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| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Myocardialbridging and milking effect of the left anterior descending coronary artery:normal variant or obstruction显示文摘 | Nob le J Bou rassaMG Pettderdc R | | 0，，： | 1 |
| 3 | Effect of tocopherol ex- tract,Staphylococcus carnosus culture, and celery concen- trate addition on quality parameters of organic and conven- tional dry- cured sausages显示文摘 | Magrinya N Bou R Tres A | 2009 | Journal of Agricultural and Food Chemistry2009，57，： | 1 |
| 4 | Rostral ventrolateral medulla and respiratory rhythmgenesis in mice显示文摘 | Hilaire G Bou C Monteau R | 1997 | Neurosci Lett1997，224，1： | 1 |
| 5 | Sleeve gastrectomy in a 10-year-old child显示文摘 | Baltasar A Serra C Bou R | 2008 | Obes Surg2008，18，6： | 1 |
| 6 | Oxidation of non-phenolic substances: An expanded role for laccase in lignin biodegradadation显示文摘 | Bou Rbonnais R Paice M | 1990 | FEBS Lett1990，267，： | 1 |
| 7 | Effect of tocopherol extract, Staphylococcus carnosus culture, and celery concentrate addition on quality parameters of organic and conventional dry-cured sausages显示文摘 | MAGRINYA N BOU R TRES A | 2009 | Journal of Agricultural and Food Chemistry2009，57，19： | 1 |
| 8 | Use of a Roux limb to correct esophagogastric junction fistulas after sleeve gastrectomy 显示文摘 | Baltasar A Bou R Bengochea M | | Obes Surg0，17，10： | 1 |
| 9 | Quality assessment of frying fats and fried snacks during continuous deep-fat frying at different large-scale producers显示文摘 | Bou R Navas J A Codony T R | 2012 | Food Control2012，27，1： | 1 |
| 10 | Duodenal switch:an effective therapy for morbid obesity-intermediate reults显示文摘 | Baltasar A Bou R Bengochea M et a1 | 2001 | Obes Surg2001，11，1： | 1 |
| 11 | Soil carbon dynamics following afforestation of a tropical savannah with Eucalyptus in Congo 显示文摘 | Epron D Marsden C Thongo M’Bou A Saint-Andre L d’Annunzio R Nouvellon Y | 2009 | Plant Soil2009，323，： | 1 |
| 12 | Enzymatic delignification o f k raft pul- pusing laccase and amediator显示文摘 | Bou rbonnais R | 1996 | TAPPI J1996，79，： | 1 |
| 13 | Nosocomial outbreak of Pseudomonas aeruginosa infections related to a flexible bronchoscope显示文摘 | Bou R Aguilar A Perpifiin J | 2006 | J Hosp Infect2006，64，2： | 1 |
| 14 | Rostral ventrolateral medulla and respiratory rhythmogenesis in mice显示文摘 | Hilaire G Bou C Monteau R | 1997 | Neurosci Lett1997，224，1： | 1 |
| 15 | Sequential hormonal changes in 21 patients with recurrent Cushing' s disease after successful pituitary surgery显示文摘 | Bou Khalil R Baudry C Guignat L | 2011 | Eur J Endocrino12011，165，5： | 1 |
| 16 | Complications and outcome of implantable infusion pumps:apropos of 60 cases显示文摘 | Yazigi A Yazbeck P Bou Saba R | 1994 | Ann Fr Anesth Reanim1994，13，3： | 1 |
| 17 | Suitability of saturated aldehydes as lipid oxidation markers in washed turkey meat显示文摘 | Pignoli G Bou R Rodriguez- Estrada MT | 2009 | Meat Sei2009，83，3： | 1 |
| 18 | Suitability of saturated aldehydes as lipid oxidation markersin washed turkey meat显示文摘 | PIGNOLI G BOU R RODRIGUEZ-ESTRADA M etal | 2009 | Meat Science2009，83，3： | 1 |
| 19 | The stereognostie ability of natural dentitions versus implant-supported fixed prostheses or overdentures显示文摘 | Jaeobs R Bou Serhal C van Steenberghe D | 1997 | Clin Oral Investig1997，1，2： | 1 |
| 20 | Efficientsyntheses of the unknown quinolinocinnolines;syn-thesis of neocryptolepines显示文摘 | Haddadin M J Bou Zerdan R M Kurth M J | 2010 | Organic Letters2010，12，23： | 1 |
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