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| 1 | Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update显示文摘Gallbladder cancer is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developing countries. Late diagnosis and deprived prognosis are major problems for treatment of gallbladder carcinoma. The dramatic associations of this orphan cancer with various genetic and environmental factors are responsible for its poorly defined pathogenesis. An understanding to the relationship between epidemiology, molecular genetics and pathogenesis of gallbladder cancer can add new insights to its undetermined pathophysiology. Present review article provides a recent update regarding epidemiology, pathogenesis, and molecular genetics of gallbladder cancer. We systematically reviewed published literature on gallbladder cancer from online search engine Pub Med(http://gffzz16a62c593b5540ceh0uokf95xcwc96pu9.ffgz.tsg.suse.edu.cn/pubmed). Various keywords used for retrieval of articles were Gallbladder, cancer Epidemiology, molecular genetics and bullion operators like AND, OR, NOT. Cross references were manually searched from various online search engines(http://gffzz16a62c593b5540ceh0uokf95xcwc96pu9.ffgz.tsg.suse.edu.cn/pubmed,http://gffzz141dfffa132442b5s0uokf95xcwc96pu9.ffgz.tsg.suse.edu.cn/, http://gffzz4cb95a154d71438ch0uokf95xcwc96pu9.ffgz.tsg.suse.edu.cn/home.jsp). Most of the articles published from 1982 to 2015 in peer reviewed journals have been included in this review. | Aarti Sharma Kiran Lata Sharma Annapurna Gupta Alka Yadav Ashok Kumar | 2017 | World Journal of Gastroenterology2017，23，22： | 68 |
| 2 | Lapatinib plus capecitabine in treating HER2-positive advanced breast cancer:efficacy,safety,and biomarker results from Chinese patients显示文摘Overexpression of human epidermal growth factor receptor-2(HER2) in metastatic breast cancer(MBC) is associated with poor prognosis.This single-arm open-label trial(EGF109491;NCT00508274) was designed to confirm the efficacy and safety of lapatinib in combination with capecitabine in 52 heavily pretreated Chinese patients with HER2-positive MBC.The primary endpoint was clinical benefit rate(CBR).Secondary endpoints included progression-free survival(PFS),time to response(TTR),duration of response(DoR),central nervous system(CNS) as first site of relapse,and safety.The results showed that there were 23 patients with partial responses and 7 patients with stable disease,resulting in a CBR of 57.7%.The median PFS was 6.34 months(95% confidence interval,4.93-9.82 months).The median TTR and DoR were 4.07 months(range,0.03-14.78 months) and 6.93 months(range,1.45-9.72 months),respectively.Thirteen(25.0%) patients had new lesions as disease progression.Among them,2(3.8%) patients had CNS disease reported as the first relapse.The most common toxicities were palmar-plantar erythrodysesthesia(59.6%),diarrhea(48.1%),rash(48.1%),hyperbilirubinemia(34.6%),and fatigue(30.8%).Exploratory analyses of oncogenic mutations of PIK3CA suggested that of 38 patients providing a tumor sample,baseline PIK3CA mutation status was not associated with CBR(P = 0.639) or PFS(P = 0.989).These data confirm that the lapatinib plus capecitabine combination is an effective and well-tolerated treatment option for Chinese women with heavily pretreated MBC,irrespective of PIK3CA status. | Bing-He Xu Ze-Fei Jiang Daniel Chua Zhi-Min Shao Rong-Cheng Luo Xiao-Jia Wang Dong-Geng Liu Winnie Yeo Shi-Ying Yu Beth Newstat Alka Preston Anne-Marie Martin Hai-Dong Chi Li wang | 2011 | Chinese Journal of Cancer2011，30，5： | 17 |
