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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 3 | Laser-plasma interactions in ignition-scale hohlraum plasmas显示文摘 | MacGOWAN B J AFEYAN B B BACK C A | 1996 | Physics of Plasmas1996，3，5： | 1 |
| 4 | Detailed measurements of a diffusive supersonic wave in a radiatively heated foam显示文摘 | Back C A Bauer J D Landen O L | 2000 | Phys Rev Lett2000，84，2： | 1 |
| 5 | Diffusive supersonic X-ray transport in radiatively heated foam cylinders显示文摘 | Back C A Bauer J D Hammer J H | 2000 | Phys Plasmas2000，7，5： | 1 |
| 6 | Locally recurrent globally feedforward networks: a critical review of architec- tures显示文摘 | Tsoi A C Back A D | 1994 | IEEE Transactions on Neural Networks1994，5，2： | 1 |
| 7 | Characterization of nova plasmas using an X-ray spectrometer with temporal and spatial resolution显示文摘 | BACK C A AUFFMAN R L K BELL P M | 1995 | Review of Scientific Instruments1995，66，1： | 1 |
| 8 | Locally recurrent globally feedforward networks, a critical review of architectures显示文摘 | TSOI A C BACK A D | | 0，，02： | 1 |
| 9 | Next-generation sequencing identifies novel microRNAs in peripheral blood of lung cancer patients 显示文摘 | Keller A Backes C Leidinger P | 2011 | Mol Biosyst2011，7，12： | 1 |
| 10 | Comparative study of wear - resistant DLC and fullerene - like CNx coatings produced by pulsed laser and filtered cathodic are depositions 显示文摘 | Voevodin A A Jones J G Back T C | 2005 | Surface and Coatings Technology2005，197，： | 1 |
| 11 | Characterization of Nova plasmas using an x-ray spectrometer with temporal and spatial resolution显示文摘 | Back C A Kauffman R L Bell P M | 1995 | Rev Sci Instrum1995，66，1： | 1 |
| 12 | Next-generation sequen- cing identifies novel microRNAs in peripheral blood of lung cancer patients显示文摘 | Keller A Backes C Leidinger P | 2011 | Mol Biosyst2011，7，12： | 1 |
| 13 | Color texture classification based on gravitational collapse 显示文摘 | Sa J J D Backe A R Cortez P C | 2013 | Pattern Recognition2013，46，6： | 1 |
| 14 | Occurrence in vivo of selenocystegl -tRNA^ in Escherichia coli显示文摘 | Leifclder W Stadtman C Back A | 1989 | J Biol chem1989，264，： | 1 |
| 15 | Recommen- dations on negative pressure wound therapy with instilla- tion and antimicrobial solutions-when, where and how to use: what does the evidence show? 显示文摘 | Back D A Scheuermann Poley C Willy C | 2013 | Int Wound J2013，10，1： | 1 |
| 16 | Impact of radiation therapy on acute toxicity in breast conservation therapy for early breast cancer显示文摘 | Back M Ouerrieri C Steigler A | 2004 | Clin Oncol2004，16，1： | 1 |
| 17 | Diffusive, supersonic X-ray transport in radiatively heated foam cylinders显示文摘 | Back C A Bauer J D Hammer J H | 2000 | Physics of Plasmas2000，7，5： | 1 |
| 18 | Growth of aerobic ripening bacteria at the cheese surface is limited by the availability of iron显示文摘 | MONNET C BACK A IRL1NGER F | 2012 | Applied and Environmental Microbiology2012，78，9： | 1 |
| 19 | Cadmium and cobalt desorption kinetics from soil clays:Effect of sorption period显示文摘 | MCLAREN R G BACKES C A RATE A W | 1998 | Soil Science Sociaty of American Journal1998，62，： | 1 |
| 20 | Diffusive,supersonic X-ray transport in radiatively heated foam cylinders显示文摘 | Back C A Bauer J D Hammer J H | 2000 | Phys Plasmas2000，7，5： | 1 |
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