|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | EAF Quantum-新型电弧炉炼钢技术显示文摘概述了EAF Quantum电弧炉的最新发展和设计概况。Quantum电弧炉提高了自动化水平,在原料使用、废钢操作、运行和维修等方面进一步增大了灵活性和可靠性,降低了电能成本,在污染物排放和噪声治理方面具有较大优势。通过与现代连铸和轧制技术相结合,EAF Quantum电弧炉是长材和带钢短流程生产的理想选择。 | Apfel Jens Beile Hannes Winkhold Achim | 2018 | 河北冶金2018，，10： | 8 |
| 2 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 3 | MICROSTRUCTURE OF INTERFACE BETWEEN HVOF SPRAYED WC-Co COATING AND SPRING STEEL SUBSTRATE显示文摘MICROSTRUCTUREOFINTERFACEBETWEENHVOFSPRAYEDWC-CoCOATINGANDSPRINGSTEELSUBSTRATE￥ShaoBeiling;LiuAnsheng;WangXiaohua;LiYonghong;... | Shao Beiling Liu Ansheng Wang Xiaohua Li Yonghong Zou Linying Wang Jing Zhang Jianguo Shi Changyong Zhou Yiru(General Research institute For Nonferrous Metals,Beijing 100088) | 1996 | 中国有色金属学会会刊:英文版1996，6，4： | 3 |
| 4 | Can Fluorine-18 Fluoroestradiol Positron Emission Tomography–Computed Tomography Demonstrate the Heterogeneity of Breast Cancer In Vivo?显示文摘 | Zhongyi Yang Yifei Sun Yongping Zhang Jing Xue Mingwei Wang Wei Shi Beiling Zhu Silong Hu Zhifeng Yao Herong Pan Yingjian Zhang | 2013 | Clinical Breast Cancer2013，，： | 2 |
| 5 | The E670G SNP in the PCSK9 gene is associated with polygenic hypercholesterolemia in men but not in women显示文摘 | EVANS D BEIL F U | 2006 | BMC Med Genet2006，7，： | 1 |
| 6 | Integration and acceleration of virtual microscopy as the key to successful implementation into the routine diagnostic process显示文摘 | Wienert S Beil M Saeger K | 2009 | Diagn Pathol2009，4，： | 1 |
| 7 | Differential glucocorticold effects on repair mechanisms and NF-kappaB activity in the intestinal epithelium显示文摘 | Goke M N Schneider M Beil W | 2002 | RegulPept2002，105，3： | 1 |
| 8 | An inverse-optimization-based auction mechanism to support a multi- attribute RFQ process显示文摘 | Beil D R Wein L M | 2003 | Management Science2003，49，11： | 1 |
| 9 | A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein显示文摘 | Spiess C Beil A Ehrmann M | 1999 | Cell1999，97，3： | 1 |
| 10 | Microgeographic edaphic differetiation in hordein polymorphism of wild barley显示文摘 | Nevo E Beiles A Storch N | 1983 | Theoretical and Applied Genetics1983，64，： | 1 |
| 11 | Population genetic response to microsite ecological stress in wild barley, Hordum spontaneum 显示文摘 | Owuor E D Fahima T Beiles A | 1997 | Mol Ecol1997，6，： | 1 |
| 12 | Proliferation of T-cells, macrophages, neutrophilic granulocytes and fibroblast-like cells in the synovial membrane of patients with rheumatioid arthritis 显示文摘 | Schaser K Kinne RW Beil H | 1996 | Verh Dtsch Ges Pathol1996，80，： | 1 |
| 13 | Rare variants in the lipoprotein lipase (LPL) gene are common in hypertriglyceridemia but rare in Type III hyperlipidemia显示文摘 | D. Evans J. Arzer J. Aberle F.U. Beil | 2010 | Atherosclerosis2010，，： | 1 |
| 14 | Formation of bioorganic amines during the maturity process of raw meat products,for example of cervelat sausages显示文摘 | Trevno E Beil D Steinhart H | 1997 | Food Chemistry1997，60，： | 1 |
| 15 | An inverse-optimization-based auction mechanism to support a multi-attribute RFQ process显示文摘 | Beil D R Wein L M | 2003 | Management Science2003，49，11： | 1 |
| 16 | Natural selection of allozyme polymorphisms:a microsite test revealing ecolgical genetic differentiation in wild barley显示文摘 | Nevo E Beiles A Kaplan D | 1986 | Evolution1986，40，： | 1 |
| 17 | Export growth,capacity utilization,and productivity growth:evidence from the Canadian manufacturing plants显示文摘 | John R B Wulong Gu Beiling Yan | 2013 | Review of Income and Wealth2013，59，4： | 1 |
| 18 | Prevalence of Helicobacter pylori and occurrence of gastroduodenal lesions in patients with liver cirrhosis显示文摘 | Kirchner GI Beil W Bleck JS | | 0，，01： | 1 |
| 19 | Helicobacter pylori augments the acid inhibitory effect of omeprazole on parietal cells and gastric H+/K+-ATPase显示文摘 | Beil W Sewing KF Busche R | 2001 | Gut2001，48，2： | 1 |
| 20 | Different basal expression of type Tl and T2 cytokines in peripheral lymphocytes of patients with adenocarcinomas and benign hyperplasia of the prostate 显示文摘 | Elsasser- Beile V Gieerschner D Jantscheff P | 2003 | Anticancer Res2003，23，40： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员