| 3 | Co-gasification of coal and biomass an emerging clean energy technology: Status and prospects of development in Indian context显示文摘Co-gasification of coal and biomass is emerging as potential clean fuel technology to achieve high thermodynamic efficiency with relatively low CO2 emission. The coal and biomass have been exclusively gasified more than a century to obtain gas–liquid fuels and the production of chemicals. Co-gasification has higher efficiency than the solitary coal gasification because the cellulose, hemicellulose and lignin content of biomass help to ignite and enhance the rate of gasification. It is suggested that the extensive research on carbon reactivity pattern, heat release, reaction kinetics, etc. may support to reduce the uncertainties in the co-gasification performance of coal and biomass blends, particularly in India. The prospects of co-gasification technology in Indian context have been discussed considering the abundance of varieties of coal and biomass. The suitability of existing gasifier procedures and their limitations with operating parameters like temperature, residence time, density optimisation, feed rate, agglomeration intensity, the tar formation and techno-economics involved are described. Also, this paper reviews the research highlights of the history of co-gasification and the advancement in upcoming challenges like a design of gasifier, access and preparation of biomass, disposal of residue, environmental concerns and reassurance to the operators for execution of large and small-scale projects. | Alka D.Kamble Vinod Kumar Saxena Prakash Dhondiram Chavan Vinod Atmaram Mendhe | 2019 | International Journal of Mining Science and Technology2019，29，2： | 5 |
| 4 | 不同社会群体特征对内隐领导因素的影响显示文摘研究发现,中国人内隐领导理论的内容由个人品德、目标有效性、人际能力和多面性四个因素构成。不同的年龄、职业和教育水平等评分者的特点,对领导诸因素的评分有着显著的影响。综合分析发现,教育水平是影响内隐领导因素评分的主要变量。另外,各组都倾向于把人际能力作为领导最大的特质来加以评分。 | 凌文辁 方俐洛 高晶 Alka Kanna | 1992 | 心理学报1992，24，1： | 5 |
| 5 | Antitumor Activity of Diallyl Sulfide in Two-StageMouse Skin Model of Carcinogenesis显示文摘It has been reported that diallyl sulfide (DAS), a sulfur-containing volatile compound in garlic (Allium sativum ), exerts anticarcinogenic activity in various rodent tumor models. In the present study, the antitumor property of DAS was tested in Swiss albino mice in the two steqe initiation-promotion mouse skin carcinogenesis. Skin cancers were initiated topically with a single subcarcinOgenic dose (52μg) of 7, 12-dimethyl benz (a) anthracene (DMBA). Promotion was performed by twice weekly applications of 12-O-tetradecanoyl phorbol-13-acetate (TPA) at a dose of 5μg/animal for 32 weeks. DAS was applied topically (250μg/animal) thrice weekly for 3 weeks for anti-initiating and 1 h prior to each promotion treatment for anti-promoting studies. The results showed that the treatment schedule of DAS can effectively delay the onset of tumorigenesis and reduce the cumulative number of tumors and the average number of tumors per mouse. In groups in which DAS applied prior to initiation or promotion, a significant population of the aniinals remained tumor-free till the termination of experiment. These findings suggest that DAS can effectively inhibit chemically induced mouse skincarcinogenesis. | ALKA SINGH AND YOGESHWER SHUKLA(Laboratory of Environmental Chrcinogenesis, Industrial ToxicologyResearch Centre, P. O. Box 80, M. G. Marg,Lucknow-226 001, India) | 1998 | Biomedical and Environmental Sciences1998，11，3： | 5 |
