|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular mechanism about lymphogenous metastasis of hepatocarcinoma cells in mice显示文摘AIM To investigate the correlation between lymphogenous metastasis and matrix metalloproteinases (MMPs) activity and the expression of Fas Iigand of tumor cells in lymph nodes.METHODES Fifty-six inbred 615-mice were equally divided into 2 groups and inoculated with Hca-F and Hca-P cells. Their lymph node metastatic rates were examined.Growth fraction of lymphocytes in host lymph nodes was detected by flow cytometry. The Hca-F and Hca-P cells were cultured with extract of lymph node, liver or spleen.The quantity of MMPs in these supernatants was examined by zymographic analysis. The expression of Fas ligand,PCNA, Bcl-2 protein of Hca-F and Hca-P cells in the mice were examined by immunohistochemistry. The apoptosis signals of macrophages in lymph nodes were observed with in situ DNA fragmentation.RESULTS On the 28th day post-inoculation, the lymph node metastatic rate of Hca-F was 80% (16/20), whereas that of Hca-P was 25% (5/20). The growth fraction of lymphocytes was as follows: in the Hca-F cells, the proliferating peak of lymphocytes appeared on the 14th day post-inoculation and then decreased rapidly, while in HcaP cells, the peak appeared on the 7th day post-inoculation and then kept at a high level. With the extract of lymph node, the quantity of the MMP-9 activity increased (P<0.01) and active MMP-9 and MMP-2 were produced by both Hca-F and Hca-P tumor cells, which did not produce MMPs without the extract of lymph node or with the extracts of the liver and spleen. The expression of Fas Ligand of Hca-F cells was stronger than that of Hca-P cells (P<0.01). The expressions of PCNA and Bcl-2 protein of Hca-F cells in the tumors of inoculated area were the same as that of Hca-P cells. In situ DNA fragmentation showed that the positive signals of macrophages were around HcaF cells.CONCLUSION Secretion of MMPs which was associated with metastatic ability of Hca-F and Hca-P tumor cells depends on the environment of lymph nodes. The increased expression of Fas ligand protein of Hca-F tumor cells with high lymphogenous metastatic potential in lymph nodes may help tumor cells escape from being killed by host lymphocytes. | Li Hou Ying Li Yong-Hua Jia Bo Wang Yi Xin Mao-Ying Ling Shen Lü Department of Pathology,Dalian Medical University,Dalian 116027,Liaoning Province,ChinaDepartment of Biochemistry,Dalian Medical University,Dalian 116027,Liaoning Province,China | 2001 | World Journal of Gastroenterology2001，7，4： | 47 |
| 2 | Hepatic venous outflow reconstruction in adult right lobe living donor liver transplantation without middle hepatic vein显示文摘背景重建困难、挑战性在没有中间的肝的静脉(MHV ) 的成年正确脑叶生活施主肝移植(LDLT ) 的肝的静脉的流出。门静脉和静脉的流出阻塞的过多的灌注将导致接枝的尖锐拥挤,最终导致主要 nonfunction。尽管各种各样的重建模式在许多国家被探索了,当前没有清楚的一致。在这研究,我们描述一种技术没有 MHV.Methods A ,用正确脑叶接枝在 LDLT 与劣等的静脉 cava ( IVC )在流出吻合阻止接枝的“ chocking ”回顾的分析从没有 MHV ,用正确脑叶接枝经历 LDLT 的 55 个接受者在临床的数据上被进行或肝的静脉的流出的重建。施主的恰好肝的静脉(RHV ) 与接受者 IVC 的三角形的开始被吻合;劣等的恰好肝的静脉(IRHV ) 足够大,直接被吻合到 IVC。大 saphenous 静脉(GSV ) 被用于重要 MHV tributaries.Results 的重建没有死亡发生在任何施主。55 个接受者,复杂并发症发生在 6,包括 hepaticvein 苛评(1 个盒子) , small-for-size 症候群(1 ) ,肝的动脉血栓(1 ) ,肠的流血(1 ) ,胆汁漏(1 )(1 ) ,左 subphrenic 脓肿和肺的感染。三个病人的一个总数死了,从 small-for-size 症候群的并且二从多重系统机关 failure.Conclusions,多重洞的垂直吻合与肝的静脉流出被重建。这种技术减轻生活施主的外科的风险,保证优秀静脉的排水,并且阻止脉管的 thromboses 和主要 nonfunction。 | WU Hong YANG Jia-yin YAN Lü-nan LI Bo ZENG Yong WEN Tian-fu ZHAO Ji-chun WANG Wen-tao XU Ming-qing LU Qiang CHEN Zhe-yu MA Yu-kui LI Jin | 2007 | Chinese Medical Journal2007，，11： | 27 |
| 3 | Comparison of parathyroid hormone (1-34) and elcatonin in postmenopausal women with osteoporosis: an 18-month randomized, multicenter controlled trial in China显示文摘 | LI Ying XUAN Miao WANG Bo YANG Jun ZHANG Hong ZHANG Xiu-zhen GUO Xiao-hui Lü Xiao-feng XUE Qing-yun YANG Gang-yi JI Qiu-he LIU Zhi-min LI Cheng-jiang WU Tian-feng SHENG Zheng-yan LI Peng-qiu TONG Jiu-cui | 2013 | Chinese Medical Journal2013，，3： | 24 |
