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| 1 | “辨状论质”看中药材苦杏仁走油显示文摘通过苦杏仁走油前后的质量比较,探讨苦杏仁走油变质现象的感官判别及其物质内涵。该研究对苦杏仁样品走油前后的脂肪油含量、酸值、过氧化值进行了测定,并采用HPLC,GC-MS分别检测了苦杏仁苷、苦杏仁脂肪酸等。利用电子感官仪器(色度仪、电子鼻)量化并对比苦杏仁样品走油前后的颜色、气味;同时与上述结果作相关性分析。结果显示苦杏仁走油后颜色由黄白变棕黄,出现酸味;苦杏仁苷含量下降,酸值、过氧化值显著增高,脂肪酸成分发生变化;药材的外表特征与内在质量的变化具有显著相关性。'感官分析-质量鉴别系统'能为预测中药化学成分的含量、初步判断中药优劣及质量实时监测提供一定科学依据;为中药贮藏的'事先预测、事中干预、事后鉴别'提供新的思路与参考。 | 拱健婷 赵丽莹 Rudolf Bauer 米文娟 李阳 李佳慧 任智宇 徐东 赵婷 闫永红 | 2016 | 中国中药杂志2016，41，23： | 26 |
| 2 | Deeper Chemical Perceptions for Better Traditional Chinese Medicine Standards显示文摘Traditional Chinese medicines (TCMs), a complex system of natural resources with many diverse components, are widely used as approved medicinal agents in China. Quality control of TCMs is a huge challenge for the government and for testing institutes and is associated with numerous scientific issues. Among these considerations include the following questions: How many components are in TCMs? How can the multiple components in TCMs be comprehensively delineated and subsequently characterized? What is the level and range of these (active) metabolites within these multiple-component TCMs, in order to recommend standards? and What are the qualities required for a marker constituent to be selected, and from a practical perspective, how can these components be assessed with low cost and in a short time? All of these factors require significant and deep thinking in order to understand the individualistic chemistry of TCM in order to develop enhanced TCM quality standards for improved and consistent patient care. In this review, the latest exploratory research in TCM chemistry analytical techniques and methods is summarized in order to begin to develop responses to these scientific issues. Advances in these methods have included multidimensional separation for liquid chromatography–high-resolution mass spectrometry (LC–HRMS), smart triggering data-dependent acquisition of LC–HRMS, target analysis with liquid chromatography–mass spectrometry (LC–MS), supercritical fluid chromatography, and data mining of large mass spectrometry (MS) datasets. In addition, two quality strategies have been introduced in order to save reference standards and the analysis time for a TCM quality standard, including the application of the single standard to determine multi-components (SSDMC) and monomethodheterotrait matrix methods. Finally, a series of future improvements for analytical methods for TCMs are proposed. | Jin-Jun Hou Jian-Qing Zhang Chang-Liang Yao Rudolf Bauer Ikhlas A. Khan Wan-Ying Wu De-an Guo | 2019 | Engineering2019，5，1： | 9 |
| 3 | 新形势·新策略--网络药理学与中药新药研发显示文摘'网络药理学与生物医药发展国际论坛'于2018年8月23-25日在江苏省连云港市召开。本次论坛由中国科协海智办、国际药理学联合会天然药物药理学分会、中国药理学会、中国药学会、江苏省科学技术协会、江苏省食品药品监督管理局和连云港市人民政府共同主办,中国药理学会网络药理学专业委员会承办,江苏康缘药业股份有限公司协办,中国药理学会网络药理学专业委员会主任委员周文霞教授和常务委员、江苏康缘药业股份有限公司董事长肖伟教授共同担任论坛主席。有来自美国、澳大利亚、奥地利、中国大陆和中国澳门等多个国家和地区的97名代表出席本次论坛。国家卫生健康委员会科技教育司监察刘登峰专员应邀参会。论坛针对国际、国内网络药理学研究的现状、最新进展和发展前沿等有关问题进行了综合讨论,展示了该研究领域的新技术、新进展和新应用。为促进国内外学术交流,本文对部分专家的观点和意见进行了整理,以期为促进我国网络药理学和生物医药研究与发展起到积极的推动作用。 | 韩露 程肖蕊 伯晓晨 曹亮 陈纯 陈洛南 陈禹保 段大跃 方坚松 高丽 高莉 高耀 李美娜 李学军 刘艾林 刘骏 秦雪梅 Bauer RUDOLF 宋文婷 Alastair STEWART 孙蓉 孙妩弋 田俊生 王永华 王忠 魏伟 肖伟 徐峰 徐筱杰 张文娟 张媛媛 赵静 周文霞 张永祥 | 2018 | 中国药理学与毒理学杂志2018，0，11： | 5 |
| 4 | Triterpenes and triterpene glycosides from Paradrymonia macrophyl显示文摘 | Christian T Hildebert Wagner Rudolf Bauer | 1996 | Phytochemistry1996，40，： | 1 |
