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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis显示文摘 | Benjamin MP Tang Guy D Eslick Jonathan C Craig Anthony S McLean | 2007 | The Lancet Infectious Diseases2007，，3： | 3 |
| 3 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 4 | Measuring the efectiveness of cataract surgery:the reliability and validity of a visual function outcomes instrument显示文摘 | Lawrence D Brogan C Benjamin L | 1999 | Br J Ophthalmol1999，83，1： | 1 |
| 5 | Rapamycin passes the torch:a new generation of m TOR inhibitors显示文摘 | Benjamin D Colombi M Moroni C | 2011 | Nature review s Drug Discovery2011，10，11： | 1 |
| 6 | Value of post-licensure data on benefits and risks of vaccination to inform vaccine policy: The example of rotavirus vaccines显示文摘 | Umesh D Parashar Margaret M Cortese Daniel C Payne Benjamin Lopman Catherine Yen Jacqueline E Tate | 2015 | Vaccine2015，，： | 1 |
| 7 | Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse显示文摘 | BENJAMIN M A McKAY D M YANG P C | 2000 | Gut2000，47，1： | 1 |
| 8 | The varia- ble response of dry land corn yield to soil water content at planting 显示文摘 | NIELSEN D C VIGIL M F BENJAMIN J G | 2009 | Agriculture Water Manage2009，96，： | 1 |
| 9 | Basic fibroblast growth factor-induced cell death is effected through sustained activation of p38MAPK and up-regulation of the death receptor p75NTR显示文摘 | Andrew J K W Benjamin C D James R B | 2004 | J Biol Chem2004，279，47： | 1 |
| 10 | Numerical analysis of the performance of a thermal ejector in a steam evaporator显示文摘 | Li X C Wang T Benjamin D | 2010 | Applied Thermal Engineering2010，30，： | 1 |
| 11 | Magnetic resonance coupling as a potential means for wireless power transfer to multiple small receivers显示文摘 | BENJAMIN L C JAMES F H DANIEL D S | 2009 | IEEE transactions on power electronics2009，24，7： | 1 |
| 12 | Orthostatic tolerance after spaceflight 显示文摘 | Lynda D Lane Benjamin D Levine | 1996 | J Appl Physiol1996，81，1： | 1 |
| 13 | Stem cell self-renewal in intestinal crypt显示文摘 | Benjamin D S Hans C | 2011 | Experimental cell research2011，317，： | 1 |
| 14 | Retail leasing:the determinants of shopping center rents显示文摘 | Benjamin J D Boyal G W Sirmans C F | 1990 | Journal of the American Real Estate and Urban Economics Association1990，，： | 1 |
| 15 | Quantifying effects of soilconditions on plant growth and crop production显示文摘 | BENJAMIN J G NIELSEN D C VIGIL M F | 2003 | Geoderma2003，116，： | 1 |
| 16 | The variable response of dry land corn yield to soil water content at planting显示文摘 | Nielsen D C Vigil M F Benjamin J G | 2009 | Agricultal watermanagement2009，96，： | 1 |
| 17 | Walbridge self-stratifying coatings for metallic substrates显示文摘 | BENJAMIN S C CARR D J | 1996 | Progress in Organic Coatings1996，，28： | 1 |
| 18 | Heat capacity of aqueous monoethanolamine, diethanolamine, N-methyldiethanolamine, and N-methyldiethanolamine-based blends with carbon dioxide显示文摘 | Ralph H Weiland John C Dingman Benjamin Cronin D | 1997 | Journal of Chemical & Engineering Data1997，42，： | 1 |
| 19 | Experimental techniques in the field of pipeline integrity显示文摘 | Freire J L F Vieira R D Benjamin A C | 2003 | Experimental Techniques2003，，5： | 1 |
| 20 | Self- strtifying coatings for metallic substrates 显示文摘 | BENJAMIN S CARR C WALBRIDGE D J | 1996 | Progress in Organic Coatings1996，28，3： | 1 |
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