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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 3 | Intraspecific variation in Cryptocaryon irritans 显示文摘 | BENJAMIN K D ROBERT D A | 1997 | Journal of Medical Microbiology1997，4，1： | 1 |
| 4 | Basic fibroblast growth factor-induced cell death is effected through sustained activation of p38MAPK and up-regulation of the death receptor p75NTR显示文摘 | Andrew J K W Benjamin C D James R B | 2004 | J Biol Chem2004，279，47： | 1 |
| 5 | Pool fires-An empirical correlation显示文摘 | Benjamin D Ditch John L de Ris Thomas K Blanchat etal | 2013 | Combustion and Flame2013，160，12： | 1 |
| 6 | Cronobacter, the emergent bacterial pathogen Enterobacter sakazakii comes of age; MLST and whole genome sequence analysis显示文摘 | Forsythe S J Benjamin D Jolley A K | 2014 | BMC Genomics2014，15，1： | 1 |
| 7 | An intervention to promote healthy weight:Nutrition and Physical Activity Self-Assessment for Child Care(NAP SACC)theory and design显示文摘 | Ammerman A S Ward D S Benjamin S E Ball S C Sommers J K Molloy M | 2007 | Preventing chronic disease2007，4，3： | 1 |
| 8 | Dysnatremias and Survival in Adult Burn Patients: A Retrospective Analysis显示文摘 | Stewart Ian J Morrow Benjamin D Tilley Molly A Snow Brian D Gisler Christopher Kramer Keith W Aden James K Renz Evan M Chung Kevin K | 2013 | American Journal of Nephrology2013，，1： | 1 |
| 9 | The interrelationship between markets for new and ud durable goods显示文摘 | BENJAMIN D K KORMENDI R C | 1974 | Journal of Law and Eco- nomics1974，17，： | 1 |
| 10 | Occupational risks and injuries in non-agricultural immigrant Latiuo workers 显示文摘 | PRANSKY G MOSHENBERG D BENJAMIN K | 2002 | Am J lnd Med2002，42，2： | 1 |
| 11 | Antibiotic-impregnated Calcium Sulfate Use in Combat-related Open Fractures显示文摘 | Helgeson Melvin D Potter Benjamin K Tucker Christopher J Frisch Michael Shawen Scott B | 2009 | Orthopedics (Online)2009，，5： | 1 |
| 12 | Early predictors of in hospital death in infectve endocarditis显示文摘 | Chu V H Cabell C H Benjamin d k | 2004 | Circulation2004，109，： | 1 |
| 13 | Percutaneous closure of atrial septal defects leads to normalisati-on of atrial and ventricular volumes显示文摘 | Karen S L Benjamin K D Payman M | 2008 | J Cardiovasc Magn Reson2008，10，5： | 1 |
| 14 | aL Com-bined Optimization of Spatial and Temporal Filter forImproving Brain-Computer Interfacing 显示文摘 | GUIDO D BENJAMIN B MATTHIAS K et | 2006 | IEEETransactions on Biomedical Engineering2006，53，11： | 1 |
| 15 | Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry 显示文摘 | Benjamin E J Rice K M Arking D E | 2009 | Nat Genet2009，41，8： | 1 |
| 16 | Analysis of vanillyl- mandelic acid and homovanillic acid by UPLC-MS/MS in serum for diagnostic testing for neuroblastoma 显示文摘 | Sadilkova K Dugaw K Benjamin D | 2013 | Cliniea Chimica Ac- ta2013，424，： | 1 |
| 17 | Neo- natal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months显示文摘 | BENJAMIN D K STOLL B J FANAROFF A A | 2006 | Pediatrics2006，117，1： | 1 |
| 18 | Group B streptococcal meningitis: cerebrospinal fluid parameters in the era of intrapartum antibiotic prophylaxis 显示文摘 | ANSONG A K SMITH P B BENJAMIN D K | 2009 | Early Hum Dev2009，85，10： | 1 |
| 19 | When to suspect fungal infection in neonates: A clinical comparison of Candida albieans and Candida parapsilosis fungemia with eo- agulase- negative staphylo- eoccal bacteremia 显示文摘 | BENJAMIN D K ROSS K MCKINNEY R E | 2000 | Pediatrics2000，106，4： | 1 |
| 20 | Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous nonsmall-cell lung carcinoma显示文摘 | Lebanony D Benjamin H Gilad S Ezagouri M Dov A Ashkenazi K | | 0，，： | 1 |
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