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| 1 | A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility显示文摘Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particularly in those with hypogonadism,elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic–pituitary–testicular axis by suppressing follicle-stimulating hormone(FSH)and luteinizing hormone(LH)production and impaired spermatogenesis.Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase endogenous testosterone production and improve spermatogenesis in the setting of infertility is an off-label option for treatment.We carried out a systematic review and meta-analysis of the literature of the past 30 years in order to evaluate the benefits of the use of aromatase inhibitors in the medical management of infertile/hypoandrogenic males.Overall,eight original articles were included and critically evaluated.Either steroidal(Testolactone)or nonsteroidal(Anastrozole and Letrozole)aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile.While the evidence is promising,future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications. | Francesco Del Giudice Gian Maria Busetto Ettore De Berardinis Isabella Sperduti Matteo Ferro Martina Maggi Martin S Gross Alessandro Sciarra Michael L Eisenberg | 2020 | Asian Journal of Andrology2020，22，4： | 5 |
| 2 | Major early complications from diagnostic and therapeutic ERCP: a prospective multicenter study显示文摘 | Silvano Loperfido Giampaolo Angelini Giorgio Benedetti Fausto Chilovi Franco Costan Franco De Berardinis Massimo De Bernardin Andrea Ederle Paolo Fina Agostino Fratton | 1998 | Gastrointestinal Endoscopy1998，，1： | 2 |
| 3 | Functional Annotation of the Arabidopsis Genome Using Controlled Vocabularies显示文摘 | BERARDINI T Z MUNDODI S REISER L | 2004 | Plant Physiol2004，135，： | 1 |
| 4 | Utilization of mango peels as a source of pectin and polyphenolics 显示文摘 | Berardini N Kndler M Schieber A | 2005 | Innovative Food Sci & Emerging Tech2005，6，4： | 1 |
| 5 | Petersen coil regulators analysis using a real-time digital simulator显示文摘 | Brenna M De Berardinis E Delli Carpini L | | 0，，3： | 1 |
| 6 | ^13C-methacetin breath test for monitoring hepatic function in cirrhotic patients before and after liver transplantation显示文摘 | Petrolati A Festi D De Berardinis G | 2003 | Aliment Pharmacol Ther2003，18，8： | 1 |
| 7 | Microglial activation in chronic neurodegenerative diseases:roles of apoptotic neurons and chronic stimulation显示文摘 | Minghetti L Ajmone-Cat MA De Berardinis MA | 2005 | Brain Res Rev2005，48，2： | 1 |
| 8 | Additive value to clinical judgement of blood neutrophil gelatinase-associated lipocalin in diagnosis of acute kidney injury and prediction of mortality in patients hospitalized from the emergency department显示文摘 | Di Somma S Magrini L De Berardinis B | 2012 | Critical Care2012，16，1： | 1 |
| 9 | Utilization of mango peels as a source of pectin and poly phenolics显示文摘 | Berardini N Knodler M Schieber A | 2005 | Innovative Food Science and Emerging Technologies2005，6，4： | 1 |
| 10 | Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimer's disease 显示文摘 | Combrinck M Williams J De Berardinis MA | 2006 | J N eurol Neurosurg Psychiatry2006，77，1： | 1 |
| 11 | Prognostic value of circulating tumor cells in nonmuscle invasive bladder cancer; a CellSearch analysis显示文摘 | Gazzaniga P Gradilone A de Berardinis E | 2012 | Annals of Oncology2012，23，9： | 1 |
| 12 | The Arabidopsis information resource (TAIR): a model organism database providing a centralized, curated gateway to Arabidopsis biology, research materials and community 显示文摘 | Rhee S Y Beavis W Berardini T Z | 2003 | Nucleic Acids Research2003，31，： | 1 |
| 13 | HASTY,the Arabidopsis ortholog of exportin 5/MSN5,regulates phase change and morphogenesis显示文摘 | Bollman K M Aukerman MJ Park M Y Hunter C Berardini T Z | 2003 | Development2003，130，8： | 1 |
| 14 | Beyond aerobic glycolysis:transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis显示文摘 | De Berardinis RJ Mancuso A Daikhin E | 2007 | Proc Natl Acad Sci U S A2007，104，19： | 1 |
| 15 | A retrospective study of clinical and radiologic outcomes of 69 consecu- tive maxillary sinus augmentations associated with func- tional endoscopic sinus surgery 显示文摘 | Falco A Amoroso C Berardini M | 2015 | Int J Oral Maxillofac Implants2015，30，3： | 1 |
| 16 | Phage-display of antigenic peptides applied to vaccine design 显示文摘 | Fanutti C Del Polo G De Berardinis P | 1998 | Biochem Soc T1998，26，1： | 1 |
| 17 | Utilization of mango peels as a source of pectin and polyphenolics显示文摘 | Nicolai Berardini | 2005 | Innovative food science and emerging technolo- gies2005，6，4： | 1 |
| 18 | Open laboratories:Operational and safety issues or how to determine if open laboratories will work for you显示文摘 | Baum J S Di Berardinis L J | 2006 | Journal of Chemical Health&Safety2006，13，1： | 1 |
| 19 | Functional annotation of the Arabidopsis genome using controlled vocabularies显示文摘 | Berardini T Z Mundodi S Reiser L | 2004 | Plant Physiol2004，135，： | 1 |
| 20 | Microglial activation in chronic neurodegenerative diseases: roles of apoptotic neurons and chronic stimulation 显示文摘 | Minghetti L Ajmone-Cat MA De Berardinis MA | 2005 | Brain Res Brain Res Rev2005，48，： | 1 |
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