| 5 | Traditional Chinese medicine research in the post-genomic era: Good practice, priorities, challenges and opportunities显示文摘 | Halil Uzuner Rudolf Bauer Tai-Ping Fan De-an Guo Alberto Dias Hani El-Nezami Thomas Efferth Elizabeth M. Williamson Michael Heinrich Nicola Robinson Peter J. Hylands Bruce M. Hendry Yung-Chi Cheng Qihe Xu | 2012 | Journal of Ethnopharmacology2012，，3： | 1 |
| 6 | Two Acetylenic compounds from Echinarea pallida Roots显示文摘 | Rudolf bauer I A Khan V Wray Wagner H | 1987 | Phytochemistry1987，26，4： | 1 |
| 7 | Alkamides from the Roots of Echinarea angustifolia 显示文摘 | Rudolf bauer Peter Ruminger Hildebert Wagner | 1989 | Phytochemistry1989，28，2： | 1 |
| 8 | mRNA expression oprofiles for the response of human tumor cell lines to the antimalarial drugs artesunate,arteether,and artemether显示文摘 | Thomas Efferth Armin Olbrich Rudolf Bauer | 2002 | Biochemical Pharmacology2002，64，4： | 1 |
| 9 | Thermal wave probing of pyroelectric distributions in the surface region of ferroelectric materials: a new method for the analysis显示文摘 | Bernd Ploss Rudolf Emmerieh Siegfried Bauer | 1992 | Journal of Applied Physics1992，72，： | 1 |
| 10 | Inhibition of Leukotriene Biosynthesis by Quinolone Alkaloids from the Fruits of Evodia rutaecarpa显示文摘 | Michael Adams Olaf Kunert Ernst Haslinger Rudolf Bauer | 2004 | Planta Med2004，，10： | 1 |
| 11 | Quality Criteria and Phytopharmaceutical: Can Acceptable Drug Standards be achieved? 显示文摘 | Rudolf Bauer | 1998 | Drug Information Journal1998，32，： | 1 |
| 12 | Herba lycopi lucidi - zelan显示文摘 | Hildebert Wagner Rudolf Bauer Xiao Peigen | 1999 | Chinese Drug Monographs and Analysis1999，2，12： | 1 |
| 13 | Quality Criteria and Phytopharmaceutical: Can Acceptable Drug Standards Be Achieved 显示文摘 | Rudolf Bauer | 1998 | Drug information Journal1998，32，： | 1 |
| 14 | Quality Criteria and Phytopharmaceutical: Can Acceptable Drug Standards be achieved显示文摘 | Rudolf Bauer | 1998 | Drug Information Journal1998，32，： | 1 |
| 15 | Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich’in Native Americans显示文摘The Gwich’in,which belong to the Athapaskan language group of Native Americans live in the borderland between Alaska and Canada.We analyzed 29 medicinal plants of this tribe for their growth inhibitory activity against CCRF-CEM T-cell acute lymphoblastic leukemia(T-ALL)cells.The anti-leukemic activity of these plants has not been investigated as yet.Considering the poor cure rates of some ALL forms,there might be a great potential for medicinal plants as resource for natural products to treat T-ALL.We found that the hexane extracts of three plants revealed considerable growth inhibition on CCRF-CEM cells.The 50%inhibition concentrations(IC50)were 6.63±0.03μg/ml for Cladina mitis,8.65±0.38μg/ml for Picea mariana(needles),and 9.67±1.36μg/ml for Artemisia frigida.Further investigations are required to isolate the active constituents of these plants. | Katharina DEEG Tolga EICHHORN Gladys ALEXIE Nadine KRETSCHMER Kai ANDERSCH Rudolf BAUER Thomas EFFERTH | 2012 | Natural Products and Bioprospecting2012，2，1： | 1 |
| 16 | Traditional Chinese medicine research in the post-genomic era: Good practice, priorities, challenges and opportunities显示文摘 | Halil Uzuner Rudolf Bauer Tai-Ping Fan De-an Guo Alberto Dias Hani El-Nezami Thomas Efferth Elizabeth M. Williamson Michael Heinrich Nicola Robinson Peter J. Hylands Bruce M. Hendry Yung-Chi Cheng Qihe Xu | 2012 | Journal of Ethnopharmacology2012，，3： | 1 |
| 17 | Quality criteria and phytopharmacuticals: can acceptable drug standards be achieved 显示文摘 | Rudolf Bauer | 1998 | Drug Information Journal1998，，32： | 1 |
