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| 1 | 膝关节粘连:治疗和预防研究新进展显示文摘背景:膝关节粘连严重影响了患者术后的日常生活,而传统的治疗方式疗效有限。降低膝关节粘连发生率是提高手术预期疗效的关键,也是临床医学上需要急待解决的重要问题。目的:对膝关节粘连的各类研究文献进行分析,总结近10年的研究成果,为防治膝关节粘连提供新的思路和方法。方法:由第一作者检索Pub Med数据库,查找2006至2016年的文献,英文检索词为'tissue adhesions,arthrofibrosis,joint stiffness,prevent,treatment',共检索到1 500余篇相关文献,59篇符合纳入标准。结果与结论:(1)近年来大量学者研究发现,创伤/手术引起膝关节出血、炎症反应,造成血管内皮细胞生长因子和白细胞介素6高表达,增加了成纤维细胞的活性,导致大量胶原蛋白沉积,发生粘连;(2)改进传统治疗方式和运用微创技术治疗膝关节粘连取得了一定的疗效,但仍存在再粘连风险;(3)关节腔内用药预防膝关节粘连在基础研究方面获得了显著成果,可成为预防膝关节粘连的一种有效方案,但临床可行性存在争议,需进一步深入研究,寻找疗效确切、不良反应小的药物。 | 吴海啸 王鹏 张超 Egiazaryan KA Ratyev AP Melnichenko SY Kuzin VV Skoroglyadov AV | 2017 | 中国组织工程研究2017，21，36： | 12 |
| 2 | Biobased polyurethanes for biomedical applications显示文摘Polyurethanes(PUs)are a major family of polymers displaying a wide spectrum of physico-chemical,mechanical and structural properties for a large range of fields.They have shown suitable for biomedical applications and are used in this domain since decades.The current variety of biomass available has extended the diversity of starting materials for the elaboration of new biobased macromolecular architectures,allowing the development of biobased PUs with advanced properties such as controlled biotic and abiotic degradation.In this frame,new tunable biomedical devices have been successfully designed.PU structures with precise tissue biomimicking can be obtained and are adequate for adhesion,proliferation and differentiation of many cell’s types.Moreover,new smart shape-memory PUs with adjustable shape-recovery properties have demonstrated promising results for biomedical applications such as wound healing.The fossil-based starting materials substitution for biomedical implants is slowly improving,nonetheless better renewable contents need to be achieved for most PUs to obtain biobased certifications.After a presentation of some PU generalities and an understanding of a biomaterial structure-biocompatibility relationship,recent developments of biobased PUs for non-implantable devices as well as short-and long-term implants are described in detail in this review and compared to more conventional PU structures. | Sophie Wendels Luc Av´erous | 2021 | Bioactive Materials2021，6，4： | 6 |
| 3 | Incretin manipulation in diabetes management显示文摘Incretin-based therapies have revolutionized the medical management of type 2 diabetes mellitus(T2DM) in the 21 st century. Glucagon-like peptide-1(GLP-1) suppresses appetite and gastric motility, and has trophic effects on pancreas, cardio-protective and renal effects. GLP-1 analogues and dipeptidyl peptidase-4 inhibitors form the incretin-based therapies. Significant reduction of hemoglobin A1 c when used as monotherapy