A K Gunther E Birgit S | 2001 | Scripta Materialia2001，44，4： | 1 |
| 11 | Transcranial Doppler ultrasonic assessment of middle cerebral artery blood flow velocity changes during verbal and visuospatial cognitive tasks 显示文摘 | Wolfgang H Bernd RE Birgit K | 1994 | Neuropsychology1994，32，12： | 1 |
| 12 | Differential regulation of vascular endothelial growth factor and its receptor fms-like-tyrosine kinase is mediated by nitric oxide in rat renal mesangial cells显示文摘 | Stefan F Birgit S Heiko K | 1999 | Biochem J1999，338，： | 1 |
| 13 | Alectin affinity workflow targeting glycosite–specific,cancer–related carbohydrate structures in trypsin–digested human plasma显示文摘 | Penelope M Drakea Birgit Schillingb Richard K Nilesa | 2011 | Analytical Biochemistry2011，408，1： | 1 |
| 14 | Dissolution and forming of cellulose with ionic liquids 显示文摘 | Birgit K Christoph M Frank M | 2008 | Cellulose2008，，15： | 1 |
| 15 | Nucleation of Ω phase in an Al-Cu-Mg-Mn-Ag alloy aged at temperatures below 200℃显示文摘 | MUKHOPADHYAY A K GUNTHER E BIRGIT S | 2001 | Scripta Matefialia2001，44，4： | 1 |
| 16 | Genetic algorithms and ne, ural net works tbr the quantitative analysis of ternary mixtures using sur face plasmon resonance显示文摘 | Frank D Birgit K Gunter G | 2003 | Chmrnometrics and Intelligent Labora tory Systems2003，65，： | 1 |
| 17 | New developments in dissolving and processing of cellulose in ionic liquids显示文摘 | Frank H Birgit K | 2008 | Macromol Syrup2008，262，： | 1 |
| 18 | Preparation of Ti02/epoxy nano-composites by ultrasonic dispersion and their structure propertyrelationship显示文摘 | Birgit B Frank H Alois K S | 2011 | Ultrasonic Sonochemistry2011，18，1： | 1 |
| 19 | A prospective multicenter study of treosulfan in elderly patients with recurrent ovarian cancer: results of a planned safety analysis显示文摘 | Sven Mahner Gülten Oskay-?zcelik Elke Heidrich-Lorsbach Stefan Fuxius Harald Sommer Peter Klare Antje Belau Birgit Ruhmland Thomas Heuser Heinz K?lbl Susanne Markmann Jalid Sehouli | 2012 | Journal of Cancer Research and Clinical Oncology2012，，8： | 1 |
| 20 | Synthesis and properties of anionic cellulose ethers: influence of functional groups and molec- ular weight on flowability of concrete显示文摘 | Simone K Birgit B | 2003 | Carbohydrate Polymers2003，53，4： | 1 |
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