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| 1 | Contrast-enhanced ultrasound for detection and diagnosis of renal clear cell carcinoma显示文摘背景肾的清楚的房间癌(RCCC ) 是最普通的恶意的肾的肿瘤。它是高度恶意的,不在它的 eady 阶段引起临床的症状,并且不能用常规超声被诊断。这研究被瞄准调查时间紧张的模式和特征为 RCCC 和它有病理地诊断的 RCCC 的 42 个病人经历了的病理学的 basis.Methods 弄弯的提高对比的超声(CEUS ) 在外科前的 CEUS 检查。病人的肾用 Technos MPX DU8 在对比代理人的注射以后被设想。我们分析了有常规超声的 RCCC 的察觉率在附近是的 CEUS 模式,时间紧张曲线,和病理学的 findings.Results 71% ,当用 CEUS 的率是 100% 时。更大的肿瘤(33 个案例) 与有缺点的充满显示出不一致的改进。CEUS 模式被划分成 4 种类型:打字,“在并且外面快”(26.19% , 11/42 ) ;打字,“在快、慢外面”(40.48% , 17/42 ) ;打字,“在并且外面同时”(16.67% , 7/42 ) ;并且打字“在并且外面慢”(16.67% , 7/42 ) 。所有类型有靠近的关联到病理学的基础。“ CEUS 的时间紧张曲线由 3 个阶段组成了,灌注阶段,回归分阶段执行,并且落后阶段。类型的盒子并且仅仅有一个灌注和回归阶段,那些类型并且有一个灌注阶段,回归分阶段执行,并且落后阶段。时间紧张曲线的定量分析证明损害的 time-to-peak ( TTP )比正常肾的实质的短( P < 0.0001 ),吝啬的价值起来损害的绝对值的斜坡率比 ipsilateral 正常的高肾的实质( P < 0.0001 ),并且损害的绝对值的降下斜坡率的吝啬的价值比 ipsilateral 正常的低肾的实质( P < 0.0001 ) .Conclusions CEUS 在检测小 ve 是有用的尽管有几个不同 CEUS 模式,“在并且外面快”的类型和类型“在快、慢外面”说明了有靠近的关联到病理学的 angiogenesis 的大多数盒子。“白霜紧张曲线也显示出一些特殊特征。这些数据能为 RCCC 的临床的诊断提供珍贵信息。 | DONG Xiao-qiu SHEN Yi XU Li-wei XU Chun-mei BI Wei WANG Xiao-min | 2009 | Chinese Medical Journal2009，，10： | 38 |
| 2 | Simultaneous Fe(Ⅲ) reduction and ammonia oxidation process in Anammox sludge显示文摘In recent years, there have been a number of reports on the phenomenon in which ferric iron(Fe(Ⅲ)) is reduced to ferrous iron [Fe(Ⅱ)] in anaerobic environments, accompanied by simultaneous oxidation of ammonia to NO2-, NO3-, or N2.However, studies on the relevant reaction characteristics and mechanisms are rare. Recently, in research on the effect of Fe(Ⅲ) on the activity of Anammox sludge, excess ammonia oxidization has also been found.Hence, in the present study, Fe(Ⅲ) was used to serve as the electron acceptor instead of NO2-,and the feasibility and characteristics of Anammox coupled to Fe(Ⅲ) reduction(termed Feammox) were investigated. After 160 days of cultivation, the conversion rate of ammonia in the reactor was above 80%, accompanied by the production of a large amount of NO3-and a small amount of NO2-. The total nitrogen removal rate was up to 71.8%. Furthermore,quantities of Fe(Ⅱ) were detected in the sludge fluorescence in situ hybridization(FISH) and denaturated gradient gel electrophoresis(DGGE) analyses further revealed that in the sludge, some Anammox bacteria were retained, and some microbes were enriched during the acclimatization process. We thus deduced that in Anammox sludge, Fe(Ⅲ) reduction takes place together with ammonia oxidation to NO2-and NO3-along with the Anammox process. | Xiang Li Yong Huang Heng-wei Liu Chuan Wu Wei Bi Yi Yuan Xin Liu | 2018 | Journal of Environmental Sciences2018，30，2： | 30 |
| 3 | Effect of Intravenous Administration of Liposomal Prostaglandin E1 on Microcirculation in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Intervention显示文摘 | Li-Ye Wei Xiang-Hua Fu Wei Li Xi-Le Bi Shi-Ru Bai Kun Xing Yan-Bo Wang | 2015 | Chinese Medical Journal2015，，9： | 27 |
| 4 | Differentiation of isolated human umbilical cord mesenchymal stem cells into neural stem cells显示文摘AIM:To investigate whether umbilical cord human mesenchymal stem cell(UC-MSC)was able to differentiate into neural stem cell and neuron in vitro.·METHODS:The umbilical cords were obtained from pregnant women with their written consent and the approval of the Clinic Ethnics Committee.UC-MSC were isolated by adherent culture in the medium contains 20%fetal bovine serum(FBS),then they were maintained in the medium contain 10%FBS and induced to neural cells in neural differentiation medium.We investigated whether UC-MSC was able to differentiate into neural stem cell and neuron in vitro by using flow cytometry,reverse transcriptase-polymerase chain reaction(RT-PCR)and immunofluorescence(IF)analyzes.