and in combination regimens, favorable effects on body weight, and low risk of hypoglycemia are their unique therapeutic benefits. Their safety and tolerability are comparable to other anti-diabetic medications. Concern about elevated risk of pancreatitis has been discarded by two recent meta-analyses. This article discusses the therapeutic manipulation of incretin system for the management of T2 DM. | Joseph M Pappachan AV Raveendran Rajagopalan Sriraman | 2015 | World Journal of Diabetes2015，6，6： | 6 |
| 4 | 骨骼肌缺血再灌注损伤及发病机制初探显示文摘目的 探讨骨骼肌缺血再灌注损伤过程的微循环变化、组织学改变以及多肽含量变化和意义。方法 42只雄性大鼠随机分为留伴行神经组和去伴行神经组 ,建立标准骨骼肌缺血再灌注模型。采用激光多谱勒及显微放大分析系统、组织学方法以及凝胶电泳方法等观察缺血再灌注损伤变化。结果 缺血再灌注损伤后的骨骼肌微血管管径在 2 0分钟时恢复率基本达到高峰约 6 0 % ,此后为平台期 :90分钟最高峰 ,为 75 %。主干血管流速率亦在 2 0分钟基本达到上限。病理检查显示 :缺血的骨骼肌纤维呈空泡状 ,核形态增大 ,染色加深 ,红细胞严重聚集。凝胶蛋白电泳提示 :缺血骨骼肌中分子量2 0KD左右的多肽显著增加。结论 骨骼肌缺血再灌注损伤发生后 ,骨骼肌的微循环发生不同程度的破坏 ,及因之导致骨骼结构损伤和异常的 2 0KD多肽含量明显增加 ,以及红细胞凝聚 ,白细胞的改变 。 | 张俐 Seaber AV Urbaniak JR | 2001 | 中国骨伤2001，14，11： | 4 |
| 5 | 串联式三效溴化锂吸收式制冷循环热力计算分析显示文摘根据本文作者完成的溴化锂溶液热力性能计算机计算模块(应用范围0~220℃),对一种串联式三效溴化锂吸收式制冷循环进行了热力计算分析,指出其热力性能系数(COP)比双效溴化锂吸收式制冷循环高(30~40)%,其最高溶液温度高于200~220℃。 | 申江 陈天及 陈向东 基莫费也夫斯基LS 巴让尼科AV | 1998 | 流体机械1998，26，9： | 4 |
| 6 | Traditional uses,phytochemistry and pharmacology of Clerodendron glandulosum Coleb - a review显示文摘Present review for the first time provides a complete botanical description and information on ethnomcdicinal uses of Clerodendron glandulosum.Coleb(CG:Fam.Verbenaceae).Recent studies conducted from our laborator) provide pharmacological evidence for its anti-hypertensive,antidiabetic and anti-obesity potentials.Further,its beneficial potential in preventing in vitro and in vivo non-alcoholic steatohepatitis and atherosclerosis and potent hcpatoprotective and free radical scavenging abilities along with its acute and sub- chronic toxicologiesl evaluations are also reported from our laboratory.In keeping with its traditional uses,CG extract was capable of ameliorating experimentally induced hypertension,diabetes and obesity.Its beneficial potential against NASH induced oxidative stress and atherosclerosis can be attributed to its potent free radical scavenging potential.Non—toxic nature of CG leaf extract further provides added merit to its reported pharmacological properties.The present review summarizes the pioneering scientific evidence for the pharmacological effects of CG against related metabolic disorders like hypertension,diabetes and obesity along with anti oxidant potential and beneficial elicits against non alcoholic steatohepatitis. | Ravirajsinh N Jadeja Menaka C Thounaojam Thouchom Brojendro Singh Ranjitsinh V Devkar AV Ramachandran | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，1： | 3 |
