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| 1 | Midkine secretion protects Hep3B cells from cadmium induced cellular damage显示文摘AIM: To evaluate role of midkine secretion during Cadmium (Cd) exposure in the human hepatocyte cell line Hep3B cells. METHODS: Different dosages of Cd (0.5-1-5-10 μg/mL) were applied to Hep3B cells and their effects to apoptosis, lactate dehydrogenase (LDH) leakage and midkine secretion were evaluated as time dependent manner. Same experiments were repeated with exogenously applied midkine (250-5000 pg/mL) and/or 5 μg/mL Cd.RESULTS: Cd exposure induced prominent apoptosis and LDH leakage beginning from lower dosages at the 48th h. Cd induced midkine secretion with higher dosages (P < 0.001), (control, Cd 0.5-1-5-10 μg/mL respectively: 1123 ± 73, 1157 ± 63, 1242 ± 90, 1886 ± 175, 1712 ± 166 pg/mL). Exogenous 500-5000 pg/mL midkine application during 5 μg/mL Cd toxicity prevented caspase-3 activation (control, Cd toxicity, 250, 500, 1000, 2500, 5000 pg/mL midkine+ Cd toxicity, respectively: 374 ± 64, 1786 ± 156, 1545 ± 179, 1203 ± 113, 974 ± 116, 646 ± 56, 556 ± 63 cfu) LDH leakage and cell death in Hep3B cells (P < 0.001). CONCLUSION: Our results showed that midkine secretion from Hep3B cells during Cd exposure protects liver cells from Cd induced cellular damage. Midkine has anti-apoptotic and cytoprotective role during Cd toxicity. Further studies are needed to explain the mechanism of midkine secretion and cytoprotective role of midkine during Cd exposure. Midkine may be a promising theurapatic agent in different toxic hepatic diseases. | Nuray Yazihan Haluk Ataoglu Ethem Akcil Burcu Yener Bulent Salman Cengiz Aydin | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 2 | Erythropoietin attenuates hydrogen peroxide - induced damage of hepatocytes 显示文摘 | Yazihan N Ataoglu H Yener B | 2007 | Turk J Gastroenterol2007，8，4： | 1 |
| 3 | Primary renal lymphoma and xanthogranulomatous pyelonephritis in childhood显示文摘 | Karadeniz C Oguz A Ataoglu O | 2002 | J Nephrol2002，15，5： | 1 |
| 4 | Internet addiction and sleep disturbance symptoms among T urkish high school students显示文摘 | Fatih Canan Osman Yildirim Gjergji Sinani Onder Ozturk Tuba Yildirim Ustunel Ahmet Ataoglu | 2013 | Sleep and Biological Rhythms2013，，： | 1 |
| 5 | Histopathological parameters with Ki-67 andbcl-2 in the prognosis of meningiomas according to WHO 2000 clas-sification显示文摘 | Uzum N Ataoglu GA | 2008 | J Tumori2008，94，3： | 1 |
| 6 | Apoptosis:an underlying factor for accelerated periodontal disease associated with diabetes in rats 显示文摘 | Tunali M Ataoglu T Celik I | 2014 | Clin Oral Investig2014，18，7： | 1 |
| 7 | Antibacterial effect of selected root-end filling materials 显示文摘 | Eldeniz AU Hadimli HH Ataoglu H | 2006 | J Endod2006，32，： | 1 |
| 8 | Interlcukin-13, tumor ne- crosis factor-α levels and neutrophil elastase activity in peri-im- plant crevicular fluid显示文摘 | Ataoglu H Alptekin NO Haliloglu S | 2002 | Clin Oral Implants Res2002，13，5： | 1 |
| 9 | Large cavernous hemangioma of the kidney presenting as a solid renal mass显示文摘 | Gogus C Kilic S Ataoglu O | 2001 | Int Urol Nephrol2001，33，4： | 1 |
| 10 | Temporomandibular internal derangement: correlation of MRI findings with clinical symptoms of pain and joint sounds in patients with bruxing behaviour显示文摘 | Guler N Yatmaz PI Ataoglu H | 2003 | Dentomaxillofac Radiol2003，32，5： | 1 |
| 11 | An Analytical Model for Compressive Creep Behavior of HDPE Used in Plastic Pipe Manufacturing显示文摘 | S. Sezer S. Ataoglu A. N. Gulluoglu N. Kadioglu | 2008 | Polymer-Plastics Technology and Engineering2008，，12： | 1 |
| 12 | Routine antibiotic prophylaxis is not necessary during operations to remove third molars显示文摘 | Ataoglu H Oz GY Candirli C | 2008 | BrJ Oral Maxillofac Surg2008，46，2： | 1 |
| 13 | Neck circumference,metabolic syndrome and obstructive sleep apnea syndrome;evaluation of possible linkage显示文摘 | Ahbab S Ataoglu HE Tuna M | | 0，，： | 1 |
| 14 | Effects of depression and anxiety on life of patients with rheumatoid arthritis, knee osteo arthritis and fibromyalgia syndrome显示文摘 | Ozcetin A Ataoglu S Kocer E | 2007 | West Indian Med2007，56，2： | 1 |
| 15 | Vertebral osteoblastoma:are radiologic structural changes necessary for diagnosis?显示文摘 | Orbay T Ataoglu 0 Tali ET | 1999 | Sing Neurol1999，51，： | 1 |
| 16 | Procalcitonin :a novel cardiac marker with prognostic value in acute coronary syndrome 显示文摘 | Ataoglu HF Yilmaz F Uzunhasan I | 2010 | J Int Med Res2010，38，1： | 1 |
| 17 | Interleukin-1beta,tumor necrosis factor-alpha levels and neutrophil elastase activity inperi-implant crevicular fluid显示文摘 | Ataoglu H Alptekin NO Haliloglu S | 2002 | Clin Oral Implants Res2002，13，5： | 1 |
| 18 | Inflammatory fibroid polyp of the ileum causing intussusception: a case report 显示文摘 | GONUL II ERDEM O ATAOGLU O | 2004 | Turk J Gastroenterol2004，15，1： | 1 |
| 19 | The prevalence of metabolic syndrome in different ethnic groups in Turkey 显示文摘 | Kumbasar B Yenigun M Ataoglu HE | 2013 | J Int Med Res2013，41，1： | 1 |
| 20 | Eryxhropoie- tin reduces llpopolysaccharide-induced cell Damage and mid- kine secretion in U937 human histiocytic lyrnphoma cells显示文摘 | YAZIHAN N KARAKURT O ATAOGLU H | 2008 | Advances in Therapy2008，25，5： | 1 |
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