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| 1 | Cancer chemoprevention by phytochemicals:potential molecular targets,biomarkers and animal models显示文摘最近的研究强烈显示了某些消费日报的 dietaryphytochemicals 能有癌症对转基因的老鼠癌症模型和癌症的保护的效果由代谢物从外长或内长的来源导出的致癌物,照耀和 carcinogenic 调停了。这些饮食的混合物得到的癌症保护的效果被相信对包括除去和抗氧化剂酶的细胞的防卫系统的正式就职部分地至少到期系统,以及抑制反煽动性并且反房间生长发信号小径在房间周期拘捕或 cell-death.In 达到顶点这评论,我们包括原子因素 kappaB ( NF-kappaB )的调整总结潜在的机制, cyclooxygenases-2 ( COX-2 ),使活跃之物 protein-1 ( AP-1 ), 激活mitogen 的蛋白质家族 ases ( MAPK )和阶段 II 的正式就职细胞的除去和抗氧化剂酶主要由抗氧化剂反应元素调停了()在通过 nuclearfactor-erythroid 2-related 因素 2 的这些基因( Nrf2 )的倡导者区域以内,帽子 n 领子(计算机数值控制)的一个成员basicregion白氨酸拉链抄写因素的家庭。另外,我们也用 dietarychemopreventive 混合物考察几动物模型 ofcarcinogenesis 和这些动物模型的癌症 chemopreventive 功效研究。最后,我们讨论调停的 byNrf2, NF-kappa B, AP-1, MAPKS 和 COX-2,它被认为在肿瘤开始,提升和前进起枢轴的作用处理的细胞的发信号串联,并且能为指向癌症预防和治疗的药的设计正在答应分子的目标。 | Ki Han KWON Avantika BARVE Siwang Yu Mou-Tuan HUANG Ah-Ng Tony KONG | 2007 | Acta Pharmacologica Sinica2007，28，9： | 5 |
| 2 | Regulation of Nrf2- and AP-l-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells显示文摘 | Sujit NAIR Avantika BARVE Tin-Oo KHOR Guo-xiang SHEN Wen LIN Jefferson Y CHAN Li CAI Ah-Ng KONG | 2010 | Acta Pharmacologica Sinica2010，31，9： | 5 |
| 3 | Thyroid function and mortality in older men:a prospective study显示文摘 | Avantika CW Stephanie H Samuels MH | 2012 | J Clin Endocrinol Metabol2012，7，3： | 1 |
| 4 | Thyroid function and prevalent and incident metabolic syndrome in older adults: the health, ageing and body composition study显示文摘 | Avantika C.Waring NicolasRodondi StephanieHarrison Alka M.Kanaya Eleanor M.Simonsick IvaMiljkovic SuzanneSatterfield Anne B.Newman Douglas C.Bauer | 2012 | Clinical Endocrinology2012，，6： | 1 |
| 5 | Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (?/?) mice显示文摘 | Rong Hu Changjiang Xu Guoxiang Shen Mohit R. Jain Tin Oo Khor Avantika Gopalkrishnan Wen Lin Bandaru Reddy Jefferson Y. Chan Ah-Ng Tony Kong | 2006 | Cancer Letters2006，，2： | 1 |
| 6 | Facilitating Trade in Organic Food Products: The Case of India and ASEAN显示文摘 | Arpita Mukherjee Avantika Kapoor | 2018 | Journal of Agricultural Science and Technology(B)2018，8，4： | 0 |
| 7 | Nrf2-mediated antioxidant and detoxifying enzyme induction by a combination of curcumin and sulforaphaneNrf2-mediated antioxidant and detoxifying enzyme induction by a combination of curcumin and sulforaphane显示文摘The dietary phytochemicals curcumin(CUR) and sulforaphane(SFN) have shown remarkable cancer chemopreventive effects in many model systems. This study was designed to investigate the induction of Nrf2-mediated antioxidant enzymes by combining doses of CUR and SFN and the effect of their combination on the Nrf2-ARE(antioxidant response element) response in Hep G2-C8 cells. We hypothesized that the combination of the polyphenol CUR and the isothiocyanate SFN could enhance the induction of AREs and Nrf2-target enzymes. Hep G2-C8 cells were treated with a combination of low doses of CUR, SFN or both. The induction of Nrf2-mediated antioxidant and phase II detoxifying enzymes–heme oxygenase-1(HO-1) and UDP-glucuronosyltransferase-1A(UGT1A)–was measured by real-time RT-PCR and western blotting. ARE-luciferase activity was also quantified. Low doses of CUR(10 μM) and SFN(12.5 μM) significantly induced the expression of HO-1 and UGT1A1 proteins. Through the use of chemical inhibitors of mR NA and protein synthesis, the combination of CUR and SFN was shown to affect the transcriptional regulation of both HO-1 and UGT1A1. Additionally, the combination of CUR and SFN synergistically induced the expression of Nrf2- and ARE-luciferase activity in Hep G2-C8 cells. Thus, CUR and SFN at low concentrations augment therapeutic effects in Hep G2-C8 cells. The enhanced ARE-luciferase activity of combined CUR and SFN treatment could partly explain the significant induction of the Nrf2-target enzymes HO-1 and UGT1A1. Taken together, our results suggest that combining low doses of CUR and SNF could be a promising strategy for cancer chemoprevention in humans. | Francisco Fuentes Yury Gomez Ximena Paredes-Gonzalez Avantika Barve Sujit Nair Siwang Yu Constance Lay Lay Saw Ah-Ng Tony Kong | 2016 | Journal of Chinese Pharmaceutical Sciences2016，25，8： | 0 |
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