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| 1 | Synchronous occurrence of gastrointestinal stromal tumors and other primary gastrointestinal neoplasms显示文摘AIM: To review clinical and pathologic features of Gas-trointestinal stromal tumors (GISTs) occurring synchro-nously with other primary gastrointestinal neoplasms.METHODS: Twenty-eight patients with primary GIST were treated at our institution between 1989 and 2005. Clinical and pathologic records were reviewed. RESULTS: The gastrointestinal stromal tumor occurred simultaneously with other primary GI malignancies in 14% of all patients with GIST. The synchronous stromal tumors were located in the stomach and were incidentally found during the operation. The coexistent neoplasms were colon adenocarcinoma, gastric cancer (2 cases) and gastric lymphoma.CONCLUSION: The synchronous occurrence of GISTs and other gastrointestinal malignancies is more common than it has been considered. The development of gastrointestinal stromal tumors and other neoplasms may involve the same carcinogenic agents. | Marek Wronski Bogna Ziarkiewicz-Wroblewska Barbara Gornicka Wlodzimierz Cebulski Maciej Slodkowski Aleksander Wasiutynski Ireneusz W Krasnodebski | 2006 | World Journal of Gastroenterology2006，12，33： | 14 |
| 2 | Alcohol,nutrition and liver cancer:Role of Toll-like receptor signaling显示文摘This article reviews the evidence that ties the development of hepatocellular carcinoma (HCC) to the natural immune pro-inflammatory response to chronic liver disease, with a focus on the role of Toll-like receptor (TLR) signaling as the mechanism of liver stem cell/progenitor transformation to HCC. Two exemplary models of this phenomenon are reviewed in detail. One model applies chronic ethanol/lipopolysaccharide feeding to the activated TLR4 signaling pathway. The other applies chronic feeding of a carcinogenic drug, in which TLR2 and 4 signaling pathways are activated. In the drug-induced model, two major methyl donors, S-adenosylmethionine and betaine, prevent the upregulation of the TLR signaling pathways and abrogate the stem cell/progenitor proliferation response when fed with the carcinogenic drug. This observation supports a nutritional approach to liver cancer prevention and treatment. The observation that upregulation of the TLR signaling pathways leads to liver tumor formation gives evidence to the popular concept that the chronic pro-inflammatory response is an important mechanism of liver oncogenesis. It provides a nutritional approach, which could prevent HCC from developing in many chronic liver diseases. | Samuel W French Joan Oliva Barbara A French Fawzia Bardag-Gorce | 2010 | World Journal of Gastroenterology2010，16，11： | 11 |
| 3 | Addition of senna improves quality of colonoscopy preparation with magnesium citrate显示文摘AIM: To prospectively investigate the effectiveness and patient’s tolerance of two low-cost bowel cleansing preparation protocols based on magnesium citrate only or the combination of magnesium citrate and senna. METHODS: A total of 342 patients who were referred for colonoscopy underwent a colon cleansing protocol with magnesium citrate alone (n = 160) or magnesium citrate and senna granules (n = 182). The colonoscopist rated the overall efficacy of colon cleansing using an established score on a 4-point scale. Patients were questioned before undergoing colonoscopy for side effects and symptoms during bowel preparation. RESULTS: The percentage of procedures rescheduled because ofinsufficient colon cleansing was 7% in the magnesium citrate group and 4% in the magnesium citrate/senna group (P = 0.44). Adequate visualization of the colonic mucosa was rated superior under the citramag/senna regimen (P = 0.004). Both regimens were well tolerated, and did not significantly differ in the occurrence of nausea, bloating or headache.However, abdominal cramps were observed more often under the senna protocol (29.2%) compared to the magnesium citrate only protocol (9.9%, P < 0.0003). CONCLUSION: The addition of senna to the bowel preparation protocol with magnesium citrate significantly improves the cleansing outcome. | Stergios Vradelis Evangelos Kalaitzakis Yalda Sharifi Otto Buchel Satish Keshav Roger W Chapman Barbara Braden | 2009 | World Journal of Gastroenterology2009，15，14： | 3 |
| 4 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 5 | Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis显示文摘 | Herbert L Bonkovsky Qaiser Jawaid Kristina Tortorelli Paula LeClair Joseph Cobb Richard W Lambrecht Barbara F Banner | 1999 | Journal of Hepatology1999，，3： | 2 |
| 6 | Oxidative methylamination of some nitropyridines显示文摘 | Barbara S Marian W | 1999 | J Prakt Chem1999，341，1： | 1 |
| 7 | Comparative genetic characterization of porcine circovirus type 2 samples from German wild boar populations显示文摘 | Sebastian K Hermann W Barbara H | 2005 | Vet Microbiol2005，109，： | 1 |
| 8 | The impact of Er,Cr: YS- GG laser on the shear strength of the bond between dentin and ce- ramie is dependent on the adhesive material显示文摘 | Barbara C Gundula M J0rg W | 2012 | Lasers Med Sci2012，27，4： | 1 |
| 9 | Properties of trehalase from different organs of alfalfa, Medicago sativa 显示文摘 | Barbara W M Eliza M Wanda M | 2005 | Acta Physio Plant2005，27，1： | 1 |
| 10 | Skeletal muscle determination and differentiation: story of a core regulato- ry network and its context 显示文摘 | KYUSON Y BARBARA W | 1996 | Current Opinion in Cell Biology1996，8，： | 1 |
| 11 | Reclaiming Applied Anthropology: Its Past, Present Future 显示文摘 | Barbara R Merrill S Van W J | 2006 | American Anthropologist2006，108，1： | 1 |
| 12 | Immunohistochemical analysis of the activation of NF-kappaB and expression of associated cytokines and adhesion molecules in human models of allergic inflammation显示文摘 | SUSAN J W BARBARA A L DONALD A | 1999 | J Pathol1999，189，2： | 1 |
| 13 | Degradabletransport network : Travel time budget of travelerswith heterogeneous risk aversion显示文摘 | HONG K LUO X W BARBARA W Y | 2006 | TransportationResearch Part B2006，40，9： | 1 |
| 14 | A library and the disciplines: A collaborative project assessing the impact of eBooks and mobile devices on student learning显示文摘 | Barbara C G Roy W R Brooke H | 2014 | The Journal of Academic Librarianship2014，40，3： | 1 |
| 15 | B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration显示文摘 | TAKASHI M BARBARA T LIU W H | 2007 | Gynecologic Oncology2007，106，： | 1 |
| 16 | The American customer satisfaction index: Nature, purpose and findings 显示文摘 | Fornell C Johnson M D Aderson E W Cho J Barbara E Bryant | 1996 | Journal of Marketing1996，60，： | 1 |
| 17 | Recovery of cognitive functions following nonprogressive brain injury显示文摘 | BARBARA A W | 1998 | Current Opinion in Neurobiology1998，，8： | 1 |
| 18 | Cross-sector partnerships to address social issues: challenges to theory and practice显示文摘 | John W Selsky & Barbara Parker | 2005 | Journal of Management2005，31，6： | 1 |
| 19 | Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein ε 4 allele 显示文摘 | Ruth OH Barbara S Nate W | 2008 | JPsychiatr Res2008，42，： | 1 |
| 20 | The benefits & potentialhealth hazards posed by the prebiotic inulin-a review显示文摘 | Piotr H Barbara J L Iwona W | 2010 | Polish Journal of Food and Nutrition Sciences2010，60，3： | 1 |
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