| 6 | Anti-arthritis activity of roots of Hemidesmus indicus R.Br.(Anantmul)in rats显示文摘Objective:To investigate the protective effects of hydroalcoholic and its fractions from roots of Hemidesmus indicus on arthritis in in vitro models of rodents.Methods:Preliminary phytochemical analysis and thin-layer chromoatography were performed to analyze constituents of hydroalcoholic extract and its three fraction namely ethyl acetate fraction,chloroform fraction and residual fraction of mot of Hemidesmus indicus.Arthritis rats models were established by Complete Freund’s Adjuvant.The parameters including paw edema,body weight,arthritic index,erythrocyte sedimentation rate,serum rheumatoid factor,serum C-reactive protein,serum nitrite level,and histopathology of synovial joints were observed.Methotrexate was taken as positive control.Results:Rats treated with hydroalcoholic extract(450 mg/kg,p.o.),ethyl acetate (75 mg/kg,p.o.),chloroform(60 mg/kg,p.o) and residual fractions(270 mg/kg,p.o.),showed significant decrease in physical and biochemical parameters compared with arthritic model rats. Hydroalcoholic extract and its ethyl acetate fraction of Hemidesmus indicus showed significantly higher anti-arthritic activity than chloroform and residual fraction.Histopathological analysis demonstrated that both of hydroalcoholic extract and its ethyl acetate fraction had comparable anti-arthritic activity with methotrexates.Conclusions:The present study suggests that Hemidesmus indicus has protective activity against arthritis and the activity might be attributed to presence of terpenoid in hydroalcoholic extract,as well as in ethyl acetate fraction. | Alka Mehta Neeraj K Sethiya Chetan Mehta GB Shah | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 4 |
| 7 | Fabrication of three-dimensional graphene anode for augmenting performance in microbial fuel cells显示文摘In the present work,we have reported the synthesis of 3D graphene structures by simple chemical reduction method for application in microbial fuel cell(MFC)as an anode.The synthesis procedure includes synthesis of graphene oxide by modified Hummers method followed by simultaneous reduction of graphene oxide and the formation of hydrogels.The 3D graphene structures are characterized using X-ray diffraction and Raman spectroscopy techniques.Electrochemical characterization is carried out to study the capacitive properties and impedance studies of electrodes in conductive electrolyte.3D graphene electrodes show remarkably high capacitive current,charge storage and lower charge transfer resistance as estimated through cyclic voltammetry and Nyquist plots.In order to evaluate the performance of 3D graphene electrodes in MFC,power density and polarization curves are recorded in three configurations by varying terminal electron acceptors(TEA)viz.,dissolved oxygen(MFC-DO),potassium ferricyanide and MFC without TEA(MFC-NDO).3D graphene electrodes exhibits maximum power density of 0.49 mW/m^(2) in potassium ferricyanide followed by MFC-DO(0.36 mW/m^(2))and MFC-NDO(0.34 mW/m^(2)).Present work highlights the viability of chemically synthesized 3D graphene electrodes as an efficient anode material in MFC. | Alka Pareek J.Shanthi Sravan S.Venkata Mohan | 2019 | Carbon Resources Conversion2019，2，2： | 3 |
| 8 | Microbial Biomass Dynamics in a Tropical Agroecosystem: Influence of Herbicide and Soil Amendments显示文摘除草剂的影响独自并且在有有在土壤的动力学上对比资源质量的土壤修正案的联合,微生物引起的生物资源 C (MBC ) , N (MBN ) ,和 P (MBP ) 在热带 dryland agroecosystem 在 rice-wheat-summer 休闲庄稼顺序通过二个年度周期被学习。实验与有 N in the forms of 化肥,小麦稻草, Sesbania aculeata,和农场院子粪肥(FYM ) 的相等的数量的各种各样的土壤修正案独自或在联合包括了除草剂(butachlor ) 的申请。微生物引起的生物资源显示出的土壤在两个庄稼周期的不同时间的变化,减少了从对形成谷物的舞台植物,然后在庄稼成熟舞台增加了到最大值。土壤 MBC 在处理由在减少的独自一个的处理在成长大米的时期期间订的除草剂 + FYM,除草剂 + 小麦稻草,除草剂 + 化肥,和除草剂跟随了的除草剂 + Sesbania aculeata 是最高的。在成长小麦的时期和夏天休闲期间,而除草剂 + FYM,除草剂 + Sesbania,和除草剂 + 化肥治疗显示出类似的层次,土壤 MBC 为除草剂 + 小麦稻草治疗达到了最大值。除了土壤 MBN 在成长大米的时期期间在在除草剂 + 小麦稻草处理上的除草剂 + 化肥处理是更高的之外,土壤 MBN 的全面趋势类似于土壤 MBC 和 MBP 的那些。尽管有通过在有除草剂的联合的外长的土壤修正案的 N 的相等的数量的增加,玷污微生物引起的生物资源回答差别到处理。修正案的资源质量更多在动力学上读了影响玷污微生物引起的生物资源,它可以在干燥热带为 rainfed agroecosystems 的长期的可持续性有含意。 | Alka SINGH Mahesh Kumar SINGH Nandita GHOSHAL | 2016 | Pedosphere2016，26，2： | 3 |
