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| 1 | Chimeric antigen receptor (CAR)-transduced natura killer cells in tumor immunotherapy显示文摘生来的杀手(NK ) 房间是在基于房间的癌症免疫疗法的潜在的受动器房间,特别地在 hematological 恶意的控制。妄想的抗原受体(汽车) 是由熔化到一个细胞内部的发信号领域的一个细胞外的抗原识别领域组成的人工地修改的熔化蛋白质。遗传上与一辆汽车修改的 T 房间在 hematological 癌症的治疗表明了显著成功。把房间比作 T, CAR-transduced NK 房间(CAR-NK ) 展览几优点例如在临床的使用的安全,他们由认出癌症房间的机制,和他们在临床的样品的丰富。人的主要 NK 房间和 NK-92 房间线是成功地在现出症状之前的潜、临床的试用对 hematological 癌症和稳固的肿瘤表示汽车的 transduced。然而,许多挑战和障碍留下,例如修改汽车的主要 NK 房间的前 vivo 扩大和 NK 房间的低 transduction 效率。许多策略和技术被开发了在基于汽车的免疫疗法改进安全和治疗学的功效。而且, NK 房间表示许多激活的受体(NKR ) 例如 CD16, NKG2D, CD226 和 NKp30,它可能明确地认出在肿瘤房间上表示的 ligands。基于 NKR 识别的原则,指向 NKR 的策略很快正在出现。给在基于房间的免疫疗法多半为癌症治疗正在答应新策略的这评论, CAR-NK 和 NKR-NK 描述的有希望的临床的进步。 | Yuan HU Zhi-gang TIAN Cai ZHANG | 2018 | Acta Pharmacologica Sinica2018，39，2： | 34 |
| 2 | Tumor immunotherapy: New aspects of natural killer cells显示文摘A group of impressive immunotherapies for cancer treatment, including immune checkpoint-blocking antibodies,gene therapy and immune cell adoptive cellular immunotherapy, have been established, providing new weapons to fight cancer. Natural killer(NK) cells are a component of the first line of defense against tumors and virus infections. Studies have shown dysfunctional NK cells in patients with cancer. Thus, restoring NK cell antitumor functionality could be a promising therapeutic strategy. NK cells that are activated and expanded ex vivo can supplement malfunctional NK cells in tumor patients. Therapeutic antibodies, chimeric antigen receptor(CAR), or bispecific proteins can all retarget NK cells precisely to tumor cells. Therapeutic antibody blockade of the immune checkpoints of NK cells has been suggested to overcome the immunosuppressive signals delivered to NK cells.Oncolytic virotherapy provokes antitumor activity of NK cells by triggering antiviral immune responses. Herein,we review the current immunotherapeutic approaches employed to restore NK cell antitumor functionality for the treatment of cancer. | Yangxi Li Rui Sun | 2018 | Chinese Journal of Cancer Research2018，30，2： | 13 |
| 3 | The pathogenic role of innate lymphoid cells in autoimmune-related and inflammatory skin diseases显示文摘Innate lymphoid cells(ILCs),as an important component of the innate immune system,arise from a common lymphoid progenitor and are located in mucosal barriers and various tissues,including the intestine,skin,lung,and adipose tissue.ILCs are heterogeneous subsets of lymphocytes that have emerging roles in orchestrating immune response and contribute to maintain metabolic homeostasis and regulate tissue inflammation.Currently,more details about the pathways for the development and differentiation of ILCs have largely been elucidated,and cytokine secretion and downstream immune cell responses in disease pathogenesis have been reported.Recent research has identified that several distinct subsets of ILCs at skin barriers are involved in the complex regulatory network in local immunity,potentiating adaptive immunity and the inflammatory response.Of note,additional studies that assess the effects of ILCs are required to better define how ILCs regulate their development and functions and how they interact with other immune cells in autoimmune-related and inflammatory skin disorders.In this review,we will distill recent research progress in ILC biology,abnormal functions and potential pathogenic mechanisms in autoimmune-related skin diseases,including systemic lupus erythematosus(SLE),scleroderma and inflammatory diseases,as well as psoriasis and atopic dermatitis(AD),thereby giving a comprehensive review of the diversity and plasticity of ILCs and their unique functions in disease conditions with the aim to provide new insights into molecular diagnosis and suggest potential value in immunotherapy. | Suqing Zhou Qianwen Li Haijing Wu Qianjin Lu | 2020 | Cellular & Molecular Immunology2020，17，4： | 2 |
