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| 1 | Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms. | Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，36： | 8 |
| 2 | Deteimination and Confirmation of Melamine Residues in Catfish,Trout, Tilapia, Salmon, and Shrimp by Liquid Chromatography with Tandam Mass Spectrometry显示文摘 | Andersen W C Turnipseed S B Karbiwnyk C M | 2008 | Journal of Agricultural and Food Chemistry2008，56，12： | 1 |
| 3 | Efficacy of olanzapine and olanzapine- fluoxetine combination in the treatment of bipolar I depression显示文摘 | Andersen SW Sanger TM | 2003 | Arch Gen Psychiatry2003，6011，： | 1 |
| 4 | Axin-mediated CKI phosphorylation of beta -catenin at Set 45:a molecular switch for the Wnt pathway显示文摘 | Amit S Hatzubai A Birman Y Andersen J S Ben Shushan E Mann M | 2002 | Genes Dev2002，16，： | 1 |
| 5 | The effect of physical training in chronic heart failure显示文摘 | Andersen K Jónsdóttir S Sigurethsson AF | 2006 | Laeknabladid2006，92，11： | 1 |
| 6 | Optically stimulated luminescence dating of young estuarine sediments:a comparison with210Pb and 137Cs dating显示文摘 | Madsen A T Murray A S Andersen T J | 2005 | Marine Geology2005，214，： | 1 |
| 7 | The influence of temperature and storage time at RT on nucleation of the β' phase in a 6082 Al-Mg-Si alloys显示文摘 | Marioara C D Andersen S J Jansen J | 2003 | Acta Materialia2003，51，： | 1 |
| 8 | Importance of temperature, nitrate, and pH for phosphate release from aerobic sediments of four shal- low, eutrophic lakes 显示文摘 | Jensen H S Andersen F Q | 1992 | Limnology and Oceanography1992，37，3： | 1 |
| 9 | The prognostic value of intraepithdial and stromal CD3- , CDll7- and CD13s- positive cells in non-small cell lung carcinoma 显示文摘 | A1-Shibli K A1-Saad S Andersen S | 2010 | APMIS2010，118，5： | 1 |
| 10 | The structural relation betweenprecipitates in Al-Mg-Si alloys显示文摘 | ANDERSEN S J MARIOARA C D VISSERS R FROSETH A ZANDBERGEN H W | 2007 | Materials Science andEngineering A2007，444，： | 1 |
| 11 | Nueleolar pro- teome dynamics显示文摘 | Andersen J S Lam Y W Leung A K | 2005 | Nature2005，433，： | 1 |
| 12 | Diurnal variation of nitrogen cycling in coastal, marine sediments显示文摘 | T. K. Andersen M. H. Jensen J. S?rensen | 1984 | Marine Biology1984，，2： | 1 |
| 13 | Femtosec- ond laser-assisted cataract surgery with integrated optical coher- ence tomography显示文摘 | Palanker D V Blumenkranz M S Andersen D | 2010 | Sci Transl Med2010，2，58： | 1 |
| 14 | Movement quality and links to measures of fitness in firefighters显示文摘 | Me Gill S Frost D Andersen J | 2013 | Work2013，45，3： | 1 |
| 15 | Continuum secondary structure captures protein flexibility 显示文摘 | ANDERSEN C A F PALMER A G BRUNAK S | 2002 | Structure2002，10，2： | 1 |
| 16 | Randomised trial of endoscopic endoprosthesis versus operative bypass in malig- nant obstructive jaundice 显示文摘 | Andersen J R Sorensen S M Kruse A | 1989 | Gut1989，30，8： | 1 |
| 17 | Imagery of Denmark among Visitors to Danish Fine Arts Exhibitions in Scotland显示文摘 | Andersen R Prentice Guerin S | 1997 | Tourism Management1997，，18： | 1 |
| 18 | Investigation of a dynamic seawater intrusion event using strontium isotopes (^87Sr/^86Sr)显示文摘 | JORGENSEN N O ANDERSEN M S ENGESGAARD P | 2008 | Journal of Hydrology2008，348，： | 1 |
| 19 | Association between HLA-G genotype and risk of pre-eclampsia:a case-control study using family triads显示文摘 | Andersen AM Melbye M | 2004 | Mol Hum Reprod2004，10，4： | 1 |
| 20 | Fate of estrogens in a municipal sewage treatment plant 显示文摘 | ANDERSEN H SIEGRIST H BENT H S | 2003 | Environ Sci Technol2003，37，18： | 1 |
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