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| 1 | The breast tumor microenvironment alters the phenotype and function of natural killer cells显示文摘生来的杀手(NK ) 房间是有识别并且消除转变房间的能力的天生的有免疫力的房间。在肿瘤以内,然而,许多研究把 NK 房间描述了为非功能。联系肿瘤的 NK 房间的发展阶段并且这怎么可以联系到功能,没被探索。我们从 polyoma 中间 T 抗原(pyMT ) 检验了 NK 房间的发展状态转基因的老鼠(MMTV-pMT ) 胸肿瘤。在 pyMT 肿瘤, NK 房间是不成熟的是由他们 DX5 和他们的 CD27 低 CD11b 低 显型。这些不成熟的 NK 房间也增加了 NKG2A 的表示并且表示了 NKp46, perforin,和 granzyme B 的底层。相反,从一样的老鼠孤立的脾的 NK 房间维持了他们的成熟和他们激活标记的表示。描出肿瘤微型环境是否直接改变 NK 房间,我们采纳地转移了标记的 NK 房间并且在怒气和肿瘤跟随了他们的激活地位。到达了肿瘤的 NK 房间与到达了怒气的那些相比在三天转移以内有 NKp46 的半表示。以修改肿瘤微型环境并且估计 intratumoral NK 房间的粘性,我们与 IL-12 和 anti-TGF-β 治疗了 pyMT 肿瘤;。在一星期处理以后,联系肿瘤的 NK 房间的成熟被增加;因此,显示这些房间拥有能力成熟并且变得激活。NK 房间怎么被肿瘤微型环境修改的更好的理解将帮助开发策略的 A 瞄准了对肿瘤支持有免疫力的回答。 | Tamara Krnetal Amy Gillgrass Marianne Chew Ali A. Ashkar | 2016 | Cellular & Molecular Immunology2016，13，5： | 7 |
| 2 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 3 | Humanized mice are susceptible to Salmonella typhi infection显示文摘Salmonella enterica serovar Typhi is a pathogen that only infects humans.Currently,there is no animal model for studying this pathogen.Recently,alymphoid RAG2^(-/-)/γc^(-/-) mice engrafted with human leukocytes,known as humanized mice,have been successfully utilized to develop experimental models for several human-specific viral infections,including HIV,human-like dengue fever and hepatitis C virus.Little is known about the usefulness and feasibility of the humanized mouse model for the study of human-specific bacterial pathogens,such as S.typhi.The aim of this study was to determine if Salmonella enterica serovar Typhi could establish productive infection in humanized mice.Here we report that intravenous inoculation of S.typhi into humanized mice,but not controls,established S.typhi infections.High bacterial loads were found in the liver,spleen,blood and bone marrow of mice reconstituted with human leukocytes,but not in the unreconstituted control mice.Importantly,S.typhi-infected humanized mice lost significant body weight,and some of the infected mice displayed neurological symptoms.Our data suggest,for the first time,that humanized mice are susceptible to S.typhi challenge and that this model can be utilized to study the pathogenesis of S.typhito develop novel therapeutic strategies. | M Firoz Mian Elisabeth A Pek Meghan J Chenoweth Ali A Ashkar | 2011 | Cellular & Molecular Immunology2011，8，1： | 2 |
| 4 | Assessment of requirements for IL-15 and IFN-'y regulatory factors in uterine NK cell differenti- ation and function during pregnancy 显示文摘 | Ashkar AA Black GP Wei Q | 2003 | J hnmunol2003，7，6： | 1 |
| 5 | Laparoscopic cholecystectomy and the umbilicus显示文摘 | Nassar AH Ashkar KA Rashed AA | 1997 | British Journal of Surgery1997，，05： | 1 |
| 6 | Receptor-Iigand interaction between CD44 and osteopontin (Eta-1)显示文摘 | Weber G F Ashkar S Glimcher M J | 1996 | Science1996，2，5248： | 1 |
| 7 | Toll - like receptor 9, CpG DNA and innate immunity 显示文摘 | ASHKAR A A ROSENTHAL K L | | Curr Mol Med0，2，6： | 1 |
| 8 | Eta-I ( osteopon- tin): an early component of type-1 (cell-mediated) immunity 显示文摘 | Ashkar S Weber GF Panoutsakopoulou V | 2000 | Science2000，287，5454： | 1 |
| 9 | Receptor ligand interaction between CD44 and osteopontin (Eta-1) 显示文摘 | Weber GF Ashkar S Olimcher MJ | 1996 | Science1996，271，5248： | 1 |
| 10 | Laparoscopic cholecystectomy and the umbilicus显示文摘 | Nassar AH Ashkar KA Rashed AA | 1997 | Br J Surg1997，84，5： | 1 |
| 11 | Partial duration series modeling under the assumption of a poissonian flood count显示文摘 | Ashkar F Rousselle J | 1987 | Journal of Hydrology1987，，90： | 1 |
| 12 | Eta--1 (osteo- ponln) : an early component of type--1 (cell--mediated) immunity 显示文摘 | Ashkar S Weber GF Panoutsakoppulou V | 2000 | Science2000，287，5454： | 1 |
| 13 | A bivariate analysis of the volume and duration of low-flow events显示文摘 | Ashkar F Jabi N EI Issa M | 1998 | Stochastic Hydrology and Hydraulics1998，12，： | 1 |
| 14 | Receptor-ligand inter- action between CD44 and osteopontin (Eta-1) 显示文摘 | Weber GF Ashkar S Glimcher MJ | 1996 | Science1996，271，5248： | 1 |
| 15 | Enrichment of Y Chromosome Bearing Bull Spermatozoa by Swim-up Through a Column显示文摘 | A Azizeddin FA Ashkar WA King | 2014 | Reprod Dom Anim2014，49，： | 1 |
| 16 | The effect of low-level laser therapy during orthodontic movement:a preliminary study显示文摘 | Youssef M Ashkar S Hamade E | 2008 | Lasers Med Sci2008，23，1： | 1 |
| 17 | Eta-1 ( Osteopontin ) : an early component of type-1( cell-mediated ) immunity 显示文摘 | Ashkar S Weber GF Panoutsakopoulou V | 2000 | Science2000，287，5454： | 1 |
| 18 | Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy显示文摘 | Ashkar AA Black GP Wei Q | 2003 | J Immunol2003，171，6： | 1 |
| 19 | Decidual natural killer cells: key regulators of placental development (a review)显示文摘 | B.Anne Croy Sirirak Chantakru Souad Esadeg Ali A Ashkar Qingxia Wei | 2002 | Journal of Reproductive Immunology2002，，1： | 1 |
| 20 | A Interleukin-15 expression affects homeostasis and function of B cells through NK cell-derived interferon-gamma显示文摘 | GILL N PALTSER G ASHKAR A | 2009 | Cell Immunol2009，258，1： | 1 |
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