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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | SFRP4 expression correlates with epithelial mesenchymal transitionlinked genes and poor overall survival in colon cancer patients显示文摘BACKGROUND Colon cancer is among the most commonly diagnosed cancers in the United States with an estimated 97220 new cases expected by the end of 2018.It affects 1.2 million people around the world and is responsible for about 0.6 million deaths every year.Despite decline in overall incidence and mortality over the past 30 years,there continues to be an alarming rise in early-onset colon cancer cases(<50 years).Patients are often diagnosed at late stages of the disease and tend to have poor survival.We previously showed that the WNT“gatekeeper”gene,secreted frizzled-related protein 4(SFRP4),is over-expressed in early-onset colon cancer.SFRP4 is speculated to play an essential role in cancer by inhibiting the epithelial mesenchymal transition(EMT).AIM To investigate the correlation between SFRP4 expression and EMT-linked genes in colon cancer and how it affects patient survival.METHODS SFRP4 expression relative to that of EMT-linked genes and survival analysis were performed using the University of California Santa Cruz Cancer Browser interface.RESULTS SFRP4 was found to be co-expressed with the EMT-linked markers CDH2,FN1,VIM,TWIST1,TWIST2,SNAI1,SNAI2,ZEB1,ZEB2,POSTN,MMP2,MMP7,MMP9,and COL1A1.SFRP4 expression negatively correlated with the EMTlinked suppressors CLDN4,CLDN7,TJP3,MUC1,and CDH1.The expression of SFRP4 and the EMT-linked markers was higher in mesenchymal-like samples compared to epithelial-like samples which potentially implicates SFRP4-EMT mechanism in colon cancer.Additionally,patients overexpressing SFRP4 presented with poor overall survival(P=0.0293).CONCLUSION Considering the implication of SFRP4 in early-onset colon cancer,particularly in the context of EMT,tumor metastasis,and invasion,and the effect of increased expression on colon cancer patient survival,SFRP4 might be a potential biomarker for early-onset colon cancer that could be targeted for diagnosis and/or disease therapy. | Landry E Nfonsam Jana Jandova Hunter C Jecius Pamela N Omesiete Valentine N Nfonsam | 2019 | World Journal of Gastrointestinal Oncology2019，11，8： | 4 |
| 3 | Buffering in optical packet switches显示文摘 | D K Hunter M C Chia I Andonovic | 1998 | IEEE Journal of Lightwave Technology1998，16，12： | 2 |
| 4 | 基于影像表现预测骨关节炎进展显示文摘目前常用X线检查评估骨关节炎(OA)进展,MRI可了解OA初期至晚期关节功能丧失阶段进展规律。最新研究表明,MRI检测到的关节结构异常变化,如软骨缺损和骨髓水肿增加,软骨体积和厚度减少,软骨成分改变等可用于评估OA进展。肥胖、肌肉萎缩、关节内外翻、代谢性疾病、炎症和关节疼痛等临床危险因素及软骨损伤、骨髓水肿、半月板病变、滑膜炎等影像学特征等关节结构因素均与OA进展有关。改善这类危险因素,可减缓疾病进展;利用MRI监测疾病进展,发现新的危险因素,并对危险因素进行干预,有助于阻断OA进展。对处于高危险因素人群进行临床试验研究,可减少试验样本量和随访时间,增强临床试验研究效率。该文主要介绍OA进展的最新流行病学和临床研究证据,以及与OA进展相关的危险因素。 | 徐勤光 韦宋谱 王学宗 丁道芳 庞坚 郑昱新 曹月龙 詹红生 Ding C Zhang Y Hunter D | 2013 | 国际骨科学杂志2013，34，2： | 2 |
| 5 | A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration显示文摘 | Hadlock T Sundback C Hunter D | | 0，，： | 2 |
| 6 | Resistance to ammonia stress of Penaeus monodon Fabricius Juvenile fed diets supplemented with astaxanthin 显示文摘 | PAN C H CHIEN Y H HUNTER B T | 2003 | J Exp Marine Biol Ecol2003，297，1： | 1 |
| 7 | Apramycin-resistant Escheriehia coli isolated from pigs and a stockman显示文摘 | Hunter J E B Bennett M Hart C A | 1994 | Epidemiol infect1994，112，： | 1 |
| 8 | Long-circulating and target-specific nanoparticles :theory to practice显示文摘 | MOGHIMI S M HUNTER A C MURRAY J C | 2001 | Pharmacol Rev2001，53，2： | 1 |
| 9 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 10 | Effects of exogenous excitatory amino acid neurotransmitters on blood-brain barrier disruption in focal cerebral ischemia显示文摘 | Chi OZ Hunter C Liu X | 2009 | Neurochem Res2009，34，7： | 1 |
| 11 | The ABC ontology and model显示文摘 | LAGOZE C HUNTER J | 2001 | Journal of Digital Information2001，1，2： | 1 |
| 12 | Preparation of a New Crystal form Manganese Dioxide: λ-MnO2 显示文摘 | Hunter J C J | 1981 | Solide State Chem1981，39，2： | 1 |
| 13 | The dynamic compression testing of solids by the method of the split Hopkinson pressure bar显示文摘 | Davies E D Hunter S C | 1963 | Journal of the Mechanics and Physics of Solids1963，，11： | 1 |
| 14 | Determining the most profitable target value for a production process 显示文摘 | Hunter W G Kartha C P | 1977 | Journal of Quality Technology1977，9，4： | 1 |
| 15 | Dabco-metalloporphyrin binding: ternary complexes, host-guest chemistry and the mea- surement of 'rr-lr interactions显示文摘 | Hunter C A Meah M N Sanders J K M | 1990 | Journal of the American Chem- ical Society1990，112，15： | 1 |
| 16 | Rcsistancetoammonias monndon fabricius juvenile fed diets supplemented astaxanthin显示文摘 | Pan C H Chien Y H Hunter B T | 2003 | J Exp Marine Biol Ecol2003，297，35： | 1 |
| 17 | Cloning and nucleotide sequencing of the Clostridium perfringens epsilon-toxin gene and its expression in Escherichia coli 显示文摘 | HUNTER S E CLARKE I N KELLY D C | 1992 | Infect Immun1992，60，： | 1 |
| 18 | 显示文摘 | Duff M C Hunter D B Burger A | 2008 | Appl Surf Sci2008，254，9： | 1 |
| 19 | Preparation of a new crystal form of manganese dioxide: λ- MnO2显示文摘 | Hunter J C | 1981 | J Solid State Chem1981，39，2： | 1 |
| 20 | In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes显示文摘 | Janice A Niklas J Patrick O' Neill Timothy C Hunter | 1991 | Mutat Res1991，250，： | 1 |
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