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| 1 | Natural killer cell-triggered vascular transformation:maternal care before birth?显示文摘Natural killer(NK)cells are found in lymphoid and non-lymphoid organs.In addition to important roles in immune surveillance,some NK cells contribute to angiogenesis and circulatory regulation.The uterus of early pregnancy is a non-lymphoid organ enriched in NK cells that are specifically recruited to placental attachment sites.In species with invasive hemochorial placentation,these uterine natural killer(uNK)cells,via secretion of cytokines,chemokines,mucins,enzymes and angiogenic growth factors,contribute to the physiological change of mesometrial endometrium into the unique stromal environment called decidua basalis.In humans,uNK cells have the phenotype CD56^(bright) CD16^(dim) and they appear in great abundance in the late secretory phase of the menstrual cycle and early pregnancy.Gene expression studies indicate that CD56^(bright) CD16^(dim) uterine and circulating cells are functionally distinct.In humans but not mice or other species with post-implantation decidualization,uNK cells may contribute to blastocyst implantation and are of interest as therapeutic targets in female infertility.Histological and genetic studies in mice first identified triggering of the process of gestation spiral arterial modification as a major uNK cell function,achieved via interferon(IFN)-c secretion.During spiral arterial modification,branches from the uterine artery that traverse the endometrium/decidua transiently lose their muscular coat and ability to vasoconstrict.The expression of vascular markers changes from arterial to venous as these vessels dilate and become low-resistance,high-volume channels.Full understanding of the vascular interactions of human uNK cells is difficult to obtain because endometrial time-course studies are not possible in pregnant women.Here we briefly review key information concerning uNK cell functions from studies in rodents,summarize highlights concerning human uNK cells and describe our preliminary studies on development of a humanized,pregnant mouse model for in vivo investigations of human uNK cell functions. | Jianhong Zhang Zhilin Chen Graeme N Smith B.Anne Croy | 2011 | Cellular & Molecular Immunology2011，8，1： | 19 |
| 2 | Leukocyte driven-decidual angiogenesis in early.pregnancy显示文摘成功的怀孕并且长期,出生后母亲并且后代心脏、脉管、新陈代谢的健康在怀孕期上要求关键母亲的心血管的改编。在怀孕 decidualizing 子宫以内,协调了脉管,免疫学的和 stromal 房间变化发生。可观的注意在开始蜕膜的螺线被给了房间到子宫的生来的杀手(uNK ) 的角色动脉的改变,通常完成由的一个过程在老鼠并且在人中间怀孕期。然而,白血球角色在早得多,区域特定,蜕膜的脉管的改变现在正在被定义。对免疫者的兴趣支持房间的脉管的改变被在象不孕,周期性的自发的流产, preeclampsia (PE ) 和胎儿的生长限制那样的人的 gestational 复杂并发症被报导的脉管的错误驾驶。适当母亲的心血管的回答在怀孕期间保护母亲和他们的孩子免受以后的心血管的疾病风险举起的伤害。对在有 hemochorial 胎座式的种类的怀孕的最早子宫的回答之一是 stromal 细胞 decidualization,它为 angiogenesis 和白血球招募创造唯一的壁龛。在早蜕膜 basalis,将抱发展中的胎盘并且提供主要的血容器支持成熟胎盘的功能的培植地点的方面,白血球极大地被充实并且显示专业化性质。UNK 房间,在早蜕膜 basalis 的最丰富的白血球子集,有 angiogenic 能力并且为正常早蜕膜的 angiogenesis 是必要的。在决定的 uNK 房间和他们的角色的规定母亲并且子孙在怀孕上的心血管的健康并且产后被讨论。 | Patricia DA Lima Jianhong Zhang Caroline Dunk Stephen J Lye B Anne Croy | 2014 | Cellular & Molecular Immunology2014，11，6： | 8 |
| 3 | Ly49 receptors activate angiogenic mouse DBA+ uterine natural killer cells显示文摘 | Patricia DA Lima Megan M Tu Mir Munir A Rahim Annie R Peng B Anne Croy Andrew P Makrigiannis | 2014 | Cellular & Molecular Immunology2014，11，5： | 3 |
