|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Preparation and self-assembly of amphiphilic polymer with aggregation-induced emission characteristics显示文摘An amphiphilic polymer bearing tetraphenylethene (TPE) moiety was synthesized by convenient reactions. The polymer exhibits unique aggregation-induced emission (AIE) characteristics and can self-assemble to size-tunable particles in DMF/water mixtures. The polymer nanoparticles can be used for cell imaging, which provides a potential stable fluorescent tool to monitor the distribution of drugs and bioconjugates in living cells. | QIN AnJun ZHANG Ya HAN Ning MEI Ju SUN JingZhi FAN WeiMin TANG Ben Zhong | 2012 | Science China Chemistry2012，55，5： | 16 |
| 2 | Gastric stimulation for weight loss显示文摘The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight loss.Behavior and lifestyle therapy are safe treatments for obesity in the short term,but the durability of the weight loss is limited.Although promising obesity drugs are in development,the currently available drugs lack efficacy or have unacceptable side effects.Surgery leads to long-term weight loss,but it is associated with morbidity and mortality.Gastric electrical stimulation(GES) has received increasing attention as a potential tool for treating obesity and gastrointestinal dysmotility disorders.GES is a promising,minimally invasive,safe,and effective method for treating obesity.External gastric pacing is aimed at alteration of the motility of the gastrointestinal tract in a way that will alter absorption due to alteration of transit time.In addition,data from animal models and preliminary data from human trials suggest a role for the gut-brain axis in the mechanism of GES.This may involve alteration of secretion of hormones associated with hunger or satiety.Patient selection for gastric stimulation therapy seems to be an important determinant of the treatment's outcome.Here,we review the current status,potential mechanisms of action,and possible future applications of gastric stimulation for obesity. | Meir Mizrahi Ami Ben Ya'acov Yaron Ilan | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 3 | Oral administration of a non-absorbable plant cellexpressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis显示文摘AIM To evaluate the immunomodulatory effect of oral administration of PRX-106 in the high-fat diet model.METHODS For 22 wk, C57BL/6 HFD-fed mice received daily oral treatments with BY-2 cells expressing recombinant antitumor necrosis factor alpha fusion protein(PRX-106). Mice were followed for serum liver enzyme and triglyceride levels, liver histology and intrahepatic and systemic FACS.RESULTS The orally administered non-absorbable PRX-106 w a s b i o l o g i c a l l y a c t i v e. A l t e r e d d i s t r i b u t i o n o f CD4+CD25+Fox P3+ between the liver and spleen and an increase in the intrasplenic-to-intrahepatic CD4+CD25+Fox P3+ ratio and a decrease in the intrasplenic-to-intrahepatic CD8+CD25+Fox P3+ ratio were observed. An increase in intrahepatic NKT cells and a decrease in the intrasplenic-to-intrahepatic NKT ratio were noted. Assessment of the CD4-to-CD8 ratios showed sequestration of CD8+ lymphocytes in the liver. These effects were associated with a decrease in serum triglyceride levels, decrease in the aspartate aminotransferase levels, serum glucose levels, and HOMA-IR score. A decrease in hepatic triglycerides content was observed in the high dose-treated mice.CONCLUSION Orally administered PRX-106 shows biological activity and exerts an immunomodulatory effect, alleviating liver damage. The data suggest that PRX-106 may provide an oral immunotherapy for nonalcoholic steatohepatitis. | Yaron Ilan Ami Ben Ya'acov Yehudit Shabbat Svetlana Gingis-Velitski Einat Almon Yoseph Shaaltiel | 2016 | World Journal of Gastroenterology2016，22，39： | 3 |
| 4 | Beta glycosphingolipidssuppress rank expression and inhibit natural killer T cell andCD8+ accumulation in alleviating aortic valve calcification显示文摘 | Shuvy M Ben YA Zolotarov L | 2009 | IntJ Immunopath Ph2009，22，4： | 1 |
