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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Neuroanatomy of lower gastrointestinal pain disorders显示文摘Chronic abdominal pain accompanying intestinal inflammation emerges from the hyperresponsiveness of neuronal,immune and endocrine signaling pathways within the intestines,the peripheral and the central nervous system.In this article we review how the sensory nerve information from the healthy and the hypersensitive bowel is encoded and conveyed to the brain.The gut milieu is continuously monitored by intrinsic enteric afferents,and an extrinsic nervous network comprising vagal,pelvic and splanchnic afferents.The extrinsic afferents convey gut stimuli to second order neurons within the superficial spinal cord layers.These neurons cross the white commissure and ascend in the anterolateral quadrant and in the ipsilateral dorsal column of the dorsal horn to higher brain centers,mostly subserving regulatory functions.Within the supraspinal regions and the brainstem,pathways descend to modulate the sensory input.Because of this multiple level control,only a small proportion of gut signals actually reaches the level of consciousness to induce sensation or pain.In inflammatory bowel disease(IBD)and irritable bowel syndrome(IBS)patients,however,long-term neuroplastic changes have occurred in the brain-gut axis which results in chronic abdominal pain.This sensitization may be driven on the one hand by peripheral mechanisms within the intestinal wall which encompasses an interplay between immunocytes,enterochromaffin cells,resident macrophages,neurons and smooth muscles.On the other hand,neuronal synaptic changes along with increased neurotransmitter release in the spinal cord and brain leads to a state of central wind-up.Also life factors such as but not limited to inflammation and stress contribute to hypersensitivity.All together,the degree to which each of these mechanisms contribute to hypersensitivity in IBD and IBS might be diseaseand even patient-dependent.Mapping of sensitization throughout animal and human studies may significantly improve our understanding of sensitization in IBD and IBS.On the long run,this knowledge can be put forward in potential therapeutic targets for abdominal pain in these conditions. | Wim Vermeulen Joris G De Man Paul A Pelckmans Benedicte Y De Winter | 2014 | World Journal of Gastroenterology2014，20，4： | 7 |
| 3 | Cardiac biomarkers in pediatric heart disease:A state of art review显示文摘Every year there are more than 11000 hospitalizations related to heart failure in children resulting in significant morbidity and mortality.Over the last two decades,our understanding,diagnosis and management of pediatric heart failure is evolving but our ability to prognosticate outcomes in pediatric heart acute heart failure is extremely limited due to lack of data.In adult heart failure patients,the role of cardiac biomarkers has exponentially increased over the last two decades.Current guidelines for management of heart failure emphasize the role of cardiac biomarkers in diagnosis,management and prognostication of heart failure.It is also noteworthy that these biomarkers reflect important biological processes that also open up the possibility of therapeutic targets.There is however,a significant gap present in the pediatric population with regards to biomarkers in pediatric heart failure.Here,we seek to review available data regarding cardiac biomarkers in the pediatric population and also explore some of the emerging biomarkers from adult literature that may be pertinent to pediatric heart failure. | Benedict A Fernandes Kevin O Maher Shriprasad R Deshpande | 2016 | World Journal of Cardiology2016，8，12： | 6 |
