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| 1 | Implementation of enteral feeding protocol in an intensive care unit: Before-and-after study显示文摘AIM To determine the effects of implementing an enteral feeding protocol on the nutritional delivery and outcomes of intensive care patients.METHODS An uncontrolled, observational before-and-after study was performed in a tertiary mixed medical-surgical intensive care unit(ICU). In 2013, a nurse-driven enteral feeding protocol was developed and implemented in the ICU. Nutrition and outcome-related data from patients who were treated in the study unit from 2011-2012(the Before group) and 2014-2015(the After group) were obtained from a local electronic database, the national Population Registry and the hospital's Infection ControlService. Data from adult patients, readmissions excluded, who were treated for at least 7 d in the study unit were analysed. RESULTS In total, 231 patients were enrolled in the Before and 249 in the After group. The groups were comparable regarding demographics, patient profile, and severity of illness. Fewer patients were mechanically ventilated on admission in the After group(86.7% vs 93.1% in the Before group, P = 0.021). The prevalence of hospitalacquired infections, length of ICU stay and ICU, 30-and 60-d mortality did not differ between the groups. Patients in the After group had a lower 90-d(P = 0.026) and 120-d(P = 0.033) mortality. In the After group, enteral nutrition was prescribed less frequently(P = 0.039) on day 1 but significantly more frequently on all days from day 3. Implementation of the feeding protocol resulted in a higher cumulative amount of enterally(P = 0.049) and a lower cumulative amount of parenterally(P < 0.001) provided calories by day 7, with an overall reduction in caloric provision(P < 0.001). The prevalence of gastrointestinal symptoms was comparable in both groups, as was the frequency of prokinetic use. Underfeeding(total calories < 80% of caloric needs, independent of route) was observed in 59.4% of the study days Before vs 76.9% After(P < 0.001). Inclusion in the Before group, previous abdominal surgery, intraabdominal hypertension and the sum of gastrointestinal symptoms were found to be independent predictors of insufficient enteral nutrition.CONCLUSION The use of a nurse-driven feeding protocol improves the delivery of enteral nutrition in ICU patients without concomitant increases in gastrointestinal symptoms or intra-abdominal hypertension. | Martin Padar Gerli Uusvel Liis Starkopf Joel Starkopf Annika Reintam Blaser | 2017 | World Journal of Critical Care Medicine2017，6，1： | 22 |
| 2 | 胃癌高发区cagA^(+)幽门螺杆菌的感染显示文摘目的研究胃癌高发区不同人群幽门螺杆菌(Hp)cagA+亚型感染状况,探讨HpcagA+亚型感染与胃癌高发流行的关系.方法用ELISA方法检测了全部受检者的抗Hp抗体及抗cagA抗体,并用13C尿素酶呼吸实验(13C-UBT)方法检测了70名儿童Hp感染状况.结果胃癌高发区成人Hp感染率为747%,儿童Hp感染率为686%;成人cagA+亚型感染率为65%,儿童为714%.77名癌症患者的Hp和cagA+亚型感染率均为597%,其中胃癌患者(n=38)Hp和cagA+亚型感染率分别为50%和553%,均低于其他癌症患者(n=39)的感染率(692%和641%).结论胃癌高发区成人、儿童及癌症患者HpcagA+亚型感染率相当高,表明Hp感染,尤其是cagA+的Hp感染与当地胃癌高发有明显的关系. | 张联 江骥 潘凯枫 刘伟东 马峻岭 周彤 Perez-Perez GI Blaser Mj 昌云生 游伟程 | 1998 | 华人消化杂志1998，6，1： | 18 |
| 3 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 4 | Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems显示文摘 | Annika Reintam Blaser Manu L. N. G. Malbrain Joel Starkopf Sonja Fruhwald Stephan M. Jakob Jan Waele Jan-Peter Braun Martijn Poeze Claudia Spies | 2012 | Intensive Care Medicine2012，，3： | 4 |
| 5 | Helicobacter pylori in Health and Disease显示文摘 | Timothy L. Cover Martin J. Blaser | 2009 | Gastroenterology2009，，6： | 4 |
