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| 1 | Impact of poly chlorinated biphenyl (Aroclor 1254) and vitamin C on antioxidant system of rat ventral prostate显示文摘Aim:To evaluate the effect of polychlorinated biphenyls (PCB) and vitamin C on ventral prostatic antioxidant system in adult male rats.Methods:A group of 20 adult male rats were administered ip Aroclor 1254 in corn oil at a dose of 2 mg.kg^-1·day^-1 for 30 days.Ten control rats were administered only the vehicle.After 30 days the treated rats were divided at random into 2 sub-groups of 10 animals each.One sub-group received vitamin C at a dose of 500 mg.kg^-1·day^-1 for 10 days.The other group was maintained as Aroclor 1254 control.Twenty-four hours after the last treatment the rats were killed by decapitation.Ventral prostatic homogenate was prepared and used for the estimation of enzymatic antioxidants,including superoxide dismutase (SOD),catalase (CAT) and glutathione-S-transferase (GST) and hydrogen peroxide (H2O2),lipid peroxidation (LPO) and prostatic acid phosphatase.The serum levels of total T3,total T4,TSH,testosterone and estradiol were also assayed.Results:The body weight and ventral prostatic weight were reduced in PCB treated rats.The activities of SOD,CAT,GST and acid phosphatase were decreased while the levels of H2O2 and lipid peroxidation were increased in the ventral prostate of PCB treated rats.Administration of vitamin C restored these parameters.Serum levels of thyroid hormones,estradiol and testosteron ewere decreased in PCB treated animals.Administration of vitamin C restored the thyroid hormone levels.Conclusion:PCB induces oxidative stress and decreases the antioxidant enzymes in the ventral prostate of adult male rats;the effects could be reversed by the administration of vitamin C.(Asian J Androl 2004 Mar;6:19-22) | M. Sridhar P. Venkataraman S. Dhanammal A. Arunkumar M.M. Aruldhas N. Srinivasan J. Arunakaran | 2004 | Asian Journal of Andrology2004，6，1： | 5 |
| 2 | Alternative splicing enhances transcriptome complexity in desiccating seeds显示文摘Before being dispersed in the environment, mature seeds need to be dehydrated. The survival of seeds after dispersal depends on their low hydration in combination with high desiccation tolerance. These characteristics are established during seed maturation. Some key seed maturation genes have been reported to be regulated by alternative splicing(AS). However, so far AS was described only for single genes and a comprehensive analysis of AS during seed maturation has been lacking. We investigated gene expression and AS during Arabidopsis thaliana seed development at a global level, before and after desiccation. Bioinformatics tools were developed to identify differentially spliced regions within genes. Our data suggest the importance and shows the peculiar features of AS during seed desiccation. We identified AS in 34% of genes that are expressed at both timepoints before and after desiccation. Most of these AStranscript variants had not been found before in other tissues.Among the AS genes some seed master regulators could be found. Interestingly, 6% of all expressed transcripts were not transcriptionally regulated during desiccation, but only modified by AS. We propose that AS should be more routinely taken into account in the analysis of transcriptomic data to prevent overlooking potentially important regulators. | Arunkumar Srinivasan Jose M. Jimenez-Gomez Fabio Fornara Wim J. J. Soppe Vittoria Brambilla | 2016 | Journal of Integrative Plant Biology2016，58，12： | 2 |
| 3 | Garlic Compound, Diallyl Disulfide Induces Cell Cycle Arrest in Prostate Cancer Cell Line PC-3显示文摘 | Arumugam Arunkumar Marati Radhakrishnan Vijayababu Narasimman Srinivasan Maria Michael Aruldhas Jagedeesan Arunakaran | 2006 | Molecular and Cellular Biochemistry (-)2006，，1： | 1 |
| 4 | Garlic compound, diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC-3 显示文摘 | Arunkumar A Vijayababu MR Srinivasan N | 2006 | Mol Cell Biochem2006，288，12： | 1 |
| 5 | Garlic compound, diallyl disulfide induces cell cycle ar-rest in prostate cancer cell line PC-3显示文摘 | Arunkumar A Vijayababu MR Srinivasan N | 2006 | Mol Cell Bio-chem2006，288，12： | 1 |
| 6 | Garlic compound,diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC-3显示文摘 | Arunkumar A Vijayababu M R Srinivasan N | 2006 | Mol Cell Biochem2006，288，12： | 1 |
| 7 | Garlic compound, diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC - 3显示文摘 | Arunkumar A Vijayababu MR Srinivasan N | 2006 | Mol Cell Biochem2006，288，12： | 1 |
| 8 | Garlic compound,diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC-3显示文摘 | Arunkumar A Vijayababu MR Srinivasan N | 2006 | Mol Cell Biochem2006，288，12： | 1 |
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