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| 1 | MicroRNA in rectal cancer显示文摘In rectal cancer,one of the most common cancers worldwide,the proper staging of the disease determines the subsequent therapy.For those with locally advancedrectal cancer,a neoadjuvant chemoradiotherapy(CRT) is recommended before any surgery.However,response to CRT ranges from complete response(responders) to complete resistance(non-responders).To date we are not able to separate in advance the first group from the second,due to the absence of a valid biomarker.Therefore all patients receive the same therapy regardless of whether they reap benefits.On the other hand almost all patients receive a surgical resection after the CRT,although a watch-and-wait procedure or an endoscopic resection might be sufficient for those who responded well to the CRT.Being highly conserved regulators of gene expression,micro RNAs(mi RNAs) seem to be promising candidates for biomarkers.Many studies have been analyzing the mi RNAs expressed in rectal cancer tissue to determine a specific mi RNA profile for the ailment.Unfortunately,there is only a small overlap of identified mi RNAs between different studies,posing the question as to whether different methods or differences in tissue storage may contribute to that fact or if the results simply are not reproducible,due to unknown factors with undetected influences on mi RNA expression.Other studies sought to find mi RNAs which correlate to clinical parameters(tumor grade,nodal stage,metastasis,survival) and therapy response.Although several mi RNAs seem to have an impact on the response to CRT or might predict nodal stage,there is still only little overlap between different studies.We here aimed to summarize the current literature on rectal cancer and mi RNA expression with respect to the different relevant clinical parameters. | azadeh azizian jens gruber b michael ghadimi jochen gaedcke | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 3 |
| 2 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021，5，4： | 3 |
| 3 | A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations显示文摘 | Sreenath V. Sharma Diana Y. Lee Bihua Li Margaret P. Quinlan Fumiyuki Takahashi Shyamala Maheswaran Ultan McDermott Nancy Azizian Lee Zou Michael A. Fischbach Kwok-Kin Wong Kathleyn Brandstetter Ben Wittner Sridhar Ramaswamy Marie Classon Jeff Settleman | 2010 | Cell2010，，1： | 2 |
| 4 | Clean synthesis of novel spiro[indene-2,2'-[1,3,5]-oxathiazine]-1,3-diones in water显示文摘In this work,we have designed an efficient and convenient method for the synthesis of novel spiro[indene-2,2'-[1,3,5]oxathiazine]-1,3-diones by the one-pot,three component condensation of tetramethyl guanidine,ninhydrin,and isothiocyanates in water.Easy purification,green reaction conditions,easy performance and good yields are some advantages of this procedure. | Mahboobeh Salehpour Javad Azizian Hassan Kefayati | 2017 | Chinese Chemical Letters2017，28，5： | 1 |
| 5 | Kinetic models of sorption A theoretical analysis 显示文摘 | Azizian S | 2004 | J Colloid Iriterf Sci2004，276，1： | 1 |
| 6 | Analysis of Temperature Distribution in Cast-Resin Dry-Type Transformers显示文摘 | Rahimpour E Azizian D | 2007 | Electrical En- gineering2007，89，4： | 1 |
| 7 | A rapid method for the quantification of fatty acids in fats and oils with emphasis on trans fatty acids using fourier transform near infrared spectroscopy (FT-NIR) 显示文摘 | AZIZIAN H KRAMER J K G | 2005 | Lipids2005，40，8： | 1 |
| 8 | On the parameter extraction of a five-parameter double-diode model of photovoltaic cells and modules显示文摘 | Hejri M Mokhtari H Azizian M R | 2014 | IEEE Journal of Photovoltaics2014，，4： | 1 |
| 9 | Adsorption of methyl violet onto granular activated carbon: equilibrium, kinetics and modeling 显示文摘 | AZIZIAN S HAERIFAR M BASHIRI H | | Chem Eng J0，146，1： | 1 |
| 10 | Optimization of dispersed carbon nanoparticles synthesis for rapid desulfurization of liquid fuel显示文摘Stringent regulations and environmental concerns make the production of clean fuels with low sulfur content compulsory for the petroleum refining industry.Because of ease of operation without high energy consumption,the adsorption of sulfur compounds seems the most promising process.Central composite design was used to optimize parameters influencing the synthesis of dispersed carbon nanoparticles(CNPs),a new class of sorbents,in order to obtain an excellent adsorbent for desulfurization of liquid fuel.The optimized dispersed CNPs,which are immiscible in liquid fuel,can effectively adsorb different benzothiophenic compounds.Equilibrium adsorption was achieved within 2 min for benzothiophene,dibenzothiophene,and 4,6-dimethyldibenzothiophene with removal efficiency values of 75 %,83 %,and 52 %,respectively.The rate of desulfurization by the prepared CNPs in the present work is seven times higher than the previously reported CNPs.Optimized CNPs were characterized by different techniques.Finally,the effect of the mass of CNPs on the removal efficiency was studied as well. | Effat Kianpour Saeid Azizian | 2016 | Petroleum Science2016，13，1： | 1 |
| 11 | Kinetic models of sorption:a theoretical analysis 显示文摘 | Azizian S | 2004 | Journal of Colloid and Interface Science2004，276，1： | 1 |
| 12 | Environmental impact of highway construction and repair materials on surface and ground waters 显示文摘 | AZIZIAN M F NELSON P O THAYUMANAVAN P | 2003 | Waste Management2003，23，： | 1 |
| 13 | LV dyssynchrony assessed with phase analysison gated myocardialperfusion spect can predict response to crt in patients with end-stage heart failure显示文摘 | Azizian N Rastgou F Ghaedian T | 2014 | Res Cardiovasc Med2014，3，4： | 1 |
| 14 | Kinetic models of sorption: A theoretical analysis 显示文摘 | Azizian S | 2004 | Journal of Colloid and Interface Science2004，276，： | 1 |
| 15 | Hydrolyses of sucrose by heterogeneous catalysts显示文摘 | ILOUKHANI H AZIZIAN S SAMADANI N | 2001 | Reaction Kinetics and Catalysis Letters2001，72，2： | 1 |
| 16 | Monitoring abundance and expression of 'Dehalococcoides' species chloroethene-reductive dehalogenases in a tetrachloroethene-dechlorinating flow column显示文摘 | Behrens S Azizian M F McMurdie P J | 2008 | Appl Environ Microbiol2008，74，18： | 1 |
| 17 | Selective desulfurization of model diesel fuel by carbon nanoparticles as adsorbent显示文摘 | Naviri Fallah R Azizian S Reggers G | 2012 | Industrial & Engineering Chemistry Research2012，51，14： | 1 |
| 18 | A Facile One - Pot Synthesis of New Spiro Pyrrolidine - Oxindoles Under Ultrasonic Irradiation in DMSO- H2O 显示文摘 | Azizian J Saffar - Teluri A Asadi A | 2006 | Lett Org Chem2006，3，： | 1 |
| 19 | Journal of Colloid and Interface Science 显示文摘 | Azizian S | 2004 | 276(1): 47-522004，276，1： | 1 |
| 20 | Gender effects on mood and cigarette craving during early abstinence and resumption of smoking 显示文摘 | Xu J Azizian A Monterosso J | 2008 | Nicotine Tob Res2008，10，11： | 1 |
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