| 4 | Approximate Solution of Oil Film Load-carrying Capacity of Turbulent Journal Bearing with Couple Stress Flow显示文摘The instability of the rotor dynamic system supported by oil journal bearing is encountered frequently, such as the half-speed whirl of the rotor, which is caused by oil film lubricant with nonlinearity. Currently, more attention is paid to the physical characteristics of oil film due to an oil-lubricated journal bearing being the important supporting component of the bearing-rotor systems and its nonlinear nature. In order to analyze the lubrication characteristics of journal bearings efficiently and save computational efforts, an approximate solution of nonlinear oil film forces of a finite length turbulent journal bearing with couple stress flow is proposed based on Sommerfeld and Ocvirk numbers. Reynolds equation in lubrication of a finite length turbulent journal bearing is solved based on multi-parametric principle. Load-carrying capacity of nonlinear oil film is obtained, and the results obtained by different methods are compared. The validation of the proposed method is verified, meanwhile, the relationships of load-carrying capacity versus eccentricity ratio and width-to-diameter ratio under turbulent and couple stress working conditions are analyzed. The numerical results show that both couple stress flow and eccentricity ratio have obvious influence on oil film pressure distribution, and the proposed method approximates the load-carrying capacity of turbulent journal bearings efficiently with various width-to-diameter ratios. This research proposes an approximate solution of oil film load-carrying capacity of turbulent journal bearings with different width-to-diameter ratios, which are suitable for high eccentricity ratios and heavy loads. | ZHANG Yongfang WU Peng GUO Bo L Yanjun LIU Fuxi YU Yingtian | 2015 | Chinese Journal of Mechanical Engineering2015，28，1： | 10 |
| 5 | Cytokine production during the inhibition of acute vascular rejection in a concordant hamster-to-rat cardiac xenotransplantation model显示文摘当前的学习的目的是调查 interleukin (IL ) 的角色的背景 -2, 干扰素(IFN ) ,在一致 hamster-to-rat 的 IL-4 和 IL-10 心脏的 xenotransplantation 模型。方法 A hamster-to-rat 心脏的移植作为金色的叙利亚的仓鼠心的接受者用 SD 老鼠被执行。60 只 SD 老鼠的一个总数被划分成四个组并且如下对待:控制组(n=15 ) ;脾切除术组(n=15 ) ;CsA 组(n=15 ) ;CsA + 脾切除术组(n=15 ) 。IL-2, IFN- , IL-4 和 IL-10 的层次被酶测量连接 immunosorbent 试金(ELISA ) 。Sera 在每个组在不同时间点被收获:白天 1,和 3 象日子一样,异种皮移植停止在控制组和 CsA 组跳动;白天 1, 3, 7, 14 和 30 在脾切除术组和 CsA+splenectomy 组。P-selectin 和细胞间的粘附 molecule-1 (ICAM-1 ) 的表示被异种皮移植的 immunohistochemical 分析在心脏的 xenotransplantation 以后检验。IL-2 和 IFN- 的结果浆液层次是 upregulated 在未经治疗(白天 3 ) 并且与 CsA + 脾切除术相比的对待脾切除术的动物(白天 7 ) 对待动物(白天 7 ) 。IL-10 是在跟随脾切除术 + CsA 的长期的幸存接受者的 upregulated。既不 P-selectin 也不 ICAM-1 表示在长期的幸存异种皮移植被检测。结论浆液 IL-2 和 IFN- 被提高跟随尖锐脉管的拒绝。浆液 IL-10 在跟随一致心脏的 xenotransplantation 的长期的幸存老鼠被相关到免疫力的抑制和保护的效果。 | ZHANG Xiao-gang Lü Yi WANG Bo LI Hui YU Liang LIU Chang WU Zheng LIU Xue-min | 2007 | Chinese Medical Journal2007，，2： | 10 |
| 6 | Land cover mapping using time series HJ-1 / CCD data显示文摘It is very difficult to have remote sensing data with both high spatial resolution and high temporal frequency; thus, two categories of land-use mapping methodology have been developed separately for coarser resolution and finer resolution data. The first category uses time series of data to retrieve the variation of land surface for classification, which are usually used for coarser resolution data with high temporal frequency. The second category uses fine spatial resolution data to classify different land surface. With the launch of Chinese satellite constellation HJ-1in 2008, four 30 m spatial resolution CCDs with about 360 km coverage for each one onboard two satellites made a revisit period of two days, which brought a new type of data with both high