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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | The relationship between the quantum yield of photosynthetic electron transport and quenching of chlorophyll fluorescence显示文摘 | Genty B Briantails J M Baker N R | 1989 | Biochim Biophys Acta1989，990，： | 1 |
| 3 | Commonality in the deter- minants of expected stock returns显示文摘 | Haugen R A Baker N L | 1996 | Journal of Fi- nancial Economics1996，41，3： | 1 |
| 4 | Applications of chlorophyll fluorescence can improve crop production strategies: an examination of future possibilities 显示文摘 | Baker N R Rosenqvist E | 2004 | Journal of Experimental Botany2004，55，403： | 1 |
| 5 | Accuracy of devices used for self-monitoring of blood glucose显示文摘 | Johnson R N Baker J R | 1998 | Ann Clin Biochem1998，35，1： | 1 |
| 6 | Influence of copper on the structural characteristics of carbon nanofibers produced from the cobaltcatalyzed decomposition of ethylene显示文摘 | CHAMBERS A RODRIGUEZ N M BAKER R T K | 1996 | J Mater Res1996，11，2： | 1 |
| 7 | The relationship between the quantum yield of photosynthetic electorn transport and quenching of chloorphyll fluorcscence显示文摘 | Genty B Brianais J M Baker N R | 1989 | Biochim Biophys Acta1989，199，： | 1 |
| 8 | The relationship be-tween the quantum yield of photosynthetic electron transportand quenching of chlorophyll fluorescence 显示文摘 | Genty B E Briantais M J Baker N R | 1989 | BiochemistryBiophysics Acta1989，990，： | 1 |
| 9 | The rdat~onship between the quantum yield of photosynthetic electron transport and quenching of chlorophyll fluorescence显示文摘 | GENTY B BRIANTAIS J M BAKER N R | 1989 | Biochimicaet Biophysiea Aeta1989，990，1： | 1 |
| 10 | The structure of glucose-fructose oxidoreductase from Zymomonas mobilis:an osmoprotective periplasmic enzyme containing non-dissociable NADP显示文摘 | KINGSTON R L SCOPES R K BAKER E N | 1996 | Structure1996，4，12： | 1 |
| 11 | Thermal decay of Fiber Bragg gratings written in Boron and Germanium codoped silica fiber显示文摘 | BAKER S R ROUKE H N BAKER V | 1997 | J Lightwave Technol1997，15，： | 1 |
| 12 | Chlorophyll Fluorescence: a probe of photosynthesis invivo显示文摘 | Baker N R | 2008 | PlantBiol2008，59，： | 1 |
| 13 | The relationship between quantum yield of photosynthetic electron transport and quenching of chlorophyll fluorescence显示文摘 | Genty B Briantais J M Baker N R | 1989 | Biochim Biophys Acta1989，，990： | 1 |
| 14 | A quantitative determination of photochemical and non-photochemical quenching during the slow phase of chlorophyll fluorescence induction curve of bean leaves显示文摘 | Bradbury M Baker N R | 1984 | Biochimica et Biophysica Acta1984，765，： | 1 |
| 15 | The relationshipbetween the quantum yield of photosynthetic electrontransport and quenching of chlorophyll fluorescence显示文摘 | Genty B Briantais J M Baker N R | 1989 | Biochimica et Biophysica Acta1989，990，1： | 1 |
| 16 | Exploratory analysis of the difference between temperature observations recorded by ASOS and conventionnal methods 显示文摘 | Guttman R N Baker C B | 1966 | Bulk Amer Meteor Soc1966，77，： | 1 |
| 17 | Optimizing the exper-imental design for ankle dorsiflexion fMRI显示文摘 | Macintosh BJ Mraz R Baker N | 2004 | Neuroimage2004，22，4： | 1 |
| 18 | Chlorophyll Fluorescence: A Probe of Photosynthesis In Vivo显示文摘 | Baker N R | 2008 | Annual Review of Plant Biology2008，59，1： | 1 |
| 19 | New relationships be- tween breast microealcifications and eancer显示文摘 | Baker R Rogers K D Shepherd N | 2010 | Br J Cancer2010，103，7： | 1 |
| 20 | The relationship between the quantum yield of photosynthetic electron transport and quenching of chlorophyll fluorexcence显示文摘 | GENTY B BRIANTAIS J M BAKER N R | 1989 | Biochim Biophys Acta1989，990，： | 1 |
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