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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 4 | XIAP regulates akt activity and caspase-3-dependent cleavage during eisplatin-induced apoptosis in human ovarian epithelial cancer eells显示文摘 | Eric A Gordon B M Benjamin K T | 2001 | Cancer Res2001，61，5： | 1 |
| 5 | Condensed tannin biosynthesis genes are regulated separately from other flavonoid biosynthesis genes in apple fruit skin显示文摘 | Adam M T Benjamin E U Robinson S P | 2006 | Plant Science2006，170，： | 1 |
| 6 | The skeletal attachment of ten-dons-tendon“entheses”显示文摘 | Benjamin M Kumai T Milz S | 2002 | Comp Biochem Physiol A Mol IntegrPhysiol2002，133，4： | 1 |
| 7 | Effects of landscape corridors on seed dispersal by birds显示文摘 | DOUGLAS J L BENJAMIN M B JOSHUA J T | 2006 | Science2006，309，7： | 1 |
| 8 | Performance of different soil model configurations in simulating ground surface temperature and surface fluxes 显示文摘 | Smimova T G Brown J M Benjamin S G | 1997 | Monthly Weather Review1997，125，8： | 1 |
| 9 | The skeletal attachment of tendons:tendon'enthuses”显示文摘 | Benjamin M Kumai T Milz S | | 0，，： | 1 |
| 10 | Estimating the ozone-forming potential of urban trees and shrubs显示文摘 | BENJAMIN M T WINER A M | 1998 | Atmospheric Environment1998，32，： | 1 |
| 11 | The skeletal attachment of tendons-tendon 'entheses' 显示文摘 | Benjamin M Kumai T Milz S | 2002 | Comp Biochem Physiol A Mol Integr Physiol2002，4，： | 1 |
| 12 | Performance of different soil model configurations in simulating ground surface temperature and surface fluxes 显示文摘 | Smirnova T G Brown J M Benjamin S G et ai | 1997 | Mon Wea Rev1997，125，： | 1 |
| 13 | MRI of Adnexal Masses in Pregnancy显示文摘 | Nicholas A T Benjamin M Y Bonnie N J | | 0，，： | 1 |
| 14 | Parameterization of cold season processes in the MAPS land- surface scheme 显示文摘 | Smirnova T G Brown J M Benjamin S G | 2000 | J Geophys Res2000，105，3： | 1 |
| 15 | Low-emitting urban forests: A taxonomic methodology for assigning isoprene and monoterpene emission rates显示文摘 | BENJAMIN M T SUDOL M BLOCH L | 1996 | Atrnos Environ1996，30，： | 1 |
| 16 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vosodilation of the brachial artery:A report of the international brachial artery reactivity task force显示文摘 | Corretti M C Anderson T J Benjamin E J | 2002 | J Am Coll Cardiol2002，39，2： | 1 |
| 17 | Evolution of bank ef- ficiency in Brazil: A DEA approach 显示文摘 | Roberta B S Geraldo S S Benjamin M T | 2010 | European Journal of Opera- tional Research2010，202，1： | 1 |
| 18 | Hand, foot, and mouth disease in China, 2008–12: an epidemiological study显示文摘 | Weijia Xing Qiaohong Liao Cécile Viboud Jing Zhang Junling Sun Joseph T Wu Zhaorui Chang Fengfeng Liu Vicky J Fang Yingdong Zheng Benjamin J Cowling Jay K Varma Jeremy J Farrar Gabriel M Leung Hongjie Yu | 2014 | The Lancet Infectious Diseases2014，，： | 1 |
| 19 | The skeletal attachment of tendons-tendon entheses显示文摘 | Benjamin M Kumai T | | 0，，： | 1 |
| 20 | In vivo T(lrho) and T(2)mapping of articular cartilage in osteoarthritis of the knee using 3T MRI显示文摘 | Li Xi Benjamin M C Link T M | 2007 | Osteoarthritis Cartilage2007，15，7： | 1 |
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