spatial resolution and high temporal frequency. Therefore, by taking the spatiotemporal advantage of HJ-1/CCD data we propose a new method for finer resolution land cover mapping using the time series HJ-1/CCD data, which can greatly improve the land cover mapping accuracy. In our two study areas, the very high resolution remote sensing data within Google Earth are used to validate the land cover mapping results, which shows a very high mapping accuracy of 95.76% and 83.78% and a high Kappa coefficient of 0.9423 and 0.8165 in the Dahuofang area of Liaoning Province and the Heiquan area of Gansu Province respectively. | ZHONG Bo MA Peng NIE AiHua YANG AiXia YAO YanJuan Lü WenBo ZHANG Hang LIU QinHuo | 2014 | Science China Earth Sciences2014，57，8： | 9 |
| 7 | Effects of bile acids on proliferation and ultrastructural alteration of pancreatic cancer cell lines显示文摘AIM: Pancreatic cancer in the head is frequently accompanied by jaundice and high bile acid level in serum. This study focused on the direct effects of bile acids on proliferation and ultrastructural alteration of pancreatic cancer.METHODS: Pancreatic cancer cell lines PANC-1, MIA PaCa2 and PGHAM-1 were explored in this study. The cell lines were cultured in media supplemented with certain bile acids,CA, DCA, LCA, TCDC, TDCA and GCA. Their influence on cell growth was measured with MTT assay after 72 h of incubation. Cell cycles of PANC-1 cells in 40 μM of bile acids media were analyzed by flow cytometry. Ultrastructural alteration of PANC-1 cells induced by DCA was observed using scanning and transmission electron microscope (SEM and TEM).RESULTS: At various concentrations of bile acids and incubation time, no enhanced effects of bile acids on cell proliferation were observed. Significant inhibitory effects were obtained in almost all media with bile acids. DCA and CA increased the percentage of G0+G1 phase cells, while GCA and TDCA elevated the S phase cell number. After 48 h of incubation in DCA medium, PANC-1 cells showed some structural damages such as loss of their microvilli and vacuolization of organelles in cytoplasm.CONCLUSION: Bile acids can reduce proliferation of pancreatic cancer cells due to their direct cytotoxicity. This result implies that elevation of bile acids in jaundiced serum may inhibit pancreatic cancer progression. | Zheng Wu Yi Lü Bo Wang Chang Liu Zuo-Ren Wang Department of Hepatobiliary Surgery,The First Hospital of Xi’an Jiaotong University,Xi’an 710061,Shaanxi Province,China | 2003 | World Journal of Gastroenterology2003，9，12： | 8 |
| 8 | Modification of Inclusions in Liquid Iron by Mg Treatment显示文摘Effect of Mg addition on the compositions of inclusions were studied. The results show that Mg can minimize the inclusions of steel obviously. Under the present condition, Mg deoxidation products of low-S content experimental steel would be changed in the order of Al2O3→MgAl2O4→Mg–Al–O–S→Mg–O–S. Mg deoxidation products of high-S content experimental steel generate Mg–S(–O)+MnS type inclusions, except for usual oxysulfide. And it is consistent with the results of thermodynamics calculation. Mg is preferred to react with oxide, compared with sulfide. The reaction reaches the equilibrium after 1 min or 5 min. It shows that the number and diameter of inclusions in all experimental steel samples are well under control, helping to improve the properties of steel. | Tong-sheng ZHANG De-yong WANG Chun-wei LIU Mao-fa JIANG Ming L Bo WANG Si-xun ZHANG | 2014 | Journal of Iron and Steel Research(International)2014，21，S1： | 8 |