·RESULTS:A substantial number of UC-MSC was harvested using the tissue explants adherent method at about 2wk.Flow cytometric study revealed that these cells expressed common markers of MSCs,such as CD105(SH2),CD73(SH3)and CD90.After induction of differentiation of neural stem cells,the cells began to form clusters;RT-PCR and IF showed that the neuron specific enolase(NSE)and neurogenic differentiation 1-positive cells reached 87.3%±14.7%and 72.6%±11.8%,respectively.Cells showed neuronal cell differentiation after induced,including neuron-like protrusions,plump cell body,obviously and stronger refraction.RT-PCR and IF analysis showed that microtubule-associated protein 2(MAP2)and nuclear factor-M-positive cells reached 43.1%±10.3%and 69.4%±19.5%,respectively.·CONCLUSION:Human umbilical cord derived MSCscan be cultured and proliferated in vitro and differentiate into neural stem cells,which may be a valuable source for cell therapy of neurodegenerative eye diseases. | Song Chen Wei Zhang Ji-Ming Wang Hong-Tao Duan Jia-Hui Kong Yue-Xin Wang Meng Dong Xue Bi Jian Song | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 22 |
| 5 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 6 | Predictive role of interleukin-6 and CAT score in mechanical ventilation in patients with chronic obstructive pulmonary disease at the acute exacerbation stage in the emergency department显示文摘BACKGROUND:The study aimed to evaluate the predictive role of interleukin-6(IL-6)and chronic obstructive pulmonary disease(COPD)assessment test(CAT)score in mechanical ventilation(MV)in COPD patients at the acute exacerbation stage in the emergency department(ED).METHODS:For a one-year period,among adult patients in the ED who met the criteria of acute exacerbation of COPD,158 who received MV within 48 hours after admission were compared to 294 who didn't require MV within the same period after admission.IL-6 level and CAT score were compared between the two groups.The predicted value of IL-6 and CAT score was assessed by logistic regression analysis and a receiver operating characteristic(ROC)curve.RESULTS:The IL-6 and CAT scores in the 158 MV patients were much higher than those without.IL-6 and CAT scores were independent predictors of MV within 48 hours using logistic regression analysis(IL-6:odds ratio[OR]1.053,95%confidence interval[CI]1.039–1.067,P<0.001;CAT score:OR 1.122,95%CI 1.086–1.159,P<0.001).The combination of IL-6 and CAT scores(area under ROC curve[AUC]0.826,95%CI 0.786–0.866,P<0.001)improved the accuracy of predicting MV within 48 hours when compared with IL-6(AUC 0.752,95%CI 0.703–0.800,P<0.001)and CAT scores alone(AUC 0.739,95%CI 0.692–0.786,P<0.001).The sensitivity and specificity were 69.6%,74.1%,75.32%and 63.6%,respectively.CONCLUSION:The combined of IL-6 and CAT scores is useful for evaluating the risk of COPD patients at acute exacerbation in ED,and can provide a predictive value for MV or not within 48 hours. | Wei Bi Yan Sun Lin-qin Ma Cai-jun Wu | 2020 | World Journal of Emergency Medicine2020，11，2： | 17 |
| 7 | A PP2C-1 Allele Underlying a Quantitative Trait Locus Enhances Soybean l O0-Seed Weight显示文摘栽培大豆可以在驯服期间失去某有用基因 loci。从野大豆的基因的基因渗入能拓宽基因背景并且改进大豆农学的特点。在这研究,通过 recombinant 的整个染色体的定序,生来的线人口源于在野大豆 ZYD7 和栽培大豆 HN44 之间的一个十字,并且为种子重量量的特点 loci 印射,我们发现从野大豆 ZYD7 的磷酸酶 2C-1 ( PP2C-1 )等位基因在种子重量/尺寸贡献增加。PP2C-1 可以由提高覆盖物的房间尺寸并且激活一个子集完成这功能播种特点相关的基因。我们发现 PP2C-1 与 GmBZR1 被联系, Arabidopsis BZR1 的大豆 ortholog,之一在发信号的 brassinosteroid (BR ) 给抄写因素调音,并且便于 dephosphorylated GmBZR1 的累积。相反,有在 N 终点的一些氨基酸的变化的 PP2C-2 等位基因没展出这功能。而且,我们证明 GmBZR1 能在转基因的植物支持种子重量 / 尺寸。通过栽培大豆就职的分析,我们发现 40% 检验就职没有 PP2C-1 等位基因,建议这些就职能被这等位基因的介绍改进。一起拿,我们的学习识别精英等位基因 PP2C-1,它能在由分子帮助繁殖的这等位基因的那操作可以增加的大豆,和针尖提高种子重量或尺寸在大豆的生产和另外的荚 / 庄稼。 | Xiang Lu Qing Xiong Tong Cheng Qing-Tian Li Xin-Lei Liu Ying-Dong Bi Wei Li Wan-Ke Zhang Biao Ma Yong-Cai Lai Wei-Guang Du Wei-Qun Man Shou-Yi Chen Jin-Song Zhang | 2017 | Molecular Plant2017，10，5： | 17 |
