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| 1 | 中国人群长期饮水氟接触与骨折关系调查研究显示文摘国外有关饮水氟浓度与骨折关系的报道结果不一致 ,为深入研究饮水中不同浓度的氟对人群骨折的影响 ,采用环境流行病学回顾性调查方法 ,按统一设计的调查方法与询问表 ,调查了 6个饮水氟浓度不同地区人群 (氟浓度分别为 0 2 5~ 0 34、0 5 8~ 0 73、1 0 0~ 1 0 6、1 45~ 2 19、2 6 2~ 3 5 8、4 32~ 7 97mg L)的骨折发生情况及其影响因素。内容包括 :氟暴露水平、骨折情况、人口构成、病史、体格检查、吸烟史、饮酒史、饮水量和膳食营养等。各组≥ 5 0岁的调查人数分别为 136 3、140 7、1370、15 74、10 5 1、15 0 1人 ,共计 82 6 6人。统计分析结果表明 ,饮水中的氟是其主要摄氟来源。 6组人群的全部骨折率分别为 7 41%、6 40 %、5 11%、6 0 4%、6 0 9%和 7 40 % ;自然骨折率分别为 3 0 1%、2 2 1%、1 31%、1 6 5 %、1 43%和 3 6 6 % ,二者均与饮水氟浓度之间呈现U型曲线相关关系。其中以饮水氟为 1 0 0~ 1 0 6mg L组人群的骨折率最低 ,与最低和最高饮水氟组的骨折率比较有显著性差别 (P <0 0 1)。 6组人群髋部骨折率依次为 0 37%、0 43%、0 37%、0 89%、0 76 %和 1 2 0 % ,虽未出现U型曲线关系 ,但仍以饮水氟为 4 32~ 7 97mg L组人群的髋部骨折率最高 ,显著高于 1 0 0~ 1 0 | 梁超轲 吉荣娣 曹静祥 程溆 葛相金 高玉真 张淑兰 卢振明 王景占 马凤 吴云鹏 应波 张妍 孙淑庄 Li Yiming Barry P Katz | 2001 | 卫生研究2001，30，5： | 4 |
| 2 | Functional oesophago-gastric junction imaging显示文摘尽管有它在疾病的角色,仍然没有权威的方法估计 oesophago 胃的连接胜任(OGJ ) 。传统地, OGJ 作为指示物与更低的食道的括约肌压力用测压法被估计了。更最近,这被显示了不对倒流是括约肌功能和胜任的一个很可靠的标记。混乱象胃食道的倒流疾病那样并且到更小的 extend 弛缓不能仍然完成病人的一个重要数字。这评论看使用作为阻抗测面积池知道在一只袋子的扩张期间在 OGJ 介绍几何学和压力的一种新技术。收集的数据能被重建进 OGJ 行动的一个动态代表。这被显示了提供 OGJ 的一个有用代表并且由于 endoluminal 治疗以依从和膨胀性显示出变化到 OGJ 的胜任。 | Barry P McMahon Asbjφrn M Drewes Hans Gregersen | 2006 | World Journal of Gastroenterology2006，12，18： | 3 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | Maternal cigarette smoking,metabolic gene polymorphism, and infant birth weight 显示文摘 | Wang XB Barry Z Colleen P | 2002 | JAMA2002，287，： | 2 |
| 5 | Mesenchymal stem cells: clinical applications and biological characterization显示文摘 | Frank P Barry J.Mary Murphy | 2003 | International Journal of Biochemistry and Cell Biology2003，，4： | 2 |
| 6 | Computation of flow through the oesophagogastric junction显示文摘Whilst methods exist to indirectly measure the effects of increased flow or gastro-oesophageal refluxing, they cannot quantitatively measure the amount of acid travelling back up into the oesophagus during reflux, nor can they indicate the flow rate through the oesophagogastric junction (OGJ). Since OGJ dysfunction affects flow it seems most appropriate to describe the geometry of the OGJ and its effect on the flow. A device known as the functional lumen imaging probe (FLIP) has been shown to reliably measure the geometry of and pressure changes in the OGJ. FLIP cannot directly measure flow but the data gathered from the probe can be used to model flow through the junction by using computational flow dynamics (CFD). CFD uses a set of equations known as the Navier-Stokes equations to predict flow patterns and is a technique widely used in engineering. These equations are complex and require appropriate assumptions to provide simplifications before useful data can be obtained. With the assumption that the cross-sectional areas obtained via FLIP are circular, the radii of these circles can be obtained. A cubic interpolation scheme can then be applied to give a high-resolution geometry for the OGJ. In the case of modelling a reflux scenario, it can be seen that at the narrowest section a jet of fluid squirts into the