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| 1 | Caspofungin in salvage treatment of severe pneumocystis pneumonia: case report and literature review显示文摘 | MU Xiang-dong QUE Cheng-li HE Bing WANG Guang-fa LI Hai-chao | 2009 | Chinese Medical Journal2009，，8： | 20 |
| 2 | Sequential use of transarterial chemoembolization and percutaneous cryosurgery for hepatocellular carcinoma显示文摘AIM: To evaluate the efficacy of sequential use of transarterial chemoembolization (TACE) and percutaneous cryosurgery for unresectable hepatocellular carcinoma (HCC). METHODS: Four hundred and twenty patients were enrolled in this study. The patients, who were considered to have unresectable tumors due to their location or size or comorbidity, were divided into sequential TACE-cryosurgery (sequential) group (n = 290) and cryosurgery alone (cryoalone) group (n = 130). Patients in the sequential group tended to have larger tumors and a greater number of tumors than those in the cryo-alone group. Tumors larger than 10 cm in diameter were only seen in the sequential group. TACE was performed with the routine technique and percutaneous cryosurgery was conducted under the guidance of ultrasound 2-4 wk after TACE. RESULTS: During a mean follow-up period of 42 ± 17 mo (range, 24-70 mo), the local recurrence rateat the ablated area was 17% for all patients, 11% and 23% for patients in sequential group and cryoalone groups, respectively (P = 0.001). The overall 1-, 2-, 3-, 4and 5-year survival rate was 72%, 57%, 47%, 39% and 31%, respectively. The 1and 2-year survival rates (71% and 61%) in sequential group were similar to those (73% and 54%) in cryo-alone group (P = 0.69 and 0.147), while the 4and 5-year survival rates were 49% and 39% in sequential group, higher than those (29% and 23%) in cryo-alone group (P = 0.001). Eighteen patients with large HCC (> 5 cm in diameter) survived for more than 5 years after sequential TACE while no patient with large HCC (> 5 cm in diameter) survived more than 5 years after cryosurgery. The overall complication rate was 24%, and the complication rates were 21% and 26% for the sequential and cryo-alone groups, respectively (P = 0.06). The incidence of hepatic bleeding was higher in cryo-alone group than in sequential group (P = 0.02). Liver crack only occurred in two patients of the cryoalone group. CONCLUSION: Pre-cryosurgical TACE can increase the cryoablation efficacy and decrease its adverse effects, especially bleeding. Sequential TACE and cryosurgery may be the better procedure for unresectable HCC, especially for large HCC. | Ke-Cheng Xu Li-Zhi Niu Qiang Zhou Yi-Ze Hu De-Hong Guo Zheng-Ping Liu Bing Lan Feng Mu Ying-Fei Li Jian-Sheng Zuo | 2009 | World Journal of Gastroenterology2009，15，29： | 13 |
| 3 | Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients显示文摘 | Hui Yu Li-Fang Xie Kang Chen Gang-Yi Yang Xiao-Yan Xing Jia-Jun Zhao Tian-pei Hong Zhong-Yan Shan Hong-Mei Li Bing Chen Xu-Lei Tang Ling Qi Jing Yang Yuan Fang Ting Li Shuang-ShuangWang Ya-Qi Yin Yi-Ming Mu | 2016 | Chinese Medical Journal2016，，7： | 7 |
| 4 | A Preliminary Study of Holocene Climate Change and Human Adaptation in the Horqin Region显示文摘人的活动在在 Horqin 区域的 Holocene 期间,东北中国,广泛地被记录了。作为人的活动的一个重要代理记录,在沉积的黑碳(BC ) 被连接了到气候变化和人的改编。位于南方 Horqin 的 loess-paleosol 节为这研究被选择。环境的 Holocene 气候变化和人的改编被分析 BC,器官的碳(OC ) 和另外的代理讨论。结论包括了:(1 ) 在 3900 cal BP 前,人的活动是仔细,与天赋有关,环境和文化开发被气候统治变化。例如,耕地 Hongshan 文化的快速的衰落被细微减少在 ∼5000 cal BP 在温度引起;(2 ) 在 3900-3200 cal BP,自然上的社会逐渐地减少了的人的重依赖和那些的能力期间,适应环境的人的社会被提高。然而,耕作主导的更低的 Xiajiadian 文化被 pastoralist 尽管如此代替上面的 Xiajiadian 文化由于在 ∼3200 cal BP 的一个极其冷却的事件;(3 ) 在迟了的 Holocene 时期期间,人的活动力量上的气候变化的显著影响在人的劳动技巧由于清楚的改进减少了。在这以后,因为人掌握了生产率的更强大的工具,人的生活式样被文化开发而非气候变化影响。 | MU Yan QIN Xiaoguang ZHANG Lei XU Bing | 2014 | Acta Geologica Sinica(English Edition)2014，88，6： | 6 |
