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| 1 | The PI3K/AKT Pathway and Renal Cell Carcinoma显示文摘The phosphatidylinositol 3 kinase(PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway,and thus is frequently activated as a cancer driver.More importantly,the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades,providing many potential targets for cancer therapy.Renal cell carcinoma(RCC) is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies.The PI3K/AKT pathway is modestly mutated but highly activated in RCC,representing a promising drug target.Indeed,PI3 K pathway inhibitors of the rapalog family are approved for use in RCC.Recent large-scale integrated analyses of a large number of patients have provided a molecular basis for RCC,reiterating the critical role of the PI3K/AKT pathway in this cancer.In this review,we summarize the genetic alterations of the PI3K/AKT pathway in RCC as indicated in the latest large-scale genome sequencing data,as well as treatments for RCC that target the aberrant activated PI3K/AKT pathway. | Huifang Guo Peter German Shanshan Bai Sean Barnes Wei Guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonasch Gordon B.Mills Zhiyong Ding | 2015 | Journal of Genetics and Genomics2015，42，7： | 39 |
| 2 | Stability Limitation and Analytical Evaluation of Voltage Droop Controllers for VSC MTDC显示文摘This paper presents a systematic analysis of DC voltage stability of a multi-terminal VSC-HVDC(MTDC)system,with the emphasis on a comparative study of the most ubiquitous droop control configurations.The paper introduces a general framework for the analysis of various droop control configurations employed in MTDC systems.This framework is then used to compare leading droop control configurations in terms of their impact on the relative stability,performance and robustness of the overall MTDC system.A generalized analytical MTDC model that contains detailed models of AC and DC system components is derived.Limitations imposed by DC power flow,DC inductor,cable modeling and AC network impedance on DC system stability are identified.Classical and multivariable frequency response analysis and eigenvalue analysis are applied to open-loop and closed-loop models to compare the stability and robustness of five leading droop controllers,with the focus on feedback signal selection and controller parameterization.This paper also proposes an active stabilizing controller,which takes the form of a modified constant power control,to enhance the controllability and robustness of the DC voltage control. | Wenyuan Wang Mike Barnes Ognjen Marjanovic | 2018 | CSEE Journal of Power and Energy Systems2018，4，2： | 34 |
| 3 | An Overview of MODIS Radiometric Calibration and Characterization显示文摘中等分辨率成像分光辐射函数(MODIS ) 是为 NASA 观察系统(曙光女神) 的地球的关键仪器之一,当前操作地和 Aquasatellites。MODIS 是在传感器的以前的产生上的主要进展以它的光谱,空间,并且时间分辨率。它有 36 光谱带:有从 0.41 ~ 2.1 μ m 的中心波长的 20 个反射太阳的乐队(RSB ) 和有从 3.7 ~ 14.4 μ m 的中心波长的 16 个热放射性的乐队(TEB ) ,在三空间分辨率做观察:250 m (bands1-2 ) , 500 m (乐队 3-7 ) ,和 1km (乐队 8-36 ) 。MODIS 们是有宽 field-of-view 的跨轨道的扫描辐射计,提供在不到 2 天内的地球的一篇完全的全球报道。BothTerra 和水 MODIS 通过了广泛预先发射在各种各样的层次的刻度和描述。在轨道,刻度和描述任务用它 on-boardcalibrators (OBC ) 被执行包括一太阳更弥漫(SD ) 并且一个太阳的更弥漫的稳定性监视器(SDSM ) ,投出 v 的扁平的面板黑人身体(BB ) ,和一个 spectro 公制辐射仪的刻度集会(SRCA ) 。Inthis 纸,我们在场 MODIS 刻度的概述和描述活动,方法论,和课学习了从预先发射描述和在里面轨道操作。在这篇论文讨论的 Keyissues 包括监视察觉者的噪音特征的在里面轨道努力,追踪太阳更弥漫并且光学降级,并且更新 sensor'sresponse 对扫描角度。通过 MODIS 学习的经验和课玩了并且将继续在未来传感器的设计和描述起主要作用。 | Xiaoxiong XIONG William BARNES | 2006 | Advances in Atmospheric Sciences2006，23，1： | 29 |
| 4 | 上皮-肌上皮癌显示文摘 | Seethala R R Barnes E L Hunt J L 刘飞飞(摘译) 张仁亚(审校) | 2007 | 临床与实验病理学杂志2007，23，1： | 23 |
| 5 | 慢性阻塞性肺疾病的治疗前景显示文摘 | Peter J Barnes | 2006 | 中华医学杂志2006，86，41： | 17 |