| 9 | Preparation of the UPOV Guidelines for the Conduct of Tests for Distinctness, Uniformity and Stability–Tea Plant [Camellia sinensis (L.) O. Kuntze]显示文摘Distinctness, Uniformity and Stability (DUS) testing is the technical base of Plant Variety Protection (PVP) and the scientific basis for the approval of Plant Breeder’s Rights (PBR). DUS Test Guidelines are not only the technical manuals for the DUS testing authorities to conduct the testing, but also the technical standards for the competent authorities to examine the DUS of new varieties of plants. Tea plant, originated from Yunnan Province, China, is a very important woody cash species in the world. The International Union for the Protection of New Varieties of Plants (UPOV) DUS Test Guidelines for tea plant is the first Test Guidelines prepared by China for the UPOV. In this article, the subject, selection, and determination of characteristics, states of expression of characteristics and the selection of example varieties, assessment of the UPOV DUS Test Guidelines for tea plant were elucidated in detail. Finally, the proposal of PVP for tea plant in China was also proposed. The preparation of UPOV DUS Test Guidelines for tea plant will have important significance both for promoting the development of PVP and increasing the status of international PVP fields for China. | CHEN Liang YU Fu-lian YAO Ming-zhe Lü Bo YANG Kun DU Yuan-yuan | 2008 | Agricultural Sciences in China2008，7，2： | 7 |
| 10 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 11 | Clinical and angiographic characteristics of premenopausal women with coronary artery disease显示文摘当中年的 men.It 的疾病广泛地被接受,背景冠的动脉疾病( CAD )通常被考虑因为荷尔蒙 protection.Based ,为绝经前的女人的 CAD 的风险是低的,没有足够的 concern.Even nowthere ,更绝经前的女人受不了咽峡炎和心肌的梗塞,这仍然是有限的详细数据为了描述绝经前的 CAD patients.This 的 characteristicsmechanism 和预后,文章瞄准了到分析临床所有 P < 0.05 )我们在绝经前的 CAD 发现了单个容器的更多的经常的参与的 .Although (43.2%对 26.9%P=0 ),并且三倍的容器在绝经后( 56-60 岁) CAD 病人(33.8%对 20.4%P=0 )更严重的损害(90%)在留给主要(2.9%对1.1%, P=0.048 )并且近似左前面的下降动脉(男孩)(28.2%对 16.6%P=0 )在绝经前的 CAD ,组是有胸不快的绝经前的女人总是被发现把明显的 atherosclerosismore 使倾向了被定位的 found. | DOU Ke-fei XU Bo YANG Yue-jin Lü Rong QIU Hong YANG Wei-xian MU Zhao-wei GAO Run-lin GAO Zhan CHEN Ji-lin QIAO Shu-bin LI Jian-jun QIN Xue-wen LIU Hai-bo WU Yong-jian CHEN Jue YAO Min YOU Shi-jie YUAN Jin-qing DAI Jun | 2008 | Chinese Medical Journal2008，，23： | 5 |
| 12 | Transdiaphragnatic exposure for direct atrioatrial anastomosis in liver transplantation显示文摘在 Budd-Chiari 症候群的背景肝移植仍然保持争论;然而,一些改进技术导致更好的结果。我们为 Budd-Chiari 症候群与 atrioatrial 吻合报导肝移植的中期的后续结果并且与结束阶段肝 disease.Methods 为病人与 atrioatrial 吻合探索肝移植的指示九个病人(六 Budd-Chiari 症候群,一结束阶段 hepatolithiasis ,一 hepatocellular 癌和一医不好的牙槽的包虫病)从 199 在四川大学的韦斯特中国医院里与 atrioatrial 吻合经历了肝移植八个肝移植使用的 cadaveric orthotopic 肝和一个一生活施主肝。起作用的技术都是为直接 atrioatrial 吻合和由在 venovenous bypass.Results 的帮助下的 cryopreserved 静脉 cava 接枝的劣等的静脉 cava 的代替的 transdiaphragmatic 暴露肝移植是成功的。二个病人收缩了肺的感染和尖锐拒绝发生在另一种情况中。与合适的治疗,所有病人恢复了很好并且有生活的好质量。迄今为止,他们被跟随了在上面为超过 24 个月。唯一的死亡跟随了在为直接 atrioatrial 吻合和劣等的静脉 cava 的 cryopreserved 静脉 cava graftreplacement 的肝 transplantation.Conclusions Transdiaphragmatic 暴露以后的三年是的肝的癌的复发为有因此扩大肝移植的指示的结束阶段肝疾病的病人可能。 | XU Ming-qing CHEN Zhe-yu YAN Lü-nan ZENG Yong WEN Tian-fu LI Bo ZHAO Ji-chun WANG Wen-tao YANG Jia-yin | 2010 | Chinese Medical Journal2010，，24： | 5 |
| 13 | A Diagnostic Analysis on the Effect of the Residual Layer in Convective Boundary Layer Development near Mongolia Using 20th Century Reanalysis Data显示文摘Although the residual layer has already been noted in the classical diurnal cycle of the atmospheric boundary layer,its effect on the development of the convective boundary layer has not been well studied. In this study, based on 3-hourly20 th century reanalysis data, the residual layer is considered as a common layer capping the convective boundary layer. It is identified daily by investigating the development of the convective boundary layer. The region of interest is bounded by(30°–60° N, 80°–120° E), where a residual layer deeper than 2000 m has been reported using radiosondes. The lapse rate and wind shear within the residual layer are compared with the surface sensible heat flux by investigating their climatological means, interannual variations and daily variations. The lapse rate of the