oesophagus at a higher velocity than the fluid surrounding it. This jet has a maximum velocity of almost 2 ms-1 that occurs where the OGJ is at its narrowest. This simple prediction of acid ‘squirting’ into the oesophagusillustrates how the use of numerical methods can be used to develop a better understanding of the OGJ. This initial work using CFD shows some considerable promise for the future. | Barry P McMahon Karl D Odie Kenneth W Moloney Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，9： | 2 |
| 7 | Surgical management of primary and recurrent retroperitoneal liposarcoma显示文摘 | Neuhaus SJ Barry P Clark MA | | 0，，02： | 2 |
| 8 | Management of venous thromboembolism: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians显示文摘 | SNOW V QASEEM A BARRY P | 2007 | Ann Intern Med2007，146，3： | 1 |
| 9 | High precision sampling for chromatographic separation显示文摘 | Barry E B Stuart P C Leitner J E | 1973 | Anal Chem1973，45，14： | 1 |
| 10 | A multi-center phase I study of clofambine, etopeside and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia 显示文摘 | Hijiya N Gaynon P Barry E | | Leukemia0，23，12： | 1 |
| 11 | Physiological adaptations that allow for the exploitation of high sulfide,low oxygen seep sites in the Monterey Bay; with emphasis on Vesicomyid clams显示文摘 | GOFFREDI S K BARRY J P BUCK K R | 1999 | Comparative Biochemistry and Physiology-Part A:Molecular & Integrative Physiology1999，124，1： | 1 |
| 12 | Comparative histological and biometric study of the coronary,radial and left internal thoracic arteries显示文摘 | Barry MM Foulon P Touati G | 2003 | Surg Radiol Anat2003，25，： | 1 |
| 13 | Effects of high rearing densities and loading rateson the growth and stress responses of juvenile rainbow trout显示文摘 | Procarione L S Barry T P Maltson J A | 1999 | N Am Aquaculture1999，61，2： | 1 |
| 14 | The development of Akabane virus-induced congenital abnormalities in cattle 显示文摘 | Kirkland P D Barry R D Harper P A | 1988 | Vet Rec1988，122，24： | 1 |
| 15 | Influence of environmen- tal Vertical wind shear on the intensity of hurricanne-strength tropical cyclones in the Australian region显示文摘 | Linda A P Barry N H Noel E D | 2005 | Mon Wea Rev2005，133，： | 1 |
| 16 | comparison of dot blot, ELISA, and RT-PCR Assays for Detection of two cucumber mosaic virus isolates infecting banana in Hawaii显示文摘 | Hu J S Li H P Barry K at al | 1995 | Plant Disease1995，79，9： | 1 |
| 17 | Poly (ethylenimine)-mediated transfection:a new paradigm for gene delivery显示文摘 | Barry MA Sadhu P | 2000 | JBiomed Mater Res2000，51，3： | 1 |
| 18 | Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition显示文摘 | Coping 1 S Barry M Liston P | 2003 | Immunity2003，18，3： | 1 |
| 19 | Globalization,Urbanization and Nutritional Change in the Developing World显示文摘 | Michelle A M Barry M P | 2004 | Journal of Agricultural and Development Economics2004，1，2： | 1 |
| 20 | Air monitoring in the Arctic: results of selected persistent organic polutant for 1992 显示文摘 | Fellin P Barrie L A Dougherty D | 1996 | Environ Toxicol Chem1996，15，： | 1 |
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