| 6 | A survey of the state-of-the-art in patch-based synthesis显示文摘This paper surveys the state-of-the-art of research in patch-based synthesis. Patch-based methods synthesize output images by copying small regions from exemplar imagery. This line of research originated from an area called 'texture synthesis', which focused on creating regular or semi-regular textures from small exemplars. However, more recently, much research has focused on synthesis of larger and more diverse imagery, such as photos, photo collections, videos, and light fields. Additionally, recent research has focused on customizing the synthesis process for particular problem domains, such as synthesizing artistic or decorative brushes, synthesis of rich materials, and synthesis for 3D fabrication. This report investigates recent papers that follow these themes, with a particular emphasis on papers published since 2009,when the last survey in this area was published. This survey can serve as a tutorial for readers who are not yet familiar with these topics, as well as provide comparisons between these papers, and highlight some open problems in this area. | Connelly Barnes Fang-Lue Zhang | 2017 | Computational Visual Media2017，3，1： | 12 |
| 7 | 三维超高场7T高分辨磁敏感加权像静脉造影(英文)显示文摘目的超高场磁共振具有高信噪比和独特的磁敏感对比,使其在无创性脑血管造影尤其是对小静脉的检测有明显优势。本文探讨如何在超高场磁共振7T优化和获取高质量的磁敏感加权像(SWI)静脉造影。方法选择10例正常志愿者作为研究对象,采集一系列7TSWI静脉造影数据并与3T结果作对比。选择参数TR=30~45ms,TE=13~26ms,带宽(BW)=80~140Hz/pixel,翻转角(FA)=10~25?;所有的数据用同样的图像后处理方式得到最小信号叠加投影(mIP)的SWI静脉造影像,并进行定量化分析。结果图像优化后,我们得到高分辨率的7T静脉造影图像。根据静脉血的T2*选择优化TE:16ms(7T),28ms(3T);FA:15?(3T和7T)。相对于3T,7TSWI图像有较高的信噪比和静脉与周围组织的对比度,并显示出更多的微小静脉。结论超高场SWI静脉造影对于显示微小静脉具有明显的优势。 | Yulin Ge Samuel Barnes Samantha Heller Daniel K.Sodickson Lin Tang E.Mark Haacke Jianping Dai Robert I.Grossman | 2010 | 磁共振成像2010，1，2： | 8 |
| 8 | Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer显示文摘AIM To study tumor response, and tolerability of arterially directed embolic therapy(ADET) with polyethylene glycol embolics loaded with irinotecan for the treatment of colorectal cancer liver metastases(CRC-LM). Secondary objectives were to monitor quality of life, time to progression and survival of patients.METHODS Patients were included in the study if they were affected by CRC-LM, refractory to systemic chemotherapy, treated with ADET using polyethylene glycol embolics, and had liver involvement < 50%. Tumor response, performance status(PS), tumor marker antigens, and quality of life(QoL) were monitored at 1, 3 and 6 mo after ADET. QoL was assessed with the Palliative Performance Scale(PPS).RESULTS We treated 50 consecutive CRC-LM patients with ADET using polyethylene glycol embolics. Their tumor response one month after ADET was: 28% of complete response(CR), 48% of partial response(PR), 8% stable disease(SD), and 16% of progression. Tumor response 3 mo after ADET was CR 24%, PR 38%, SD 19% and progression disease(PD) 19%. Tumor response 6 mo after ADET was CR 18%, PR 44%, SD 21% and PD 18%. QoL was 90% PPS at each time point. Median time to progression for patients who progressed was 2.5 mo(range 0.8-6). Median follow-up was 14 mo(0.8-25 range). ADETs were performed with no complications. Observed side effects(mild or moderate intensity) were: Pain in 32% of patients, increase of transaminase levels in 20% and fever in 14%, whereas 30% of patients did not complain any adverse event. CONCLUSION The treatment of unresectable CRC-LM with ADET using polyethylene glycol microspheres loaded with irinotecan was effective in tumor response and resulted in mild toxicity, and good QoL. | Giammaria Fiorentini Riccardo Carandina Donatella Sarti Michele Nardella Odysseas Zoras Stefano Guadagni Riccardo Inchingolo Massimiliano Nestola Alessandro Felicioli Daniel Barnes Navarro Fernando Munoz Gomez Camillo Aliberti | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 6 |
| 9 | 大运河常州段水质变化及其影响因素显示文摘根据目前已建立的基本水质数据库,对大运河常州段的水质现状和趋势作了分析。利用质量平衡,建立了污染物量和水质之间的直观关系,发现了繁忙的机动船只运输对运河产生油污染的同时,会对水体中溶解氧产生有益的贡献。 | 柳洪 David Barnes Rob(rooks) | 1994 | 上海环境科学1994，13，8： | 4 |
| 10 | 加拿大基层医疗改革的创新型及多元化策略显示文摘基层医疗卫生服务体系在世界各国的医疗卫生服务系统中均发挥着重要作用。在过去十年中,加拿大省及地方卫生系统运用了多种方法改善基层医疗卫生服务,改革方案涵盖了目标医疗组织架构、医疗服务者薪酬、医疗服务者数量、医疗服务质量及安全性等方面,改革成果大大提升了家庭医学这个专业实践领域的吸引力,家庭医学吸引了越来越多的医学应届毕业生。这对我国健全基层医疗卫生服务体系具有重要借鉴意义。为此,本刊特别翻译和报道了加拿大基层医疗改革的创新型及多元化策略,敬请关注! | Erin Strumpf Jean-Frédéric Levesque Natalie Coyle Brian Hutchison Marsha Barnes Robert J.Wedel 魏亚萌 | 2015 | 中国全科医学2015，18，31： | 4 |