residual layer and the convective boundary layer depth correspond well in their seasonal variations and climatological mean patterns. On the interannual scale, the correlation coefficient between their regional averaged(40°–50°N, 90°–110° E) variations is higher than that between the surface sensible heat flux and convective boundary layer depth. On the daily scale, the correlation between the lapse rate and the convective boundary layer depth in most months is still statistically significant during 1970–2012. Therefore, we suggest that the existence of a deep neutral residual layer is crucial to the formation of a deep convective boundary layer near the Mongolian regions. | HAN Bo ZHAO Cailing L Shihua WANG Xin | 2015 | Advances in Atmospheric Sciences2015，32，6： | 5 |
| 14 | Hybrid uncertainties-based analysis and optimization design of powertrain mounting systems显示文摘In this study,a hybrid uncertainties-based analysis and optimization method is presented for the designs of the powertrain mounting system(PMS)involving mixed uncertainties.In the presented method,the PMS parameters with sufficient data are treated as random variables,while those with limited information are defined as interval variables.Then,an uncertainty-based analysis method called as hybrid interval-random perturbation-central difference method(HIRP-CDM),is proposed to compute the hybrid interval-random outputs of the inherent characteristics of the PMS in concerned directions.In addition,the hybrid interval-random-Monte Carlo method(HIR-MCM)is developed to verify the computational accuracy of HIRP-CDM.Next,an optimization model mixed uncertainties is built up for the PMS design based on HIRP-CDM,in which the hybrid intervalrandom outputs of the concerned inherent characteristics are adopted to construct the design objective and constrains.The complex optimization problem can be effectively settled by means of HIRP-CDM.The effectiveness of the presented method is verified by a numerical example. | CAI BoHao SHANGGUAN Wen-Bin LÜHui BO Tao | 2020 | Science China(Technological Sciences)2020，63，5： | 4 |
| 15 | Involvement of the ipsilateral and contralateral cerebellum in the acquisition of unilateral classical eyeblink conditioning in guinea pigs显示文摘 | Bo HU Xi LIN Lü-shuai HUANG Li YANG Hua FENG Jian-feng SUI | 2009 | Acta Pharmacologica Sinica2009，30，2： | 4 |
| 16 | A New Rhamphorhynchid Pterosaur(Pterosauria) from the Middle Jurassic Tiaojishan Formation of Western Liaoning,China显示文摘A new Sordes-like pterosaur Jianchangopterus zhaoianus gen.et sp.nov.is erected based on a almost complete skeleton with skull preserved.It is characterized by the following characters:seven and six pairs of upper jaw and lower jaw teeth respectively;the development of a recess on maxilla;the evenness of the dental margin in lateral view;a distinct central ridge along dorsal surface of the mandibular symphysis;wing phalanx 4 with strongly curved shaft approximately 96%the length of the wing phalanx 1.The... | Junchang Lü Xue BO | 2011 | Acta Geologica Sinica(English Edition)2011，85，5： | 4 |
| 17 | Shikonin attenuates hyperhomocysteinemia-induced CD4E^+T cell inflammatory activation and atherosclerosis in ApoE^−/− mice by metabolic suppression显示文摘T cell metabolic activation plays a crucial role in inflammation of atherosclerosis.Shikonin(SKN),a natural naphthoquinone with anti-inflammatory activity,has shown to exert cardioprotective effects,but the effect of SKN on atherosclerosis is unclear.In addition,SKN was found to inhibit glycolysis via targeting pyruvate kinase muscle isozyme 2(PKM2).In the present study,we investigated the effects of SKN on hyperhomocysteinemia(HHcy)-accelerated atherosclerosis and T cell inflammatory activation in ApoE^−/− mice and the metabolic mechanisms in this process.Drinking water supplemented with Hcy(1.8 g/L)was administered to ApoE^−/− mice for 2 weeks and the mice were