| 18 | CURRENT AND FUTURE APPROACHES TO THE QUALITY OF CONTROL OF CHINESE HERBAL MEDICINES显示文摘Quality of control of Chinese herbal medicines is currently mainly based on specifications of pharmacopoeias.Challenges are the limited specificiity of some of these methods,the use of various grades and processed materials,which cannot easily be distinguished,and the increasing use of granules,which are so far not considered in most pharmacopoeias.For identity and purity testing,microscopy and TLC fingerprint analysis are | Rudolf Bauer | 2015 | World Journal of Traditional Chinese Medicine2015，1，4： | 0 |
| 19 | Quality Considerations of Traditional Medicines显示文摘Thank you very much for inviting me to this event.It is a good discussion among different fields from Europe,Australian and China on the issue of herbal medicines.For a lot of issues have been discussed by experts and today is the 2nd day of this symposium,there is a little disadvantage for me to give this speech.So I will try to reduce what have been said as far as possible and try to provide different ideas and perspectives. | Rudolf Bauer | 2019 | World Journal of Integrated Traditional and Western Medicine2019，5，4： | 0 |
| 20 | Comprehensive Metabolic Profiling of Modified Gegen Qinlian Decoction by Ultra-high-Performance Liquid Chromatography-Diode Array Detection-Q-Exactive-Orbitrap-Electrospray Ionization-Mass Spectrometry/Mass Spectrometry and Application of High-Performance显示文摘Objective:Gegen Qinlian decoction(GQD)is a classical traditional Chinese medicine formulation which has been used for almost 2000 years.At Guang'anmen Hospital,Beijing,a modified GQD version(m GQD)with seven instead of four herbal ingredients has been applied to treat Type 2 diabetes.Quality control is a crucial prerequisite for the therapeutic application of herbal medicines.For the identification of products derived from classical GQD,the Chinese Pharmacopeia requires the analysis of only three marker compounds.Because m GQD is a more complex mixture containing seven herbs and hundreds of constituents,the pharmacopoeia method for GQD is inadequate.Materials and Methods:A more comprehensive characterization of the formula's constituents has been developed using ultra-high-performance liquid chromatography-diode array detection(UHPLC-DAD)-Q-Exactive-mass spectrometry(MS)in electrospray ionization positive and negative mode.Moreover,a new method for the fingerprint analysis of m GQD via high-performance thin-layer chromatography(HPTLC)has been established.Results:Altogether,91 compounds have been assigned to their originating plants and 84 substances were identified either by comparison with authentic references or with data from the literature.The HPTLC method is based on the application of two different mobile phases and is able to detect both lipophilic and hydrophilic constituents of m GQD.Conclusions:The modified GQD was extensively characterized by UHPLC combined with DAD and Q-Exactive Orbitrap high-resolution MS detection,leading to the assignment and identification of compounds present in the decoction.In addition,a new method for the fingerprint analysis of the m GQD using HPTLC was established,which allows fast and simple identification of the herbal ingredients in the mixture. | Xuehong Nöst Eva-Maria Pferschy-Wenzig Xiao-Tong Yu Min Li Xiao-Lin Tong Rudolf Bauer | 2021 | World Journal of Traditional Chinese Medicine2021，7，1： | 0 |
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