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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with Parkinsonism linkedm to chromosome 17显示文摘 | Isaacs A Baker M Wavrant-De Vrieze F | 1998 | Genomics1998，，51： | 2 |
| 3 | Dynamic mechanical studies of nitrocellulose/nitroglycerine mixtures 显示文摘 | Baker F S Vertt G J | 1987 | Polymer1987，28，： | 1 |
| 4 | Lidar-measured winds from space: a key component for weather and climate prediction 显示文摘 | BAKER W E EMMITT G D ROBERTSON F | 1995 | Bulletin of the American Meteorological Society1995，76，6： | 1 |
| 5 | Polyisonitriles III Synthesis and Racemization of Optically Active Poly(-phenylethylisonitrile)显示文摘 | MILLICH F BAKER G K | 1969 | Macromolecules1969，2，： | 1 |
| 6 | Psychological adjustment of cancer caregivers with multiple roles显示文摘 | Kim Y Baker F Spillers R L | 2006 | Psycho-Oncol2006，15，9： | 1 |
| 7 | 1α-hydroxylat-edchole-calciferol compounds act additively with microbial phytaseto improve phosphorus,zinc andmanganese utilization inchicks fed soy-based diets显示文摘 | Biehl R R Baker D H Deluca H F | 1995 | Journal of Nutrition1995，125，9： | 1 |
| 8 | Diagnosis and treatment of prostate cancer:summary of NICE guidance显示文摘 | Graham J Baker M Macbeth F | 2008 | BMJ2008，336，： | 1 |
| 9 | Intrusion-related gold deposits associated with tungsten-tin provinces显示文摘 | Tompson J F H Sillitoe R H Baker T | 1999 | Mineralium Deposita1999，34，： | 1 |
| 10 | The influence of social sup- port on depressive symptoms in cancer patients: Age and gender differences显示文摘 | Hann D Baker F Denniston M | 2002 | J Psyehosom Res2002，52，5： | 1 |
| 11 | A bovine pericardium rigid prosthesis for left ventricle restoration:12 years of follow-up显示文摘 | Silveira Filho LM Petrucci O Vilarinho KA Baker RS Garcia F Oliveira PP | | 0，，02： | 1 |
| 12 | Can small and medium enterprises benefit from skill - biased technologi- cal change? 显示文摘 | SANDULLI F D BAKER P M L? PEZ-S? NCHEZ J I | 2013 | Journal of Business Research2013，66，10： | 1 |
| 13 | An extension of Willard finite basis theorem: conguence meet - semidistributive varieties of finite critical depth 显示文摘 | Baker K A McNulty G F Wang J | 2004 | Algebra Universalis2004，52，23： | 1 |
| 14 | Deficient cellular immunity in endometriosis 显示文摘 | Dmowski W P Steele R W Baker G F | 1981 | Am J Obstet Gynecol1981，141，4： | 1 |
| 15 | A molecular analysis of doublesex, a bifunctional gene that controls both male and female sexual differentiation in Drosophila melanogaster 显示文摘 | Baker B S Wolfner M F | 1988 | Genes Dev1988，2，4： | 1 |
| 16 | Evolving concepts of biological control of plantpathogens显示文摘 | Baker K F | 1987 | Annu Rev Phytopathol1987，，25： | 1 |
| 17 | Molecular Cloning and Characterization of Human and Murine Dnase Ⅱ显示文摘 | Baker K P Baron W F Henzel W J etal | 1998 | Gene1998，215，： | 1 |
| 18 | Nucleation and growth of carbon deposits from the nickel catalyzed decomposition of acetylene显示文摘 | Baker R T K Barber M A Feates F S | 1972 | J Catal1972，26，： | 1 |
| 19 | Kinetic analysis of urea transport from plasma to milk in dairy cows显示文摘 | Baker L D Ferguson J D Ramber C F | 1992 | J Dairy Sci1992，75，： | 1 |
| 20 | Measurements of the cross wind forces on trains 显示文摘 | Baker C J F Lopez - Calleja F Jones J | 2004 | Journal of Wind Engineering and Industrial Aerodynamics2004，，92： | 1 |
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