injected with SKN(1.2 mg/kg,i.p.)or vehicle every 3 days.We showed that SKN treatment markedly attenuated HHcy-accelerated atherosclerosis in ApoE^−/− mice and significantly decreased inflammatory activated CD4^+T cells and proinflammatory macrophages in plaques.In splenic CD4^+T cells isolated from HHcy-ApoE^−/− mice,SKN treatment significantly inhibited HHcy-stimulated PKM2 activity,interferon-γsecretion and the capacity of these T cells to promote macrophage proinflammatory polarization.SKN treatment significantly inhibited HHcy-stimulated CD4^+T cell glycolysis and oxidative phosphorylation.Metabolic profiling analysis of CD4^+T cells revealed that Hcy administration significantly increased various glucose metabolites as well as lipids and acetyl-CoA carboxylase 1,which were reversed by SKN treatment.In conclusion,our results suggest that SKN is effective to ameliorate atherosclerosis in HHcy-ApoE^−/− mice and this is at least partly associated with the inhibition of SKN on CD4^+T cell inflammatory activation via PKM2-dependent metabolic suppression. | Si-lin Lü Guo-hui Dang Jia-cheng Deng Hui-ying Liu Bo Liu Juan Yang Xiao-long Ma Yu-tong Miao Chang-tao Jiang Qing-bo Xu Xian Wang Juan Feng | 2020 | Acta Pharmacologica Sinica2020，41，1： | 4 |
| 18 | Optimization of corn-stalk skin flake-wood shaving composite technology显示文摘We focused on the optimization of corn-stalk skin flake-wood shaving composite technology. We studied the effects of material-mixture ratio, glue content, hotpressing temperature, and hot-pressing time on the appearance, physical, and mechanical properties of the composite by the orthogonal experiment method. Our findings yielded highly significant results in all three cases: the effects of the material-mixture ratio on 2 h of thickness swelling(2h TS)and the modulus of rupture(MOR); the effects of glue content on 2h TS, internal bond strength, and modulus of elasticity(MOE); and the effects of hot-pressing temperature on MOR and MOE. Product optimization is achieved when the ratio of corn stalk skin flake to wood shaving is 3:7, the glue content is 12 %, the hot-pressing temperature is 150 °C, and the hot-pressing time is 4.5 min. | Haixiang L Xianquan Zhang Bo Yu | 2015 | Journal of Forestry Research2015，26，3： | 3 |
| 19 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 20 | Isolation and Expression Analysis of Two Genes Encoding Cinnamate 4-Hydroxylase from Cotton(Gossypium hirsutum)显示文摘Two genes(GhC4H1 and GhC4H2) that encode putative cotton cinnamate 4-hydroxylases that catalyze the second step in the phenylpropanoid pathway were isolated from developing cotton fibers. GhC4H1 and GhC4H2 each contain open reading frames of 1 518 base pairs(bp) in length and both encode proteins consisting of 505 amino acid residues. They are 90.89% identical to each other at the amino acid sequence level and belong to class I of plant C4 Hs. GhC4H1 and GhC4H2 genomic DNA are 2 247 and 2 161 bp long, respectively, and contain two introns located at conserved positions relative to the coding sequence. GhC4H1 and GhC4H2 promoters were isolated and found to contain many cis-elements(boxes P, L and AC-I element) previously identified in the promoters of other phenylpropanoid pathway genes. Histochemical staining showed GUS expression driven by the GhC4H1 and GhC4H2 promoters in ovules and fibers tissues. GhC4H1 and GhC4H2 were also widely expressed in other cotton tissues. GhC4H2 expression reached its highest level during the elongation stage of fiber development, whereas GhC4H1 expression increased during the secondary wall development period in cotton fibers. Our results contribute to a better understanding of the biochemical role of GhC4H1 and GhC4H2 in cotton fiber development. | NI Zhi-yong LI Bo Neumann M Peter Lü Meng FAN Ling | 2014 | Journal of Integrative Agriculture2014，13，10： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员