| 8 | Ethnopharmacology, Phytochemistry, Pharmacology, Toxicology and Clinical Applications of Radix Astragali显示文摘Radix Astragali(RA),a traditional Chinese medicine from the dried root of Astragalus species,is widely distributed throughout the temperate regions of the world.The major bioactive constituents of RA are triterpene glycosides,flavonoids,saponins,and alkaloids,and these compounds mostly exert pharmacological activities on the cardiovascular,immune,respiratory,and hepatic systems.This review summarizes the recent studies on RA and provides a comprehensive summary regarding the status of resources,ethnopharmacology,phytochemistry,pharmacology,toxicology,clinical application,and patent release of RA.We hope this review can provide a guidance for further development of therapeutic agents from RA. | ZHANG Chun-hong YANG Xiao WEI Jing-ran CHEN Na-mu-han XU Jian-ping BI Ya-qiong YANG Min GONG Xue LI Zi-yan REN Kai HAN Qi-heng ZHANG Lei LI Xue JI Ming-yue WANG Cong-cong LI Min-hui | 2021 | Chinese Journal of Integrative Medicine2021，27，3： | 16 |
| 9 | Adsorption removal of thiocyanate from aqueous solution by calcined hydrotalcite显示文摘A hydrotalcite with Mg/Al molar ratio 2 was prepared by co-precipitation method and was characterized by XRD, TG/DTA, Zeta potential and BET surface area. The hydrotalcite was calcined at 500℃, with the dehydration from interlayer, the dehydroxilation from the brucite-like layer and the decomposition of carbonate successively, transformed into the mixed oxide type. The removal of thiocyanate from aqueous solution by using the original hydrotalcite and calcined hydrotalcite(HTC-500) was investigated. The results showed that the thiocyanate adsorption capacity of calcined hydrotalcite was much higher than that of the original form. Calcined hydrotalcite was particularly effective at removing thiocyanate, and that the effective range of pH for the thiocyanate removal are between 5.5—10.0. The experimental data of thiocyanate removal fit nicely with Langmuir isotherm, and the saturated adsorption uptake was 96.2 mg SCN-/g HTC-500. The adsorption of thiocyanate by calcined hydrotalcite follows first-order kinetics. And the intercalation to the structure recovery for calcined hydrotalcite. But the presence of additional anions could affect the adsorption behavior of thiocyanate. | LI Yu-jiang YANG Min ZHANG Xiao-jin WU Tao CAO Nan WEI Na BI Yan-jun WANG Jing | 2006 | Journal of Environmental Sciences2006，18，1： | 15 |
| 10 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 11 | Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes显示文摘Objective To examine the association between serum uric acid levels and cardiovascular disease risk among individuals without diabetes. Methods We investigated the association between serum uric acid levels and the risk of prevalent cardiometabolic diseases, 10-year Framingham risk for coronary heart disease, and 10-year risk for atherosclerotic cardiovascular diseases(ASCVD) among 8,252 participants aged ≥ 40 years without diabetes from Jiading district, Shanghai, China. Results Body mass index, waist circumference, blood glucose, glycated hemoglobin, blood pressure, and serum lipids increased progressively across the sex-specific quartiles of uric acid(all P trend < 0.05). Compared with individuals in the lowest quartile, those