| 6 | Mild to moderate intra-abdominal hypertension: Does it matter?显示文摘This review summarizes the epidemiology, pathophysiological consequences and impact on outcome of mild to moderate(Grade Ⅰ to Ⅱ) intra-abdominal hypertension(IAH), points out possible pitfalls in available treatment recommendations and focuses on tasks for future research in the field. IAH occurs in about 40% of ICU patients. Whereas the prevalence of abdominal compartment syndrome seems to be decreasing, the prevalence of IAH does not. More than half of IAH patients present with IAH grade Ⅰ and approximately a quarter with IAH grade Ⅱ. However, most of the studies have addressed IAH as a yes-or-no variable, with little or no attention to different severity grades. Even mild IAH can have a negative impact on tissue perfusion and microcirculation and be associated with an increased length of stay and duration of mechanical ventilation. However, the impact of IAH and its different grades on mortality is controversial. The influence of intra-abdominal pressure(IAP) on outcome most likely depends on patient and disease characteristics and the concomitant macro- and microcirculation. Therefore, management might differ significantly. Today, clear triggers for interventions in different patient groups with mild to moderate IAH are not defined. Further studies are needed to clarify the clinical importance of mild to moderate IAH identifying clear triggers for interventions to lower the IAP. | Liivi Maddison Joel Starkopf Annika Reintam Blaser | 2016 | World Journal of Critical Care Medicine2016，5，1： | 4 |
| 7 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 8 | Gastrointestinal symptoms during the first week of intensive care are associated with poor outcome: a prospective multicentre study显示文摘 | Annika Reintam Blaser Martijn Poeze Manu L. N. G. Malbrain Martin Bj?rck Heleen M. Oudemans-van Straaten Joel Starkopf | 2013 | Intensive Care Medicine2013，，5： | 3 |
| 9 | Coadaptation of Helicobacter pylori and humans: ancient history, modern implications显示文摘 | Atherton John C Blaser Martin J | 2009 | Journal of Clinical Investigation2009，，9： | 2 |
| 10 | Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome显示文摘 | Andrew W. Kirkpatrick Derek J. Roberts Jan Waele Roman Jaeschke Manu L. N. G. Malbrain Bart Keulenaer Juan Duchesne Martin Bjorck Ari Leppaniemi Janeth C. Ejike Michael Sugrue Michael Cheatham Rao Ivatury Chad G. Ball Annika Reintam Blaser Adrian Regli Zs | 2013 | Intensive Care Medicine2013，，7： | 2 |
| 11 | The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells显示文摘 | William J. Harris Xu Huang James T. Lynch Gary J. Spencer James R. Hitchin Yaoyong Li Filippo Ciceri Julian G. Blaser Brigit F. Greystoke Allan M. Jordan Crispin J. Miller Donald J. Ogilvie Tim C.P. Somervaille | 2012 | Cancer Cell2012，，4： | 2 |
| 12 | Helicobacter pylori and gastrointestinal adenocarcinomas显示文摘 | Peek R M Jr blaser M J | 2002 | Nat Res Cancer2002，2，1： | 1 |
| 13 | Immunological mechanisms in specific immunotherapy显示文摘 | Sehmidt Weber CB Blaser K | 2004 | Springer Semin Immunopathol2004，25，4： | 1 |
| 14 | The interaction between caveolin-t and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk 显示文摘 | Arpaia E Blaser H Quintela-Fandino M | 2012 | Oncogene2012，31，7： | 1 |
| 15 | Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans显示文摘 | Portal-Celhay C Bradley ER Blaser MJ | 2012 | BMC Microbiol2012，12，： | 1 |
| 16 | Beta-galactoside- binding protein secreted by activated T cells inhibits antigen- induced proliferation of T cells显示文摘 | Blaser C Kaufinann M Muller C | 1998 | Eur J Immunnl1998，25，8： | 1 |
| 17 | Genomes of Helicobacter pylori from native Peruvians suggest admixture of ancestral and modem lineages and reveal a westem type cag-pathogenicity island显示文摘 | Blaser S Manjulata Devi Irshad Ahmed | 2006 | BMC Genomics2006，27，7： | 1 |
| 18 | Regulation and role of transforming growth factor-b in immune tolerance induction and inflammation显示文摘 | Schmidt-Weber C B Blaser K | 2004 | Current Opinion in Immunology2004，16，6： | 1 |
| 19 | Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation 显示文摘 | Schmidt-Weber CB Blaser K | 2004 | Curt Opin Immunol2004，16，5： | 1 |
| 20 | Antitumor ac- tivities of ATP-competitive inhibitors of mTOR in colon cancer cells显示文摘 | Blaser B Waselle L Dormond-Meuwly A | 2012 | BMC Cancer2012，12，： | 1 |
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