| 5 | High levels of circulating GM-CSF^(+) CD4^(+) T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study显示文摘Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients. | Huihuang Huang Siyu Wang Tianjun Jiang Rong Fan Zheng Zhang Jinsong Mu Ke Li Yonggang Wang Lei Jin Fang Lin Jie Xia Lijian Sun Biao Xu Chengcheng Ji Jing Chen Juan Chang Bo Tu Bing Song Chao Zhang Fu-Sheng Wang Ruonan Xu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 6 | Feasibility study on continuous spinal analgesia in all stages of labor显示文摘To the Editor:Most researchers in China are concerned that the whole labor process of traditional continuous epidural analgesia(CEA)will hinder the maternal force in the second stage of labor.In contrast,a local anesthetic drug can be used for a relatively long time.Excessive intraspinal administration may inhibit the contraction of the uterine smooth muscle,[1]which may lead to a longer labor stage,increased oxytocin use,and increased rates of forceps delivery,cesarean section,and neonatal asphyxia.Therefore,some obstetricians and midwives in China choose to stop epidural labor analgesia when the cervix opens to 7 to 8 cm or at complete cervical dilation.Thus,most parturients cannot enjoy ideal full-term labor analgesia. | Jia-Wei Ji Ming-Jun Xu Bing Han Li Chen Xiao-Jie Mu | 2020 | Chinese Medical Journal2020，，5： | 5 |
| 7 | Substantial transition to clean household energy mix in rural China显示文摘The household energy mix has significant impacts on human health and climate,as it contributes greatly to many health-and climate-relevant air pollutants.Compared to the well-established urban energy statistical system,the rural household energy statistical system is incomplete and is often associated with high biases.Via a nationwide investigation,this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector,while electricity comprised∼20%.Stacking(the use of multiple sources of energy)is significant,and the average number of energy types was 2.8 per household.Compared to 2012,the consumption of biomass and coals in 2017 decreased by 45%and 12%,respectively,while the gas consumption amount increased by 204%.Increased gas and decreased coal consumptions were mainly in cooking,while decreased biomass was in both cooking(41%)and heating(59%).The time-sharing fraction of electricity and gases(E&G)for daily cooking grew,reaching 69%in 2017,but for space heating,traditional solid fuels were still dominant,with the national average shared fraction of E&G being only 20%.The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030,particularly in less-developed rural and mountainous areas.In some non-typical heating zones,the increased share of E&G for heating was significant and largely driven by income growth,but in typical heating zones,the time-sharing fraction was<5%and was not significantly increased,except in areas with policy intervention.The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition.Higher income,higher education,younger age,less energy/stove stacking and smaller family size positively impacted the clean energy transition. | Guofeng Shen Rui Xiong Yanlin Tian Zhihan Luo Bahabaike Jiangtulu Wenjun Meng Wei Du Jing Meng Yuanchen Chen Bing Xue Bin Wang Yonghong Duan Jia Duo Fenggui Fan Lei Huang Tianzhen Ju Fenggui Liu Shunxin Li Xianli Liu Yungui Li Mu Wang Ying Nan Bo Pan Yanfang Pan Lizhi Wang Eddy Zeng Chao Zhan Yilin Chen Huizhong Shen Hefa Cheng Shu Tao | 2022 | National Science Review2022，9，7： | 4 |
| 8 | Gastroesophageal Varices (Bleeding) and Splenomegaly: The Initial Manifestations of Some Pancreatic Body and Tail Carcinoma显示文摘INTRODUCTION The most common symptoms of the pancreatic body and tail carcinoma are epigastric pain,asthenia and back pain.However,these symptoms are nonspecific,which as a consequence leads to late diagnosis as well as a low resection rate between 10% and 30%,with a 5 years overall survival rate below 10%.[1] That how to increase early diagnosis of the pancreatic body and tail carcinoma has been a difficult problem since then.Sometimes the pancreatic body and tail carcinoma can induce splenic vein occlusion,leading to pancreatic sinistral portal hypertension (PSPH).PSPH is defined as a pathological condition of splanchnic venous hypertension localized within the left-sided gastrosplenic region in pancreatic diseases. | Xiao-Bin Li Luo Zhao Quan Liao Qiang Xu Tai-Ping Zhang Lin Cong Bing Mu | 2015 | Chinese Medical Journal2015，，4： | 3 |
| 9 | LRP16 gene protects mouse insulinoma MIN6 cells against fatty acid-induced apoptosis through Akt/FoxO1 signaling显示文摘 | LI Xiao-jin GUO Qing-hua WANG Xuan XUE Bing SUN Lian-qing MENG Qu-tao LU Ju-ming MU Yi-ming | 2012 | Chinese Medical Journal2012，，10： | 3 |