| 11 | Soil and water conservation measures improve soil carbon sequestration and soil quality under cashews显示文摘Land degradation is becoming a serious problem in the west coast region of India where one of the world's eight biodiversity hotspots,the‘Western Ghats’,is present.Poor land management practices and high rainfall have led to increasing problems associated with land degradation.A long-term(13-year)experiment was done to evaluate the impact of soil and water conservation measures on soil carbon sequestration and soil quality at three different depths under cashew nut cultivation on a 19%slope.Five soil and water conservation measures-continuous contour trenches,staggered contour trenches,halfmoon terraces,semi-elliptical trenches,and graded trenches all with vegetative barriers of Stylosanthes scabra and Vetiveria zizanoides and control were evaluated for their influence on soil properties,carbon sequestration,and soil quality under cashews.The soil and water conservation measures improved significantly the soil organic carbon,soil organic carbon stock,carbon sequestration rate and microbial activity compared to the control condition(without any measures).Among the measures tested,continuous contour trenches with vegetative barriers outperformed the others with respect to soil organic carbon stock,sequestration rate,and microbial activity.The lower metabolic quotient with the measures compared to the control indicated alleviation of environmental stress on microbes.Using principal component analysis and a correlation matrix,a minimum dataset was identified as the soil available nitrogen,bulk density,basal soil respiration,soil pH,acid phosphatase activity,and soil available boron and these were the most important soil properties controlling the soil quality.Four soil quality indices using two summation methods(additive and weighted)and two scoring methods(linear and non-linear)were developed using the minimum dataset.A linear weighted soil quality index was able to statistically differentiate the effect of soil and water conservation measures from that of the control.The highest value of the soil quality index of 0.98 was achieved with continuous contour trenches with a vegetative barrier.The results of the study indicate that soil and water conservation measures for cashews are a potential strategy to improve the soil carbon sequestration and soil quality along with improving crop productivity and reducing the erosion losses. | Gopal Ramdas Mahajan Bappa Das Sandrasekaran Manivannan Begur Lakshminarasimha Manjunath Ram Ratan Verma Sujeet Desai Rahul Mukund Kulkarni Ashish Marotrao Latare Reshma Sale Dayesh Murgaonkar Kiran Puna Patel Shaiesh Morajkar Ashwini Desai Natasha Barnes Heena Mulla | 2021 | International Journal of Sediment Research2021，36，2： | 4 |
| 12 | Hemodynamic improvement using methylene blue after calcium channel blocker overdose显示文摘Dear editor,Calcium channel blocker overdoses are often fatal despite standard treatment. Methylene blue is a novel adjunct that should be considered in refractory cases.Currently accepted therapeutic modalities include intravenous fluids, calcium, vasopressors and high-dose insulin euglycemic therapy, however shock may | Sophia Ahmed Stacey Barnes | 2019 | World Journal of Emergency Medicine2019，10，1： | 3 |
| 13 | Global distribution and prevalence of hepatitis C virus genotypes显示文摘 | Jane P. Messina Isla Humphreys Abraham Flaxman Anthony Brown Graham S. Cooke Oliver G. Pybus Eleanor Barnes | 2015 | Hepatology2015，，1： | 3 |
| 14 | Bedside placement of nasojejunal tubes: a randomised-controlled trial of spiral- vs straight-ended tubes显示文摘 | Clement W.Y Lai Rachel Barlow Mark Barnes A.Barney Hawthorne | 2003 | Clinical Nutrition2003，，3： | 3 |
| 15 | Form Finding and Analysis of Tension Structures by Dynamic Relaxation显示文摘 | Michael R. Barnes | 2009 | International Journal of Space Structures2009，，2： | 3 |
| 16 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 17 | Opportunities and limitations for image-based remote sensing in precision crop management显示文摘 | M.S. Moran Y. Inoue E.M. Barnes | 1997 | Remote Sensing of Environment1997，，3： | 3 |
| 18 | 轮胎未来发展趋势的研究显示文摘 | Jason Barnes 张学山 | 2003 | 轮胎工业2003，23，12： | 3 |
| 19 | Immnohistochemical detection of p53 protein in mammry carcinoma:an important new independent indicator of prognosis显示文摘 | Barnes DM Dublin EA Fisher CJ | 1993 | Hum Pathol1993，24，： | 2 |
| 20 | Her-2/neuoncogene protein and prognosis in gastricadenocarcinoma 显示文摘 | Masood S Barker E A Barnes E | 1991 | Mod Pathol1991，4，： | 2 |
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