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| 1 | Role of Akt signaling in resistance to DNA-targeted therapy显示文摘The Akt signal transduction pathway controls most hallmarks of cancer. Activation of the Akt cascade promotes a malignant phenotype and is also widely implicated in drug resistance. Therefore, the modulation of Akt activity is regarded as an attractive strategy to enhance the efficacy of cancer therapy and irradiation. This pathway consists of phosphatidylinositol 3 kinase(PI3K), mammalian target of rapamycin, and the transforming serine-threonine kinase Akt protein isoforms, also known as protein kinase B. DNA-targeted agents, such as platinum agents, taxanes, and antimetabolites, as well as radiation have had a significant impact on cancer treatment by affecting DNA replication, which is aberrantly activated in malignancies. However, the caveat is that they may also trigger the activation of repairing mechanisms, such as upstream and downstream cascade of Akt survival pathway. Thus, each target can theoretically be inhibited in view of improving the potency of conventional treatment. Akt inhibitors, e.g., MK-2206 and perifosine, or PI3K modulators, e.g., LY294002 and Wortmannin, have shown some promising results in favor of sensitizing the cancer cells to the therapy in vitro and in vivo, which have provided the rationale for incorporation of these novel agents into multimodality treatment of different malignancies. Nevertheless, despite the acceptable safety profile of some of these agents in the clinical studies, with regard to the efficacy, the results are still too preliminary. Hence, we need to wait for the upcoming data from the ongoing trials before utilizing them into the standard care of cancer patients. | Abolfazl Avan Ravi Narayan Elisa Giovannetti Godefridus J Peters | 2016 | World Journal of Clinical Oncology2016，7，5： | 12 |
| 2 | Frozen shoulder-A prospective randomized clinical trial显示文摘AIM To compare the results of arthroscopic capsular release with intra-articular steroid injections in patients of frozen shoulder.METHODS Fifty-six patients with frozen shoulder were randomised to one of two treatment groups: Group 1, complete 360 degree arthroscopic capsular release and group 2, intra-articular corticosteroid injection(40 mg methyl prednisolone acetate). Both groups were put on active and passive range of motion exercises following the intervention. The outcome parameters were visual analogue scale(VAS) score for pain, range of motion and Constant score which were measured at baseline, 4, 8, 12, 16 and 20 wk after intervention.RESULTS All the parameters improved in both the groups. The mean VAS score improved significantly more in the group 1 as compared to group 2 at 8 wk. This greater improvement was maintained at 20 wk with P value of 0.007 at 8 wk, 0.006 at 12 wk, 0.006 at 16 wk and 0.019 at 20 wk. The Constant score showed a more significant improvement in group 1 compared to group 2 at 4 wk, which was again maintained at 20 wk with P value of 0.01 at 4, 8, 12 and 16 wk. The gain in abduction movement was statistically significantly more in arthroscopy group with P value of 0.001 at 4, 8, 12, 16 wk and 0.005 at 20 wk. The gain in external rotation was statistically significantly more in arthroscopy group with P value of 0.007 at 4 wk, 0.001 at 8, 12, and 16 wk and 0.003 at 20 wk. There was no statistically significant difference in extension and internal rotation between the two groups at any time. CONCLUSION Arthroscopic capsular release provides subjective and objective improvement earlier than intra-articular steroid injection. | Rudra Narayan Mukherjee R M Pandey Hira Lal Nag Ravi Mittal | 2017 | World Journal of Orthopedics2017，8，5： | 11 |
| 3 | Bioavailability and metabolism of fucoxanthin in rats:structural characterization of metabolites by LC-MS (APCI) 显示文摘 | Ravi Kumar Sangeetha Narayan Bhaskar Sounder Divakar | 2010 | Mol Cell Biochem2010，，333： | 1 |
| 4 | Bioavailability and metabolism of fucoxanthinin rats:structural characterization of metabolites by LC- MS(APCI)显示文摘 | Ravi Kumar Sangeetha Narayan Bhaskar Sounder Divakar | 2010 | Mol Cell Biochem2010，333，： | 1 |