| 10 | Ginsenoside Rb1 relieves glucose fluctuationinduced oxidative stress and apoptosis in Schwann cells显示文摘Cultured Schwann cells were treated with 5.6 mM and 50 mM glucose alternating every 8 hours to simulate intermittent high glucose. The present study analyzed the neuroprotective effects of 1, 10 and 100 μM ginsenoside Rb1 on oxidative damage and apoptosis in Schwann cells induced by intermittent high glucose. Flow cytometry demonstrated that ginsenoside Rb1 reduced intermittent high glucose-mediated reactive oxygen species production. Enzyme linked immunosorbent assay showed that 8-hydroxy-2-deoxy guanosine levels in Schwann cells decreased following ginsenoside Rb1 treatment. Quantitative real-time reverse transcription-PCR and western blot assay results revealed that ginsenoside Rb1 inhibited intermittent high glucose-upregulated Bax expression, but antagonized intermittent high glucose-downregulated Bcl-2 expression in Schwann cells. These effects were most pronounced with 100 μM ginsenoside Rb1. These results indicate that ginsenoside Rb1 inhibits intermittent high glucose-induced oxidative stress and apoptosis in Schwann cells. | Bing Xue Lianqing Sun Xiaojin Li Xuan Wang Ying Zhang Yiming Mu Linlang Liang | 2012 | Neural Regeneration Research2012，7，30： | 2 |
| 11 | Evaluation of the in vitro antimicrobial properties of ultraviolet A/riboflavin mediated crosslinking on Candida albicans and Fusarium solani显示文摘AIM:To evaluate the antimicrobial properties of ultraviolet A(UVA)(365 nm)/riboflavin against Candida albicans and Fusarium solani.METHODS:Two fungus isolates were cultured in vitro and prepared with 10-fold serial PBS dilutions of cell concentration.For each dilution of fungus suspension,the concentration(colony-forming units/mL,CFU/mL)and the inactivation ratio of fungal cells were evaluated under 4 conditions:no treatment(control),UVA(365 nm)/riboflavin,riboflavin,and UVA(365 nm).RESULTS:The cell concentration decreased in UVA(365 nm)/riboflavin group for Candida albicans at each dilution and Fusarium solani at dilutions of 104,103,102CFU/mL,when compared with that in control,riboflavin,and UVA(365 nm)groups(P<0.01).No difference of cell concentration was detected amongst the culture of control,riboflavin,and UVA(365 nm)groups for the two fungus.There is a negative correlation between suspension concentration(log-transformed)and the inactivation ratio in UVA(365 nm)/riboflavin group for Candida albicans and Fusarium solani(P<0.01).CONCLUSION:According to the standard protocol of corneal collagen cross-linking,UVA(365 nm)/riboflavin combination treatment is found to moderately inactivate the viability of Candida albicans and Fusarium solani in vitro.The inactivation ratio was found to increase withthe decrease of cell concentration under UVA(365 nm)/riboflavin condition. | Bing Sun Zhi-Wei Li Hai-Qun Yu Xiang-Chen Tao Yong Zhang Guo-Ying Mu | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 2 |
| 12 | Processes and mechanisms of multi-collapse of loess roads in seasonally frozen ground regions: A review显示文摘Usually, the collapsible loess widely distributed across the world can serve as a type of foundation soil that meets its strength requirement after dense compaction and elimination of collapsibility. However, many problems such as cracks and differential settlement still occur in loess roads in the seasonally frozen ground regions after several years of operation. Many studies have demonstrated that these secondary or multiple collapses primarily result from the repeated freezing-thawing, wetting-drying, and salinization-desalinization cycles. Therefore, we conducted a research program to(1) monitor the in-situ ground temperatures and water content in certain loess roads to understand their changes,(2) study the effects of freezing-thawing, wetting-drying, and salinization-desalinization cycles on geotechnical properties and micro-fabrics of compacted loess in the laboratory, and(3) develop mitigative measures and examine their engineered effectiveness, i.e., their thermal insulating and water-proofing effects in field and laboratory tests. Our results and advances are reviewed and some further research needs are proposed. These findings more clearly explain the processes and mechanisms of secondary and multiple collapse of loess roads. We also offer references for further study of the weakening mechanisms of similar structural soils. | GuoYu Li Wei Ma Fei Wang YanHu Mu YunCheng Mao Xin Hou Hui Bing | 2015 | Research in Cold and Arid Regions2015，7，4： | 2 |
