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| 1 | Minimally invasive surgery for esophageal achalasia显示文摘Esophageal achalasia is the most commonly diagnosed primary esophageal motor disorder and the second most common functional esophageal disorder. Current therapy of achalasia is directed toward elimination of the outflow resistance caused by failure of the lower esophageal sphincter to relax completely upon swallow- ing. The advent of minimally invasive surgery has nearly replaced endoscopic pneumatic dilation as the fi rst-line therapeutic approach. In this editorial, the rationale and the evidence supporting the use of laparoscopic Hel- ler myotomy combined with fundoplication as a primary treatment of achalasia are reviewed. | Luigi Bonavina | 2006 | World Journal of Gastroenterology2006，12，37： | 9 |
| 2 | Long-term results of endosurgical and open surgical approach for Zenker diverticulum显示文摘AIM: To assess the effectiveness of minimally invasive versus traditional open surgical approach in the treatment of Zenker diverticulum. METHODS: Between 1976 and 2006, 297 patients underwent transoral stapling (n = 181) or stapled diverticulectomy and cricopharyngeal myotomy (n = 116). Subjective and objective evaluations of the outcome of the two procedures were made at 1 and 6 mo after operation, and then every year. Long-term follow-up data were available for a subgroup of patients at a minimum of 5 and 10 years. RESULTS: The operative time and hospital stay were markedly reduced in patients undergoing the endosurgical approach. Overall, 92% of patients undergoing the endosurgical approach and 94% of those undergoing the open approach were symptom-free or were significantly improved after a median follow-up of 27 and 48 mo, respectively. At a minimum follow-up of 5 and 10 years, most patients were asymptomatic after both procedures, except for those individuals undergoing an endosurgical procedure for a small diverticulum (< 3 cm). CONCLUSION: Both operations relieve the outflow obstruction at the pharyngoesophageal junction, indicating that cricopharyngeal myotomy has an important therapeutic role in this disease independent of the resection of the pouch and of the surgical approach. Diverticula smaller than 3 cm represent a formal contraindication to the endosurgical approach because the common wall is too short to accommodate one cartridge of staples and to allow complete division of the sphincter. | Luigi Bonavina Davide Bona Medhanie Abraham Greta Saino Emmanuele Abate | 2007 | World Journal of Gastroenterology2007，13，18： | 4 |
| 3 | Incidence and treatment of mediastinal leakage after esophagectomy:Insights from the multicenter study on mediastinal leaks显示文摘BACKGROUND Mediastinal leakage(ML) is one of the most feared complications of esophagectomy. A standard strategy for its diagnosis and treatment has beendifficult to establish because of the great variability in their incidence and mortality rates reported in the existing series.AIM To assess the incidence, predictive factors, treatment, and associated mortality rate of mediastinal leakage using the standardized definition of mediastinal leaks recently proposed by the Esophagectomy Complications Consensus Group(ECCG).METHODS Seven Italian surgical centers(five high-volume, two low-volume) affiliated with the Italian Society for the Study of Esophageal Diseases designed and implemented a retrospective study including all esophagectomies(n = 501) with intrathoracic esophagogastric anastomosis performed from 2014 to 2017.Anastomotic MLs were defined according to the classification recently proposed by the ECCG.RESULTS Fifty-nine cases of ML were recorded, yielding an overall incidence of 11.8%(95%CI: 9.1%-14.9%). The surgical approach significantly influenced the occurrence of ML: the proportion of leakage was 10.5% and 9% after open and hybrid esophagectomy(HE), respectively, and doubled(20%) after totally minimally invasive esophagectomy(TMIE)(P = 0.016). No other predictive factors were found. The 30-and 90-d overall mortality rates were 1.4% and 3.2%,respectively; the 30-and 90-d leak-related mortality rates were 5.1% and 10.2%,respectively; the 90-d mortality rates for TMIE and HE were 5.9% and 1.8%,respectively. Endoscopy was the first-line treatment in 49% of ML cases, with the need for retreatment in 17.2% of cases. Surgery was needed in 44.1% of ML cases.Endoscopic treatment had the lowest mortality rate(6.9%). Removal of the gastric tube with stoma formation was necessary in 8(13.6%) cases.CONCLUSION The incidence of ML after esophagectomy was high mainly in the TMIE group.However, the general and specific(leak-related) mortality rates were low. Early treatment(surgical or endoscopic) of severe leaks is mandatory to limit related mortality. | Uberto Fumagalli Gian Luca Baiocchi ANDrea Celotti Paolo Parise ANDrea Cossu Luigi Bonavina Daniele Bernardi Giovanni de Manzoni Jacopo Weindelmayer Giuseppe Verlato Stefano Santi Giovanni Pallabazzer Nazario Portolani Maurizio Degiuli Rossella Reddavid Stefano de Pascale | 2019 | World Journal of Gastroenterology2019，25，3： | 3 |
