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| 1 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 2 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 3 | Research on the Characters of the Cutting Force in Vibration Cutting Particle Reinforced Metal Matrix Composites SiC_p/Al显示文摘In this paper, turning experiments of machining particle reinforced metal matri x composites(PRMMCs) SiC p/Al with PCD tools have been carried out. The cutting force characteristics in ultrasonic vibration turning compared with that in com mon turning were studied. Through the single factor experiments and multiple fac tor orthogonal experiments, the influences of three kinds of cutting conditions such as cutting velocity, amount of feed and cutting depth on cutting force were analyzed in detail. Meanwhile, according to the experimental data, the empirica l formula of main cutting force in ultrasonic vibration turning was conclude d. According to the test results, the cutting force is direct proportion to cutt ing depth basically according to the relation between cutting force and other fa ctors, which is similar to that of common cutting, so is the feed rate, but the influence is not so big. The influence of cutting speed is larger than that of f eed rate on cutting force because the efficient cutting time increases in vibrat ion cycle with the increase of cutting speed, which causes cutting force to incr ease. The research results indicate: (1) Ultrasonic vibration turning possesses much lower main cutting force than that in common turning when adopting smaller cutting parameters. If using larger cutting parameters, the difference will inco nspicuous. (2) There are remarkable differences of cutting force-cutting veloci ty characteristics in ultrasonic vibration turning from that in common turning m ainly because built-up edge does not emerge in ultrasonic turning unlike common turning in corresponding velocity range. (3) In ultrasonic vibration cutting, t he influence of cutting velocity on cutting force is most obvious among thre e cutting parameters and the influence of feed is smallest. So adopting lower cu tting velocity and larger cutting depth not only can reduce cutting force effect ively but also can ensure cutting efficiency. (4) The conclusions are useful in precision and super precision manufacturing thin-wall pieces. | LIU Chuan-shao 1, ZHAO Bo 1,2, GAO Guo-fu 1, JIAO F eng 1 (1. Department of Mechanical Engineering, Jiaozuo Institute of Techno logy, Henan 454000, China 2. Institute of Mechanical Engineering, Shanghai Jiaotong University, Shanghai 200030, China) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 3 |
| 4 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 5 | Equal contributions anti credit given to authors in critical care medicine journals during a 10-yr )eriod显示文摘 | Wang F Tang L Bo L L et at | 2012 | Critieal Care Medieine2012，40，3： | 1 |
| 6 | Isolation of a strain of Acidithiobacillus caldus and its role in bioleaching of chalcopyrite显示文摘 | ZHOU Q G BO F BO Z H XI L JIAN G FEI L F HUA C X | 2007 | World Journal of Microbiology and Biotechnology2007，23，9： | 1 |
| 7 | Transient postoperative vascular endothelial growth factor(VEGF)-neutralisation improves graft survival in corneas with partly regressed inflammatory neovascularisation显示文摘 | Bachmann BO Luetjen-Drecoll E Bock F | 2009 | Br J Ophthalmol2009，93，8： | 1 |
| 8 | Reciprocal control of osteoblast/ehondroblast and osteoblast/adipoeyte differentiation of multipotential clonal human marrow stroreal F/STRO-1 (+) cells显示文摘 | Ahdjoudj S Lasmoles F Oyajobi BO | 2001 | J Cell Biochem2001，81，1： | 1 |
| 9 | Fluid-dynamic boundary layers in CFB boilers 显示文摘 | ZHANG W N JOHNSSON F BO L | 1995 | Chemical Engineering Science1995，50，2： | 1 |
| 10 | Preparation and properties of super-hydrophobic coating on magnesium alloy显示文摘 | Bo Y Liang F Jia H | 2010 | Appl Surf Sci2010，257，5： | 1 |
| 11 | Bovine lacto ferrin for Helicobacter pylori eradication: an open, randomized, muhicentre study显示文摘 | DI MARIO F ARAGONA G DAL BO N | 2006 | Aliment Pharmacol Ther2006，23，8： | 1 |
| 12 | Surgical treatment of phyllodes tumor of the breast显示文摘 | Salvadori B Cusumano F Del Bo R et a/ | 1989 | Caneer1989，63，12： | 1 |
| 13 | Surgical treatment of phyllodes tumors of the breast显示文摘 | Salvadori M Cusumano F Del Bo R | | 0，，： | 1 |
| 14 | Nonvolatile two-step, two- color holography with continuous-wave lights for both congruent and near-stoichiometric LiNBO3:Fe 显示文摘 | SHEN yan ZHANG Guo-quan BO F U | 2004 | J Appl Phys2004，96，10： | 1 |
| 15 | Trans-areola single-site endoscopic thyroidectomy :pilot study of 35 cases显示文摘 | Youben F Bo W Chunlin Z | 2012 | Surg Endosc2012，26，4： | 1 |
| 16 | Subglottic secretion drai nage for preventing ventilator-associated pneumonia: an updated meta-analysis of randomized controlled trials显示文摘 | Wang F Bo L Tang L | 2012 | J Trauma Acute Care Surg2012，72，12： | 1 |
| 17 | Contrasting styles of mineralization in the Chinese Altai and East Junggar, NW China: implications for the accretionary history of the southern Altaids显示文摘 | Wan Bo Xiao Wenjiao Zhang Lianchang Windley Brian F Han Chunming Quinn Cameron D | 2011 | Journal of the Geological Society2011，，： | 1 |
| 18 | Comparison and optimization of single-phase liquid cooling devices for the heat dissipation of high-power LED arrays 显示文摘 | BLADIMIR R BO F PETERSON G P | 2013 | Applied Thermal Engineering2013，59，： | 1 |
| 19 | Determination of amoxicillin in plasma samples by capillary electro-phoresis显示文摘 | Herndndez M Bo rrull F Calull M | 1999 | J Chromatograph(B)1999，731，： | 1 |
| 20 | Pulmonary infections in transplant recipients显示文摘 | Küpeli E Eyübo(g)lu F(O) Haberal M | | 0，，： | 1 |
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