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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Subtype-selective antagonists of lysophosphatidic acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques显示文摘 | ROTHER E BRANDL R BAKER D L | 2003 | Circulation2003，108，6： | 2 |
| 3 | Phytoremediation of soil metals显示文摘 | Rufus L Chaney Minnie Malik Yin M Li Sally L Brown Eric P Brewer J Scott Angle Alan JM Baker | 1997 | Current Opinion in Biotechnology1997，，3： | 2 |
| 4 | An evaluation of the quantitative and radiation features of a scanning X-ray transverse axial tomograph:The EMI scanner显示文摘 | McCullough E C Baker H L House O W | 1974 | Radiat Phys1974，111，3： | 2 |
| 5 | Lucas-kanade 20 years on:a unifying framework显示文摘 | Baker S Matthews L | 2004 | International Journal of Computer Vision2004，53，3： | 1 |
| 6 | Lead-induced anemia: doseresponse relationships and evidence for a threshold 显示文摘 | Schwartz J Landrigan P J Baker E L | 1990 | American Journal Public Health1990，80，： | 1 |
| 7 | Dose laparoscopic abdom inoperineaf resection of the rectum compromise long-term survival显示文摘 | White EE Titu L | 2002 | D is Colon Rectum2002，45，9： | 1 |
| 8 | Performance of growing and finishing cattle supplemented with a slow-release urea product and urea显示文摘 | TEDESCHI L O BAKER M J KETCHEN D J | 2002 | Canadian Journal of Animal Science2002，82，： | 1 |
| 9 | Sequence and characterization of 6 Lea proteins and their genes from cotton显示文摘 | BAKER J DENNSTEELE C DARE L | 1988 | Plant Molecular Biology1988，11，3： | 1 |
| 10 | Conservative man- agement of a myxoid endometrial stromal sarcoma in a 16-year-old mulliparous woman 显示文摘 | Stadsvold J L Molpus K L Baker J J | 2005 | Gynecol Oncol2005，99，1： | 1 |
| 11 | Is elfidermal cell prolitbra- tion in psoriatic skin grafts on nude mice driven by T-cell derived cytokines?显示文摘 | Baker BS Brenl L Valdimarsson H el al | 1992 | Br J Dennatol1992，126，： | 1 |
| 12 | Commonality in the deter- minants of expected stock returns显示文摘 | Haugen R A Baker N L | 1996 | Journal of Fi- nancial Economics1996，41，3： | 1 |
| 13 | The role of the family in the treatment of anorexia nervosa显示文摘 | Liebman R Minuehin S Baker L | 1974 | J Am Acad Child Psychiatry1974，13，2： | 1 |
| 14 | Psychological adjustment of cancer caregivers with multiple roles显示文摘 | Kim Y Baker F Spillers R L | 2006 | Psycho-Oncol2006，15，9： | 1 |
| 15 | Electron spin resonance and spin trap investigation of free radicals in cigarette smoke:development of a quantification procedure 显示文摘 | Baum S L Anderson I G M Baker R R | 2003 | Anal Chim Acta2003，481，： | 1 |
| 16 | The anatomy and clinical applications of the buccal fat pad显示文摘 | Stuzin JM Wagstrom L Kawamoto HK Baker TJ Wolfe SA | 1990 | Plast Reconstr Surg1990，85，1： | 1 |
| 17 | Use of catalysts in biomass gasification显示文摘 | L K Mudge E G Baker | 1985 | Solar Energy Eng1985，107，： | 1 |
| 18 | Physiological characterization of root Zn2+ absorption to shoots in Zn hyperaccumulator and nonaccumulator species of Thlaspi显示文摘 | LASAT M M BAKER A J M KOCHIAN L V | 1996 | Plant Physiology1996，112，： | 1 |
| 19 | An analysis of clinical outcomes using color doppler testicular ultrasound for testicular torsion显示文摘 | Baker L A Sigman D Mathews R I | 2000 | Pediatrics2000，105，31： | 1 |
| 20 | Freeze/thaw and pH effects on freshwater dissolved organic matter fluorescence and absorbance properties from a number of UK locations 显示文摘 | SPENCER R G BOLTON L BAKER A | 2007 | Water Research2007，41，13： | 1 |
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