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| 1 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014,16,1: | 48 |
| 2 | Depression, anxiety, and cardiac morbidity outcomes after coronary artery bypass surgery: a contemporary and practical review显示文摘到日期的研究显示冠的动脉的数字绕过外科病人由消沉影响了的接枝(CABG )( 即,专业,次要,心境恶劣) 在 30% 所有情况和 40% 之间接近。在 CABG 外科病人的 psychosocial 因素上的长期的实验兴趣与病态的增加的风险加亮一个协会在短、长期。最近的证据建议消沉和焦虑在独立于医药因素的 CABG 外科以后为死亡和病态增加风险,尽管行为、生物的机制糟糕被理解。不过既不消沉也不焦虑似乎显著地影响 neuropsychological 机能障碍,消沉为事件谵妄授与风险。跟随最近的文学的全面概述,实际忠告为订进可能的考虑屏蔽帮助在 CABG 外科病人之中改进焦虑和消沉的识别的临床医生被描述。当代的干预和使随机化的、控制审判的概述被描述,与为未来 CABG 外科研究的建议一起。 | Phillip J Tully Robert A Baker | 2012 | Journal of Geriatric Cardiology2012,9,2: | 17 |
| 3 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013,13,9: | 12 |
| 4 | Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?显示文摘这章探索 capacitation 和 apoptosis 是他们的普通依赖在反应的氧种类(ROS ) 的继续的产生上加入的连接过程的可能性。根据这个模型的意见, capacitation 在当细胞内部的 ROS 产生的后果,刺激细胞内部的营地产生,禁止酷氨酸磷酸酶活动并且由白朊从精子表面在他们的移动以前提高 oxysterols 的形成,跟随他们的版本进女繁殖的道的 spematozoa 被开始。由使能够的 ROS 的继续的产生精子的人口最后压到这些房间的有限能力保护自己免受氧化应力的伤害。作为精子的 over-capacitation 导致的结果,老朽的一个状态和截断的内在的 apoptotic 串联的激活由提高的 mitochondrial ROS 产生,类脂化合物 peroxidation,活动性损失, caspase 激活和 phosphatidylserine 外表表现描绘了。后者可能在指示吞噬细胞的白血球衰老的、垂死的精子的移动应该是由 proinflammatory cytokines 的产生无伴侣的一个沉默过程是特别地重要的。这些观察表明中央角色在定义精子的生活和死亡由氧化还原作用化学玩了。这些机制的知识可以帮助我们设计新奇答案专业化房间高度支持并且保存这些的功能。 | Robert J Aitken Mark A Baker Brett Nixon | 2015 | Asian Journal of Andrology2015,17,4: | 7 |
| 5 | The importance of depression and alcohol use in coronary artery bypass graft surgery patients:risk factors for delirium and poorer quality of life显示文摘ObjectiveTo 调查消沉,焦虑和压力是否增加风险因为谵妄和在冠的动脉以后的生活(QOL ) 的差的质量绕过(CABG ) 180 个 CABG 病人的 surgery.MethodsA 总数(63.5 ± 的吝啬的年龄;10.1 年, 82.2% 男性) 完成了基线和手术后的自我报告问询表估计悲痛和 QOL。事件谵妄与结构化的临床的会见手术后地被诊断,病人们在在 63 个人(35% 样品) 开发的 consciousness.ResultsDelirium 为混乱和骚乱 post-operatively 每天被监视。在为 covariates 的调整以后,谵妄显著地与消沉被联系[机会比率(或) :1.08;95% 信心间隔(CI ) :1.03-1.13, P = 0.003 ] ,焦虑(或:1.07;95% CI:1.02-1.13, P = 0.01 ) 并且应力(或:1.05;95% CI:1.00-1.09, P = 0.03 ) 。外科手术前的消沉分数与更差的 QOL 包括被联系身体疼痛(β=− 0.39, P = 0.013 ) ,活力(β=− 0.32, P = 0.020 ) ,社会工作(β=− 0.51, P ≤0.001 ) ,感情的角色功能(β=− 0.44, P = 0.003 ) 并且一般健康(β=− 0.33, P = 0.038 ) 。在 covariates 之中,白酒使用的有害层次一致地与更差的 QOL.ConclusionsDepression 被联系,而消沉,焦虑和压力与谵妄风险被联系,白酒使用的有害层次一致地与更差的 QOL 被联系。这些调查结果点将推进在经历冠的 revascularization 的冠的心疾病人口检验消沉和白酒使用的有害层次的研究。 | Joanne M Humphreys Linley A Denson Robert A Baker Phillip J Tully | 2016 | Journal of Geriatric Cardiology2016,13,1: | 5 |
| 6 | The 'omics revolution and our understanding of sperm cell biology显示文摘 | Mark A Baker | 2011 | Asian Journal of Andrology2011,13,1: | 4 |
