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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 ( RRMI ) protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC)显示文摘 | Lee J J Maeng C H Back S K | 2010 | Lung Cancer2010，70，2： | 1 |
| 3 | Constitutively wilted 1,a member of the rice YUCCA gene family,is required for maintaining water homeostasis and an appropriate root to shoot ratio显示文摘 | Woo Y M Park H J Su'udi M Yang J I Park J J Back K Park Y M An G | 2007 | Plant Molecular Biology2007，65，1： | 1 |
| 4 | Volatile components in flavour concentrates from crayfish processing waste显示文摘 | Cha Y J Back H H Hsieh T C Y | 2006 | Journal of the Science of Food and Agriculture2006，58，2： | 1 |
| 5 | Adding robustness to nominal output-feedback controllers for uncertain nonlinear systems:A nonlinear version of disturbance observer 显示文摘 | Back J Shim H | 2008 | Automatica2008，44，10： | 1 |
| 6 | ^1H MR Spectroscopy of the brain: absolute quantification of metabolites显示文摘 | Jacobus J F Backes W H Nicolay K | 2006 | Radiology2006，240，2： | 1 |
| 7 | Resveratrol:A review of preclinical studies for human cancer prevention显示文摘 | Athar M Back J H Tang X W | 2007 | Toxicology and Applied Pharmacology2007，224，3： | 1 |
| 8 | Natural algorithms for choosing source locations in active control systems 显示文摘 | Back K H Elliott S J | 1995 | Journal of Sound and Vibration1995，186，2： | 1 |
| 9 | Diffusive supersonic X-ray transport in radiatively heated foam cylinders显示文摘 | Back C A Bauer J D Hammer J H | 2000 | Phys Plasmas2000，7，5： | 1 |
| 10 | Investigation of influence of thermal accom- modation on oscillating micro - flow 显示文摘 | Park J H Back S W | 2004 | International Journal of Heat and Mass Transfer2004，47，6： | 1 |
| 11 | Soluble receptor of advanced glycated endproducts is associated with plaque vulnerability in patients with acute myocardial infarction显示文摘 | Park H J Back J Y Shin WS | | 0，，07： | 1 |
| 12 | Comparing nu- merical data and text information from annual reports u- sing self - organizing maps 显示文摘 | Back B Toivonen J Vanharanta H | 2001 | International Journal of Accounting Information Systems2001，4，2： | 1 |
| 13 | Two-year field study shows little evidence that PPO-transgenic rice affects the structure of soil microbial communities显示文摘 | Chun Y J Kim H J Park K W Jeong S C Lee B Back K Kim H M and Kim C G | | 0，，： | 1 |
| 14 | Submucosal bipolar radiofrequency thermal ablation of inferior turbinates:a long term follow-up with subjective and objective assessment显示文摘 | Back L J Hytonen M L Malmberg H O | 2002 | Laryngoscope2002，112，10： | 1 |
| 15 | ^1H MR spectroscopy of the brain:absolute quantification of metabolites显示文摘 | Jansen J F Backes W H Nicolay K | 2006 | Radiology2006，240，2： | 1 |
| 16 | lH MR spectroscopy of the brain:absolute quantification of metabolites显示文摘 | Jansen J F Backes W H Nicolay K | 2006 | Radiology2006，240，2： | 1 |
| 17 | Secrets for mobile agent using one time proxy signature显示文摘 | H Kim J Back B Lee K Kim | 2001 | Cryptography and Information Security2001，2，2： | 1 |
| 18 | Microstructure and mechanical properties of mechanically alloyed and solid-state sintered tungsten heavy alloys显示文摘 | Ryu H J Hong S H Back W H | 2000 | Mater Sci Eng A2000，291，： | 1 |
| 19 | Resveratrol: a review of preclinical studies for human cancer prevention显示文摘 | Athar M Back J H Tang X W | 2007 | Toxicol Appl Pharmacol2007，224，3： | 1 |
| 20 | Complications encountered in the treatment of benign thyroid nodules with US-guided radiofrequency ablation : a m ulticenter study显示文摘 | Back J H Lee JH Sung J Y | 2012 | Radiology2012，262，： | 1 |
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