| 4 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 5 | Covered nitinol stents for the treatment of esophageal strictures and leaks显示文摘AIM:To compare 2 different types of covered esophageal nitinol stents(Ultraflex and Choostent) in terms of efficacy,complications,and long-term outcome.METHODS:A retrospective review of a consecutive series of 65 patients who underwent endoscopic placement of an Ultraflex stent(n = 33) or a Choostent(n = 32) from June 2001 to October 2009 was conducted.RESULTS:Stent placement was successful in all patients without hospital mortality.No significant differences in patient discomfort and complications were observed between the Ultraflex stent and Choostent groups.The median follow-up time was 6 mo(interquartile range 3-16 mo).Endoscopic reintervention was required in 9 patients(14%) because of stent migration or food obstruction.No significant difference in the rate of reintervention between the 2 groups was observed(P = 0.8).The mean dysphagia score 1 mo after stent placement was 1.9 ± 0.3 for the Ultraflex stent and 2.1 ± 0.4 for the Choostent(P = 0.6).At 1-mo follow-up endoscopy,the cover membrane of the stent appeared to be damaged more frequently in the Choostent group(P = 0.34).Removal of the Choostent was possible up to 8 wk without difficulty.CONCLUSION:Ultraflex and Choostent proved to be equally reliable for palliation of dysphagia and leaks.Removal of the Choostent was easy and safe under mild sedation. | Davide Bona Letizia Laface Luigi Bonavina Emmanuele Abate Moshe Schaffer Ippazio Ugenti Stefano Siboni Rosaria Carrinola | 2010 | World Journal of Gastroenterology2010，16，18： | 2 |
| 6 | Current status of minimally invasive endoscopic management for Zenker diverticulum显示文摘Surgical resection has been the mainstay of treatment of pharyngoesophageal(Zenker) diverticula over the past century. Developments in minimally invasive surgery and new endoscopic devices have led to a paradigm change. The concept of dividing the septum between the esophagus and the pouch rather than resecting the pouch itself has been revisited during the last three decades and new technologies have been investigated to make the transoral operation safe and effective. The internal pharyngoesophageal myotomy accomplishedthrough the transoral stapling approach has been shown to effectively relieve outflow obstruction and restore physiological bolus transit in patients with medium size diverticula. Transoral techniques, either through a rigid device or by flexible endoscopy, are gaining popularity over the open surgical approach due the low morbidity, the fast recovery time and the fact that the procedure can be safely repeated. We provide an analysis of the the current status of minimally invasive endoscopic management of Zenker diverticulum. | Alberto Aiolfi Federica Scolari Greta Saino Luigi Bonavina | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，2： | 2 |
| 7 | Presentation and sur- gicalmanagement of bronchogenic and esophageal duplication cysts inadults显示文摘 | Cioffi U Bonavina LG De Simone M | 1998 | Chest Chicago1998，113，6： | 1 |
| 8 | Magnetic augmentation of the lower esophageal sphincter: results of a feasibility clinical trial 显示文摘 | Bonavina L Saino GI Bona D | 2008 | J Gastrointest Surg2008，12，12： | 1 |
| 9 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
| 10 | Surgical therapy of esophageal leiomyoma显示文摘 | BONAVINA L SEGALIN A ROSATI R | 1995 | J Am Coll Surg1995，181，： | 1 |
| 11 | Esophagectomy by video-assisted laparoscopic and trans-mediastinal approach显示文摘 | Bonavina L Bona D Abraham M | 2002 | Chit Ital2002，54，3： | 1 |
| 12 | Laparoscopic approach to esophageal achalasia显示文摘 | Rosati F Fumagalli U Bonavina L | 1995 | Am J Surg1995，169，4： | 1 |
| 13 | Thoracoscopic treatment of iatrogenic chylothorax after esophageal surgery显示文摘 | Bonavina L Incarbone R Peracchia A | 1998 | Proceedings of the Second International Congress of Thoracic Surgery1998，179，： | 1 |
| 14 | Magnetic augmentation of the lower esophageal sphincter: results of a feasibility clinical trial 显示文摘 | Bonavina L Saino GI Bona D | 2008 | J Gastroi-ntest Surg2008，12，12： | 1 |
| 15 | Surgical therapy of esophageal leiomyoma 显示文摘 | Bonavina L Segalin A Rosati R | 1995 | Am Coll Surg1995，181，3： | 1 |
| 16 | Esophagectomy via laparoscopy and transmediastinal endodissection显示文摘 | Bonavina L Incarbone R Bona D | 2004 | J Laparoendosc Adv Surg Tech A2004，14，1： | 1 |
| 17 | Presentation and surgical management of bronchogenic and esophageal duplication cysts in adults显示文摘 | Cioffi U Bonavina LG De Simone M | 1998 | Chest Chicago1998，113，6： | 1 |
| 18 | Laparoscopic approach to esophageal achalasia显示文摘 | Fumagalli U Bonavina L | 1995 | Am J Surg1995，169，4： | 1 |
| 19 | Adenoearcinoma of the cardia: the choice of surgical treatment 显示文摘 | PERAECHIA A BARDINI R BONAVINA L | 1987 | Ital Surg Sci1987，17，2： | 1 |
| 20 | Laparoscopic approach to esophageal achalasia显示文摘 | Rosati F Fumagalli U Bonavina L | 1995 | Am J Surg1995，169，4： | 1 |
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