| 4 | Management of syndesmotic injuries:What is the evidence?显示文摘Ankle fractures are accompanied by a syndesmotic injury in about 10% of operatively treated ankle fractures. Usually, the total rupture of the syndesmotic ligaments with an external rotation force is associated with a Weber type B or C fracture or a Maisonneuve fracture. The clinical assessment should consist of a comprehensive history including mechanism of injury followed by a specific physical examination. Radiographs, and if in doubt magnetic resonance imaging, are needed to ascertain the syndesmotic injury. In the case of operative treatment the method of fixation, the height and number of screws and the need for hardware removal are still under discussion. Furthermore, intraoperative assessment of the accuracy of reduction of the fibula in the incisura using fluoroscopy is difficult. A possible solution might be the assessment with intraoperative three-dimensional imaging. The aim of this article is to provide a current concepts review of the clinical presentation, diagnosis and treatment of syndesmotic injuries. | Marc Schnetzke Sven Y Vetter Nils Beisemann Benedict Swartman Paul A Grützner Jochen Franke | 2016 | World Journal of Orthopedics2016，7，11： | 4 |
| 5 | Review: Improving our knowledge of male mosquito biology in relation to genetic control programmes显示文摘 | Rosemary Susan Lees Bart Knols Romeo Bellini Mark Q. Benedict Ambicadutt Bheecarry Hervé Christophe Bossin Dave D. Chadee Jacques Charlwood Roch K. Dabiré Luc Djogbenou Alexander Egyir-Yawson René Gato Louis Clément Gouagna Mo’awia Mukhtar Hassan Shakil A | 2013 | Acta Tropica2013，，： | 2 |
| 6 | Green Infrastructure: Smart Conservation for the 21st Century显示文摘 | Benedict M A Mcmahon E T | 2002 | Renewable Resources Journal2002，，3： | 1 |
| 7 | Modeling theperformance of a solar pond as a source of thermal energy显示文摘 | Rubin H Benedict B A Bachu S | 1984 | Solar Energy1984，32，6： | 1 |
| 8 | Chemical strategies to design textured materials:From microporous and mesoporous oxides to nanonetworks and hierarchical structures显示文摘 | Galo J de A A Soler-Illia Clément Sanchez Benedicte Lebeau | 2002 | Chemical Reviews2002，102，11： | 1 |
| 9 | An integrated genetic map of the African human malaria vector mosquito,Anopheles gambiae显示文摘 | ZHENG L BENEDICT M Q CORNEL A J | 1996 | Genetics1996，143，： | 1 |
| 10 | Diversity of biosurfactant producing microorganisms isolated from soils contaminated with diesel oil显示文摘 | Fa' tima Menezes Bentoa Fla' vio A de Oliveira Camargoa Benedict C Okekeb | 2005 | Microbiological Research2005，160，： | 1 |
| 11 | Cotton fiber development kinetics of cell elongation and seeondary wall thickening显示文摘 | SCHUBER A M BENEDICT C R | 1973 | Crop Science1973，13，6： | 1 |
| 12 | Note on the use olr aniline in the preparation olr amino acids显示文摘 | Benedict H C A | 1929 | J Am Chem Soc1929，51，： | 1 |
| 13 | The lung as an alternative route of delivery for insulin in controlling postprandial glucose levels in patients with diabetes显示文摘 | BENEDICT G W DOBS A S | 1998 | Chest1998，114，9： | 1 |
| 14 | Identification of phases in zinc alloy powders using electron backscatter diffraction显示文摘 | Martin G Perez Edward A Kenik Matthew J O'Keefe F Scott Miller Benedict Johnson | 2006 | Mater Sci Eng A2006，424，： | 1 |
| 15 | Biological phosphorus removal: A technology evaluation 显示文摘 | Tetreault M J Benedict A H Kaempfer C | 1986 | Water Environment Federation1986，58，8： | 1 |
| 16 | The significance of compliance and persistence in the treatment of diabetes,hypertension and dyslipidaeadult population in rural and urban China:the Beijing eye study显示文摘 | Cramer J Benedict A Muszbek N | 2008 | Am J Hypertens2008，21，10： | 1 |
| 17 | Eval- uation of adjunctive ketamine to benzodiazepines for man- agement of alcohol withdrawal syndrome 显示文摘 | WONG A BENEDICT N J ARMAHIZER M J et M | 2015 | Alan Pharma- tother2015，49，1： | 1 |
| 18 | Intranasal insulin improves memory in humans 显示文摘 | Benedict C Hallschmid M Hatke A | 2004 | Psychoneuroendocrinol2004，29，10： | 1 |
| 19 | Neuroprotective effects of sulforaphane after contusive spinal cord injury 显示文摘 | Benedict AL Mountney A Hurtado A | 2012 | J Neurotrauma2012，29，16： | 1 |
| 20 | Clinical targeting of the TNF and TNFR superfamilies 显示文摘 | Croft M Benedict C A Ware C F | 2013 | Nat Rev Drug Discov2013，12，2： | 1 |
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