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| 1 | Neoadjuvant chemotherapy with cisplatin, 5-FU, and leucovorin (PLF) in locally advanced gastric cancer: a prospective phase II study显示文摘 | Katja Ott Andreas Sendler Karen Becker Hans-Joachim Dittler Hermann Helmberger Raimonde Busch Christian Kollmannsberger J. Rüdiger Siewert Ulrich Fink | 2003 | Gastric Cancer2003，，3： | 3 |
| 2 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 3 | Oscillometric twenty-four-hour ambulatory blood pressure values in healthy children and adolescents: a multicenter trial including 1141 subjects显示文摘 | Soergel M Kirsehstein M Busch C Danne T Gellermann J Holl R | 1997 | J Pediatr1997，130，2： | 1 |
| 4 | Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection显示文摘 | DREW W L MINER R C BUSCH D F | 1991 | J Infect Dis1991，163，： | 1 |
| 5 | Developing and shedding inhibitions:how MHC class Ⅱ molecules reach maturity显示文摘 | Busch R Mellins ED | 1996 | Curr Opin Immunol1996，8，： | 1 |
| 6 | Efficacy of periartieular multimodal drug injection in total knee arthroplasty:a randomized trial显示文摘 | Busch CA Shore B J Bhandari R | 2006 | J Bone Joint Surg(Am)2006，88，： | 1 |
| 7 | New natural draft cooling tower of 200m of height 显示文摘 | Busch D Harte R Krtzig Montag W B U | 2002 | Engineering Structures2002，24，12： | 1 |
| 8 | Morbidity if temporary loop ileostomies显示文摘 | Bakx R Busch OR Bemelman WA Veldink GJ | 2004 | Dig Surg2004，21，： | 1 |
| 9 | TP53mutation and survival in chronic lymphocytic leukemia显示文摘 | ZENZ T EICHHORST B BUSCH R | 2010 | J Clin Oncol2010，28，： | 1 |
| 10 | Sequential chemo- immunotherapy of fludarabine, Mitoxantrone, and cyclop- hosphamide induction followed by alemtuzumab consoli- dation is effective in T-cell prolymphocytic leukemia 显示文摘 | Hopfinger G Busch R Pflug N | 2013 | Cancer2013，119，12： | 1 |
| 11 | ApoE-epsi- lon4 is associated with reduced memory in long-standing intractable temporal lobe epilepsy显示文摘 | BUSCH R M LINEWEAVER T T NAUGLE R I | 2007 | Neurology2007，68，6： | 1 |
| 12 | Beyond blood pressure:new roles for angiotensin Ⅱ显示文摘 | LUCIUS R GALLINAT S BUSCHE S | 1999 | Cell Mol Life Sci1999，56，1112： | 1 |
| 13 | A survey of micro-actuator technologies for future spacecraft missions显示文摘 | GILBERTSON R G BUSCH J D | 1996 | The Journal of The British Interplanetary Society1996，49，： | 1 |
| 14 | Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer显示文摘 | Du KL Mick R Busch TM | 2006 | Lasers Surg Med2006，38，5： | 1 |
| 15 | DNA binding of Jun and Fos bZip domains:homodimers and heterodimers induce a DNA conformational change in solution显示文摘 | John M Leppik R Busch SJ | | 0，，22： | 1 |
| 16 | Cyclophuspharnide, adriamycin, vincristine and prednisone plus rituximab ( CHOP-R ) in tludarabine (F) refractory chronic lymphocytic leukemia (CLL) or CLL with au- toimmune cytopenia (AIC) or Richter 's transformation (RT) : final analysis of a phase II study of the German CLI~ Study Gruup 显示文摘 | Jenke P Eichhorst B Busch R | 2011 | Blood (ASH annual meeting Abstracts)2011，，： | 1 |
| 17 | Hand-assisted laparoscopic splenectomy显示文摘 | Bemelman W A de Wit L T Busch O R | 2000 | Surg Endosc2000，14，11： | 1 |
| 18 | Regulatory elements of the floral homeotie gene AGAMOUS identified by phylogenetic footprinting and shadowing显示文摘 | HONG R L HAMAGUCHI L H BUSCH M A WEIGEL D | 2003 | The Plant Cell2003，15，： | 1 |
| 19 | Study of a proposed 200m high natural draught cooling tower at power plant Frimmersdorf, Germany 显示文摘 | Busch D Harte R Niemann H | 1998 | Engineering Structures1998，20，10： | 1 |
| 20 | Rituximab for the second-and third-line therapy of idiopathic membranous nephropathy:a prospective single center study using a new treatment strategy显示文摘 | Busch M Rüster C Schink(o)the C | | 0，，02： | 1 |
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