| 7 | β-TCP/α-CSH复合材料骨支架在骨缺损治疗中的应用研究进展显示文摘骨缺损的治疗是骨科面临的世界性难题之一,目前公认的治疗方法是通过骨组织工程支架进行修复填充。理想的骨组织工程支架应具备生物相容性、骨传导性、骨诱导性及降解性,同时具有合适的孔径、孔隙率和机械强度。单一材料由于其理化性质的局限性,无法满足临床需要。β-磷酸三钙(β-TCP)/α-半水硫酸钙(α-CSH)复合材料骨支架由于其在生物相容性、可吸收性及机械强度等方面的优势,在体内和体外试验中都取得了一定的效果,但β-TCP/α-CSH复合材料骨支架的机械强度会随α-CSH的完全降解而消失,因此目前其临床研究主要集中在颌面和口腔领域。β-TCP/α-CSH复合材料骨支架修复骨缺损是目前临床上较有潜力的治疗方案,其联合干细胞移植可能是未来提高临床骨缺损修复率的新方向。 | 吴海啸 张超 Goryaeva GL Kuzin VV Skoroglyadov AV | 2016 | 山东医药2016，56，32： | 3 |
| 8 | 前列腺癌预防试验和非那雄胺:文献回顾显示文摘作者评价在前列腺癌预防试验(PCPT)中观察到的PSA急剧变化和高级别前列腺癌之间的联系能否解释PCPT中服用非那雄胺者高级别前列腺癌发现率高于服用安慰剂者这一现象。回顾2006年2月1日以前发表的文献和国际会议资料,从中寻求证据解释PCPT结果, | D'Amico AV 叶雄俊(摘译) 张小东(校) | 2007 | 中华泌尿外科杂志2007，28，5： | 3 |
| 9 | 基于概率和模糊模式的人机系统优化设计方法(英文)显示文摘讨论了基于概率和模糊模式设计自动化人机系统的可能性.论述了面向对象结构化设计技术.检验了对于概率和模糊模式的功效指数积分法.分析了ETS功能块的性质和可靠性.阐述了关于面向对象功能网络(OOFN)的系列 ETS最优化的通用方案.证明了必要和充分的最优化条件.通过生产系统和逻辑推理机制,提出了一种直接变量选择法. | MG格瑞夫 AV杜布罗夫斯基 YeB特索伊 | 2001 | 哈尔滨理工大学学报2001，6，5： | 2 |
| 10 | Lifetime recreational exercise activity and risk of brest carcinoma in situ显示文摘 | Patel AV Press MF Meeske K | 2003 | Cancer2003，98，10： | 2 |
| 11 | 用加倍单倍体群体研究甘蓝型油菜种子颜色和春化作用的遗传显示文摘 | Deyn.,AV 李万渠 | 1995 | 国外农学(油料作物)1995，，1： | 2 |
| 12 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 13 | Mechanisms of antineplastic action of somatostatin analogs显示文摘 | Pollak MN Schally AV | 1998 | Proc Soc Exp Biol Med1998，217，2： | 2 |
| 14 | 卡铂与顺铂的小儿临床药动学及药效学研究进展及剂量方案显示文摘卡铂与顺铂的小儿临床药动学及药效学研究进展及剂量方案彭彬BOddyAV,EnglishMW,PearsonADJ,PriceL,TilbyMJ,NewellDR英国纽卡素大学肿瘤研究所药理室,儿肿瘤科,血病研究室顺铂与卡铂是目前治疗实体瘤的有效抗癌药... | 彭彬 Bodd.,AV | 1995 | 癌症1995，14，6： | 2 |
| 15 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 16 | Inhibitory effects of antagonists of bombesin/gastrin releasing peptide ( GRP ) and somatostatin analog ( RC160) on growth of HT-29 human colon cancers in nude mice显示文摘 | Radulovic S Schally AV | 1994 | Acta oncologicd1994，33，6： | 2 |
| 17 | Inhibitory effect of bombesin gastrin releasing peptide antagonist RC-3095 and high dose of somatostatin analogue RC-160 on nitrosamine-induced pancreatic cancers in hamsters 显示文摘 | Szepeshazi K Schally AV Cai RZ | 1991 | Cancer Res1991，51，3： | 2 |
| 18 | Gastricstumpcancer: what is the risk显示文摘 | Safatle Ribeiro AV Ribeiro JU Reynolds JC | 1998 | Dig Dis1998，16，3： | 1 |
| 19 | Photoselective vaporization of the prostate for the Treatment of benign prostate hyperplasia: 12 month results from the lust United states multicenter prospective trial 显示文摘 | Te AE Malloy TR Kaisary AV | 2004 | J Urol2004，172，2： | 1 |
| 20 | The evaluation of eustachian tube function in patients with chronic otitis media显示文摘 | Yuceturk AV Unlu HH Okumus M | 1997 | Clin Otolaryngol1997，22，： | 1 |
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