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| 1 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 2 | G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis显示文摘Estrogens play important roles in the development and progression of multiple tumor types.Accumulating evidence points to the significance of estrogen action not only in tumors of hormonally regulated tissues such as the breast,endometrium and ovary,but also in the development of colorectal cancer(CRC).The effects of estrogens in physiological and pathophysiological conditions are mediated by the nuclear estrogen receptorsαandβ,as well as the membranebound G protein-coupled estrogen receptor(GPER).The roles of GPER in CRC development and progression,however,remain poorly understood.Studies on the functions of GPER in the colon have shown that this estrogen receptor regulates colonic motility as well as immune responses in CRC-associated diseases,such as Crohn’s disease and ulcerative colitis.GPER is also involved in cell cycle regulation,endoplasmic reticulum stress,proliferation,apoptosis,vascularization,cell migration,and the regulation of fatty acid and estrogen metabolism in CRC cells.Thus,multiple lines of evidence suggest that GPER may play an important role in colorectal carcinogenesis.In this review,we present the current state of knowledge regarding the contribution of GPER to colon function and CRC. | Damian Jacenik Ellen J Beswick Wanda M Krajewska Eric R Prossnitz | 2019 | World Journal of Gastroenterology2019，25，30： | 6 |
| 3 | Properties of trehalase from different organs of alfalfa, Medicago sativa 显示文摘 | Barbara W M Eliza M Wanda M | 2005 | Acta Physio Plant2005，27，1： | 1 |
| 4 | Enigma variations for peptides and their transporters in higher plants 显示文摘 | Wanda M Waterworth Clifford M | 2006 | Annals of Botany2006，98，： | 1 |
| 5 | Frequency-doubling via quadrupole and dipole-interface interactions in optical fibers 显示文摘 | WANDA M H STERBERG U | 1990 | Proc Spie1990，1148，： | 1 |
| 6 | Processing and Interactive Editing of Huge Point Clouds from 3D Scanners显示文摘 | WANDA M BERNER A BOKELOH M | 2008 | Computers & Graphics2008，32，2： | 1 |
| 7 | Ovomucoid is not Superior to egg white testing in Predicting Tolerance to Baked Egg显示文摘 | Lisa M B William J S Wanda P | 2013 | The Journal of Allergy and Clinical Immunology:In Practice2013，1，4： | 1 |
| 8 | Fumonisin Toxicosis in Swine: An Overview of Porcine Pulmonary Edema and Currrent Perspectives显示文摘 | Wanda M | 2001 | Environmental Health Perspectives2001，5，109： | 1 |
| 9 | The preemptive analgesic effect of rofecoxib after ambulatory arthroscopic knee surgery显示文摘 | Scott SR Shailesh B Holly M Wanda J Joseph S | 2002 | Anesth Analg2002，94，： | 1 |
| 10 | The effectiveness of Acupressure for the Control and Management of Chemotherapy-related Acute and Delayed Nausea:A Randomized Controlled Trial显示文摘 | Alexander M Wanda R John H | 2014 | Journal of Pain and Symptom Management2014，47，1： | 1 |
| 11 | Hydrodeoxygenation of hydroxy, methoxy and methyl phenols with molybdenum oxide/nickel oxide/alumina catalyst显示文摘 | Kallury R K M R Wanda M Restivo Thomas T TidweU | 1985 | Journal of Catalysis1985，96，2： | 1 |
| 12 | lntramadullary changes the spinal cord in cervical spondylotic myelopathy显示文摘 | Wanda E Ohmura M Yonenobu K | 1995 | Spine1995，20，20： | 1 |
| 13 | community tourism planning a self-assessment instrument显示文摘 | DONALD G R HEATHER M WANDA G | 2004 | Annals of Tourism Research2004，31，3： | 1 |
| 14 | Se- quential cloud-point extraction for toxicological screen- ing analysis of medicaments in human plasma by high pressure liquid chromatography with diode array detec- tor显示文摘 | MADEJ K PERSONA K WANDAS M | 2013 | J Chromatogr A2013，1312，： | 1 |
| 15 | Construction of recombinant attenuated Salmonella enterica serovar typhimuriurn vaccine vector strains for safety in newborn and infant mice 显示文摘 | Gunn B M Wanda S Y Burshell D | 2010 | Clini Vaccine Immunol2010，17，3： | 1 |
| 16 | Laparosco- pic treatment of subxiphoid incisional hernias in cardiac transplant patients显示文摘 | Eisenberg D Wanda M Popescu WM | 2008 | JSLS2008，12，3： | 1 |
| 17 | Norisoprenoids from aerial parts of Cichorium pumilum 显示文摘 | Wanda K Klaudia M Edward S | 2004 | Biochem Syst Ecol2004，32，3： | 1 |
| 18 | Bone healing after unreaming intramedullary nailing显示文摘 | Wanda K Ritter G | 1994 | Unfallchirurgie1994，97，： | 1 |
| 19 | Perioperative management of the patient with a coronary stent显示文摘 | Popescu Wanda M | 2010 | Current Opinion in Anaesthesiology2010，23，1： | 1 |
| 20 | Intramadullary changes the spinal cord in cervical spondylotic myelopathy 显示文摘 | Wanda E Ohmura M Yonenobu K | 1995 | Spine1995，20，20： | 1 |
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