| 13 | Nr2e1 Downregulation Is Involved in Excess Retinoic Acid-induced Developmental Abnormality in the Mouse Brain显示文摘Objective This study aimed to investigate the expression pattern and function of Nuclear receptor subfamily 2 group E member 1(Nr2e1) in retinoic acid(RA)-induced brain abnormality. Methods The mouse model of brain abnormality was established by administering 28 mg/kg RA, and neural stem cells(NSCs) were isolated from the mouse embryo and cultured in vitro. Nr2e1 expression was detected by whole mount in situ hybridization, RT-PCR, and Western blotting. Nr2e1 function was determined by transducing Nr2e1 shRNA into NSCs, and the effect on the sonic hedgehog(Shh) signaling pathway was assessed in the cells. In addition, the regulation of Nr2e1 expression by RA was also determined in vitro. Results Nr2e1 expression was significantly downregulated in the brain and NSCs of RA-treated mouse embryos, and knockdown of Nr2e1 affected the proliferation of NSCs in vitro. In addition, a similar expression pattern of Nr2e1 and RA receptor(RAR) α was observed after treatment of NSCs with different concentrations of RA. Conclusion Our study demonstrated that Nr2e1 could be regulated by RA, which would aid a better understanding of the mechanism underlying RA-induced brain abnormality. | YU Juan GUO Qian MU Jian Bing ZHANG Ting LI Ren Ke XIE Jun | 2017 | Biomedical and Environmental Sciences2017，30，3： | 2 |
| 14 | Human activity during the late Pleistocene in the Lop Nur region, northwest China: Evidence from a buried stone artifact显示文摘The Lop Nur region, in the east part of Tarim Basin, was an important transportation junction between west and east,north and south Eurasia. However, previous studies on prehistoric human activity have concentrated mostly on the Bronze Age,whereas that during the Stone Age remains largely unresearched. Here, we present a new direct evidence of human activity in the late Pleistocene, recorded on a grinding stone buried in a lacustrine sediment section of the Lop Nur region. The grain size distribution of the sediment section indicates that the site was probably in the center of a lake with weak hydrodynamic environment. Therefore, the stone artifact can only be carried to here by people instead of river and it was never move as soon as left here. Results of radiocarbon dating, the evident stratigraphic relations between the stone artifact and the sedimentary formation, indicate that the human activity could extend to approximately 13 ka BP. Furthermore, the results of starch-grain and use-wear analyses suggest that ancient humans gathered seeds of Triticeae, roots, and tubers and used the grinding stone to simply process selected plant as plant foodstuffs during this period. It implies that the environmental conditions in the river delta of the Lop Nur were inhabitable during the late Pleistocene. | Kangkang LI Xiaoguang QIN Xiaoyan YANG Bing XU Lei ZHANG Guijin MU Dong WEI Chunxue WANG Yong WU Xiaohong TIAN Yongchong LIN Wen LI Jiaqi LIU Yinxin JIAO | 2018 | Science China Earth Sciences2018，61，11： | 1 |
| 15 | Interwoven nickel(II)-dimethylglyoxime nanowires in 3D nickel foam for dendrite-free lithium deposition显示文摘Metal skeletons,such as Nickel Foam(NF) has attracted worldwide interests as stable host for lithium metal anode because of its high stability,large specific surface area and high conductivity.However,most metal skeletons have lithophobic surface and uneven current distribution that result in sporadic lithium nucleation and uncontrolled dendrites growth.Herein,we describe a sequential immersing strategy to generate interwoven Nickel(Ⅱ)-dimethylglyoxime(Ni-DMG) nanowires at NF to obtain composite skeleton(NDNF),which can be used as an stable host for Li metal