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| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Molecular characterization of FOX- 4, a new AmpC-type plasmid-mediated beta-lactamase from an Escherichia coli strain isolated in Spain 显示文摘 | Bou G Oliver A Ojeda M | 2000 | Antimicrob Agents Chemother2000，44，9： | 1 |
| 3 | Lipidomics era: Accomplish-ments and challenges显示文摘 | Bou Khalil M Hou W Zhou H | 2010 | Mass Spectrometry Reviews2010，29，6： | 1 |
| 4 | Inorganic arsenicimpairs proliferation and cytokine expression in human primary Tlymphocytes显示文摘 | Morzadec C Bou Ezz Edine F Macoch M | 2012 | Toxicology2012，300，12： | 1 |
| 5 | Molecular characterization of FOX-4, a new AmpC-type plasmid-mediated beta-lactamase from art Escherichia coli strain isolated in Spain 显示文摘 | Bou G Oliver A Ojeda M | 2000 | Anti- microb Agents Chemother2000，44，9： | 1 |
| 6 | Age-related equations for above-and below-ground biomass of a Eucalyptus hybrid in Congo显示文摘 | Saint-Andre L M' Bou A T Mabiala A | 2005 | Forest Ecology and Management2005，205，： | 1 |
| 7 | Factors associated with improved toxicity and tolerability of intraperitoneal chemotherapy in advanced - stage epithelial ovarian cancers 显示文摘 | Teefey P Bou Zgheib N Apte S M | 2013 | Am J Obstet Gynecol2013，208，6： | 1 |
| 8 | Oxidation of non-phenolic substances: An expanded role for laccase in lignin biodegradadation显示文摘 | Bou Rbonnais R Paice M | 1990 | FEBS Lett1990，267，： | 1 |
| 9 | Molecular characterization of FOX-4,a new AmpC-type plasmid-mediated beta-lactamase from an Escherichia coli strain isolated in Spain显示文摘 | Bou G Oliver A Ojeda M | | 0，，09： | 1 |
| 10 | Use of a Roux limb to correct esophagogastric junction fistulas after sleeve gastrectomy 显示文摘 | Baltasar A Bou R Bengochea M | | Obes Surg0，17，10： | 1 |
| 11 | Antimicrobial resistance and viru- lence:a successful or deleterious association in the bacterial world?显示文摘 | Beceiro A Tomds M Bou G | 2013 | Clin Microbiol Rev2013，26，2： | 1 |
| 12 | Molecular characterization of FOX- 4,a new AmpC- type plasmid- mediated beta- lactamase from an Escherichia coli strain isolated in Spain显示文摘 | Bou G Olive A Ojeda M | 2000 | Antimicrob Agents Chemother2000，44，9： | 1 |
| 13 | A piezoelectric micropump based on micromachining of silicon显示文摘 | van Lintel H T G van de Pol F C M Bou wstra S | 1998 | Sensors and Actuators1998，15，： | 1 |
| 14 | Sealing ability of the vertica 1 con- densation with different root canal sealers 显示文摘 | Yared G M Bou Dagher F | 1996 | E ndod1996，，： | 1 |
| 15 | Wastewater treatment for small communities in Catalonia(Mediterranean region)显示文摘 | Joan Garcia Rafael Mujeriego Josep M Obis Josep Bou | 2001 | Water policy2001，3，4： | 1 |
| 16 | Duodenal switch:an effective therapy for morbid obesity-intermediate reults显示文摘 | Baltasar A Bou R Bengochea M et a1 | 2001 | Obes Surg2001，11，1： | 1 |
| 17 | Soil carbon dynamics following afforestation of a tropical savannah with Eucalyptus in Congo 显示文摘 | Epron D Marsden C Thongo M’Bou A Saint-Andre L d’Annunzio R Nouvellon Y | 2009 | Plant Soil2009，323，： | 1 |
| 18 | Chemistry of the interface between Aluminium and polythylenephthalate by XPS显示文摘 | BOU M Matin J M TH LE Mogne | 1991 | Applied Surface Science1991，47，2： | 1 |
| 19 | PCR-based DNA fingerprint(REP-PCR,AP-PCR) and pulsed-field gel electrophoresis characterization of a nosocomial outbreak caused by imipenem and meropenem-resistant Acinetobacter baumannii显示文摘 | Bou G Cervero G Dominguez M A | 2000 | Clin Microbiol Infect2000，6，12： | 1 |
| 20 | Suitability of saturated aldehydes as lipid oxidation markersin washed turkey meat显示文摘 | PIGNOLI G BOU R RODRIGUEZ-ESTRADA M etal | 2009 | Meat Science2009，83，3： | 1 |
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