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| 1 | Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence显示文摘AIM To assess magnetic resonance imaging(MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease(CD).METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo(5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence(POR) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical data.RESULTS Apparent diffusion coefficient(ADC) was lower in patients with endoscopic POR compared to those with no recurrence(2.03 ± 0.32 vs 2.27 ± 0.38 × 10^(-3) mm^2/s, P = 0.032). Clermont score(10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement(RCE)(129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity(Ma RIA)(7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system(P = 0.056). ADC < 2.35 × 10^(-3) mm^2/s [sensitivity = 0.85, specificity = 0.65, positive predictive value(PPV) = 0.85, negative predictive value(NPV) = 0.65] and RCE > 100%(sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cutoff values to identify endoscopic POR. Clermont score > 6.4(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), Ma RIA > 3.76(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1(sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR(114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high performances to detect endoscopic POR(sensitivity = 0.67, specificity = 0.93, PPV = 0.89 and NPV = 0.77).CONCLUSION Faecal calprotectin and MRI are two reliable tools to detect endoscopic POR in patients with CD. | Pierre Baillet Guillaume Cadiot Marion Goutte Felix Goutorbe Hedia Brixi Christine Hoeffel Christophe Allimant Maud Reymond Hélène Obritin-Guilhen Benoit Magnin Gilles Bommelaer Bruno Pereira Constance Hordonneau Anthony Buisson | 2018 | World Journal of Gastroenterology2018，24，5： | 1 |
| 2 | Random and site-specific mutagenesis of the Helicobacter pylori ferric uptake regulator provides insight into Fur structure-function relationships显示文摘 | Gilbreath J J Pich O Q Benoit S L Besold A N Cha J H Maier R J Michel S L Maynard E L Merrell D S | 2013 | Molecular Microbiology2013，89，2： | 1 |
| 3 | Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea显示文摘 | Amselem J Cuomo C A van Kan J A Viaud M Benito E P Couloux A Coutinho P M de Vries R P Dyer PS Fillinger S Fournier E Gout L Hahn M Kohn L Lapalu N Plummer K M Pradier J M Quévillon E Sharon A Simon A ten Have A Tudzynski B Tudzynski P Wincker P Andrew M Anthouard V Beever R E Beffa R Benoit I Bouzid O Brault B Chen Z Choquer M Collémare J Cotton P Danchin E G Da Silva C Gautier A Giraud C Giraud T Gonzalez C Grossetete S Güldener U Henrissat B Howlett B J Kodira C Kretschmer M Lappartient A Leroch M Levis C Mauceli E Neuvéglise C Oeser B Pearson M Poulain J Poussereau N Quesneville H Rascle C Schumacher J Ségurens B Sexton A Silva E Sirven C Soanes D M Talbot N J Templeton M Yandava C Yarden O Zeng Q Rollins J A Lebrun M H Dickman M | 2011 | PLoS Genetics2011，7，10： | 1 |
| 4 | Reducing Suicidal Ideation and Depression in Older Primary Care Patients: 24-Month Outcomes of the PROSPECT Study显示文摘 | Alexopoulos George S Reynolds Charles F Bruce Martha L Katz Ira R Raue Patrick J Mulsant Benoit H Oslin David W Have Thomas Ten | 2009 | The American Journal of Psychiatry2009，，： | 1 |
| 5 | Pulmonary embolism detection:prospective evaluation of Dula-section Helical CT versus selective pulmonary arteriography in 157 patients显示文摘 | SALAH D Q MOSTAFA E L H BENOIT M | 2000 | Radiology2000，217，： | 1 |
| 6 | A compositional classification scheme for meteoritic chondrules显示文摘 | Sears D W Jie L Benoit P H | | 0，，： | 1 |
| 7 | De- termination of chlordecone in soils by GC/MS显示文摘 | AMALRIC L BENOIT H BERREHOUC A | 2006 | In- ternational Journal of Environmental Analytical Chemistry2006，86，： | 1 |
| 8 | Synthesis of trans-(3S)-amino-(4R)-alkyl-and-(4S)-aryl-piperidines via ring-closing metathesis reaction显示文摘 | Eric H Nick K K Benoit L | 2002 | Org Lett2002，4，25： | 1 |
| 9 | Abnormal number of fetal ribs on 3-dimensional ulrasonography: associated anomalies and outcomes in 75 fetuses显示文摘 | Gindes L Benoit B Pretorius D H | 2008 | J Ultrasound Med2008，27，9： | 1 |
| 10 | Appliance energy stand- ards in Europe 显示文摘 | Paul W Benoit L Mark H | 1997 | Energy and Buildings1997，，26： | 1 |
| 11 | Growth and meat quality relations in carp显示文摘 | BENOIT F H ALAMITUALITY D MICHEL L | 1995 | Aquaculture1995，129，： | 1 |
| 12 | Improvements in the use of helium for vacuum quenching 显示文摘 | Marcia A P Benoit L H Olivier D | 1991 | Industrial Heating1991，，10： | 1 |
| 13 | Two chondrule groups each with distinctive rims in Murchison recognized by cathodoluminescence 显示文摘 | Sears D W G Benoit P H Jie L | 1993 | Meteoritics1993，28，： | 1 |
| 14 | Pulmonary embolism detection: prospective evaluation of Dula-section Helical CT versus selective pulmonary arteriography in 157 patients显示文摘 | SALAH D Q MOSTAFA E L H BENOIT M | 2000 | Radiology2000，217，： | 1 |
| 15 | Estimating agricultural use values in New York State 显示文摘 | Benoit A D Todd H K A1 Lochen G S Bills N L Boisvert R N | 1978 | Land Economics1978，54，： | 1 |
| 16 | Formation building and collision avoidance for a fleet of NAOs based on optical sensor with local positions and minimum communication显示文摘Multi-robot system has become a research hotspot because of low demand on the sensors' accuracy, high reliability, and high efficiency. To put all the robots together, formation control is a crucial problem. In this paper, we propose a local position-based method to plan trajectories and build a pyramid pattern for a fleet of NAOs in the obstacle-free environment by refering to the position-based method and giving an O(n log n) collision avoidance strategy inspired from one graph theory, where the local positions are estimated from optical sensors. To get the local positions, an integrated image processing method is developped. Firstly a mask-base is generated to store the features of NAOs, and a cross-correlation method is introduced to recognize the NAO. Subsequently, the distance and angle models are proposed to get the local information from a single image. Then, a visual compass is introduced to obtain the orientation of one NAO. After the local information exchange by the WiFi communication, a neighbor-check method is put foward to distinguish the homogeneous NAOs(all the NAOs look like the same). Further, a common frame is constructed as an artificial global frame, and straight non-intercrossing trajectories are planned according to the O(n log n) collision avoidance strategy. At last, the performance of our proposed local position-based method is verified by the simulations with up to 15 robots and the indoor experiments with 3 NAOs in a real environment. The convergence of the method has been demonstrated in both obstacle-free and static obstacle environments. | Xiaomin WANG Lorenzo BENOZZI Benoit ZERR Zexiao XIE Hélène THOMAS Benoit CLEMENT | 2019 | Science China(Information Sciences)2019，62，5： | 0 |
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