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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer显示文摘 | Bennett WP Hollstein MC He A | 1991 | Oncogene1991，6，10： | 1 |
| 3 | Cytochrome oxidase inhibition: a novel animal model of Alzheimer's disease显示文摘 | Bennett MC Diamond DM Stryker SL | 1992 | J Geriatr Psychiatry Neurol1992，5，2： | 1 |
| 4 | Treatment ofneuromyelitis optica: state-of-the-art and emerging therapies显示文摘 | Papadopoulos MC Bennett JL Verkman AS | 2014 | Nat Rev Neurol2014，10，9： | 1 |
| 5 | An Analysis Capital Guaranteed Funds显示文摘 | Bennett J.A Chen A.H Mc Ginness P | | 0，，： | 1 |
| 6 | Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation显示文摘 | Bennett MC Fleshner M | 1992 | Hippocampus1992，2，4： | 1 |
| 7 | Strategies to improve compensation for pharmaceutical care services显示文摘 | Bennett MS Blank D Bopp J James JA Osterhaus MC | 2000 | J Am Pharm Assoc2000，40，： | 1 |
| 8 | Effects of environmental enrichment and impoverishment on rat cerebral cortex显示文摘 | Diamond MC Rosenzweig MR Bennett EL | 1972 | J Neurobiol1972，3，1： | 1 |
| 9 | p53 mutation and protein accumulation during multistage human esophageal carcinogenesis显示文摘 | Bennett WP Hollstein MC Metcalf RA | 1992 | Cancer Res1992，52，21： | 1 |
| 10 | Not just a plasma membrane protein: in cardiac muscle cells alpha- H spectrin also shows a close association with myofibrils 显示文摘 | Bennett PM Baines AJ Lecomte MC | 2004 | J Muscle Res Cell Motil2004，25，2： | 1 |
| 11 | OP 35 Patterns of antidiabetic and cardiovascular medication use in early onset type 2 diabetes:a retrospective observational cohort study显示文摘 | Grimes P T Bennett K Henman MC | 2015 | Journal ofEpidemiology & Community Health2015，69，1： | 1 |
| 12 | The treatment of neuromyelitis optica显示文摘 | Kowarik MC Soltys J Bennett JL | 2014 | J Neuroophthalmol2014，34，1： | 1 |
| 13 | Pimecrolimus 1 % cream for oral erosive lichen planus : a 6-week randomized, double-blind, vehicle-controlled study with 6- week open-label extension to assess efficacy and safety显示文摘 | MC Caughey C Machan R Bennett JZ | 2011 | J Eur Acad Dermatol Venereol2011，25，9： | 1 |
| 14 | Serum oestradiol in women with and without breast disease显示文摘 | Mc Caffrey JF Mccaffrey E | 1990 | Br J Cancer1990，61，： | 1 |
| 15 | IL - 12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN - gamma显示文摘 | Zhou P Sieve MC Bennett J | 1995 | J Immunol1995，155，2： | 1 |
| 16 | The role of a-synuclein in neurodegenerative diseases显示文摘 | Bennett MC | 2005 | Pharmacol Ther2005，105，： | 1 |
| 17 | Antiarrhythmic drug target choices and screening显示文摘 | Sanguinetti MC Bennett PB | 2003 | Cir Res2003，93，6： | 1 |
| 18 | Cytochrome oxidase inhibition: a novel animal model of Alzheimer’s disease显示文摘 | Bennett MC Diamond DM Stryker SL | 1992 | JGeriatr Psychiatry Neurol1992，5，2： | 1 |
| 19 | Degradation of alpha-synuclein by proteasome 显示文摘 | Bennett MC Bishop JF Leng Y | 1999 | J Biol Chem1999，48，33： | 1 |
| 20 | Rat brain: effects of environmental enrichment on wet and dry weights 显示文摘 | Bennett EL Rosenzweig MR Diamond MC | 1969 | Science1969，163，3869： | 1 |
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