| 5 | Solution of Modified Bergman Minimal Blood Glucose-Insulin Model Using Caputo-Fabrizio Fractional Derivative显示文摘Diabetes is a burning issue in the whole world.It is the imbalance between body glucose and insulin.The study of this imbalance is very much needed from a research point of view.For this reason,Bergman gave an important model named-Bergman minimalmodel.In the present work,using Caputo-Fabrizio(CF)fractional derivative,we generalize Bergman’s minimal blood glucose-insulin model.Further,we modify the old model by including one more component known as diet D(t),which is also essential for the blood glucose model.We solve the modified modelwith the help of Sumudu transformand fixed-point iteration procedures.Also,using the fixed point theorem,we examine the existence and uniqueness of the results along with their numerical and graphical representation.Furthermore,the comparison between the values of parameters obtained by calculating different values of t with experimental data is also studied.Finally,we draw the graphs of G(t),X(t),I(t),andD(t)for different values ofτ.It is also clear from the obtained results and their graphical representation that the obtained results of modified Bergman’s minimal model are better than Bergman’s model. | Ravi Shanker Dubey Dumitru Baleanu Manvendra Narayan Mishra Pranay Goswami | 2021 | Computer Modeling in Engineering & Sciences2021，，9： | 0 |
| 6 | Avoiding second donor site and the second set of neck vessels in a case of absent peroneal skin perforators显示文摘This report describes the procedure of a case in which the skin paddle of the free fibula flap derived its supply solely from a soleal musculocutaneous perforator originating from the posterior tibial system.In contrast,the osteo-muscular component was supplied by the peroneal vascular system.We harvested the skin paddle with its vascular supply from the posterior tibial artery separately,and the osteo-muscular fibula was harvested with its supply from peroneal vessels.In this way,we avoided violation of the second donor site for the skin paddle.In addition,we used the distal end of peroneal vessels to salvage our skin paddle instead of sacrificing another set of neck vessels for anastomosis.This technique may also be utilised in cases where the neck vessels may not be available due to previous surgeries,radiation therapy,or decision by the surgery team to not sacrifice two sets of neck vessels for anastomosis. | Aditya Narayan Choudhary Rajan Arora Kripa Shanker Mishra Ravi Kiran Naalla Saket Srivastava Ajay Kumar Dewan | 2022 | Plastic and Aesthetic Research2022，9，1： | 0 |
| 7 | Penoscrotal defect:a functional,esthetic,and psychological challenge显示文摘Aim:Penoscrotal defects may be caused by a variety of events.Reconstruction of the penoscrotal region is required not only for aesthetic appearance but also for functional and psychological reasons.Numerous techniques have been described for penoscrotal reconstruction reflecting the challenge and complexity of the region involved.This suggests that no single method is satisfactory for all types and degrees of tissue defects.This prospective study was conducted in a tertiary care hospital in India,over a period of 5 years.Methods:Eighteen patients with penoscrotal defects of varying etiology were included in the study and underwent different surgical techniques.Age of the patients ranged from 20 to 60 years.The etiology of penoscrotal defect was Fournier’s gangrene in 12 cases,trauma in 4 cases,and burn in 2 cases.The patients with Fournier’s gangrene were initially treated by debridement,drainage,and antibiotics.The penoscrotal defects were treated with local flap advancement with skin grafting(n=7),pedicled anterolateral thigh flap(n=4),gracilis muscle flap with split skin grafting(n=4),and medial thigh flap(n=3).Results:There was complete healing in 16 patients with minor complications in the form of partial skin graft loss(n=1)and wound dehiscence(n=1).Results were highly satisfactory in 6 patients,satisfactory in 8 patients,and not satisfactory in 4 patients.Scarring at the donor site was limited and acceptable.Conclusion:The vast arsenal of options for penoscrotal defect coverage ranges from skin grafting to flaps,and every case needs a customized approach with regard to its feasibility,outcome,and complication rate.Flaps should be the preferred choice over the skin grafts because of the superior functional and aesthetic results and better compliance. | Durga Karki Pankaj Kumar Patel Ravi Prakash Narayan | 2016 | Plastic and Aesthetic Research2016，3，1： | 0 |
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