| 4 | Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression显示文摘 | Negoias S Croy I Gerber J eta1 | 2010 | Neuroscience2010，169，1： | 1 |
| 5 | Uterine natural killer cells: insights into lineage relationships and functions from studies of pregnancies in mutant and transgenic mice显示文摘 | Croy BA Luross JA Guimond M | 1996 | Nature Immunity1996，15，1： | 1 |
| 6 | Antimicrobial drug-resistant Escherichia coli from humans and poultry products, Minnesota and Wisconsin, 2002- 2004显示文摘 | Johnson JR Sannes MR Croy C | 2007 | Emerg Infect Dis2007，13，6： | 1 |
| 7 | Carbon Monoxide Promotes Proliferation of Uterine Natural Killer Cells and Remodeling of Spiral Arteries in Pregnant Hypertensive Heme Oxygenase-1 Mutant Mice显示文摘 | Nadja Linzke Anne Schumacher Katja Woidacki B. Anne Croy Ana C. Zenclussen | 2014 | Hypertension2014，，： | 1 |
| 8 | Antimicrobial drug-resistant Escherichia coli from humans and poultry products, minnesota and wisconsin,2002-2004 显示文摘 | JOHNSON J R SANNES M R CROY C | 2007 | Emerg Infect Dis2007，13，6： | 1 |
| 9 | A review of the natural killer cell lineage in the uterus of the mouse and of the pig 显示文摘 | Croy BA Yu ZM King GJ | 1994 | J Anim Sci1994，723，： | 1 |
| 10 | The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells显示文摘 | Obeilies NH Croy VL harrison ML | 1997 | Cancer Lett1997，115，1： | 1 |
| 11 | Two apolipoprotein E mimetic peptides, ApoE (130-149) and ApoE (141-155) 2, bind to LRPI显示文摘 | Croy JE Brandon T Komives EA | 2004 | Biochemistry2004，43，23： | 1 |
| 12 | On the Influence of Freight Trains on Humans: A Laboratory Investigation of the Impact of Nocturnal Low Frequency Vibration and Noise on Sleep and Heart Rate显示文摘 | Smith M G Croy L Ogren M | 2013 | Plos One2013，8，55： | 1 |
| 13 | A Review of Trafficking and Activation of Uterine Natural Killer Cells显示文摘 | Marianne J.Heuvel XuemeiXie ChandrakantTayade CrystalPeralta YuanFang SeanLeonard Valdemar A.Paffaro Abdol K.Sheikhi CoralMurrant BarbaraAnne Croy | 2005 | American Journal of Reproductive Immunology2005，，6： | 1 |
| 14 | Social Media in Destination Choice: Distinctive Electronic Word-of-Mouth Dimensions显示文摘 | Aaron Tham Glen Croy Judith Mair | 2013 | Journal of Travel & Tourism Marketing (-)2013，，1： | 1 |
| 15 | Visual tracking in complex scenes through pixel-wise tri-modeling 显示文摘 | YI K M JEONC H LEE B CRoI J Y | 2015 | Machine Vision and Applications2015，，： | 1 |
| 16 | Countering the Voltage Decay in High Capacity xLi2MnO3 ~ (l-x) LiMO2 Electrodes ( M = Mn, Ni, Co) for Li~ ion Batteries 显示文摘 | Jason R Croy Donghan Kim Mahalingam Balasubramanian | 2012 | Journal of The Electrochemical Society2012，159，6： | 1 |
| 17 | Decidual natural killer cells: key regulators of placental development (a review)显示文摘 | B.Anne Croy Sirirak Chantakru Souad Esadeg Ali A Ashkar Qingxia Wei | 2002 | Journal of Reproductive Immunology2002，，1： | 1 |
| 18 | Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy显示文摘 | Ashkar AA Di Santo JP Croy BA | 2000 | J Exp Med2000，192，2： | 1 |
| 19 | Update on pathways regulating the activation of uterine natural killer cells,their interactions with decidual spiral arteries and homing of their precursors to the uterus显示文摘 | Croy BA Esadeg S Chantakru S | 2003 | J Reprod Immunol2003，59，2： | 1 |
| 20 | Uterine natural killer cells: in?sights into their cellular and molecular biology from mouse mod?elling显示文摘 | Croy BA He H Esadeg S | 2003 | Reproduction2003，126，2： | 1 |
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