in the higher quartiles had a significantly higher prevalence of obesity, hypertension, and dyslipidemia(all P trend < 0.05). A fully adjusted logistic regression analysis revealed that individuals in the highest quartile had an increased risk of predicted cardiovascular disease compared with those in the lowest quartile of uric acid. The multivariate adjusted odds ratios(ORs) [95% confidence intervals(CIs)] for the highest quartiles for high Framingham risk were 3.00(2.00-4.50) in men and 2.95(1.08-8.43) in women. The multivariate adjusted ORs(95% CIs) for the highest quartile for high ASCVD risk were 1.93(1.17-3.17) in men and 4.53(2.57-7.98) in women. Conclusion Serum uric acid level is associated with an increased risk of prevalent obesity, hypertension, dyslipidemia, 10-year Framingham risk for coronary heart disease, and 10-year risk for ASCVD among Chinese adults without diabetes. | CHENG Di DU Rui WU Xue Yan LIN Lin PENG Kui MA Li Na XU Yu XU Min CHEN Yu Hong BI Yu Fang WANG Wei Qing DAI Meng LU Jie Li | 2018 | Biomedical and Environmental Sciences2018，31，2： | 13 |
| 12 | Irisin attenuates intestinal injury,oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis显示文摘BACKGROUND Acute pancreatitis(AP)is often associated with intestinal injury,which in turn exaggerates the progression of AP.Our recent study has shown that a low level of serum irisin,a novel exercise-induced hormone,is associated with poor outcomes in patients with AP and irisin administration protects against experimental AP.However,the role of irisin in intestinal injury in AP has not been evaluated.AIM To investigate the effect of irisin administration on intestinal injury in experimental AP.METHODS AP was induced in male adult mice by two hourly intraperitoneal injections of Larginine.At 2 h after the last injection of L-arginine,irisin(50 or 250μg/kg body weight)or 1 mL normal saline(vehicle)was administered through intraperitoneal injection.The animals were sacrificed at 72 h after the induction of AP.Intestinal injury,apoptosis,oxidative and endoplasmic reticulum(ER)stress were evaluated.RESULTS Administration of irisin significantly mitigated intestinal damage,reduced apoptosis,and attenuated oxidative and ER stress in AP mice.In addition,irisin treatment also effectively downregulated serum tumor necrosis factor-alpha and interleukin-6 levels and alleviated injury in the pancreas,liver and lung of AP mice.CONCLUSION Irisin-mediated multiple physiological events attenuate intestinal injury following an episode of AP.Irisin has a great potential to be further developed as an effective treatment for patients with AP. | Yi-Fan Ren Meng-Zhou Wang Jian-Bin Bi Jia Zhang Lin Zhang Wu-Ming Liu Sha-Sha Wei Yi Lv Zheng Wu Rong-Qian Wu | 2019 | World Journal of Gastroenterology2019，25，45： | 12 |
| 13 | An experimental study of fracture initiation mechanisms during hydraulic fracturing显示文摘破裂开始的机制是为水力的破裂技术的基本问题。因为在为不同水库的破裂开始机制的巨大的差别,成功的断裂技术用于孔水库的一些为折断的水库是徒劳的。用一台过程模拟设备的实验室测试被执行在不同水库证实破裂开始和繁殖的特征。破裂开始和繁殖上的外壳的压力地,限制压力,和自然破裂的影响被讨论。试验性的结果证明在洞附近的压力集中将显著地增加岩石的破裂压力。同时,在地上凿穿墙中的自然破裂将消除压力集中,它在破裂开始压力导致减少。 | Yan Tie Li Wei Bi Xueliang | 2011 | Petroleum Science2011，8，1： | 12 |
| 14 | Relative apparent diffusion coefficient: a promising tool to differentiate metastatic from benign lymph nodes in animal models显示文摘背景散开加权的成像广泛地被用来区分 lymphadenopathy 的特性。但是优先的研究之间有重要差别。学习的目的是在二个观察员独立地测量了的兔子 model.Methods 在变形、良性的淋巴节点的区别比较明显的散开系数(模数转换器) 和 rADC 的利益在有兴趣(ROI ) 的区域的不同尺寸的散开加权的图象上的每只兔子的四头肌的模数转换器。为 rADC 的适当 ROI 用 interobserver 系数被决定。rADC 被 ADClesion/ADCreference 地点计算。接收装置操作特征(巨鸟) 分析被执行在区分比较 ADC 值的诊断的值和 rADC 值从良性的淋巴 nodes.Results 变形当 ROI 包括了五个象素时, ICC 是 0.816,显示一个好 interobserver 协议。在变形、良性的淋巴节点之间的模数转换器和 rADC 价值的差别两个都是统计上重要的。在 ROC 曲线下面的区域比为 ADC 为 rADC 是更大的。与 0.640 的 rADC 标准,为区分的敏感和特性从良性的淋巴节点变形是 93 和 90,是的 respectively.Conclusion 一个参考地点,肌肉用小 ROI 揭示好重覆性, rADC 可以为在动物模型检测变形节点改进诊断精确性。 | XING Wei SHENG Jing CHEN Jie TIAN Jian-ming BI Heng-liang | 2011 | Chinese Medical Journal2011，，18： | 11 |