storage.The Ni-DMG has proved effective to realize uniform lithium nucleation and dendrite-free lithium deposition.Combing with the three dimensional(3 D) hierarchical porous structure,the composite host shows a significantly improved coulombic efficiency(CE) than pristine commercial nickel foam.Moreover,the corresponding Li‖Li symmetrical cells can run more than 700 h with low voltage hysteresis 22 mV at 1.0 mA/cm^(2),and Li@NDNF‖LiFePO;full-cell exhibits a high capacity retention of 82.03% at 1.0 C during 630 cycles.These results proved the effectiveness of metal-organic complexes in governing Li metal growth and can be employed as a new strategy for dendrite-free Li metal anode and safe Li metal batteries(LMBs). | Tianyi Zhou Yanlu Mu Jianyang Wu Bing Zhong Chengkai Yang Qian Wang Wen Liu Henghui Zhou Peng Jiang | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 16 | Removal of Giardia and Cryptosporidium in drinking water treatment:a pilotscale study显示文摘 | Hsuan-Hsien | 2003 | Water Res2003，37，5： | 1 |
| 17 | Prevention of diabetic nephropathy in rats through enhanced renal antioxidative capacity by inhibition of the proteasome显示文摘 | Zhi-Feng Luo Wei Qi Bing Feng Jiao Mu Wei Zeng Yan-Hong Guo Qi Pang Zi-Lin Ye Li Liu Fa-Huan Yuan | 2011 | Life Sciences2011，，11： | 1 |
| 18 | Cloning of Mouse Enamel Matrix Serine Proteinase Encoding Mature Protein显示文摘目的 :克隆小鼠牙胚组织中釉基质丝氨酸蛋白酶 ( EMSP1 )成熟肽编码区基因。方法 :提取出生后 7d昆明种小白鼠切牙、磨牙牙胚总 RNA,逆转录为 c DNA,设计两对特异性引物 ,采用 Touchdown PCR和嵌套 PCR方法 ,扩增出小鼠 EMSP1起始密码子至终止密码子基因片段。将目的基因连入载体 p MD- 1 8T,转化入大肠杆菌 JM1 0 9,通过蓝白筛选 ,挑选阳性克隆培养扩增 ,纯化重组质粒进行限制性酶切和核苷酸序列分析鉴定。结果 :限制性酶切图谱和核苷酸序列分析均表明所克隆 c DNA为小鼠 70 0 bp的 EMSP1成熟肽基因编码。结论 | MU Ya bing, SUN Hong chen, ZHANG Ze bing, OUYANG Jie (Dept. of Pathology, School of Stomatology, Jilin University,Changchun 130041,China) | 2003 | 吉林大学学报(医学版)2003，29，6： | 1 |
| 19 | Dysregulation of the MiR-324-5p-CUEDC2 Axis Leads to Macrophage Dysfunction and Is Associated with Colon Cancer显示文摘 | Yuan Chen Shao-Xin Wang Rui Mu Xue Luo Zhao-Shan Liu Bing Liang Hai-Long Zhuo Xiao-Peng Hao Qiong Wang Di-Feng Fang Zhao-Fang Bai Qian-Yi Wang He-Mei Wang Bao-Feng Jin Wei-Li Gong Tao Zhou Xue-Min Zhang Qing Xia Tao Li | 2014 | Cell Reports2014，，： | 1 |
| 20 | Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats显示文摘The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons;however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remains to be explored. In this study, a conductive graphene oxide composited chitosan scaffold was fabricated by genipin crosslinking and lyophilization. The prepared chitosan-graphene oxide scaffold presented a porous structure with an inner diameter of 18–87 μm, and a conductivity that reached 2.83 mS/cm because of good distribution of the graphene oxide nanosheets, which could be degraded by peroxidase. The chitosan-graphene oxide scaffold was transplanted into a T9 total resected rat spinal cord. The results show that the chitosan-graphene oxide scaffold induces nerve cells to grow into the pores between chitosan molecular chains, inducing angiogenesis in regenerated tissue, and promote neuron migration and neural tissue regeneration in the pores of the scaffold, thereby promoting the repair of damaged nerve tissue. The behavioral and electrophysiological results suggest that the chitosan-graphene oxide scaffold could significantly restore the neurological function of rats. Moreover, the functional recovery of rats treated with chitosangraphene oxide scaffold was better than that treated with chitosan scaffold. The results show that graphene oxide could have a positive role in the recovery of neurological function after spinal cord injury by promoting the degradation of the scaffold, adhesion, and migration of nerve cells to the scaffold. This study was approved by the Ethics Committee of Animal Research at the First Affiliated Hospital of Third Military Medical University(Army Medical University)(approval No. AMUWEC20191327) on August 30, 2019. | Bing Yang Pang-Bo Wang Ning Mu Kang Ma Shi Wang Chuan-Yan Yang Zhong-Bing Huang Ying Lai Hua Feng Guang-Fu Yin Tu-Nan Chen Chen-Shi Hu | 2021 | Neural Regeneration Research2021，16，9： | 1 |
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