| 4 | Shining light on the significance of NK cell CD56 brightness显示文摘CD56 is a fundamental marker in the determination of human natural killer(NK)cell subsets.The degree of CD56 expression is ubiquitously used to define human NK cell maturation,functional,and tissue-specific subsets,yet a unifying implication for the degree of CD56 expression in NK cells remains elusive.Peripheral blood(PB)-NK cells are dichotomized into CD56bright,which highly express CD56,and CD56dim,which have lower CD56 expression.Classically,CD56bright NK cells are considered to be a less mature,immunoregulatory subset with a greater propensity for cytokine production,whereas CD56dim are more mature with greater cytotoxic abilities.While PB-NK cells are primarily CD56dim with only a minor CD56bright population,NK cells in secondary lymphoid and other tissues are predominantly CD56bright.1 It has been shown that the interaction of CD56 with human fibroblast cells can promote the differentiation of CD56bright to CD56dim NK cells.2 However,considering the importance and the extent of use of this marker in NK cell biology,relatively little is known about how downregulation of CD56 contributes to NK cell maturation,what role the degree of CD56 expression plays in contexts separate from NK cell maturation,and whether CD56 has an active functional role in mature NK cells. | Sophie M.Poznanski Ali A.Ashkar | 2018 | Cellular & Molecular Immunology2018，15，12： | 1 |
| 5 | 肿瘤相关抑制性细胞在肿瘤发生发展中的作用显示文摘由于物理、化学、生物、遗传等多种因素导致机体发生肿瘤时,机体会启动固有免疫应答及适应性免疫应答去杀伤肿瘤细胞,清除异己。肿瘤细胞一方面通过改变自身抗原使机体免疫细胞无法识别,另一方面通过激活肿瘤相关抑制性细胞削弱机体的抗肿瘤免疫。 | 蒋白丽 冯建明 | 2017 | 中国现代医药杂志2017，19，4： | 1 |
| 6 | 瞬时受体电位通道M8调控NCR1/NKP46通路抑制胶质瘤细胞免疫逃逸的作用研究显示文摘目的:探讨瞬时受体电位通道M8(TRPM8)对胶质瘤细胞免疫逃逸的影响,并初步探究可能的作用机制。方法:通过实时荧光定量PCR法检测人正常胶质细胞株(SVGp12)与3种胶质瘤细胞株(U251、U373、T98G)中TRPM8基因表达;将U251细胞随机分为空白对照组、TRPM8-siRNA组、NC-siRNA组、pcDNA3.1-TRPM8组和pcDNA3.1-NC组,利用脂质体分别将TRPM8-siRNA、NC-siRNA、pcDNA3.1-TRPM8和pcDNA3.1-NC转染至U251细胞中,采用实时荧光定量PCR法和Western blot检测细胞中TRPM8基因和蛋白表达,CCK-8法、集落形成实验和流式细胞术检测细胞增殖、克隆形成及凋亡情况,乳酸脱氢酶(LDH)释放法检测NK92细胞对U251细胞的杀伤作用,ELISA法检测TNF-α、IL-2、IL-6、IFN-γ水平,流式细胞术、Western blot检测细胞调节区域因子1(NCR1)与自然杀伤因子蛋白46(NKP46)的表达。结果:3种胶质瘤细胞株U251、U373、T98G中TRPM8 mRNA表达水平均显著高于正常胶质细胞株SVGp12,其中U251细胞最高;与空白对照组相比,TRPM8-siRNA组TRPM8 mRNA和蛋白的相对表达量均下调(P<0.01),细胞活性下降(P<0.05),细胞克隆形成数目减少(P<0.01),细胞凋亡率升高(P<0.01),NK92细胞对U251细胞的杀伤率提高(P<0.01),细胞上清液中TNF-α、IL-2、IL-6及IFN-γ水平均下降(P<0.01),同时,NCR1、NKP46表达也明显增加(P<0.01);与空白对照组相比,pcDNA3.1-TRPM8组TRPM8 mRNA和蛋白的相对表达量均上调(P<0.01),细胞活性升高(P<0.05),细胞克隆形成数目增加而凋亡率下降(P<0.01),NK92细胞对U251细胞的杀伤率下降(P<0.01),细胞上清液中TNF-α、IL-2、IL-6及IFN-γ水平均升高(P<0.01),NCR1、NKP46表达减少(P<0.01)。结论:抑制TRPM8表达能够调控胶质瘤微环境中免疫抑制状态,增强NK92细胞杀伤U251细胞的能力,削弱肿瘤细胞的免疫逃逸能力,这可能与调控NCR1/NKP46通路相关。 | 徐华 张海萍 王虹伊 杨苗 赵钦 马蕾 | 2023 | 中国免疫学杂志2023，39，9： | 0 |
| 7 | 肿瘤微环境中巨噬细胞对NK细胞的调控作用显示文摘自然杀伤(NK)细胞具有MHCⅠ非依赖性,无需抗原呈递细胞刺激,就能直接杀伤肿瘤细胞,在抗肿瘤免疫过程中发挥重要的作用。但NK细胞所处的局部微环境以及细胞间的相互作用影响肿瘤部位NK细胞的增殖、成熟、效应分子分泌和功能。巨噬细胞是肿瘤组织中占比最大的一类细胞群体,巨噬细胞与NK细胞间的相互作用在抗肿瘤免疫中至关重要。本综述详细阐述了肿瘤组织中巨噬细胞对NK细胞的调控作用,以期为重编程巨噬细胞表型恢复NK细胞抗肿瘤免疫能力及开发NK细胞免疫疗法提供更多思路。 | 朱志超 何流漾 戚春建 | 2023 | 中国免疫学杂志2023，39，4： | 0 |
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