| 7 | Prognostic impact of the Bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma显示文摘Background:The Bismuth-Corlette(BC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary tree.As the right hepatic artery crosses just behind the left bile duct,we hypothesized that BCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral artery.Methods:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September 2016.Cases were assigned BC stages based on preoperative imaging.Results:Sixty-eight patients were included in the study.All underwent staging laparoscopy after which 16 cases were aborted for metastatic disease.Of the remaining 52 cases,14 cases were explored and aborted for locally advanced disease.Thirty-eight underwent attempt at curative resection.After exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for BCⅢb staged lesions compared to 80.0%of BCⅢa lesions and to 82.4%for BCⅠ-Ⅲa staged lesions(P<0.05).About 44.4%of BCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining BC stages.Conclusions:When hilar cholangiocarcinoma is preoperatively staged as BCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery. | Michael J Passeri Maria R Baimas-George Jesse K Sulzer David A Iannitti John B Martinie Erin H Baker Lee M Ocuin Dionisios Vrochides | 2020 | Hepatobiliary & Pancreatic Diseases International2020,19,2: | 3 |
| 8 | Annual growth banding in a cave stalagmite显示文摘 | Baker A Smart P Edwards R | 1993 | Nature1993,364,: | 2 |
| 9 | Local immunostimulation of the bovine mammary gland with interleukin-2显示文摘 | Nickerson S C Baker P A Trinidad P | 1989 | J Dairy Sci1989,72,7: | 2 |
| 10 | Effects of short cracks on fatigure life calculations显示文摘 | Kaynak C Ankara A Baker T J | 1996 | International Journal of Fatigue1996,18,1: | 2 |
| 11 | Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with Parkinsonism linkedm to chromosome 17显示文摘 | Isaacs A Baker M Wavrant-De Vrieze F | 1998 | Genomics1998,,51: | 2 |
| 12 | In search of the Holy Grail-a further step in understanding metal hyperaccumulation? 显示文摘 | Baker A J M Whiting S N | 2002 | New Phytologist2002,155,: | 1 |
| 13 | Methodology for assessing zinc bioavailability: efficacy estimates for zinc-methionine, zinc sulfate, and zinc oxide显示文摘 | Wedekind K J Hortin A E Baker D H | 1992 | Journal of Animal Science1992,70,1: | 1 |
| 14 | Antiscale magnetic pretreatment of reverse osmosis feedwater显示文摘 | Judd S J Parsons S A | 1997 | Desalination1997,110,12: | 1 |
| 15 | Identification of cytechrome b5-reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa显示文摘 | Krutskikh A Curry BJ | 2005 | Biol Beprod2005,73,2: | 1 |
| 16 | Direct drive wave energy converters 显示文摘 | BAKER N J MUELLER M A | 2001 | Rev Energ Ren : Power Engineering2001,,: | 1 |
| 17 | Basic functionalization of polyethylene in the melt 显示文摘 | Simons A Baker W E | 1989 | Polymer Engineering and Science1989,29,: | 1 |
| 18 | Error estimates for finite element methods for second order hyperbolic equations 显示文摘 | BAKER G A | 1973 | SIAM J Numer Anal1973,13,: | 1 |
| 19 | Mycoplasma infections in growing cattle 显示文摘 | NICHOLAS R A J BAKER S AYLING R D | 2000 | Cattle Practice2000,,8: | 1 |
| 20 | Retrograde approach for complex popliteal and tibioperoneal occlusions 显示文摘 | Montero - Baker M Schmidt A Braunlich S | 2008 | J Endovasc Ther2008,15,5: | 1 |