| 9 | The removal of heavy metals from aqueous solutions by sawdust adsorption — removal of lead and comparison of its adsorption with copper显示文摘 | Bin Yu Y Zhang Alka Shukla Shyam S Shukla Kenneth L Dorris | 2001 | Journal of Hazardous Materials2001，，1： | 2 |
| 10 | The status of antimicrobial resistance of Helicobacter pylori in Eastern Azerbaijan, Iran: comparative study according to demographics显示文摘 | Morteza Milani Reza Ghotaslou Mohammad T. Akhi Mohammad R. Nahaei Alka Hasani Mohammad H. Somi Mandana Rafeey Yaeghob Sharifi | 2012 | Journal of Infection and Chemotherapy2012，，6： | 2 |
| 11 | Quantum chemical analysis for the formation of glycine in the interstellar medium显示文摘Glycine (C2H5NO2) was the first amino acid to be detected in space by the stardust space probe in Comet Wild2, and is used by living organisms to make proteins. We discuss three different reaction paths for the formation of glycine in interstellar space from some simpler molecules detected in the interstellar medium. The possibility of the formation of glycine in interstellar space is considered by radical-radical and radical-molecule interaction schemes using quantum chemical calculations with density functional theory at the B3LYP/6-31G (d,p) level. In the chemical pathways we discuss, a few reactions are found to be totally exothermic and barrierless while others are endothermic with a very small reaction barrier, thus giving rise to a high probability of forming glycine in interstellar space. | Amresh Singh Shivani Alka Misra Poonam Tandon | 2013 | Research in Astronomy and Astrophysics2013，13，8： | 1 |
| 12 | Dabska tumor ( Endovascular papillary angioendothelioma) of testis: a case report with brief review of literature 显示文摘 | Alka B Ritambra N Yashwant K | 2006 | Diagn Pathol2006，22，1： | 1 |
| 13 | Incidence and Risk of Intestinal and Extra-intestinal Complications in Medicaid Patients with Inflammatory Bowel Disease: A 5-Year Population-Based Study显示文摘 | Gaurav Arora Gurkirpal Singh Shweta Vadhavkar Shamita B. Shah Ajitha Mannalithara Alka Mithal George Triadafilopoulos | 2010 | Digestive Diseases and Sciences2010，，6： | 1 |
| 14 | Effect of starting composition on the synthesis of nanocrystalline TiC during milling of titanium and carbon显示文摘 | Lohse B H C alka A Wexler D | 2005 | Journal of Alloys and Compounds2005，394，12： | 1 |
| 15 | The role of sawdust in the removal of unwanted materials from water 显示文摘 | Alka shukla Yu-Hui Zhang Dubey P | 2002 | Journal of Hazardous Materials2002，95，12： | 1 |
| 16 | Paclitaxel and its formulations显示文摘 | Anil KS Alka G Deepika A | 2002 | Inter J Pharmac2002，235，1： | 1 |
| 17 | A potent systemic inhibitor of plant virus infection from Aerva sanuguinolenta Blum 显示文摘 | Verma H N & Alka Srivastava | 1985 | Current Science1985，54，5： | 1 |
| 18 | Plant regeneration of Mangifera indica using liquid shaker culture to reduce phenolic exudation显示文摘 | Raghuvanshi S S Srivastava Alka | 1995 | Plant Cell Tissue and Organ Culture1995，41，1： | 1 |
| 19 | Increase security of image from attacks using digital watermarking with SVD technique显示文摘 | ANKITA D ALKA J | 2012 | International Journal of Advanced Re- search in Computer Engineering and Technology2012，1，7： | 1 |
| 20 | Paclitaxel and its formulations显示文摘 | Anil K Singla Alka Garg Deepika Aggarwal | 2002 | Int J Pharm2002，235，17： | 1 |
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