| 5 | Potential role of NKT regulatory cell ligands for the treatment of immune mediated colitis显示文摘Natural killer T lymphocytes (NKT) have been implicated in the regulation of autoimmune processes in both mice and humans. In response to stimuli, this subset of cells rapidly produces large amounts of cytokines thereby provoking immune responses, including protection against autoimmune diseases. NKT cells are present in all lymphoid compartments, but are most abundant in the liver and bone marrow. They are activated by interaction of their T-cell receptor with glycolipids presented by CD1d, a nonpolymorphic, major histocompatibility complex class I-like molecule expressed by antigen presenting cells. Several possible ligands for NKT cells have recently been suggested. β-glucosylceramide, a naturally occurring glycolipid, is a metabolic intermediate in the anabolic and catabolic pathways of complex glycosphingolipids. Like other β-glycolipids, β-glucosylceramide has an immunomodulatory effect in several immune mediated disorders, including immune mediated colitis. Due to the broad impact that NKT cells have on the immune system, there is intense interest in understanding how NKT cells are stimulated and the extent to which NKT cell responses can be controlled. These novel ligands are currently being evaluated in animal models of colitis. Here, we discuss strategies to alter NKT lymphocyte function in various settings and the potential clinical applications of natural glycolipids. | Madi El Haj Ami Ben Ya'acov Gadi Lalazar Yaron Ilan | 2007 | World Journal of Gastroenterology2007，13，44： | 1 |
| 6 | Combination of ballistic lithotripsy and transurethral prostatetomy in bladder stones with benign prostatic hyperplasia: report of 120 cases 显示文摘 | Chtourou M Ben YA Binous MY | 2001 | J Endourol2001，15，： | 1 |
| 7 | From airway inflammation to inflammatory bowel disease: eotaxin-1, a key regulator of intestinal inflammation显示文摘 | Adar T Shteingart S Ben Ya'acov A | 2014 | Clin Immunol2014，153，1： | 1 |
| 8 | Reduced liver cell death using a bandage of alginate scaffold: A novel approach for liver reconstruction after extended partial hepatectomy显示文摘 | Eyal Shteyer Ami Ben Ya’acov Lidia Zolotaryova Avital Sinai Yoav Lichtenstein Orit Papoo Olga Kryukov Tsiona Elkayam Smadar Cohen Yaron Ilan | 2014 | Acta Biomaterialia2014，，： | 1 |
| 9 | From airway inflammation to inflammatory bowel disease= eotaxin-1, a key regu- lator of intestinal inflammation显示文摘 | ADAR T SHTE1NGART S BEN YA'ACOV A | 2014 | Clin Immunol2014，153，1： | 1 |
| 10 | β-Glycoglycosphingolipid-induced augmentation of theanti-HBV immune response is associated with altered CD8and NKT lymphocyte distribution:A novel adjuvant for HBVvaccination显示文摘 | Mizrahi M Lalazar G Ben Ya'acov A | 2008 | Vaccine2008，26，21： | 1 |
| 11 | Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin:results of a phase I/II clinical trial in NASH显示文摘 | MIZRAHI M SHABAT Y BEN YA’ACOV A | 2012 | J inflame res2012，5，： | 1 |
| 12 | Combination of ballistic lithotripsy and transurethral prostatectomy bladder stones with benign prostatic hyperplasia: report of 120 cases 显示文摘 | CHTOUROU M BEN YA BINOUS MY | 2001 | J Endouro2001，15，8： | 1 |
| 13 | Epidemiologic variability of chronic inflammatory dcmyelinating polyneuropathy with different diagnostic criteria: study of a UK population 显示文摘 | Rajabally YA Simpson BS Ben S | 2009 | Muscle Nerve2009，39，43： | 1 |
| 14 | Molecular characterization of coxsacklevirus B5 isolates显示文摘 | Rezig D Ben YA Ben AH | 2004 | J Med Virol2004，72，2： | 1 |
| 15 | Beta glycosphingolipids suppress rank expression and inhibit natural killer T cell and CD8 accumulation in alleviating aortic valve calcification显示文摘 | Shuvy M Ben YA Zolotarov L | 2009 | lnt JIm munopathology and Pharmacology2009，22，4： | 1 |