| 15 | Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance显示文摘Background:Osteosarcoma is the most common bone malignancy in children and adolescents,and 20%-30%of the patients suffer from poor prognosis because of individual chemoresistance.The Hippo/yes-associated protein(YAP) signaling pathway has been shown to play a role in tumor chemoresistance,but no previous report has focused on its involvement in osteosarcoma chemoresistance.This study aimed to investigate the role of the Hippo/YAP signaling pathway in osteosarcoma chemoresistance and to determine potential treatment targets.Methods:Using the Cell Titer-Glo Luminescent cell viability assay and flow cytometry analysis,we determined the proliferation and chemosensitivity of YAP-overexpressing and YAP-knockdown osteosarcoma cells.In addition,using western blotting and the real-time polymerase chain reaction technique,we investigated the alteration of the Hippo/YAP signaling pathway in osteosarcoma cells treated with chemotherapeutic agents.Results:Mammalian sterile 20-like kinase 1(MST1) degradation was increased,and large tumor suppressor kinase1/2(LAT51/2) total protein levels were decreased by methotrexate and doxorubicin,which increased activation and nuclear translocation of YAP.Moreover,YAP increased the proliferation and chemoresistance of MG63 cells.Conclusions:The Hippo/YAP signaling pathway plays a role in osteosarcoma chemoresistance,and YAP is a potential target for reducing chemoresistance. | Dong-Yu Wang Ya-Nan Wu Jun-Qi Huang Wei Wang Meng Xu Jin-Peng Jia Gang Han Bei-Bei Mao Wen-Zhi Bi | 2016 | Chinese Journal of Cancer2016，35，7： | 10 |
| 16 | Continuous Low-dose-rate Irradiation of Iodine-125 Seeds Inhibiting Perineural Invasion in Pancreatic Cancer显示文摘 | Zheng Lu Teng-Hui Dong Pei-Ren Si Wei Shen Yi-Liang Bi Min Min Xin Chen Yan Liu | 2016 | Chinese Medical Journal2016，，20： | 9 |
| 17 | Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water显示文摘Objective The effects of arsenic exposure from drinking water, arsenic metabolism, and arsenic methylation on blood pressure(BP) were observed in this study. Methods The BP and arsenic species of 560 participants were determined. Logistic regression analysis was applied to estimate the odds ratios of BP associated with arsenic metabolites and arsenic methylation capability. Results BP was positively associated with cumulative arsenic exposure(CAE). Subjects with abnormal diastolic blood pressure(DBP), systolic blood pressure(SBP), and pulse pressure(PP) usually had higher urinary i As(inorganic arsenic), MMA(monomethylated arsenic), DMA(dimethylated arsenic), and TAs(total arsenic) than subjects with normal DBP, SBP, and PP. The i As%, MMA%, and DMA% differed slightly between subjects with abnormal BP and those with normal BP. The PMI and SMI were slightly higher in subjects with abnormal PP than in those with normal PP. Conclusion Our findings suggest that higher CAE may elevate BP. Males may have a higher risk of abnormal DBP, whereas females have a higher risk of abnormal SBP and PP. Higher urinary i As may increase the risk of abnormal BP. Lower PMI may elevate the BP. However, higher SMI may increase the DBP and SBP, and lower SMI may elevate the PP. | WEI Bing Gan YE Bi Xiong YU Jiang Ping YANG Lin Sheng LI Hai Rong XIA Ya Juan WU Ke Gong | 2017 | Biomedical and Environmental Sciences2017，30，5： | 9 |
