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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | 显示文摘 | Backes W H Bobbers P A Vanhaeringen W | 1994 | Phys Rev B1994，49，： | 1 |
| 3 | Evolutionary Computation: Comments on the History and Current State 显示文摘 | Back T Hammel U Schwefel H P | 1997 | IEEE Transactions on Evolutionary Computation1997，1，1： | 1 |
| 4 | Characterization of nova plasmas using an X-ray spectrometer with temporal and spatial resolution显示文摘 | BACK C A AUFFMAN R L K BELL P M | 1995 | Review of Scientific Instruments1995，66，1： | 1 |
| 5 | Bone-marrow transplantation in a patient with the Wiskott-Aldrich syndrome显示文摘 | Back F Albertini RJ Joo P | | 0，，7583： | 1 |
| 6 | Role of annexin A2 in the production of infectious hepatitis C virus particles 显示文摘 | Backes P Quinkert D Reiss S | 2010 | J Virol2010，84，11： | 1 |
| 7 | Human bocavirus and acute wheezing in children 显示文摘 | Allander T Jartti T Gupta S Niesters HG Lehtinen P Oster- back R | 2007 | Clin Infect Dis2007，44，7： | 1 |
| 8 | Novel morphology in enteromorpha(ulvophyceae) forming green tides 显示文摘 | Jaanika Blomster Saara Back David P Fewer | 2002 | American Journal of Botany2002，89，11： | 1 |
| 9 | Evolutionary computation:comments on the history and current state显示文摘 | Back T Hammel U Schwefel H P | | 0，，01： | 1 |
| 10 | PCB in soils and estimated soil-air exchange fluxes of selected PCB congeners in the south of Sweden 显示文摘 | Backe C Cousins I T Larsson P | 2004 | Environmental Pollution2004，128，1： | 1 |
| 11 | Lateralizatlon,connectivity and plasticity in the human central auditory system显示文摘 | LANGERS D R VAN DLJK P BACKES W H | 2005 | Neuroimage2005，28，： | 1 |
| 12 | Next-generation sequencing identifies novel microRNAs in peripheral blood of lung cancer patients 显示文摘 | Keller A Backes C Leidinger P | 2011 | Mol Biosyst2011，7，12： | 1 |
| 13 | Experimental in vestigation of electrostatic dispersion and combustion of diesel fuel jets显示文摘 | Bankston C P Back H L Kwack E Y | | 0，，03： | 1 |
| 14 | An overview of evolutionary algorithms for parameter optimization显示文摘 | Back T Schwefel H P | 1993 | Evolutionary Computation1993，1，1： | 1 |
| 15 | Novel morphology in Enteromorpha (Ulvophyceae) forming green tides显示文摘 | Blomster J Back S Fewer D P | 2002 | American Journal of Botany2002，89，11： | 1 |
| 16 | Contrast media and glomerular filtration:Dose dependence of clearance for three agents显示文摘 | Back SE Krutzen E Nilsson-Ehle P | 1988 | J Pharm Sci1988，77，： | 1 |
| 17 | Characterization of Nova plasmas using an x-ray spectrometer with temporal and spatial resolution显示文摘 | Back C A Kauffman R L Bell P M | 1995 | Rev Sci Instrum1995，66，1： | 1 |
| 18 | Novel morphology in Enteromorpha (Ulvophyceae) forming green tides显示文摘 | Blomster J Back S Fewer D P | 2002 | Am J Bot2002，89，11： | 1 |
| 19 | Next-generation sequen- cing identifies novel microRNAs in peripheral blood of lung cancer patients显示文摘 | Keller A Backes C Leidinger P | 2011 | Mol Biosyst2011，7，12： | 1 |
| 20 | Effect of Tem- perature on the Charpy Impact and CTOD Values of Type 304 Stainless Steel Pipeline for LNG Transmission 显示文摘 | Back J H Kim Y P Kim W S | 2002 | Journal of Mechanical Science and Technology2002，16，8： | 1 |
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