| 16 | “Several birds with one stone”strategy of pH/thermoresponsive flame-retardant/photothermal bactericidal oil-absorbing material for recovering complex spilled oil显示文摘Although many material designs or strategic methods have been proposed for treating oil spills and oily wastewater,the complex oily state,dealing with the harsh operating conditions of oil–water separation(such as the recovery of viscous spilled crude oil,bacteria-containing oily wastewater,and removal of spilled oil under fire),and the autorecycling of oil and absorption materials remain a great challenge.This work proposed an ingenious design strategy of“several birds with one stone”to prepare p H/thermoresponsive flame-retardant/photothermal bactericidal P-Fe_(3)O_(4)-polydopamine(PDA)@melamine–formaldehyde(MF)foams.This design makes the foams remarkably effective in the recovery of spilled viscous crude oil as well as in the separation of bacteria-containing oily emulsions,particularly for instant fire extinguishing by magnetically controlled oil absorption as well as for fire alarms.The photothermal effect and p H response induce a change in the surface wettability of the foams,facilitating excellent autoadsorption/desorption of the spilled oil.The photothermal bactericidal activity and fouling resistance of the foam are beneficial to the separation of bacteria-containing oily wastewater.Outstanding flame-retardant properties and maneuverable magnetic control enable the foam to rapidly recover the spilled oil in a large range of fires,extinguish fires instantly,and facilitate early fire warning.The proposed strategy is expected to inspire further research on treating oil spills under complex conditions. | Ya Chen Jing Lin Gaber A.M.Mersal Jianliang Zuo Jialin Li Qiying Wang Yuhong Feng Jianwei Liu Zili Liu Bin Wang Ben Bin Xu Zhanhu Guo | 2022 | Journal of Materials Science & Technology2022，，33： | 1 |
| 17 | Video-assisted thoraciscopic excision of herniated thoracic disc:description of technique and preliminary experience in the first 29 cases 显示文摘 | Regan JJ Ben YA Mack MJ | 1998 | J Spinal Disord1998，11，2： | 1 |
| 18 | Combination of ballistic lithotripsy and transurethral prostatectomy bladder stones with benign prostatic hyperplasia:report of 120 cases显示文摘 | Ben YA Binous MY | 2001 | J Endourol2001，15，8： | 1 |
| 19 | Skip residues and charge interactions in myosin II coiled - coils : implications for molecular packing 显示文摘 | Straussman R Squire J M Ben -Ya ~acov A | 2005 | J MolBiol2005，353，61： | 1 |
| 20 | Distribution of Microbiota in Fine Particulate Matter Particles in Guangzhou, China显示文摘Objective High PM2.5 concentration is the main feature of increasing haze in developing states,but information on its microbial composition remains very limited.This study aimed to determine the composition of microbiota in PM2.5 in Guangzhou,a city located in the tropics in China.Methods In Guangzhou,from March 5th to 10th,2016,PM2.5 was collected in middle volume air samplers for 23 h daily.The 16 S rDNA V4 region of the PM2.5 sample extracted DNA was investigated using high-throughput sequence.Results Among the Guangzhou samples,Proteobacteria,Bacteroidetes,Firmicutes,Cyanobacteria,and Actinobacteria were the dominant microbiota accounting for more than 90%of the total microbiota,and Stenotrophomonas was the dominant gram-negative bacteria,accounting for 21.30%–23.57%.We examined the difference in bacterial distribution of PM2.5 between Beijing and Guangzhou at the genus level;Stenotrophomonas was found in both studies,but Escherichia was only detected in Guangzhou.Conclusion In conclusion,the diversity and specificity of microbial components in Guangzhou PM2.5 were studied,which may provide a basis for future pathogenicity research in the tropics. | DONG Shi Rui HAN Ya Jing WU Jing ZENG Cheng Li ZHU Ke Hui CHEN Xiao Jing LIU Yu Mei ZOU Xiao Qian ZHENG Shao Ling WEN Zi Hao LIU Dan Dan WANG Yao HUANG Xiu Xia DU Xiu Ben HAO Jian Lei WANG Huan Yu GUO Shu JING Chun Xia YANG Guang | 2020 | Biomedical and Environmental Sciences2020，33，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员