| 18 | Disturbance of hippocampal H2S generation contributes to CUMS-induced depression-like behavior: involvement in endoplasmic reticulum stress of hippocampus显示文摘长期的无法预言的温和压力淫液模型是消沉的一个广泛地使用的试验性的模型。在马头鱼尾的怪兽的外长的导致压力的 neuronal 房间死亡仔细与消沉的致病被联系。过多、延长的 endoplasmic 蜂窝胃嗯压力扳机房间死亡。氢硫化物 H 2 S,第三内长的发信号 gasotransmitter,作为 neuromodulator 和 neuroprotectant 在大脑功能起一个重要作用。我们假设了内长的 H 2 S 产生并且嗯在马头鱼尾的怪兽的应力可能涉及导致淫液的像消沉的行为。因此,集中于是否达到高潮的现在的学习扰乱内长的 H 2 S 和起来调整嗯在马头鱼尾的怪兽的应力并且是否外长的 H 2 S 阻止导致淫液的象压抑一样行为。结果证明对待淫液的老鼠展出像消沉的行为并且海马趾嗯包括调整葡萄糖的蛋白质的起来调整的层次的压力回答 78, CCAAT/enhancer 有约束力的蛋白质相应蛋白质,和劈开的 caspase-12 表示,当时 H 2 在马头鱼尾的怪兽的 S 在对待淫液的老鼠被压制。而且,外长的 H 2 S 阻止导致淫液的像消沉的行为。这些数据显示导致淫液的像消沉的行为与内长的 H 2 S 产生并且嗯在马头鱼尾的怪兽的应力并且建议了那内长的 H 2 S 并且嗯应力是消沉的新奇处理目标。 | Huiying Tan Wei Zou Jiamei Jiang Ying Tian Zhifang Xiao Lili Bi Haiying Zeng Xiaoqing Tang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 8 |
| 19 | Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity显示文摘Photonic sensors that are able to detect and track biochemical molecules offer powerful tools for information acquisition in applications ranging from environmental analysis to medical diagnosis.The ultimate aim of biochemical sensing is to achieve both quantitative sensitivity and selectivity.As atomically thick films with remarkable optoelectronic tunability,graphene and its derived materials have shown unique potential as a chemically tunable platform for sensing,thus enabling significant performance enhancement,versatile functionalization and flexible device integration.Here,we demonstrate a partially reduced graphene oxide(prGO)inner-coated and fiber-calibrated Fabry-Perot dye resonator for biochemical detection.Versatile functionalization in the prGO film enables the intracavity fluorescent resonance energy transfer(FRET)to be chemically selective in the visible band.Moreover,by measuring the intermode interference via noise canceled beat notes and locked-in heterodyne detection with Hz-level precision,we achieved individual molecule sensitivity for dopamine,nicotine and single-strand DNA detection.This work combines atomic-layer nanoscience and high-resolution optoelectronics,providing a way toward high-performance biochemical sensors and systems. | Zhongxu Cao Baicheng Yao Chenye Qin Run Yang Yanhong Guo Yufeng Zhang Yu Wu Lei Bi Yuanfu Chen Zhenda Xie Gangding Peng Shu-Wei Huang Chee Wei Wong Yunjiang Rao | 2019 | Light(Science & Applications)2019，8，1： | 8 |
| 20 | 6-DOF MOTION AND CENTER OF ROTATION ESTIMATION BASED ON STEREO VISION显示文摘A new motion model and estimation algorithm is proposed to compute the general rigid motion object′s 6-DOF motion parameters and center of rotation based on stereo vision.The object′s 6-DOF motion model is designed from the rigid object′s motion character under the two defined reference frames.According to the rigid object′s motion model and motion dynamics knowledge,the corresponding motion algorithm to compute the 6-DOF motion parameters is worked out.By the risid object pure rotation motion model and space sphere geometry knowledge,the center of rotation may be calculated after eliminating the translation motion out of the 6-DOF motion.The motion equations are educed based on the motion model and the closed-form solutions are figured out.To heighten the motion estimation algorithm′s robust,RANSAC algorithm is applied to delete the outliers.Simulation and real experiments are conducted and the experiment results are analyzed.The results prove the motion model′s correction and algorithm′s validity. | CAO Wanpeng BI Wei CHE Rensheng GUO Wenbo YE Dong | 2008 | Chinese Journal of Mechanical Engineering2008，21，2： | 8 |
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