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| 1 | Gastrointestinal complications of diabetes mellitus显示文摘Diabetes mellitus affects virtually every organ system in the body and the degree of organ involvement depends on the duration and severity of the disease,and other co-morbidities.Gastrointestinal(GI) involvement can present with esophageal dysmotility,gastro-esophageal reflux disease(GERD),gastroparesis,enteropathy,non alcoholic fatty liver disease(NAFLD) and glycogenic hepatopathy.Severity of GERD is inversely related to glycemic control and management is with prokinetics and proton pump inhibitors.Diabetic gastroparesis manifests as early satiety,bloating,vomiting,abdominal pain and erratic glycemic control.Gastric emptying scintigraphy is considered the gold standard test for diagnosis.Management includes dietary modifications,maintaining euglycemia,prokinetics,endoscopic and surgical treatments.Diabetic enteropathy is also common and management involves glycemic control and symptomatic measures.NAFLD is considered a hepatic manifestation of metabolic syndrome and treatment ismainly lifestyle measures,with diabetes and dyslipidemia management when coexistent.Glycogenic hepatopathy is a manifestation of poorly controlled type 1 diabetes and is managed by prompt insulin treatment.Though GI complications of diabetes are relatively common,awareness about its manifestations and treatment options are low among physicians.Optimal management of GI complications is important for appropriate metabolic control of diabetes and improvement in quality of life of the patient.This review is an update on the GI complications of diabetes,their pathophysiology,diagnostic evaluation and management. | Babu Krishnan Shithu Babu Jessica Walker Adrian B Walker Joseph M Pappachan | 2013 | World Journal of Diabetes2013，4，3： | 10 |
| 2 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats显示文摘Objective:To evaluate the hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatic damage in rats.Methods:The plant material was shade dried, powdered and extracted with ethanol.Liv 52 and silymarin were used as standard drugs and 2%gum acacia as a control(vehicle).Alteration in the levels of biochemical markers of hepatic damage like AST,ALT,ALP and lipid peroxides were tested,and phytochemical tests were also performed.Results:Paracetamol(2 g/kg) increased the serum levels of alanine aminotransfer (ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP) and the lipid peroxides. Treatment of Liv 52,silymarin and ethanolic extract of Terminalia paniculata(200 mg/kg) altered levels of biochemical marker and showed significant hepatoprotective activity.Ethanolic extract revealed the presence of phenolic compound and flavanoids.Our findings suggested that ethanolic bark extract of Terminalia paniculata possessed hepatoprotective activity in a dose dependent manner.Conclusions:Terminalia paniculata possesses hepatoprotective activity.It could be an effective and promising preventive agent against PCT induced hepatotoxicity. | Eesha BR Mohanbabu Amberkar V Meena Kumari K Sarath babu Vijay M Lalit M Rajput R | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 5 |
| 4 | Production and structural characterization of crystalline silver nanoparticles from Bacillus cereus isolate显示文摘 | Babu M M G Gunasekaran P | 2009 | Colloids and Surfaces B: Biointerfaces2009，74，1： | 1 |
| 5 | A crit- ical study of selected classification algorithms for Liver Disease Diagnosis 显示文摘 | Bendi V R Pmsad Babu M S Venkateswarlu N B | 2011 | International Journal of Database Management Systems(UDMS)2011，3，2： | 1 |
| 6 | Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation显示文摘 | Bhardwaj S Roy H Babu M | 2011 | Atherosclerosis2011，219，1： | 1 |
| 7 | Flavonoids from the leaves of Buchanania lanzan (Anacardiaceae) 显示文摘 | Arya R Babu V Ilyas M | 1988 | Journal of the Indian Chemical Society1988，65，12： | 1 |
| 8 | Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation显示文摘 | Seibenhener M L Babu J R Geetha T Wong H C Krishna N R Wooten M W | | 0，，18： | 1 |
| 9 | Integrating marker-assis- ted selection in crop breeding-prospects and challenges 显示文摘 | Babu R Nair S K Prasanna B M | 2004 | Cur- int Sci2004，87，： | 1 |
| 10 | Liquid-liquid extraction of brornelain and polyphenol oxidase using aqueous two-phase system显示文摘 | RAV1NDRA BABU B RASTOGI N K RAGHAVARAO K S M S | 2008 | Chemical Engineering and Processing2008，47，1： | 1 |
| 11 | Sarcolipin and phospholamban as regulators of cardiac sarcoplasmic reticulum Ca^2+ ATPase显示文摘 | Bhupathy P Babu GJ Periasamy M | 2007 | J Mol Cell Cardiol2007，42，5： | 1 |
| 12 | Surgical treatment of jugular foramen schwannomas显示文摘 | SAMII M BABU R P TATAGIBA M | 1995 | J Neurosurg1995，82，： | 1 |
| 13 | Identification and molec- ular characterization of two naturally occurring soybean mosaic vi- rus isolates that are closely related but differ in their ability to o- vercome Rsv4 resistance显示文摘 | Gagarinova A G Babu M Poysa V | 2008 | Virus Research2008，138，12： | 1 |
| 14 | Peri-procedural myocardial injury during percutaneous coronary intervention: an important target for cardio- protection显示文摘 | BABU G G WALKER J M YELLON D M | 2011 | Eur HeartJ2011，32，： | 1 |
| 15 | Isolation, purification and characterization of eollagenase from hepatopancreas of the land snail Achatina fulica 显示文摘 | INDRA D RAMALINGAM K BABU M | 2005 | Comp Biochem Physiol B Biochem Mol Biol2005，142，1： | 1 |
| 16 | Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats显示文摘 | Punithavathi D Venkatesan N Babu M | 2000 | Br J Pharmacol2000，131，2： | 1 |
| 17 | Conformations of gas-phase lysozyme ions produced from two different solution conformations显示文摘 | Mao D M Babu K R Chen Y L | 2003 | Anal Chem2003，75，6： | 1 |
| 18 | An Efficient and Cost-effective Synthesis of 3-ethoxy-4-ethoxycarbonyl-phenylacetic Acid:A Key Acid Synthon of Repaglinide 显示文摘 | SALMAN M BABU S | 2002 | Organic Process Research & Development2002，6，： | 1 |
| 19 | Surgical tretment of jugular foramen schwannomas 显示文摘 | Babu RP Tatagiba M | 1995 | J Neurosurg1995，82，： | 1 |
| 20 | Regulation of sarcoplasmic reticulum Ca2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathology显示文摘 | Periasamy M Bhupathy P Babu GJ | 2008 | Cardiovasc Res2008，77，2： | 1 |
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